Gene: Duoxa2

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Name
dual oxidase maturation factor 2
MGI ID
MGI:1914061
Synonyms
9030623N16Rik Nip2
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased KLRG1-positive NK cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal bone structure Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased bone mineral density Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.59×10-11
abnormal thoracic cage shape Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.58×10-15
decreased erythrocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.15×10-23
decreased grip strength Duoxa2tm1b(KOMP)Wtsi HOM Early adult 8.42×10-15
absent pinna reflex Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.97×10-18
long snout Duoxa2tm1b(KOMP)Wtsi HOM Early adult 8.79×10-12
increased mean corpuscular hemoglobin Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-38
abnormal joint morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.80×10-16
increased mean corpuscular hemoglobin concentration Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.53×10-05
abnormal ulna morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.06×10-17
abnormal radius morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.12×10-16
prenatal lethality prior to heart atrial septation Duoxa2tm1b(KOMP)Wtsi HOM E15.5 0.00
decreased caudal vertebrae number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.60×10-06
decreased hematocrit Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.31×10-10
increased CD4-positive, alpha beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
increased or absent threshold for auditory brainstem response Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal head morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 8.15×10-06
increased alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal humerus morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.72×10-18
decreased NK T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 7.10×10-05
decreased total body fat amount Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.37×10-11
increased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.80×10-05
increased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.70×10-06
decreased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.39×10-16
decreased bone mineral content Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.42×10-15
decreased hemoglobin content Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.30×10-07
abnormal tibia morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.38×10-19
abnormal vertebral arch morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.40×10-19
decreased mean platelet volume Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.30×10-08
decreased mature B cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
increased neutrophil cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.05×10-05
thrombocytopenia Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.00×10-05
decreased heart weight Duoxa2tm1b(KOMP)Wtsi HOM Early adult 8.30×10-11
decreased NK cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.48×10-05
decreased red blood cell distribution width Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.49×10-09
sparse hair Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.00×10-07
increased T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased Ly6C low monocyte number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 9.00×10-07
abnormal cranium morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.28×10-12
abnormal zygomatic bone morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.40×10-19
abnormal vertebrae morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.94×10-10
abnormal eyelid morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.28×10-07
decreased B cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased body length Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased leukocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.76×10-14
abnormal clavicle morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.38×10-19
abnormal snout morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.40×10-10
abnormal iris morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.95×10-05
abnormal femur morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.06×10-17

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
42 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
28 Images
Eye Morphology: Images Slit Lamp
2 Images
DSS Histology
8 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
31 Images
Spleen Immunophenotyping: Images associated with FACS analysis
114 Images
Bone marrow immunophenotyping: Images associated with FACS analysis
10 Images
Legacy Phenotype Associated Images

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View all 24 images

 Disease Models

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MGI Allele Allele Type Produced
Duoxa2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Duoxa2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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