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Gene: Duoxa2

Name

dual oxidase maturation factor 2

MGI ID

MGI:1914061

Synonyms

9030623N16Rik Nip2

Viability

Data available

Embryo viewer

N/A

Other links

MGI Ensembl

Significant phenotypes (77) Measurements chart (348) All data table (992)

Expression & images (45) Disease models (0) Order (2)

Significant

Not Significant

Not tested

View body weight measurements

Phenotype	Allele	Zyg	Life Stage	P Value
decreased transitional stage T1 B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal head morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	6.82×10^-06
increased circulating LDL cholesterol level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased circulating sodium level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.68×10^-10
increased T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal ulna morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.82×10^-17
abnormal hair growth	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	4.12×10^-07
decreased circulating amylase level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.71×10^-06
decreased immature B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
absent pinna reflex	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.05×10^-18
increased alpha-beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased total body fat amount	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.35×10^-12
decreased B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased lean body mass	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	2.09×10^-08
abnormal bone structure	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal radius morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.05×10^-16
increased T-helper cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased mature B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased CD8-positive, alpha-beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased circulating creatinine level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	6.40×10^-16
decreased circulating thyroxine level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased lean body mass	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased bone mineral content	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal humerus morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	2.51×10^-18
increased plasmacytoid dendritic cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal joint morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	5.46×10^-16
increased circulating iron level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	6.41×10^-08
decreased grip strength	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	4.20×10^-26
decreased erythrocyte cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.01×10^-14
thrombocytopenia	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	7.02×10^-08
increased circulating calcium level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	4.64×10^-11
decreased mean platelet volume	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	9.07×10^-09
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased effector memory CD8-positive, alpha-beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal cranium morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	2.11×10^-12
increased circulating cholesterol level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal eyelid morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.16×10^-07
increased CD4-positive, alpha beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased hemoglobin content	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	2.40×10^-07
abnormal zygomatic bone morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.14×10^-19
abnormal iris morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.49×10^-05
increased total body fat amount	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased effector memory T-helper cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased CD8-positive, alpha-beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased hematocrit	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	9.81×10^-08
abnormal vertebrae morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	2.21×10^-10
abnormal auditory brainstem response	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	5.10×10^-12
increased neutrophil cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
increased circulating serum albumin level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.70×10^-09
increased mean corpuscular hemoglobin	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.63×10^-19
decreased CD11b-high dendritic cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased leukocyte cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.87×10^-22
increased blood urea nitrogen level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.27×10^-05
decreased circulating glucose level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	6.29×10^-23
increased circulating total protein level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	9.30×10^-11
abnormal tibia morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.18×10^-19
decreased KLRG1-positive NK cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal thoracic cage shape	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	6.18×10^-15
abnormal vertebral arch morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.14×10^-19
decreased Ly6C low monocyte number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased follicular B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
abnormal clavicle morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.18×10^-19
abnormal femur morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.82×10^-17
increased mean corpuscular hemoglobin concentration	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.64×10^-07
abnormal snout morphology	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	5.11×10^-12
increased CD8-positive, naive alpha-beta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased NK cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased heart weight	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.01×10^-22
decreased memory-marker gamma-delta T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased red blood cell distribution width	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	3.03×10^-25
increased circulating aspartate transaminase level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	4.32×10^-05
increased circulating fructosamine level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	9.74×10^-20
increased circulating HDL cholesterol level	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased B-2 B cell number	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased body length	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	0.00
decreased bone mineral density	Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	1.74×10^-13

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Viewing: all phenotypes

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Viewing: all phenotypes

Expression

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	2	No	(3/590)		N/A
Aorta	2	No	(1/590)		N/A
Blood vessel	2	No			N/A
Bone	2	No			N/A
Brain	2	No	(3/590)		N/A
Brainstem	2	No	(2/590)		N/A
Brown adipose tissue	2	No			N/A
Cartilage tissue	2	No			N/A
Cerebellum	2	No	(3/590)		N/A
Cerebral cortex	2	No	(2/590)		N/A
Eye	2	No			N/A
Gall bladder	2	No		(2/2)	N/A
Heart	2	No	(1/590)		N/A
Hippocampus	2	No	(3/590)		N/A
Hypothalamus	2	No	(2/590)		N/A
Kidney	2	No	(20/590)		N/A
Large intestine	2	No	(10/590)		N/A
Liver	2	No			N/A
Lower urinary tract	2	No	(1/590)		N/A
Lung	2	No	(1/590)		N/A
Lymph node	2	No			N/A
Mammary gland	2	No			N/A
Esophagus	2	No			N/A
Olfactory lobe	2	No	(2/590)		N/A
Ovary	2	No	(1/590)		N/A
Oviduct	2	No			N/A
Pancreas	2	No	(5/590)		N/A
Parathyroid gland	2	No			N/A
Peripheral nervous system	2	No	(1/590)		N/A
Peyer's patch	2	No		(2/2)	N/A
Pituitary gland	2	No	(1/590)		N/A
Prostate gland	2	No	(12/590)		N/A
Skeletal muscle tissue	2	No			N/A
Skin	2	No			N/A
Small intestine	2	No	(9/590)	(2/2)	N/A
Spinal cord	2	No	(2/590)		N/A
Spleen	2	No	(2/590)		N/A
Stomach	2	No	(13/590)		N/A
Striatum	2	No	(3/590)		N/A
Testis	2	No	(5/590)	(1/2)	N/A
Thymus	2	No			N/A
Thyroid gland	2	No	(16/590)		N/A
Trachea	2	No	(2/590)		N/A
Uterus	2	No			N/A
White adipose tissue	2	No			N/A

LacZ Wholemount Images

LacZ Section Images

Duoxa2^{tm1b(KOMP)Wtsi}
testis, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
gall bladder, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
testis, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
gall bladder, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
gall bladder, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small intestine, HET, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
testis, HET, Male, WTSI

No Embryo expression data was found for this gene.

Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
31 Images

Spleen Immunophenotyping: Images associated with FACS analysis
114 Images

X-ray: XRay Images Forepaw
14 Images

X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images

DSS Histology
8 Images

X-ray: XRay Images Whole Body Lateral Orientation
14 Images

X-ray: XRay Images Skull Lateral Orientation
14 Images

Bone marrow immunophenotyping: Images associated with FACS analysis
10 Images

Anti-nuclear antibody assay
6 Images

X-ray: XRay Images Whole Body Dorso Ventral
14 Images

Legacy Phenotype Associated Images

Duoxa2^{tm1b(KOMP)Wtsi}
HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
HOM, Female, WTSI

View all 70 images

Duoxa2^{tm1b(KOMP)Wtsi}
proportional dwarf, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
head, short snout, abnormal snout morphology, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
head, abnormal snout morphology, malocclusion, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
proportional dwarf, HOM, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
proportional dwarfism, HOM, Female, WTSI

View all 24 images

Duoxa2^{tm1b(KOMP)Wtsi}
decreased brain internal capsule size, internal capsule, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
decreased brain internal capsule size, internal capsule, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
internal capsule, decreased brain internal capsule size, HOM, Male, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small pupils, HOM, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
abnormal retinal pigmentation, HOM, Female, WTSI

Duoxa2^{tm1b(KOMP)Wtsi}
small pupils, HOM, Female, WTSI

Disease Models

By phenotypic Similarity (0)
By Annotation and Orthology (0)

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MGI Allele	Allele Type	Produced
Duoxa2^{tm1b(KOMP)Wtsi}	Reporter-tagged deletion allele (post-Cre)	Mice
Duoxa2^{tm1a(KOMP)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells

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Gene: Duoxa2

Expression

IMPC lacZ Expression Data

LacZ Wholemount Images

LacZ Section Images

LacZ Section Images

Associated Images

Legacy Phenotype Associated Images

Disease Models

Order Mouse and ES Cells

This service may be affected by the Covid-19 pandemic. See how

The IMPC Newsletter

Access Data Release 13.0 Data