Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Eph receptor A7
Synonyms:
Cek11,  MDK1,  Ehk3,  Mdk1,  Ebk,  Hek11

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Epha7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Epha7 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Congenital Herpes Simplex Virus Infection
Hydranencephaly, Microcephaly ORPHA:293
Hydrocephalus, Congenital, 3, With Brain Anomalies
Dandy-Walker malformation, Holoprosencephaly, Hydranencephaly, Hydrocephalus OMIM:617967
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Craniotelencephalic Dysplasia
Arrhinencephaly, Optic nerve hypoplasia, Absent septum pellucidum, Cerebellar hypoplasia, Lissenc... OMIM:218670
Craniotelencephalic Dysplasia
Arrhinencephaly, Septo-optic dysplasia, Hydrocephalus, Cerebellar hypoplasia, Lissencephaly, Agen... ORPHA:1528
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Anencephaly, Myelomeningocele OMIM:182940
Hydrolethalus Syndrome 2
Agenesis of corpus callosum, Hydrocephalus, Anencephaly OMIM:614120
Diprosopus
Anencephaly ORPHA:1681
Fetal Akinesia Syndrome, X-Linked
Arrhinencephaly, Agenesis of corpus callosum OMIM:300073
Anencephaly 2
Anencephaly OMIM:619452
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Dandy-Walker malformation, Hydranencephaly, Hypoplasia of the brainstem, Hydrocephalus, Cerebella... OMIM:225790
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Abnormality of the diencephalon, Holoprosencephaly, Aplasia/Hypoplasia of the ce... ORPHA:2570
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Dandy-Walker malformation, Anencephaly, Hypoplasia of the brainstem, Hydrocephalus, Cerebellar hy... OMIM:615287
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Hydranencephaly, Microcephaly OMIM:601355
Microhydranencephaly
Hydranencephaly, Pachygyria, Hypoplasia of the brainstem, Cerebellar hypoplasia, Agenesis of corp... OMIM:605013
Meckel Syndrome, Type 4
Dandy-Walker malformation, Meningocele, Anencephaly, Agenesis of cerebellar vermis, Hydrocephalus... OMIM:611134
Schisis Association
Spina bifida, Anencephaly, Microcephaly ORPHA:63862
Distal Monosomy 13Q
Holoprosencephaly, Aplasia/Hypoplasia of the corpus callosum, Anencephaly, Microcephaly ORPHA:1590
Craniorachischisis
Spinal dysraphism, Anencephaly, Myelomeningocele, Cervical spina bifida ORPHA:63260
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Anencephaly, Holoprosencephaly, Aplasia/Hypoplasia of the cerebellum, Hydrocephalus,... ORPHA:1908
Meckel Syndrome, Type 10
Anencephaly OMIM:614175
Hydrolethalus
Arrhinencephaly, Anencephaly, Absent septum pellucidum, Hydrocephalus, Agenesis of corpus callosum ORPHA:2189
Meckel Syndrome, Type 2
Dandy-Walker malformation, Meningocele, Anencephaly OMIM:603194
Meckel Syndrome, Type 5
Anencephaly OMIM:611561
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hypoplasia of the brainstem, Hydranencephaly, Cerebellar hypoplasia OMIM:236500
Meckel Syndrome, Type 6
Hydrocephalus, Anencephaly OMIM:612284
Chromosome 13Q33-Q34 Deletion Syndrome
Dandy-Walker malformation, Agenesis of corpus callosum, Anencephaly, Microcephaly OMIM:619148
Iniencephaly
Dandy-Walker malformation, Anencephaly, Myelomeningocele, Holoprosencephaly, Lissencephaly, Spina... ORPHA:63259
Acrofacial Dysostosis, Rodríguez Type
Arrhinencephaly, Aqueductal stenosis ORPHA:1788
Cerebrocostomandibular Syndrome
Meningocele, Hydranencephaly, Myelomeningocele, Spina bifida, Porencephalic cyst, Cerebral calcif... ORPHA:1393
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Cerebellar vermis hypoplasia, Anencephaly, Hydrocephalus, Polymicrogyria OMIM:616546
Thoracoabdominal Syndrome
Hydrocephalus, Anencephaly OMIM:313850
Pelvis-Shoulder Dysplasia
Spina bifida, Hydrocephalus, Hydranencephaly ORPHA:2839
Trisomy 18
Anencephaly, Holoprosencephaly, Spina bifida, Aplasia/Hypoplasia of the corpus callosum, Microcep... ORPHA:3380
Pentalogy Of Cantrell
Hydrocephalus, Anencephaly ORPHA:1335
Vacterl/Vater Association
Anencephaly ORPHA:887
Microgastria-Limb Reduction Defects Association
Arrhinencephaly, Polymicrogyria, Porencephalic cyst, Fusion of the left and right thalami, Agenes... OMIM:156810
Caudal Regression Sequence
Arrhinencephaly ORPHA:3027
Meckel Syndrome, Type 1
Dandy-Walker malformation, Anencephaly, Hydrocephalus, Cerebellar hypoplasia, Olfactory lobe agen... OMIM:249000
49,Xxxxy Syndrome
Holoprosencephaly, Arrhinencephaly, Hypoplasia of the corpus callosum ORPHA:96264
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Hydrocephalus, Anencephaly OMIM:269860
Cousin Syndrome
Hydranencephaly, Hydrocephalus OMIM:260660
Vacterl With Hydrocephalus
Arrhinencephaly, Spina bifida, Hydrocephalus, Aqueductal stenosis ORPHA:3412
Meckel Syndrome
Dandy-Walker malformation, Lobar holoprosencephaly, Anencephaly, Aplasia/Hypoplasia of the corpus... ORPHA:564
Hydrolethalus Syndrome 1
Abnormal cortical gyration, Dandy-Walker malformation, Arrhinencephaly, Severe hydrocephalus, Ane... OMIM:236680
Aicardi-Goutières Syndrome
Arrhinencephaly, Multifocal cerebral white matter abnormalities, Degeneration of the striatum, Po... ORPHA:51
Limb Body Wall Complex
Anencephaly, Myelomeningocele, Spina bifida, Hydrocephalus, Spina bifida occulta ORPHA:2369
Microgastria-Limb Reduction Defect Syndrome
Abnormal cortical gyration, Arrhinencephaly, Agenesis of corpus callosum, Absent septum pellucidum ORPHA:2538
Ring Chromosome 13 Syndrome
Agenesis of corpus callosum, Anencephaly, Microcephaly ORPHA:96176
Neu-Laxova Syndrome 1
Dandy-Walker malformation, Hydranencephaly, Spina bifida, Cerebellar hypoplasia, Lissencephaly, A... OMIM:256520
Fryns Syndrome
Dandy-Walker malformation, Arrhinencephaly, Hypoplasia of the optic tract, Hypoplasia of olfactor... OMIM:229850
22Q11.2 Deletion Syndrome
Meningocele, Arrhinencephaly, Occipital myelomeningocele, Spina bifida, Hydrocephalus, Microcephaly ORPHA:567
Yunis-Varon Syndrome
Hypoplasia of the frontal lobes, Arrhinencephaly, Primary microcephaly, Pachygyria, Hydrocephalus... ORPHA:3472
Pallister-Hall Syndrome
Abnormal prolactin level, Arrhinencephaly, Adrenocorticotropic hormone deficiency, Holoprosenceph... ORPHA:672
Microphthalmia With Limb Anomalies
Arrhinencephaly, Hydrocephalus ORPHA:1106
Doors Syndrome
Dandy-Walker malformation, Arrhinencephaly, Polymicrogyria, Spina bifida occulta, Microcephaly ORPHA:79500
Charge Syndrome
Arrhinencephaly, Holoprosencephaly, Gonadotropin deficiency, Decreased response to growth hormone... OMIM:214800
Yunis-Varon Syndrome
Hypoplasia of the frontal lobes, Arrhinencephaly, Cerebellar vermis hypoplasia, Pachygyria, Cereb... OMIM:216340

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Epha7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Epha7.

No publications found that use IMPC mice or data for Epha7.

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MGI Allele Allele Type Produced
Epha7tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Epha7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Epha7tm35911(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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