Histopathology data for Pwwp3a

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #3 Large intestine [MA:0000333] 0 0
HOM M #3 Spleen [MA:0000141] 0 0
HOM F #2 Small intestine [MA:0000337] 0 0
HOM F #4 Tooth [MA:0000348] 0 0
HOM F #2 Liver [MA:0000358] 0 0
HOM M #1 Testis [MA:0000411] 0 0
HOM F #4 Pituitary gland [MA:0000176] 0 0
HOM F #2 Tibia [MA:0001361] 0 0
HOM M #3 Sternum [MA:0001331] 3 0 chronic localized Segmental sternum dislocation
HOM F #2 Thymus [MA:0000142] 0 0
HOM F #2 Mammary gland [MA:0000145] 0 0
HOM M #3 Urinary bladder [MA:0000380] 0 0
HOM M #3 Seminal vesicle [MA:0000410] 0 0
HOM F #4 Optic II nerve [MA:0001097] 0 0
HOM F #2 Pancreas [MA:0000120] 0 0
HOM M #1 Knee joint [MA:0000471] 0 0
HOM M #3 Prostate gland [MA:0000404] 0 0
HOM F #2 Brown adipose tissue [MA:0000057] 0 0
HOM M #1 Salivary gland [MA:0000346] 0 0
HOM F #2 Spinal cord [MA:0000216] 0 0
HOM M #3 Ear [MA:0000236] 0 0
HOM M #3 Uterus [MA:0000389] Not applicable
HOM M #1 Mammary gland [MA:0000145] Not applicable
HOM M #1 Tooth [MA:0000348] 0 0
HOM M #1 Thymus [MA:0000142] 0 0
HOM M #1 Pituitary gland [MA:0000176] 0 0
HOM M #3 Ovary [MA:0000384] Not applicable
HOM F #4 White adipose tissue [MA:0000058] 0 0
HOM F #4 Lymph node [MA:0000139] 0 0
HOM F #4 Trachea [MA:0000441] 0 0
HOM F #4 Nasal cavity [MA:0000284] 0 0
HOM F #4 Testis [MA:0000411] Not applicable
HOM M #3 Femur [MA:0001359] 0 0
HOM M #3 Bone marrow [MA:0000134] 0 0
HOM M #3 Epididymis [MA:0000397] 0 0
HOM F #2 Testis [MA:0000411] Not applicable
HOM M #1 Brown adipose tissue [MA:0000057] 0 0
HOM M #1 Pancreas [MA:0000120] 0 0
HOM F #4 Small intestine [MA:0000337] 0 0
HOM M #3 Skin [MA:0000151] 0 0
HOM F #2 Tooth [MA:0000348] 0 0
HOM M #3 Skeletal muscle [MA:0003148] 0 0
HOM F #4 Salivary gland [MA:0000346] 0 0
HOM F #4 Knee joint [MA:0000471] 0 0
HOM F #2 Salivary gland [MA:0000346] 0 0
HOM F #2 Epididymis [MA:0000397] Not applicable
HOM F #2 Adrenal gland [MA:0000116] 0 0
HOM M #1 Lymph node [MA:0000139] 0 0
HOM M #3 Sciatic nerve [MA:0001172] 0 0
HOM F #4 Skeletal muscle [MA:0003148] 0 0
HOM F #2 Kidney [MA:0000368] 0 0
HOM F #4 Mammary gland [MA:0000145] 0 0
HOM F #4 Thymus [MA:0000142] 0 0
HOM M #3 Esophagus [MA:0000352] 0 0
HOM F #2 Optic II nerve [MA:0001097] 0 0
HOM F #4 Tibia [MA:0001361] 0 0
HOM M #1 Gall bladder [MA:0000356] 0 0
HOM F #2 Sternum [MA:0001331] 0 0
HOM M #1 Thyroid 0 0
HOM F #4 Skin [MA:0000151] 0 0
HOM F #2 Femur [MA:0001359] 0 0
HOM F #4 Spinal cord [MA:0000216] 0 0
HOM F #4 Tongue [MA:0000347] 0 0
HOM F #2 White adipose tissue [MA:0000058] 0 0
HOM F #4 Eye [MA:0000261] 0 0
HOM F #4 Pancreas [MA:0000120] 0 0
HOM M #1 Small intestine [MA:0000337] 0 0
HOM M #3 Brain [MA:0000168] 0 0
HOM M #3 Optic II nerve [MA:0001097] 0 0
HOM M #1 Tibia [MA:0001361] 0 0
HOM M #3 Tongue [MA:0000347] 0 0
HOM F #4 Gall bladder [MA:0000356] 0 0
HOM M #1 Optic II nerve [MA:0001097] 0 0
HOM F #4 Thyroid 0 0
HOM M #3 Small intestine [MA:0000337] 0 0
HOM F #2 Thyroid 0 0
HOM M #1 Adrenal gland [MA:0000116] 0 0
HOM M #3 Tibia [MA:0001361] 0 0
HOM F #2 Gall bladder [MA:0000356] 0 0
HOM M #1 Tongue [MA:0000347] 0 0
HOM M #3 Kidney [MA:0000368] 0 0
HOM F #4 Spleen [MA:0000141] 0 0
HOM M #1 White adipose tissue [MA:0000058] 0 0
HOM F #2 Spleen [MA:0000141] 0 0
HOM M #3 Adrenal gland [MA:0000116] 0 0
HOM M #1 Kidney [MA:0000368] 0 0
HOM M #3 Lymph node [MA:0000139] 0 0
HOM M #3 White adipose tissue [MA:0000058] 0 0
HOM M #1 Stomach [MA:0000353] 0 0
HOM F #2 Skeletal muscle [MA:0003148] 0 0
HOM F #4 Kidney [MA:0000368] 0 0
HOM F #4 Seminal vesicle [MA:0000410] Not applicable
HOM M #3 Testis [MA:0000411] 0 0
HOM F #4 Urinary bladder [MA:0000380] 0 0
HOM F #2 Uterus [MA:0000389] 0 0
HOM F #2 Esophagus [MA:0000352] 0 0
HOM M #1 Spleen [MA:0000141] 0 0
HOM M #1 Lung [MA:0000415] 0 0
HOM F #4 Adrenal gland [MA:0000116] 0 0
HOM F #2 Tongue [MA:0000347] 0 0
HOM F #2 Heart [MA:0000072] 0 0
HOM M #3 Knee joint [MA:0000471] 0 0
HOM F #2 Lung [MA:0000415] 0 0
HOM M #1 Prostate gland [MA:0000404] 0 0
HOM M #3 Salivary gland [MA:0000346] 0 0
HOM F #2 Sciatic nerve [MA:0001172] 0 0
HOM M #1 Large intestine [MA:0000333] 0 0
HOM F #4 Sternum [MA:0001331] 3 0 chronic localized Segmental sternum dislocation
HOM M #1 Brain [MA:0000168] 0 0
HOM F #2 Eye [MA:0000261] 0 0
HOM F #2 Bone marrow [MA:0000134] 0 0
HOM M #1 Ear [MA:0000236] 0 0
HOM F #4 Femur [MA:0001359] 0 0
HOM F #4 Ovary [MA:0000384] 0 0
HOM M #3 Tooth [MA:0000348] 0 0
HOM F #4 Epididymis [MA:0000397] Not applicable
HOM F #2 Skin [MA:0000151] 0 0
HOM M #1 Epididymis [MA:0000397] 3 0 chronic unilateral Epididymal sperm granuloma
HOM F #2 Trachea [MA:0000441] 0 0
HOM F #2 Stomach [MA:0000353] 0 0
HOM M #1 Skeletal muscle [MA:0003148] 3 0 chronic localized Chronic inflannation, skeletal muscle
HOM M #1 Seminal vesicle [MA:0000410] 0 0
HOM M #1 Urinary bladder [MA:0000380] 0 0
HOM F #4 Prostate gland [MA:0000404] Not applicable
HOM F #2 Lymph node [MA:0000139] 0 0
HOM M #1 Skin [MA:0000151] 0 0
HOM F #2 Nasal cavity [MA:0000284] 0 0
HOM M #3 Pituitary gland [MA:0000176] 0 0
HOM M #3 Thyroid 0 0
HOM M #1 Uterus [MA:0000389] Not applicable
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM M #3 Thymus [MA:0000142] 0 0
HOM M #3 Gall bladder [MA:0000356] 0 0
HOM F #4 Lung [MA:0000415] 0 0
HOM F #4 Stomach [MA:0000353] 2 0 subacute multi-localised Gastritis, suppurative.
HOM F #4 Brain [MA:0000168] 0 0
HOM M #1 Sternum [MA:0001331] 0 0
HOM M #3 Brown adipose tissue [MA:0000057] 0 0
HOM F #2 Brain [MA:0000168] 0 0
HOM M #3 Pancreas [MA:0000120] 0 0
HOM M #1 Femur [MA:0001359] 0 0
HOM M #1 Sciatic nerve [MA:0001172] 0 0
HOM F #2 Prostate gland [MA:0000404] Not applicable
HOM M #1 Eye [MA:0000261] 0 0
HOM M #1 Esophagus [MA:0000352] 0 0
HOM M #1 Bone marrow [MA:0000134] 0 0
HOM M #1 Ovary [MA:0000384] Not applicable
HOM F #2 Urinary bladder [MA:0000380] 0 0
HOM M #1 Spinal cord [MA:0000216] 0 0
HOM F #4 Brown adipose tissue [MA:0000057] 0 0
HOM M #1 Trachea [MA:0000441] 0 0
HOM M #3 Eye [MA:0000261] 0 0
HOM F #2 Knee joint [MA:0000471] 0 0
HOM F #4 Esophagus [MA:0000352] 0 0
HOM M #3 Nasal cavity [MA:0000284] 0 0
HOM M #3 Spinal cord [MA:0000216] 0 0
HOM F #2 Pituitary gland [MA:0000176] 0 0
HOM F #2 Seminal vesicle [MA:0000410] Not applicable
HOM M #1 Nasal cavity [MA:0000284] 0 0
HOM F #4 Uterus [MA:0000389] 0 0
HOM F #4 Sciatic nerve [MA:0001172] 0 0
HOM F #4 Heart [MA:0000072] 0 0
HOM F #4 Liver [MA:0000358] 0 0
HOM F #2 Ovary [MA:0000384] 0 0
HOM F #4 Bone marrow [MA:0000134] 0 0
HOM M #3 Heart [MA:0000072] 0 0
HOM M #3 Liver [MA:0000358] 0 0
HOM F #4 Large intestine [MA:0000333] 0 0
HOM F #4 Ear [MA:0000236] 0 0
HOM M #3 Trachea [MA:0000441] 0 0
HOM F #2 Large intestine [MA:0000333] 0 0
HOM F #2 Ear [MA:0000236] 0 0
HOM M #3 Stomach [MA:0000353] 0 0
HOM M #1 Liver [MA:0000358] 0 0
HOM M #3 Lung [MA:0000415] 0 0
HOM M #1 Heart [MA:0000072] 0 0

Associated histopathology images

Pwwp3a
homozygote
Epididymis - MA term MA:0000397
Pwwp3aem1(IMPC)Tcp
experimental
Pwwp3a
homozygote
Stomach - MA term MA:0000353
Pwwp3aem1(IMPC)Tcp
experimental
Pwwp3a
homozygote
Epididymis - MA term MA:0000397
Pwwp3aem1(IMPC)Tcp
experimental
Pwwp3a
homozygote
Skeletal muscle - MA term MA:0003148
Pwwp3aem1(IMPC)Tcp
experimental

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