Gene: Nrxn1

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Name
neurexin I
MGI ID
MGI:1096391
Synonyms
neurexin I beta A230068P09Rik neurexin I alpha 9330127H16Rik neurexin I beta neurexin I beta neurexin I alpha 1700062G21Rik alpha-latrotoxin receptor (calcium-dependent) neurexin I alpha
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Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
impaired glucose tolerance Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.66×10-05
increased circulating alkaline phosphatase level Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.12×10-07
enlarged stomach Nrxn1tm1b(KOMP)Wtsi HET postnatal 0.00
increased red blood cell distribution width Nrxn1tm1b(KOMP)Wtsi HOM postnatal 8.34×10-08
decreased circulating HDL cholesterol level Nrxn1tm1b(KOMP)Wtsi HOM postnatal 3.22×10-07
decreased circulating cholesterol level Nrxn1tm1b(KOMP)Wtsi HOM postnatal 6.76×10-08
abnormal bone structure Nrxn1tm1b(KOMP)Wtsi HOM postnatal 7.95×10-08
short tibia Nrxn1tm1b(KOMP)Wtsi HOM postnatal 7.17×10-05
decreased circulating alkaline phosphatase level Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.12×10-07
decreased fasted circulating glucose level Nrxn1tm1b(KOMP)Wtsi HOM postnatal 4.94×10-05
tremors Nrxn1tm1b(KOMP)Wtsi HET postnatal 6.11×10-05
small thymus Nrxn1tm1b(KOMP)Wtsi HET postnatal 0.00
decreased grip strength Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.58×10-09
decreased lymphocyte cell number Nrxn1tm1b(KOMP)Wtsi HOM postnatal 2.08×10-10
decreased pulmonary respiratory rate Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.43×10-07
tremors Nrxn1tm1b(KOMP)Wtsi HOM postnatal 1.61×10-08
abnormal locomotor behavior Nrxn1tm1b(KOMP)Wtsi HOM postnatal 3.42×10-05
increased lean body mass Nrxn1tm1b(KOMP)Wtsi HET postnatal 1.92×10-05

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Dorso Ventral
26 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Lateral Orientation
25 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
26 Images
Echo: M-Mode Images
64 Images
Adult LacZ: LacZ Images Wholemount
7 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nrxn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nrxn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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