Gene: Nrxn1

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Name
neurexin I
MGI ID
MGI:1096391
Synonyms
alpha-latrotoxin receptor (calcium-dependent) neurexin I beta neurexin I alpha neurexin I beta neurexin I beta neurexin I alpha neurexin I alpha 1700062G21Rik A230068P09Rik 9330127H16Rik
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Nrxn1tm1b(KOMP)Wtsi HOM Early adult 2.16×10-08
short tibia Nrxn1tm1b(KOMP)Wtsi HOM Early adult 3.53×10-06
decreased circulating alkaline phosphatase level Nrxn1tm1b(KOMP)Wtsi HOM Early adult 1.73×10-06
decreased total body fat amount Nrxn1tm1b(KOMP)Wtsi HOM Early adult 1.31×10-09
abnormal bone structure Nrxn1tm1b(KOMP)Wtsi HOM Early adult 6.38×10-05
decreased fasting circulating glucose level Nrxn1tm1b(KOMP)Wtsi HOM Early adult 2.94×10-06
decreased circulating cholesterol level Nrxn1tm1b(KOMP)Wtsi HOM Early adult 1.33×10-19
impaired glucose tolerance Nrxn1tm1b(KOMP)Wtsi HOM   Early adult 4.36×10-05
increased lean body mass Nrxn1tm1b(KOMP)Wtsi HET Early adult 1.01×10-05
decreased circulating HDL cholesterol level Nrxn1tm1b(KOMP)Wtsi HOM Early adult 4.57×10-15
tremors Nrxn1tm1b(KOMP)Wtsi HOM Early adult 8.05×10-09
decreased pulmonary respiratory rate Nrxn1tm1b(KOMP)Wtsi HOM   Early adult 0.00
tremors Nrxn1tm1b(KOMP)Wtsi HET   Early adult 3.72×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/583)  (2/2)  Wholemount images
2 No  (1/583) N/A
2 No N/A
2 No  (4/583)  (2/2)  Wholemount images
2 No  (2/583)  (2/2)  Wholemount images
2 No N/A
2 No  (1/583) N/A
2 No  (3/583)  (2/2)  Wholemount images
2 No  (2/583)  (2/2)  Wholemount images
2 No  (7/407) N/A
2 No N/A
2 No N/A
2 No  (2/583) N/A
2 No  (3/583)  (2/2)  Wholemount images
2 No  (2/583)  (2/2)  Wholemount images
2 No  (21/583) N/A
2 No  (10/583) N/A
2 No N/A
2 No  (1/583) N/A
2 No  (2/583) N/A
2 No  (1/583) N/A
2 No N/A
2 No  (2/583)  (2/2)  Wholemount images
2 No N/A
2 No  (1/583) N/A
2 No N/A
2 No  (5/583) N/A
2 No  (1/563) N/A
2 No  (2/583) N/A
2 No N/A
2 No  (1/583)  (2/2)  Wholemount images
2 No  (12/583) N/A
2 No N/A
2 No  (1/583)  (1/2) N/A
2 No  (9/583) N/A
2 No  (3/583)  (2/2)  Wholemount images
2 No  (3/583) N/A
2 No  (13/583) N/A
2 No  (3/583) N/A
2 No  (6/583)  (1/2)  Wholemount images
2 No  (1/583) N/A
2 No  (17/583) N/A
2 No  (3/583) N/A
2 No N/A
2 No N/A
2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
26 Images
Echo: M-Mode Images
64 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
26 Images
Adult LacZ: LacZ Images Wholemount
7 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
X-ray: XRay Images Whole Body Lateral Orientation
25 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nrxn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nrxn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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