Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Eph receptor A7
Cek11,  MDK1,  Ehk3,  Mdk1,  Ebk,  Hek11

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Epha7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Epha7 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Congenital Herpes Simplex Virus Infection
Hydranencephaly, Microcephaly ORPHA:293
Craniotelencephalic Dysplasia
Cerebellar hypoplasia, Arrhinencephaly, Lissencephaly, Optic nerve hypoplasia, Absent septum pell... OMIM:218670
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Hydrocephalus, Congenital, 3, With Brain Anomalies
Cerebellar hypoplasia, Hydrocephalus, Hydranencephaly, Holoprosencephaly, Cerebellar agenesis, Da... OMIM:617967
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Anencephaly, Hydrocephalus, Myelomeningocele OMIM:182940
Craniotelencephalic Dysplasia
Septo-optic dysplasia, Cerebellar hypoplasia, Arrhinencephaly, Hydrocephalus, Lissencephaly, Micr... ORPHA:1528
Aprosencephaly Syndrome
Anencephaly, Aprosencephaly OMIM:207770
Anencephaly 2
Anencephaly OMIM:619452
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Fetal Akinesia Syndrome, X-Linked
Arrhinencephaly, Agenesis of corpus callosum OMIM:300073
Hydrolethalus Syndrome 2
Anencephaly, Hydrocephalus, Agenesis of corpus callosum OMIM:614120
Anencephaly ORPHA:1681
Spinal dysraphism, Myelomeningocele, Anencephaly, Sirenomelia, Cervical spina bifida ORPHA:63260
Schisis Association
Spina bifida, Anencephaly, Encephalocele, Microcephaly ORPHA:63862
Meckel Syndrome, Type 4
Meningocele, Encephalocele, Anencephaly, Hydrocephalus, Microcephaly, Hypoplasia of the corpus ca... OMIM:611134
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Hydranencephaly, Microcephaly OMIM:601355
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Aplasia/Hypoplasia of the cerebellum, Cerebral cortical atrophy, Aplasia/Hypoplasia of the corpus... ORPHA:2570
Hypoplasia of the brainstem, Cerebellar hypoplasia, Hydranencephaly, Microcephaly, Pachygyria, Ag... OMIM:605013
Distal Monosomy 13Q
Aplasia/Hypoplasia of the corpus callosum, Encephalocele, Anencephaly, Holoprosencephaly, Microce... ORPHA:1590
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Aplasia/Hypoplasia of the cerebellum, Spinal dysraphism, Encephalocele, Aplasia/Hypo... ORPHA:1908
Meckel Syndrome, Type 5
Occipital encephalocele, Anencephaly OMIM:611561
Microcephaly 20, Primary, Autosomal Recessive
Small cerebral cortex, Cerebellar hypoplasia, Simplified gyral pattern, Arrhinencephaly, Optic ne... OMIM:617914
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Meckel Syndrome, Type 2
Meningocele, Anencephaly, Encephalocele, Dandy-Walker malformation OMIM:603194
Joubert Syndrome 18
Occipital encephalocele, Arrhinencephaly, Agenesis of cerebellar vermis, Agenesis of corpus callosum OMIM:614815
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hypoplasia of the brainstem, Cerebellar hypoplasia, Agenesis of corpus callosum, Hydrocephalus, H... OMIM:225790
Meckel Syndrome, Type 10
Occipital encephalocele, Anencephaly, Dandy-Walker malformation, Cerebellar hypoplasia OMIM:614175
Arrhinencephaly, Hydrocephalus, Anencephaly, Absent septum pellucidum, Agenesis of corpus callosum ORPHA:2189
Meckel Syndrome 12
Cerebellar hypoplasia, Cerebral hypoplasia, Arrhinencephaly, Microcephaly, Agenesis of cerebellar... OMIM:616258
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hydranencephaly, Hypoplasia of the brainstem, Cerebellar hypoplasia OMIM:236500
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Cerebellar hemisphere hypoplasia, Hypoplasia of the brainstem, Cerebellar hypoplasia, Anencephaly... OMIM:615287
Spinal dysraphism, Encephalocele, Myelomeningocele, Spina bifida, Anencephaly, Hydrocephalus, Lis... ORPHA:63259
Cerebrocostomandibular Syndrome
Meningocele, Myelomeningocele, Spina bifida, Porencephalic cyst, Cerebral calcification, Hydranen... ORPHA:1393
Meckel Syndrome, Type 6
Occipital encephalocele, Anencephaly, Hydrocephalus OMIM:612284
Chromosome 13Q33-Q34 Deletion Syndrome
Encephalocele, Anencephaly, Dandy-Walker malformation, Microcephaly, Agenesis of corpus callosum OMIM:619148
Acrofacial Dysostosis, Rodríguez Type
Arrhinencephaly, Aqueductal stenosis ORPHA:1788
Pentalogy Of Cantrell
Anencephaly, Hydrocephalus, Encephalocele ORPHA:1335
Pelvis-Shoulder Dysplasia
Spina bifida, Hydranencephaly, Hydrocephalus ORPHA:2839
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Anencephaly, Hydrocephalus, Cerebellar vermis hypoplasia, Polymicrogyria OMIM:616546
49,Xxxxy Syndrome
Hypoplasia of the corpus callosum, Arrhinencephaly, Holoprosencephaly ORPHA:96264
Vacterl/Vater Association
Occipital encephalocele, Anencephaly ORPHA:887
Thoracoabdominal Syndrome
Anencephaly, Hydrocephalus OMIM:313850
Trisomy 18
Aplasia/Hypoplasia of the corpus callosum, Spina bifida, Anencephaly, Holoprosencephaly, Microcep... ORPHA:3380
Caudal Regression Syndrome
Arrhinencephaly ORPHA:3027
Orofaciodigital Syndrome Vi
Porencephalic cyst, Arrhinencephaly, Polymicrogyria, Occipital meningocele, Agenesis of corpus ca... OMIM:277170
Short-Rib Thoracic Dysplasia 12
Anencephaly, Holoprosencephaly, Hydrocephalus OMIM:269860
Vacterl With Hydrocephalus
Spina bifida, Arrhinencephaly, Hydrocephalus, Aqueductal stenosis ORPHA:3412
Meckel Syndrome
Aplasia/Hypoplasia of the corpus callosum, Encephalocele, Anencephaly, Hydrocephalus, Lobar holop... ORPHA:564
Limb Body Wall Complex
Encephalocele, Myelomeningocele, Spina bifida, Short umbilical cord, Anencephaly, Hydrocephalus, ... ORPHA:2369
Meckel Syndrome, Type 1
Cerebellar hypoplasia, Cerebral hypoplasia, Anencephaly, Hydrocephalus, Agenesis of corpus callos... OMIM:249000
Cousin Syndrome
Hydranencephaly, Hydrocephalus OMIM:260660
Aicardi-Goutières Syndrome
Porencephalic cyst, Arrhinencephaly, Cerebral calcification, Multifocal cerebral white matter abn... ORPHA:51
Hydrolethalus Syndrome 1
Severe hydrocephalus, Abnormal cortical gyration, Arrhinencephaly, Anencephaly, Agenesis of corpu... OMIM:236680
22Q11.2 Deletion Syndrome
Meningocele, Spina bifida, Arrhinencephaly, Hydrocephalus, Occipital myelomeningocele, Microcepha... ORPHA:567
Microgastria-Limb Reduction Defect Syndrome
Arrhinencephaly, Agenesis of corpus callosum, Absent septum pellucidum, Abnormal cortical gyration ORPHA:2538
Fryns Syndrome
Arrhinencephaly, Dandy-Walker malformation, Hypoplasia of olfactory tract, Hypoplasia of the opti... OMIM:229850
Neu-Laxova Syndrome 1
Primary microcephaly, Spina bifida, Short umbilical cord, Cerebellar hypoplasia, Agenesis of corp... OMIM:256520
Ring Chromosome 13 Syndrome
Anencephaly, Microcephaly, Agenesis of corpus callosum ORPHA:96176
Yunis-Varon Syndrome
Hypoplasia of the frontal lobes, Cerebellar hypoplasia, Primary microcephaly, Arrhinencephaly, Hy... ORPHA:3472
Microphthalmia With Limb Anomalies
Arrhinencephaly, Hydrocephalus ORPHA:1106
Doors Syndrome
Arrhinencephaly, Spina bifida occulta, Sirenomelia, Microcephaly, Dandy-Walker malformation, Poly... ORPHA:79500
Pallister-Hall Syndrome
Cerebellar hypoplasia, Arrhinencephaly, Holoprosencephaly, Abnormal corpus callosum morphology, A... ORPHA:672
Charge Syndrome
Arrhinencephaly, Holoprosencephaly, Microcephaly, Umbilical hernia OMIM:214800
Yunis-Varon Syndrome
Hypoplasia of the frontal lobes, Cerebellar hypoplasia, Arrhinencephaly, Microcephaly, Pachygyria... OMIM:216340


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Epha7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Epha7.

No publications found that use IMPC mice or data for Epha7.

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MGI Allele Allele Type Produced
Epha7tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Epha7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Epha7tm35911(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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