Histopathology data for Nrxn1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM F #2 Sternum [MA:0001331] Not applicable 0
HOM F #1 Brain [MA:0000168] Not applicable 0
HOM F #1 Mammary gland [MA:0000145] Not applicable
HOM M #4 Skin [MA:0000151] Not applicable 0
HOM M #3 Urinary bladder [MA:0000380] Not applicable 0
HOM M #3 Bone [MA:0001459]
HOM M #4 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #4 Liver [MA:0000358] Not applicable 0
HOM F #1 Knee joint [MA:0000471] Not applicable 0
HOM M #3 Ovary [MA:0000384] Not applicable 0
HOM F #2 Adrenal gland [MA:0000116] Not applicable 0
HOM M #3 Testes Not applicable 0
HOM F #1 Prostate Not applicable 0
HOM F #1 Nasal cavity [MA:0000284] Not applicable 0
HOM M #4 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #4 Thyroid Not applicable 0
HOM F #2 Spleen [MA:0000141] Not applicable 0
HOM F #2 Epididymis [MA:0000397] Not applicable 0
HOM M #4 Tongue [MA:0000347] Not applicable 0
HOM F #1 Spinal cord [MA:0000216] Not applicable 0
HOM M #4 Lymph node [MA:0000139] Not applicable 0
HOM M #3 Small intestine [MA:0000337] Not applicable 0
HOM M #3 Ear [MA:0000236] Not applicable
HOM F #1 Tibia [MA:0001361] Not significant
HOM M #4 Esophagus [MA:0000352] Not applicable 0
HOM M #4 Eye with optic nerve Not applicable 0
HOM F #2 Brown adipose tissue [MA:0000057] Not applicable
HOM F #2 Lung [MA:0000415] Not applicable 0
HOM M #3 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #1 Eye with optic nerve Not applicable 0
HOM F #1 Gall bladder [MA:0000356] Not applicable 0
HOM M #3 Femur [MA:0001359] Not applicable 0
HOM M #4 Large intestine [MA:0000333] Not applicable 0
HOM M #4 Trachea [MA:0000441] Not applicable 0
HOM F #2 Uterus [MA:0000389] Not applicable 0
HOM M #4 Kidney [MA:0000368] Not applicable 0
HOM M #3 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Stomach [MA:0000353] Not applicable 0
HOM F #2 Thymus [MA:0000142] Not applicable 0
HOM M #4 Urinary bladder [MA:0000380] Not applicable 0
HOM M #4 Prostate Not applicable 0
HOM F #2 Tooth [MA:0000348] Not applicable 0
HOM M #4 Knee joint [MA:0000471] Not applicable 0
HOM F #2 Bone [MA:0001459]
HOM M #3 Skin [MA:0000151] Not applicable 0
HOM F #2 Bone marrow [MA:0000134] Not applicable 0
HOM F #1 Sternum [MA:0001331] Not applicable 0
HOM F #2 Urinary bladder [MA:0000380] Not applicable 0
HOM F #1 Epididymis [MA:0000397] Not applicable 0
HOM M #4 Mammary gland [MA:0000145] Not applicable
HOM M #3 Spleen [MA:0000141] Not applicable
HOM M #4 Brain [MA:0000168] Not applicable 0
HOM M #3 Liver [MA:0000358] Not applicable 0
HOM F #2 Stomach [MA:0000353] Not applicable 0
HOM F #1 Large intestine [MA:0000333] Not applicable 0
HOM F #2 Spinal cord [MA:0000216] Not applicable 0
HOM F #2 Prostate Not applicable 0
HOM F #2 Nasal cavity [MA:0000284] Not applicable 0
HOM M #3 Thyroid Not applicable 0
HOM M #3 Skeletal muscle [MA:0003148] Not applicable 0
HOM F #2 Small intestine [MA:0000337] Not applicable 0
HOM F #2 Salivary gland [MA:0000346] Not applicable 0
HOM F #1 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #2 Ear [MA:0000236] Not applicable
HOM M #3 Lymph node [MA:0000139] Not applicable 0
HOM F #1 Thymus [MA:0000142] Not applicable 0
HOM F #2 Eye with optic nerve Not applicable 0
HOM M #4 Gall bladder [MA:0000356] Not applicable 0
HOM M #3 Pancreas [MA:0000120] Not applicable 0
HOM F #1 Esophagus [MA:0000352] Not applicable 0
HOM F #1 Brown adipose tissue [MA:0000057] Not applicable
HOM M #4 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #1 Adrenal gland [MA:0000116] Not applicable 0
HOM F #2 Heart [MA:0000072] Not applicable 0
HOM F #2 Testes Not applicable 0
HOM M #3 Tooth [MA:0000348] Not applicable 0
HOM F #1 Tongue [MA:0000347] Not applicable 0
HOM M #3 Kidney [MA:0000368] Not applicable 0
HOM F #1 Uterus [MA:0000389] Not applicable 0
HOM M #3 Lung [MA:0000415] Not applicable 0
HOM F #2 Femur [MA:0001359] Not applicable 0
HOM F #2 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #2 Tibia [MA:0001361] Not significant
HOM M #3 Trachea [MA:0000441] Not applicable 0
HOM M #3 Knee joint [MA:0000471] Not applicable 0
HOM F #1 Urinary bladder [MA:0000380] Not applicable
HOM F #2 Skin [MA:0000151] Not applicable 0
HOM M #4 Sternum [MA:0001331] Not applicable 0
HOM F #1 Bone [MA:0001459]
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM M #3 Nasal cavity [MA:0000284] Not applicable 0
HOM F #2 Thyroid Not applicable 0
HOM M #3 Bone marrow [MA:0000134] Not applicable 0
HOM F #1 Stomach [MA:0000353] Not applicable 0
HOM F #2 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #4 Epididymis [MA:0000397] Not applicable 0
HOM M #4 Uterus [MA:0000389] Not applicable 0
HOM M #4 Spleen [MA:0000141] Not applicable
HOM M #3 Brain [MA:0000168] Not applicable 0
HOM F #2 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #4 Adrenal gland [MA:0000116] Not applicable 0
HOM F #2 Kidney [MA:0000368] Not applicable 0
HOM F #1 Small intestine [MA:0000337] Not applicable 0
HOM F #2 Liver [MA:0000358] Not applicable 0
HOM F #1 Salivary gland [MA:0000346] Not applicable 0
HOM F #2 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #2 Lymph node [MA:0000139] Not applicable 0
HOM M #4 Salivary gland [MA:0000346] Not applicable 0
HOM F #2 Esophagus [MA:0000352] Not applicable 0
HOM M #3 Spinal cord [MA:0000216] Not applicable 0
HOM M #3 Gall bladder [MA:0000356] Not applicable 0
HOM M #3 Tibia [MA:0001361] Not significant
HOM M #4 Thymus [MA:0000142] Not applicable 0
HOM F #2 Trachea [MA:0000441] Not applicable 0
HOM M #4 Tooth [MA:0000348] Not applicable 0
HOM F #2 Large intestine [MA:0000333] Not applicable 0
HOM F #1 Testes Not applicable 0
HOM F #1 Femur [MA:0001359] Not applicable 0
HOM F #2 Ovary [MA:0000384] Not applicable 0
HOM F #2 Tongue [MA:0000347] Not applicable 0
HOM M #4 Lung [MA:0000415] Not applicable 0
HOM M #4 Nasal cavity [MA:0000284] Not applicable 0
HOM F #2 Pancreas [MA:0000120] Not applicable 0
HOM F #1 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #3 Heart [MA:0000072] Not applicable 0
HOM M #4 Brown adipose tissue [MA:0000057] Not applicable
HOM F #2 Knee joint [MA:0000471] Not applicable 0
HOM M #3 Sternum [MA:0001331] Not applicable 0
HOM M #3 Epididymis [MA:0000397] Not applicable 0
HOM F #1 Liver [MA:0000358] Not applicable 0
HOM M #4 Bone marrow [MA:0000134] Not applicable 0
HOM F #1 Thyroid Not applicable 0
HOM F #1 Skin [MA:0000151] Not applicable 0
HOM M #4 Bone [MA:0001459]
HOM F #1 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #3 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #4 Ovary [MA:0000384] Not applicable 0
HOM M #3 Adrenal gland [MA:0000116] Not applicable 0
HOM M #4 Femur [MA:0001359] Not applicable 0
HOM F #1 Seminal vesicle [MA:0000410] Not applicable 0
HOM F #1 Heart [MA:0000072] Not applicable 0
HOM F #1 Trachea [MA:0000441] Not applicable 0
HOM M #4 Testes Not applicable 0
HOM M #4 Pancreas [MA:0000120] Not applicable 0
HOM F #1 Kidney [MA:0000368] Not applicable 0
HOM M #3 Tongue [MA:0000347] Not applicable 0
HOM F #1 Spleen [MA:0000141] Not applicable 0
HOM F #2 Mammary gland [MA:0000145] Not applicable
HOM F #1 Ear [MA:0000236] Not applicable
HOM M #3 Eye with optic nerve Not applicable 0
HOM M #3 Salivary gland [MA:0000346] Not applicable 0
HOM M #3 Esophagus [MA:0000352] Not applicable 0
HOM F #1 Lymph node [MA:0000139] Not applicable 0
HOM M #4 Ear [MA:0000236] Not applicable
HOM F #1 Lung [MA:0000415] Not applicable 0
HOM M #4 Tibia [MA:0001361] Not significant
HOM M #4 Small intestine [MA:0000337] Not applicable 0
HOM F #2 Gall bladder [MA:0000356] Not applicable 0
HOM M #3 Uterus [MA:0000389] Not applicable 0
HOM M #4 Heart [MA:0000072] Not applicable 0
HOM M #3 Thymus [MA:0000142] Not applicable 0
HOM F #1 Tooth [MA:0000348] Not applicable 0
HOM M #4 Spinal cord [MA:0000216] Not applicable 0
HOM F #1 Ovary [MA:0000384] Not applicable 0
HOM M #4 Stomach [MA:0000353] Not applicable 0
HOM M #3 Prostate Not applicable 0
HOM F #1 Pancreas [MA:0000120] Not applicable 0
HOM M #4 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Brown adipose tissue [MA:0000057] Not applicable
HOM F #2 Brain [MA:0000168] Not applicable 0
HOM M #3 Large intestine [MA:0000333] Not applicable 0
HOM F #1 Bone marrow [MA:0000134] Not applicable 0

Associated histopathology images

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