Ucp1 | uncoupling protein 1 (mitochondrial, proton carrier)

GeneMGI:98894Synonyms: Slc25a7

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Hematopoietic system Cardiovascular system

18 No significant impact

2 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

eye hemorrhage1 supporting datasetUcp1m1HhomozygoteEarly adult1.37x10-8 
increased hematocrit1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult9.3x10-5 
thick ventricular wall1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult2.86x10-5 
cornea vascularization1 supporting datasetUcp1m1HhomozygoteEarly adult2.54x10-7 
abnormal sinus arrhythmia1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult1.07x10-5 
cataract1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult2.31x10-5 
increased erythrocyte cell number1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult8.38x10-5 
decreased circulating triglyceride level1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult6.13x10-5 
increased hemoglobin content1 supporting datasetUcp1m1HhomozygoteEarly adult9.91x10-6 
abnormal lens morphology1 supporting datasetUcp1tm1b(EUCOMM)HmguhomozygoteEarly adult7.67x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
boneheterozygoteWholemount images
100% (2/2)0% (0/394)
bone marrowheterozygoten/a0% (0/2)0% (0/22)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoteWholemount images
50% (1/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cecumheterozygoten/a0% (0/2)7.75% (22/284)
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Histopathology

IMPC related publications

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Ucp1tm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
Ucp1tm1.1(EGFP/cre/ERT2)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)ES Cell
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Ucp1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Ucp1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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