Gene: Duoxa2

Name
dual oxidase maturation factor 2
MGI ID
MGI:1914061
Synonyms
9030623N16Rik Nip2
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.52×10-06
increased or absent threshold for auditory brainstem response Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased heart weight Duoxa2tm1b(KOMP)Wtsi HOM postnatal 5.54×10-11
decreased NK cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.58×10-05
decreased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM postnatal 5.89×10-16
decreased follicular B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased Ly6C low monocyte number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.00×10-06
decreased transitional stage T1 B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal vertebral arch morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.62×10-19
abnormal tibia morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.67×10-19
decreased CD11b-high dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased total body fat amount Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.13×10-10
absent pinna reflex Duoxa2tm1b(KOMP)Wtsi HOM postnatal 4.56×10-18
decreased NK T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 6.82×10-05
increased T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased plasmacytoid dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal radius morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.21×10-16
decreased bone mineral content Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.27×10-15
increased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.75×10-05
decreased immature B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal ulna morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 4.40×10-17
decreased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal bone structure Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal head morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.04×10-05
increased CD4-positive, alpha beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased caudal vertebrae number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.20×10-06
decreased mature B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased erythrocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 6.03×10-22
decreased grip strength Duoxa2tm1b(KOMP)Wtsi HOM postnatal 8.99×10-15
decreased mean platelet volume Duoxa2tm1b(KOMP)Wtsi HOM postnatal 5.04×10-08
thrombocytopenia Duoxa2tm1b(KOMP)Wtsi HOM postnatal 8.34×10-05
increased mean corpuscular hemoglobin Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.43×10-37
abnormal humerus morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.89×10-18
decreased leukocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.31×10-13
abnormal joint morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 6.30×10-16
abnormal clavicle morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.67×10-19
increased mean corpuscular hemoglobin concentration Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.80×10-05
decreased hemoglobin content Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.39×10-07
increased effector memory CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased effector memory T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased hematocrit Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.24×10-09
abnormal eyelid morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.32×10-07
decreased memory-marker gamma-delta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
increased neutrophil cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.42×10-05
decreased B-2 B cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased red blood cell distribution width Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.14×10-09
abnormal femur morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 4.40×10-17
abnormal snout morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.01×10-11
increased CD8-positive, naive alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal hair growth Duoxa2tm1b(KOMP)Wtsi HOM postnatal 6.64×10-07
abnormal vertebrae morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.56×10-10
decreased KLRG1-positive NK cell number Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal thoracic cage shape Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.17×10-14
abnormal zygomatic bone morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.63×10-19
abnormal cranium morphology Duoxa2tm1b(KOMP)Wtsi HOM postnatal 3.02×10-12
decreased food intake Duoxa2tm1b(KOMP)Wtsi HOM postnatal 2.60×10-08
decreased body length Duoxa2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased bone mineral density Duoxa2tm1b(KOMP)Wtsi HOM postnatal 1.54×10-11

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
31 Images
Spleen Immunophenotyping: Images associated with FACS analysis
114 Images
Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
Bone marrow immunophenotyping: Images associated with FACS analysis
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Dorso Ventral
42 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Lateral Orientation
28 Images
X-ray: XRay Images Forepaw
14 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Duoxa2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Duoxa2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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