Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

murinoglobulin 1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mug1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Mug1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Otitis Media, Susceptibility To
Recurrent otitis media OMIM:166760
Anterior Segment Dysgenesis 8

The table below shows human diseases predicted to be associated to Mug1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Cirrhosis, Familial
Cirrhosis, Chronic active hepatitis, Increased circulating antibody level, Hepatitis OMIM:118900
Hemochromatosis, Neonatal
Increased serum iron, Abnormality of iron homeostasis, Hepatocellular necrosis, Hepatic fibrosis,... OMIM:231100
Abnormality of circulating enzyme level, Abnormal circulating carbohydrate concentration ORPHA:2843
Pediatric Hepatocellular Carcinoma
Hepatomegaly, Elevated alpha-fetoprotein, Hepatic fibrosis, Hepatic necrosis ORPHA:33402
Hepatocellular Carcinoma
Subacute progressive viral hepatitis, Micronodular cirrhosis, Hepatocellular carcinoma OMIM:114550
Complement Component 4B Deficiency
Chronic active hepatitis OMIM:614379
Complement Component C1S Deficiency
Hashimoto thyroiditis, Hepatitis OMIM:613783
African Iron Overload
Hepatomegaly, Hepatic fibrosis, Elevated hepatic iron concentration, Hepatocellular carcinoma, Pe... ORPHA:139507
Lymphoproliferative Syndrome, X-Linked, 2
Hepatomegaly, Inflammation of the large intestine, Folliculitis, Hepatitis, Decreased circulating... OMIM:300635
Halothane Hepatitis
Viral hepatitis, Hepatitis, Jaundice OMIM:234350
Cyanosis And Hepatic Disease
Hepatitis OMIM:219400
Macrophage Activation Syndrome
Hepatomegaly, Increased circulating interleukin 6, Hepatitis, Splenomegaly, Decreased liver funct... ORPHA:158061
Bile Acid Synthesis Defect, Congenital, 4
Hepatomegaly, Giant cell hepatitis, Elevated hepatic transaminase, Hyperbilirubinemia, Hepatic fa... OMIM:214950
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hepatomegaly, Hepatocellular necrosis, Depletion of mitochondrial DNA in liver, Micronodular cirr... OMIM:251880
Alpha-1-Antitrypsin Deficiency
Hepatomegaly, Hepatitis, Hepatic failure, Jaundice ORPHA:60
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Hepatomegaly, Hepatocellular necrosis, Elevated circulating creatine kinase concentration, Hypera... OMIM:201475
Bile Acid Synthesis Defect, Congenital, 3
Hepatomegaly, Acholic stools, Hepatitis, Splenomegaly, Cirrhosis, Elevated circulating alkaline p... OMIM:613812
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Decreased 3-hydroxyacyl-CoA dehydrogenase level, Hepatic necrosis, Abnormal circulating acetylcar... ORPHA:71212
Bile Acid Synthesis Defect, Congenital, 1
Hepatomegaly, Giant cell hepatitis, Acholic stools, Hypocholesterolemia, Hyperbilirubinemia, Sple... OMIM:607765
Autoimmune Hepatitis
Inflammation of the large intestine, Ulcerative colitis, Hepatocellular carcinoma, Fulminant hepa... ORPHA:2137
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Recurrent otitis media, Hepatitis, Splenomegaly ORPHA:444463
Carcinoid Syndrome
Elevated hepatic transaminase, Hepatic necrosis, Abnormal B-type natriuretic peptide level ORPHA:100093
Congenital Disorder Of Glycosylation, Type Iih
Elevated circulating creatine kinase concentration, Elevated circulating aspartate aminotransfera... OMIM:611182
Congenital Bile Acid Synthesis Defect Type 2
Abnormality of the intrahepatic bile duct, Hepatomegaly, Giant cell hepatitis, Abnormal serum bil... ORPHA:79303
3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hepatic steatosis, Fulminant hepatic failure, Hepatic necrosis, Decreased 3-hydroxyacyl-CoA dehyd... OMIM:231530
Porphyria Cutanea Tarda
Increased serum iron, Elevated hepatic iron concentration, Hepatocellular carcinoma, Chronic hepa... ORPHA:101330
Adult-Onset Still Disease
Myocarditis, Hepatomegaly, Pericarditis, Abnormal circulating lipid concentration, Hepatitis, Art... ORPHA:829
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Hepatomegaly, Hepatitis, Cholelithiasis, Splenomegaly, Increased circulating ferritin concentrati... OMIM:194380
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Increased LDL cholesterol concentration, Acute hepatic steatosis, Hepatitis, Macrovesicular hepat... ORPHA:209902
Immunodeficiency 56
Cholangitis, Bronchiectasis, Recurrent otitis media, Cirrhosis, Panhypogammaglobulinemia, Recurre... OMIM:615207
Primary Biliary Cholangitis
Abnormality of the intrahepatic bile duct, Hepatic fibrosis, Hepatocellular carcinoma, Increased ... ORPHA:186
Congenital Bile Acid Synthesis Defect Type 4
Giant cell hepatitis, Elevated circulating creatine kinase concentration, Cholelithiasis, Cholest... ORPHA:79095
Multiple Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Elevated circulating creatine kinase concentration, Hyperammonemia, Decreased liver... ORPHA:26791
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Abnormality of the intrahepatic bile duct, Inflammation of the large intestine, Interface hepatit... ORPHA:562639
Trichohepatoenteric Syndrome 2
Hepatomegaly, Hepatitis, Decreased serum iron, Cirrhosis, Colitis OMIM:614602
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Decreased circulating total IgA, Erythroderma, Pneumonia, Decreased circulating IgG level, Hepati... ORPHA:169160
Wilson Disease
Hepatomegaly, Hepatitis, Arthritis, Acute hepatitis, Splenomegaly, Cirrhosis, Hepatic steatosis, ... ORPHA:905
Cholestasis With Gallstone, Ataxia, And Visual Disturbance
Giant cell hepatitis, Cholelithiasis, Jaundice OMIM:214980
Autosomal Agammaglobulinemia
Sinusitis, Agammaglobulinemia, Bronchiectasis, Chronic otitis media, Hepatitis, Arthritis, Osteom... ORPHA:33110
Hepatitis, Fulminant Viral, Susceptibility To
Hepatomegaly, Fulminant hepatitis, Hepatic failure, Elevated hepatic transaminase, Hashimoto thyr... OMIM:618549
Hepatomegaly, Abnormality of iron homeostasis, Hepatitis, Cholelithiasis, Splenomegaly ORPHA:848
X-Linked Agammaglobulinemia
Sinusitis, Agammaglobulinemia, Recurrent cutaneous abscess formation, Chronic otitis media, Hepat... ORPHA:47
X-Linked Lymphoproliferative Disease
Myocarditis, Inflammation of the large intestine, Decreased circulating IgA level, Increased circ... ORPHA:2442
Immunodeficiency With Hyper-Igm, Type 1
Hepatomegaly, Stomatitis, Decreased circulating IgA level, Decreased circulating IgG level, Hepat... OMIM:308230
Congenital Isolated Acth Deficiency
Prolonged neonatal jaundice, Hyponatremia, Hepatitis ORPHA:199296
Hepatocellular Carcinoma
Hepatomegaly, Hyponatremia, Hypercalcemia, Hemobilia, Hypokalemia, Hepatic necrosis, Hyperbilirub... ORPHA:88673
Leigh Syndrome
Hepatocellular necrosis OMIM:256000
Arthrogryposis, Renal Dysfunction, And Cholestasis 2
Giant cell hepatitis, Cholestatic liver disease, Conjugated hyperbilirubinemia, Elevated hepatic ... OMIM:613404
Congenital Disorder Of Glycosylation, Type It
Hepatomegaly, Increased hepatic glycogen content, Elevated circulating creatine kinase concentrat... OMIM:614921
Multiple Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Hepatic steatosis, Elevated circulating glutaric acid concentration, Hepatic peripo... OMIM:231680
Avian Influenza
Infectious encephalitis, Pneumonia, Elevated circulating creatine kinase concentration, Hepatitis... ORPHA:454836
Griscelli Syndrome
Hepatomegaly, Abnormal circulating lipid concentration, Hepatitis, Decreased circulating antibody... ORPHA:381
Hypohidrosis-Enamel Hypoplasia-Palmoplantar Keratoderma-Intellectual Disability Syndrome
Hepatitis ORPHA:363523
Congenital Enterovirus Infection
Myocarditis, Infectious encephalitis, Hepatitis, Hyperammonemia, Cholestasis, Hepatic failure, Hy... ORPHA:292
Primary Sclerosing Cholangitis
Neoplasm of the gallbladder, Cholangiocarcinoma, Hepatitis, Splenomegaly, Hepatosplenomegaly, Uve... ORPHA:171
Graft Versus Host Disease
Inflammatory abnormality of the skin, Pneumonia, Stomatitis, Myositis, Fasciitis, Hyperbilirubine... ORPHA:39812
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Hepatomegaly, Acute hepatitis, Hyperammonemia, Decreased liver function, Hyperornithinemia OMIM:238970
Bacterial Toxic-Shock Syndrome
Sinusitis, Hypoalbuminemia, Myocarditis, Infectious encephalitis, Pneumonia, Peritonitis, Elevate... ORPHA:36234
Immune Deficiency Disease
Cholangitis, Fulminant hepatitis, Decreased circulating total IgM OMIM:242850
Bare Lymphocyte Syndrome, Type Ii
Cholangitis, Agammaglobulinemia, Infectious encephalitis, Colitis, Chronic mucocutaneous candidia... OMIM:209920
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Decreased prealbumin level, Eczema, Tubulointerstitial nephritis, Hepatitis, Splenomegaly, Gastri... ORPHA:37042
Arthrogryposis, Renal Dysfunction, And Cholestasis 1
Giant cell hepatitis, Cholestatic liver disease, Conjugated hyperbilirubinemia, Elevated hepatic ... OMIM:208085
Drug Reaction With Eosinophilia And Systemic Symptoms
Myocarditis, Tubulointerstitial nephritis, Erythroderma, Infectious encephalitis, Pustule, Inters... ORPHA:139402
Abnormality of the spleen, Splenic abscess, Pneumonia, Prostatitis, Hepatitis, Septic arthritis, ... ORPHA:31202
Immunodeficiency By Defective Expression Of Mhc Class Ii
Sinusitis, Rhinitis, Decreased circulating antibody level, Chronic mucocutaneous candidiasis, Pan... ORPHA:572
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Cholangitis, Decreased specific pneumococcal antibody level, Decreased circulating total IgM, Liv... ORPHA:183675
Legionnaires Disease
Myocarditis, Hyponatremia, Pericarditis, Infectious encephalitis, Endocarditis, Hepatitis, Pancre... ORPHA:549
Acute Liver Failure
Hepatocellular necrosis, Hepatitis, Hepatic necrosis, Hyperammonemia, Skin rash, Elevated hepatic... ORPHA:90062
Agammaglobulinemia, X-Linked
Enteroviral hepatitis, Sinusitis, Agammaglobulinemia, Infectious encephalitis, Pyoderma, Pneumoni... OMIM:300755
Sinusitis, Infectious encephalitis, Pneumonia, Bronchiectasis, Hepatitis, Osteomyelitis, Keratiti... ORPHA:1163
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Eczema, Erythroderma, Hepatitis, Arthritis, Increased circulating IgE level, Glomerulonephritis OMIM:304790
Q Fever
Myocarditis, Hepatomegaly, Pericarditis, Infectious encephalitis, Pneumonia, Endocarditis, Hepati... ORPHA:781
Autoimmune Polyendocrine Syndrome, Type Ii
Asplenia, Chronic hepatitis, Hepatitis, Chronic mucocutaneous candidiasis, Cirrhosis, Exocrine pa... OMIM:269200
Wilson Disease
Hepatomegaly, Hepatocellular carcinoma, Osteoarthritis, Cirrhosis, Hepatic failure, High noncerul... OMIM:277900
Lichen Planopilaris
Hepatitis ORPHA:525
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Enteroviral hepatitis, Sinusitis, Infectious encephalitis, Pyoderma, Pneumonia, Prostatitis, Epid... OMIM:307200
Cryoglobulinemic Vasculitis
Keratoconjunctivitis sicca, Hepatomegaly, Arthritis, Splenomegaly, Abnormality of the liver, Vira... ORPHA:91138
Lymphoproliferative Syndrome, X-Linked, 1
Hepatomegaly, Infectious encephalitis, Decreased circulating IgG level, Decreased circulating ant... OMIM:308240
Syndromic Multisystem Autoimmune Disease Due To Itch Deficiency
Cholangitis, Hepatitis, Cirrhosis, Hepatosplenomegaly, Hypersplenism, Acute hepatic failure, Thyr... ORPHA:228426
Autoimmune Disease, Multisystem, With Facial Dysmorphism
Hepatomegaly, Decreased circulating IgA level, Hepatitis, Splenomegaly, Hypersplenism, Hashimoto ... OMIM:613385
Alstrom Syndrome
Hepatomegaly, Chronic active hepatitis, Decreased HDL cholesterol concentration, Tubulointerstiti... OMIM:203800
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Hepatomegaly, Pancreatic hypoplasia, Hepatic fibrosis, Pancreatic cysts, Splenic cyst, Hepatitis,... OMIM:610199
Isolated Sedoheptulokinase Deficiency
Portal hypertension, Hepatitis, Cholestasis, Cholestatic liver disease ORPHA:440713
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Hepatomegaly, Hepatitis, Hyperammonemia, Decreased liver function, Abnormal circulating citrullin... ORPHA:415
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Psoriasiform dermatitis, Interface hepatitis OMIM:243150
Sinusitis, Cholangitis, Abnormality of the spleen, Myocarditis, Infectious encephalitis, Pneumoni... ORPHA:2552
Ebola Hemorrhagic Fever
Increased circulating antibody level, Hepatitis, Acute pancreatitis, Maculopapular exanthema ORPHA:319218
Postinfectious Vasculitis
Inflammatory abnormality of the skin, Bacterial endocarditis, Pneumonia, Increased circulating Ig... ORPHA:48435
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Hepatomegaly, Hepatocellular necrosis OMIM:618278
Dominant Beta-Thalassemia
Abnormality of iron homeostasis, Hepatic fibrosis, Hepatocellular carcinoma, Splenomegaly, Cirrho... ORPHA:231226
Autoimmune Lymphoproliferative Syndrome
Recurrent aphthous stomatitis, Hepatitis, Splenomegaly, Gastritis, Hypersplenism, Uveitis, Abnorm... ORPHA:3261
Myasthenia Gravis
Hashimoto thyroiditis, Hepatitis, Rheumatoid arthritis, Myositis ORPHA:589
Simple Cryoglobulinemia
Viral hepatitis, Pericarditis, Monoclonal immunoglobulin M proteinemia, Nephritis, Arthritis, Par... ORPHA:91139
Autoimmune Polyendocrinopathy Type 4
Keratoconjunctivitis sicca, Tubulointerstitial nephritis, Atrophic gastritis, Aplasia/Hypoplasia ... ORPHA:227990
Immunodeficiency 82 With Systemic Inflammation
Decreased circulating total IgA, Decreased circulating total IgG, Hypernatremia, Pneumonia, Bronc... OMIM:619381
Autoimmune Polyendocrinopathy Type 3
Keratoconjunctivitis sicca, Tubulointerstitial nephritis, Atrophic gastritis, Aplasia/Hypoplasia ... ORPHA:227982
Thymic Aplasia
Sinusitis, Eczematoid dermatitis, Hypocalcemic tetany, Pneumonia, Chronic otitis media, Chronic o... ORPHA:83471
Rift Valley Fever
Infectious encephalitis, Hepatitis, Increased circulating IgG level, Uveitis, Increased circulati... ORPHA:319251
Late-Onset Isolated Acth Deficiency
Hyponatremia, Hypercalcemia, Hepatitis, Hyperuricemia, Hashimoto thyroiditis ORPHA:199299
Pneumonia, Hepatitis, Arthritis, Juvenile rheumatoid arthritis, Skin rash ORPHA:1855
Mccune-Albright Syndrome
Hepatitis, Hypophosphatemia, Pancreatitis, Hepatocellular adenoma, Cholestasis ORPHA:562
Relapsing Polychondritis
Myocarditis, Pericarditis, Episcleritis, Chondritis of pinna, Chondritis, Hepatitis, Arthritis, K... ORPHA:728
Chronic Mucocutaneous Candidiasis
Cheilitis, Hepatitis, Skin rash ORPHA:1334
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
Chronic active hepatitis, Asplenia, Chronic oral candidiasis, Cholelithiasis, Chronic mucocutaneo... OMIM:240300
Mucopolysaccharidosis Type 7
Hepatitis, Splenomegaly ORPHA:584
Hyperproteinemia, Hepatomegaly, Pericarditis, Elevated serum transaminases during infections, Hep... ORPHA:509
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Inflammatory abnormality of the skin, Eczema, Infectious encephalitis, Bronchiectasis, Hepatitis,... ORPHA:391487
Sinusitis, Myocarditis, Splenic abscess, Pericarditis, Infectious encephalitis, Peritonitis, Pust... ORPHA:73263
Acute Disseminated Encephalomyelitis
Herpes simplex encephalitis, Viral hepatitis, Myelitis, Optic neuritis ORPHA:83597
Gaucher Disease
Hepatomegaly, Osteoarthritis, Hepatitis, Splenomegaly, Cirrhosis, Osteomyelitis, Increased circul... ORPHA:355
Primary Sjögren Syndrome
Keratoconjunctivitis sicca, Chronic active hepatitis, Tubulointerstitial nephritis, Lymphocytic i... ORPHA:289390
Kawasaki Disease
Myocarditis, Pericarditis, Cheilitis, Hepatitis, Arthritis, Jaundice, Skin rash, Cholecystitis, C... ORPHA:2331
Idiopathic Hypereosinophilic Syndrome
Inflammatory abnormality of the skin, Cholangitis, Eczema, Erythroderma, Portal fibrosis, Pancrea... ORPHA:3260
Combined Immunodeficiency-Enteropathy Spectrum
Psoriasiform dermatitis, Peritoneal abscess, Hepatitis, Abnormality of the ductus choledochus, Ha... ORPHA:436252
Lujo Hemorrhagic Fever
Myocarditis, Rhinitis, Fulminant hepatitis, Increased circulating lactate dehydrogenase concentra... ORPHA:319213
Occipital Horn Syndrome
Hepatitis, Cholestasis, Esophagitis, Jaundice ORPHA:198
Alström Syndrome
Hepatomegaly, Elevated gamma-glutamyltransferase level, Hepatic fibrosis, Hyperlipidemia, Hepatit... ORPHA:64
Otitis Media, Susceptibility To
Recurrent otitis media OMIM:166760
Anterior Segment Dysgenesis 8


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mug1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mug1.

No publications found that use IMPC mice or data for Mug1.

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MGI Allele Allele Type Produced
Mug1tm210840(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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