Polb | polymerase (DNA directed), beta

GeneMGI:97740Synonyms: Pol beta, A430088C08Rik

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetPolbtm1a(KOMP)WtsihomozygoteEarly adultN/A * 
increased lean body mass2 supporting datasetsPolbtm1a(KOMP)WtsiheterozygoteEarly adult1.04x10-6 
increased mean platelet volume1 supporting datasetPolbtm1a(KOMP)WtsiheterozygoteEarly adult2.85x10-7 
decreased total body fat amount1 supporting datasetPolbtm1a(KOMP)WtsiheterozygoteEarly adult3.89x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Polbtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Polbtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Polbtm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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