Gene: Duoxa2

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Name
dual oxidase maturation factor 2
MGI ID
MGI:1914061
Synonyms
9030623N16Rik Nip2
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased follicular B cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased mature B cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal tibia morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.18×10-19
abnormal vertebral arch morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.14×10-19
decreased mean platelet volume Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 4.65×10-06
increased circulating fructosamine level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.66×10-22
decreased CD11b-high dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased circulating calcium level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.85×10-13
abnormal femur morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.82×10-17
abnormal snout morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.11×10-12
increased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 2.32×10-05
abnormal auditory brainstem response Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 5.10×10-12
increased blood urea nitrogen level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.53×10-06
increased circulating iron level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 7.54×10-18
increased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.30×10-19
increased alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased circulating LDL cholesterol level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal ulna morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.82×10-17
increased CD4-positive, alpha beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal eyelid morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.16×10-07
increased circulating serum albumin level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.20×10-22
absent pinna reflex Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.05×10-18
abnormal head morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.82×10-06
decreased B cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased plasmacytoid dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal joint morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.46×10-16
increased mean corpuscular hemoglobin Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.87×10-27
increased T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal radius morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.05×10-16
decreased immature B cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased circulating cholesterol level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating amylase level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.89×10-09
decreased circulating glucose level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.09×10-06
abnormal bone structure Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.52×10-40
decreased KLRG1-positive NK cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal thoracic cage shape Duoxa2tm1b(KOMP)Wtsi HOM Early adult 6.18×10-15
increased mean corpuscular hemoglobin concentration Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.18×10-06
decreased bone mineral density Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.25×10-06
decreased grip strength Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.68×10-08
decreased erythrocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.29×10-16
decreased total body fat amount Duoxa2tm1b(KOMP)Wtsi HOM Early adult 7.85×10-05
increased fasting circulating glucose level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.39×10-31
abnormal humerus morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.51×10-18
decreased leukocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.26×10-12
decreased circulating thyroxine level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased bone mineral content Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.02×10-19
decreased hemoglobin content Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.38×10-08
abnormal iris morphology Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 3.49×10-05
increased effector memory CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased circulating creatinine level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 5.25×10-21
abnormal clavicle morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.18×10-19
increased circulating HDL cholesterol level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal vertebrae morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.21×10-10
increased circulating sodium level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.52×10-09
decreased hematocrit Duoxa2tm1b(KOMP)Wtsi HOM Early adult 1.25×10-08
abnormal cranium morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.11×10-12
abnormal zygomatic bone morphology Duoxa2tm1b(KOMP)Wtsi HOM Early adult 3.14×10-19
decreased transitional stage T1 B cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased circulating total protein level Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.77×10-16
decreased B-2 B cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased total body fat amount Duoxa2tm1b(KOMP)Wtsi HOM Early adult 8.64×10-18
increased neutrophil cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased body length Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased NK cell number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased heart weight Duoxa2tm1b(KOMP)Wtsi HOM Early adult 2.70×10-10
abnormal hair growth Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 4.12×10-07
decreased red blood cell distribution width Duoxa2tm1b(KOMP)Wtsi HOM Early adult 4.28×10-15
improved glucose tolerance Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 1.49×10-07
decreased Ly6C low monocyte number Duoxa2tm1b(KOMP)Wtsi HOM Early adult 0.00
increased T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased CD8-positive, naive alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased memory-marker gamma-delta T cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased effector memory T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM   Early adult 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No N/A
2 No  (4/584) N/A
2 No  (2/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No N/A
2 No  (2/2) N/A
2 No  (2/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No  (21/584) N/A
2 No  (10/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No  (5/584) N/A
2 No  (1/562) N/A
2 No  (2/584) N/A
2 No  (1/176)  (2/2) N/A
2 No  (1/584) N/A
2 No  (12/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (9/584)  (2/2) N/A
2 No  (3/584) N/A
2 No  (3/584) N/A
2 No  (12/584) N/A
2 No  (3/584) N/A
2 No  (6/584)  (1/2) N/A
2 No  (1/584) N/A
2 No  (16/584) N/A
2 No  (3/584) N/A
2 No N/A
2 No N/A
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
Eye Morphology: Images Slit Lamp
2 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Legacy Phenotype Associated Images

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View all 24 images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Duoxa2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Duoxa2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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