Gene Summary

Name:
glutathione S-transferase, pi 1
Synonyms:
Gst p-1,  GstpiB

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Gstp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gstp1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Abdominal Obesity-Metabolic Syndrome 1
Abdominal obesity OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Abdominal obesity OMIM:605572
Prader-Willi Syndrome (Type 2)
Truncal obesity DECIPHER:53
Prader-Willi syndrome (Type 1)
Truncal obesity DECIPHER:14
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Adenocarcinoma Of The Esophagus
Barrett esophagus, Obesity, Esophageal carcinoma ORPHA:99976
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity ORPHA:293964
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Pilomatrixoma
Pilomatrixoma OMIM:132600
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Bardet-Biedl Syndrome 18
Obesity OMIM:615995
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Adiposis Dolorosa
Painful subcutaneous lipomas, Obesity OMIM:103200
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity OMIM:618406
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity OMIM:619058
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Bardet-Biedl Syndrome 10
Obesity OMIM:615987
Cutaneous Neuroendocrine Carcinoma
Neoplasm of the outer ear, Squamous cell carcinoma of the skin, Merkel cell skin cancer, Carcinoi... ORPHA:79140
Familial Multinodular Goiter
Sertoli cell neoplasm, Pleuropulmonary blastoma, Alveolar rhabdomyosarcoma, Thyroid carcinoma, Pi... ORPHA:276399
Coronary Artery Disease, Autosomal Dominant, 1
Obesity OMIM:608320
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Apc-Related Attenuated Familial Adenomatous Polyposis
Osteoma, Fibrosarcoma, Desmoid tumors, Adrenocortical adenoma, Medulloblastoma, Multiple gastric ... ORPHA:247806
Epidermodysplasia Verruciformis, Susceptibility To, 5
Squamous cell carcinoma of the skin, Verrucae OMIM:618309
Microduplication Xp11.22P11.23 Syndrome
Obesity ORPHA:217377
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Childhood-onset truncal obesity ORPHA:71529
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Pilomatrixoma
Neoplasm of head and neck, Pilomatrixoma ORPHA:91414
Gardner Syndrome
Colon cancer, Ampulla of Vater carcinoma, Hepatoblastoma, Brain neoplasm, Osteoma, Fibrosarcoma, ... ORPHA:79665
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Cortisone Reductase Deficiency 1
Obesity OMIM:604931
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Obesity, Hyperphagia, And Developmental Delay
Obesity OMIM:613886
Coenzyme Q10 Deficiency, Primary, 2
Obesity, Overweight OMIM:614651
Bardet-Biedl Syndrome 8
Obesity OMIM:615985
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body weight, Increased body mass index OMIM:614450
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Turcot Syndrome With Polyposis
Glioma, Hepatoblastoma, Brain neoplasm, Desmoid tumors, Leukemia, Basal cell carcinoma, Glioblast... ORPHA:99818
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight ORPHA:589905
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Mosaic Variegated Aneuploidy Syndrome 7 With Inflammation And Tumor Predisposition
Pilomatrixoma, Embryonal rhabdomyosarcoma, Cervix cancer, Adenocarcinoma of the colon, Lipoma, Mu... OMIM:620189
Disabling Pansclerotic Morphea Of Childhood
Squamous cell carcinoma of the skin OMIM:620443
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased body weight, Abdominal obesity OMIM:615954
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Small for gestational age OMIM:274300
Xeroderma Pigmentosum, Complementation Group C
Basal cell carcinoma, Squamous cell carcinoma of the skin, Actinic keratosis, Cutaneous melanoma OMIM:278720
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Impaired Intellectual Development Syndrome
Gonadoblastoma, Obesity, Nephroblastoma OMIM:194072
Pseudohypoparathyroidism, Type Ib
Obesity OMIM:603233
Insulinoma
Neuroendocrine neoplasm, Pituitary prolactin cell adenoma, Zollinger-Ellison syndrome, Increased ... ORPHA:97279
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Dyskeratosis Congenita, Digenic
Basal cell carcinoma, Melanoma, Squamous cell carcinoma of the skin, Failure to thrive OMIM:620040
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 7
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:620365
Xeroderma Pigmentosum, Complementation Group B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Neoplasm, Cutaneous melanoma OMIM:610651
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Melanoma, Cachexia, Squamous cell carcinoma of the skin ORPHA:220295
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Narcolepsy 7
Obesity OMIM:614250
Wilson Disease
Increased body weight, Weight loss, Failure to thrive ORPHA:905
Adrenocortical Carcinoma
Increased body weight, Weight loss, Adrenocortical carcinoma, Lung adenocarcinoma ORPHA:1501
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Large for gestational age ORPHA:263455
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Carney Complex
Follicular thyroid carcinoma, Tall stature, Increased body weight, Neoplasm of the pharynx, Ovari... ORPHA:1359
Low Phospholipid-Associated Cholelithiasis
Obesity, Overweight, Neoplasm of the liver, Hepatocellular carcinoma ORPHA:69663
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased body weight OMIM:615830
Xeroderma Pigmentosum, Complementation Group A
Melanoma, Squamous cell carcinoma of the skin OMIM:278700
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Pituitary adenoma, Neuroendocrine neoplasm, Meningioma, Increased body weight, Renal cell carcino... ORPHA:189427
Sotos Syndrome
Increased body weight, Tall stature, Overgrowth OMIM:117550
Oculocutaneous Albinism Type 2
Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma ORPHA:79432
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin, Weight loss ORPHA:79430
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Increased body weight, Hepatocellular adenoma, Hepatocellular carcinoma ORPHA:79240
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Increased body weight, Hepatocellular adenoma, Failure to thrive ORPHA:264580
Insulin-Resistance Syndrome Type B
Lymphoma, Abnormality of body weight, Decreased body weight, Increased body weight, Hodgkin lymph... ORPHA:2298
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Squamous cell carcinoma of the skin, Failure to thrive ORPHA:79396
Lmna-Related Cardiocutaneous Progeria Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin, Papillary renal cell carcinoma, Pulmon... ORPHA:363618
Dyskeratosis Congenita, Autosomal Dominant 1
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:127550
Magel2-Related Prader-Willi-Like Syndrome
Increased body weight, Failure to thrive, Abdominal obesity ORPHA:398069
Cushing Syndrome Due To Ectopic Acth Secretion
Small cell lung carcinoma, Malignant gastrointestinal tract tumors, Pulmonary carcinoid tumor, Ne... ORPHA:99889
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Failure to thrive, Meningioma, Obesity, Neoplasm, Pilomatrixoma, Spinal cord tumor ORPHA:353281
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Disease
Increased body weight, Pituitary corticotropic cell adenoma, Truncal obesity, Abdominal obesity ORPHA:96253
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Obesity, Failure to thrive, Pilomatrixoma, Meningioma ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Obesity, Failure to thrive, Pilomatrixoma, Meningioma ORPHA:353277
Tetrasomy 9P
Pilomatrixoma ORPHA:3310

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gstp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gstp1.

No publications found that use IMPC mice or data for Gstp1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gstp1em1(IMPC)Hmgu Exon Deletion Mice
Gstp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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