Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, crystallized debris, blood vessel slightly early branching, dysplasia clusters, abnormal retinal pigmentation

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching, small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity (difficult to focus), crystallized debris, slight dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid, blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Blood vessel slightly kinked and slightly early branching

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some hemorrhage, some dysplasia

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Some lens opacity, small lesion present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, some rd8, slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; LEFT EYE: slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel crossing and slightly early branching, some rd8; RIGHT EYE: Massive hyaloid (obstructing the optic nerve and part of retina), some hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus); LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Small hyaloid,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris (difficult to focus)

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; LEFT EYE: Small crystallized debris, slight rd8. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia ; RIGHT EYE: Some rd8

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

15 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity, tiny hyaloid, tiny crystallized debris,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing, some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, crystallized debris, hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Slight lens opacity, very slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris, multiple tiny hyaloid present

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia. Lesion/abnormal pigmentation on retina

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Multiple tiny hyaloid present, blood vessel ealry branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight hemorrhage

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, tiny hyaloid, some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Krt86em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; LEFT EYE: Small crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 and dysplasia; RIGHT EYE:

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