Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
beclin 2
Synonyms:
Gm104,  Gm38100,  LOC226720

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Becn2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Becn2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Type 2 Diabetes Mellitus
Type II diabetes mellitus, Increased waist to hip ratio, Insulin resistance OMIM:125853
Maturity-Onset Diabetes Of The Young, Type 11
Maturity-onset diabetes of the young, Obesity, Diabetes mellitus, Overweight OMIM:613375
Short Stature Due To Primary Acid-Labile Subunit Deficiency
Truncal obesity, Insulin resistance ORPHA:140941
Diabetes Mellitus, Transient Neonatal, 2
Type II diabetes mellitus, Transient neonatal diabetes mellitus OMIM:610374
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Large for gestational age, Neonatal hypoglycemia OMIM:240900
Cortisone Reductase Deficiency 2
Obesity, Insulin resistance OMIM:614662
Body Mass Index Quantitative Trait Locus 20
Obesity, Hyperinsulinemia, Polyphagia, Tall stature OMIM:618406
Obesity Due To Melanocortin 4 Receptor Deficiency
Type II diabetes mellitus, Polyphagia, Hyperinsulinemia, Obesity, Childhood-onset truncal obesity ORPHA:71529
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Hypoketotic hypoglycemia, Truncal obesity, Neonatal hypoglycemia, Large for gestational age, Abno... ORPHA:293964
Insulin Autoimmune Syndrome
Fasting hypoglycemia, Insulin resistance, Insulin-resistant diabetes mellitus, Hyperinsulinemic h... ORPHA:411593
Pancreatic Beta Cell Agenesis With Neonatal Diabetes Mellitus
Neonatal insulin-dependent diabetes mellitus OMIM:600089
Hyperinsulinism Due To Insr Deficiency
Hypoglycemia, Insulin resistance, Hyperinsulinemic hypoglycemia, Recurrent hypoglycemia, Fasting ... ORPHA:263458
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Hyperinsulinemia, Polyphagia ORPHA:329249
Acanthosis Nigricans With Muscle Cramps And Acral Enlargement
Insulin resistance OMIM:200170
Maturity-Onset Diabetes Of The Young, Type 10
Hyperglycemia, Diabetic ketoacidosis, Maturity-onset diabetes of the young, Diabetes mellitus OMIM:613370
Hyperinsulinemic Hypoglycemia, Familial, 2
Hyperinsulinemic hypoglycemia, Hypoglycemia, Large for gestational age OMIM:601820
Maturity-Onset Diabetes Of The Young, Type 3
Hyperglycemia, Maturity-onset diabetes of the young, Type II diabetes mellitus OMIM:600496
Diabetes Mellitus, Ketosis-Prone
Diabetes mellitus, Insulin resistance OMIM:612227
Diabetes Mellitus, Transient Neonatal, 1
Hyperglycemia, Severe failure to thrive, Transient neonatal diabetes mellitus OMIM:601410
Hyperinsulinism Due To Hnf1A Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Polyphagia, Small for gestatio... ORPHA:324575
Obesity Due To Sim1 Deficiency
Obesity, Glucose intolerance, Hyperinsulinemia, Polyphagia ORPHA:369873
Hyperinsulinemic Hypoglycemia, Familial, 1
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, Large for gestational age OMIM:256450
Macrosomia Adiposa Congenita
Obesity, Polyphagia, Large for gestational age OMIM:248100
Type 1 Diabetes Mellitus
Hyperglycemia, Polyphagia, Diabetes mellitus, Polydipsia OMIM:222100
Growth Hormone Insensitivity Syndrome
Type II diabetes mellitus, Hypoglycemia, Insulin resistance, Failure to thrive, Truncal obesity, ... ORPHA:181393
Lipodystrophy, Familial Partial, Type 6
Abdominal obesity, Diabetes mellitus, Insulin resistance OMIM:615980
Obesity
Obesity, Decreased resting energy expenditure, Increased waist to hip ratio OMIM:601665
Wolfram-Like Syndrome, Autosomal Dominant
Glucose intolerance, Impaired glucose tolerance, Diabetes mellitus OMIM:614296
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Polyphagia, Hyperinsulinemic h... ORPHA:276580
Body Mass Index Quantitative Trait Locus 19
Obesity, Insulin resistance OMIM:617885
Obesity Due To Prohormone Convertase I Deficiency
Polyphagia, Failure to thrive, Hyperinsulinemia, Obesity, Hypoglycemic seizures, Childhood-onset ... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Polyphagia, Failure to thrive, Hyperinsulinemia, Obesity, Hypoglycemic seizures, Childhood-onset ... ORPHA:71526
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Diabetes mellitus, Polyphagia OMIM:614963
Morbid Obesity And Spermatogenic Failure
Obesity, Type II diabetes mellitus, Insulin resistance OMIM:615703
Multiple Symmetric Lipomatosis
Insulin resistance ORPHA:2398
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity, Hypoglycemic seizures, Polyphagia OMIM:609734
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Polyphagia, Hyperinsulinemic hypoglycemia, Large ... ORPHA:276575
Hyperinsulinism Due To Ucp2 Deficiency
Hypoketotic hypoglycemia, Polyphagia, Hyperinsulinemic hypoglycemia, Large for gestational age, R... ORPHA:276556
Transient Neonatal Diabetes Mellitus
Maternal diabetes, Small for gestational age, Hyperglycemia, Diabetic ketoacidosis, Maturity-onse... ORPHA:99886
Glycogen Storage Disease 0, Liver
Fasting hypoglycemia, Postprandial hyperglycemia, Neonatal hypoglycemia OMIM:240600
Obesity, Hyperphagia, And Developmental Delay
Obesity, Polyphagia OMIM:613886
Bardet-Biedl Syndrome 6
Obesity, Diabetes mellitus OMIM:605231
Bardet-Biedl Syndrome 22
Obesity, Polyphagia, Large for gestational age OMIM:617119
Hyperproinsulinemia
Hyperglycemia, Hyperinsulinemia OMIM:616214
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
Hyperglycemia, Glucose intolerance OMIM:307500
Temple Syndrome
Type II diabetes mellitus, Small for gestational age, Polyphagia, Recurrent hypoglycemia, Obesity ORPHA:254516
Renal Glucosuria
Polydipsia, Polyphagia, Glycosuria OMIM:233100
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia, Hyperglycemia, Truncal obesity, Obesity OMIM:615986
Leptin Deficiency Or Dysfunction
Obesity, Abnormal eating behavior, Polyphagia OMIM:614962
Diabetes Mellitus, Permanent Neonatal, 4
Hyperglycemia, Diabetic ketoacidosis, Type I diabetes mellitus, Small for gestational age OMIM:618858
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency
Obesity, Fasting hypoglycemia, Abnormal circulating insulin level ORPHA:171706
Familial Partial Lipodystrophy, Köbberling Type
Hyperinsulinemia, Diabetes mellitus, Insulin resistance ORPHA:79084
Insulinomatosis And Diabetes Mellitus
Hyperinsulinemic hypoglycemia, Glucose intolerance, Impaired glucose tolerance, Diabetes mellitus OMIM:147630
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Hyperostosis Frontalis Interna
Obesity, Diabetes mellitus OMIM:144800
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Diabetes Mellitus, Permanent Neonatal, 1
Hyperglycemia, Small for gestational age, Diabetes mellitus, Type I diabetes mellitus OMIM:606176
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Insulinoma
Polyphagia, Hyperinsulinemic hypoglycemia, Fasting hyperinsulinemia, Recurrent hypoglycemia, Reac... ORPHA:97279
Macrosomia With Microphthalmia, Lethal
Large for gestational age OMIM:248110
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Fasting hypoglycemia, Hypoglycemia, Small for gestational age, Insulin-resistant diabetes mellitu... OMIM:262190
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity OMIM:616521
Mody
Insulin-resistant diabetes mellitus, Hyperinsulinemic hypoglycemia, Hyperglycemia, Glucose intole... ORPHA:552
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Reactive hypoglyce... ORPHA:276608
Acromegaloid Facial Appearance Syndrome
Large for gestational age OMIM:102150
Acquired Partial Lipodystrophy
Insulin resistance ORPHA:79087
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Diabetes Mellitus, Transient Neonatal, 3
Hyperglycemia, Maternal diabetes, Transient neonatal diabetes mellitus OMIM:610582
Obesity Due To Congenital Leptin Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia ORPHA:66628
Prader-Willi Syndrome Due To Imprinting Mutation
Obesity, Polyphagia ORPHA:177910
Lipodystrophy, Familial Partial, Type 7
Glucose intolerance, Impaired glucose tolerance, Insulin resistance OMIM:606721
Diabetes Mellitus, Permanent Neonatal, 3
Hyperglycemia, Small for gestational age, Type I diabetes mellitus, Glycosuria OMIM:618857
Carcinoma Of Esophagus
Weight loss, Dysphagia, Obesity ORPHA:70482
Obesity Due To Leptin Receptor Gene Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia ORPHA:179494
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Insulin-Resistance Syndrome Type B
Fasting hypoglycemia, Type II diabetes mellitus, Abnormality of body weight, Insulin resistance, ... ORPHA:2298
Lipodystrophy, Congenital Generalized, Type 3
Diabetes mellitus, Insulin resistance OMIM:612526
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:90301
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia, Neonatal hypoglycemia OMIM:606407
Bardet-Biedl Syndrome 12
Obesity OMIM:615989
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Hypoglycemia, Small for gestational age, Insulin resistance, Failure to thrive, Truncal obesity ORPHA:73272
Narcolepsy 7
Obesity, Type II diabetes mellitus OMIM:614250
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Diabetes Mellitus, Permanent Neonatal, 2
Hyperglycemia, Type I diabetes mellitus OMIM:618856
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Obesity, Polyphagia ORPHA:411515
Placental Insufficiency
Small for gestational age, Insulin resistance ORPHA:439167
6Q16 Microdeletion Syndrome
Obesity, Polyphagia ORPHA:171829
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Hyperglycemia OMIM:618970
Bardet-Biedl Syndrome 18
Obesity OMIM:615995
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Bardet-Biedl Syndrome 2
Obesity, Diabetes mellitus OMIM:615981
Acth-Independent Macronodular Adrenal Hyperplasia 2
Hyperglycemia, Abdominal obesity, Increased body weight OMIM:615954
Congenital Generalized Lipodystrophy
Insulin resistance, Failure to thrive, Diabetes mellitus, Proportionate tall stature, Hyperinsuli... ORPHA:528
Pancreatic Agenesis 1
Failure to thrive, Neonatal insulin-dependent diabetes mellitus, Diabetes mellitus OMIM:260370
Blue Diaper Syndrome
Recurrent hypoglycemia, Increased proinsulin:insulin ratio, Increased body weight ORPHA:94086
Diabetes And Deafness, Maternally Inherited
Hyperglycemia, Type II diabetes mellitus OMIM:520000
Graves Disease, Susceptibility To, 1
Weight loss, Polyphagia OMIM:275000
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Obesity, Diabetes mellitus OMIM:610628
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Failure to thrive, Postprandial hyperglycemia, Glycosuria, Ketotic hypoglycemia ORPHA:2089
Severe Neurodegenerative Syndrome With Lipodystrophy
Hyperinsulinemia, Insulin resistance ORPHA:363400
Summitt Syndrome
Obesity OMIM:272350
Akt2-Related Familial Partial Lipodystrophy
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:79085
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity OMIM:619058
Mehmo Syndrome
Obesity, Diabetes mellitus ORPHA:85282
Pick Disease Of Brain
Polyphagia OMIM:172700
Huntington Disease
Polyphagia, Decreased body mass index, Choking episodes, Weight loss, Oral-pharyngeal dysphagia ORPHA:399
Lipodystrophy, Familial Partial, Type 1
Insulin-resistant diabetes mellitus, Hyperglycemia OMIM:608600
Frontotemporal Dementia
Polyphagia OMIM:600274
Prader-Willi Habitus, Osteopenia, And Camptodactyly
Obesity OMIM:264010
Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome
Diabetes mellitus, Insulin resistance OMIM:615381
Schaaf-Yang Syndrome
Obesity, Failure to thrive in infancy, Polyphagia OMIM:615547
Temple Syndrome
Maturity-onset diabetes of the young, Small for gestational age, Truncal obesity, Overweight OMIM:616222
Silver-Russell Syndrome
Failure to thrive in infancy, Cachexia, Insulin resistance, Recurrent hypoglycemia, Obesity ORPHA:813
Short Syndrome
Weight loss, Diabetes mellitus, Insulin resistance ORPHA:3163
Pparg-Related Familial Partial Lipodystrophy
Insulin-resistant diabetes mellitus, Maternal diabetes, Diabetes mellitus, Insulin resistance ORPHA:79083
Estrogen Resistance
Glucose intolerance, Impaired glucose tolerance, Hyperinsulinemia OMIM:615363
Hyperinsulinism Due To Hnf4A Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Glycosuria, Neonat... ORPHA:263455
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Hypoglycemia, Diabetes mellitus, Glycosuria, Large for gestational age OMIM:616026
Proprotein Convertase 1/3 Deficiency
Reactive hypoglycemia, Obesity OMIM:600955
X-Linked Acrogigantism
Polyphagia, Tall stature, Increased body mass index, Fasting hyperinsulinemia, Abnormal oral gluc... ORPHA:300373
Man1B1-Cdg
Truncal obesity, Polyphagia ORPHA:397941
Aromatase Deficiency
Type II diabetes mellitus, Tall stature, Insulin resistance, Eunuchoid habitus, Obesity ORPHA:91
Mandibuloacral Dysplasia
Insulin-resistant diabetes mellitus, Glucose intolerance, Hyperinsulinemia, Insulin resistance ORPHA:2457
Retinitis Pigmentosa
Obesity, Type II diabetes mellitus, Hyperinsulinemia ORPHA:791
Central Precocious Puberty
Obesity, Overgrowth, Increased body weight ORPHA:759
Lipodystrophy, Congenital Generalized, Type 4
Failure to thrive, Dysphagia, Hyperinsulinemia, Insulin resistance OMIM:613327
Familial Multiple Lipomatosis
Overgrowth, Insulin resistance ORPHA:199276
Luscan-Lumish Syndrome
Obesity, Overgrowth, Polyphagia OMIM:616831
Idiopathic Neonatal Atrial Flutter
Maternal diabetes, Large for gestational age ORPHA:45452
Lipodystrophy, Familial Partial, Type 3
Insulin-resistant diabetes mellitus, Maternal diabetes, Hyperinsulinemia, Hyperglycemia OMIM:604367
Bardet-Biedl Syndrome 1
Insulin resistance, Truncal obesity, Abdominal obesity, Diabetes mellitus, Obesity OMIM:209900
Bangstad Syndrome
Insulin-resistant diabetes mellitus, Small for gestational age OMIM:210740
Lipe-Related Familial Partial Lipodystrophy
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:435660
Rabson-Mendenhall Syndrome
Fasting hypoglycemia, Polydipsia, Insulin resistance, Insulin-resistant diabetes mellitus, Diabet... ORPHA:769
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hyperglycemia, Hypoglycemia, Failure to thrive OMIM:220111
Monosomy 13Q34
Obesity, Insulin resistance ORPHA:96168
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Recurrent hypoglycemia, Hyperinsulinemic hypoglycemia, Large for gestational age, Neonatal hypogl... ORPHA:79644
Familial Partial Lipodystrophy, Dunnigan Type
Diabetes mellitus, Insulin resistance ORPHA:2348
Whipple Disease
Cachexia, Polydipsia, Insulin resistance ORPHA:3452
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Laurence-Moon Syndrome
Obesity, Type II diabetes mellitus ORPHA:2377
Retinitis Pigmentosa-Intellectual Disability-Deafness-Hypogonadism Syndrome
Obesity, Type II diabetes mellitus, Hyperinsulinemia ORPHA:3085
Sim1-Related Prader-Willi-Like Syndrome
Type II diabetes mellitus, Polyphagia, Failure to thrive, Abdominal obesity, Obesity ORPHA:398079
Short Stature, Microcephaly, And Endocrine Dysfunction
Diabetes mellitus, Truncal obesity, Insulin resistance OMIM:616541
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Maturity-onset diabetes of the young, Obesity ORPHA:254531
Chromosome Xq26.3 Duplication Syndrome
Overgrowth, Polyphagia, Tall stature OMIM:300942
Primary Lipodystrophy
Type II diabetes mellitus, Insulin resistance ORPHA:90970
Bardet-Biedl Syndrome 19
Obesity OMIM:615996
Microduplication Xp11.22P11.23 Syndrome
Obesity ORPHA:217377
Cebalid Syndrome
Polyphagia OMIM:618774
Seckel Syndrome 10
Insulin resistance, Glucose intolerance, Impaired glucose tolerance, Glycosuria, Diabetes mellitus OMIM:617253
Male Hypergonadotropic Hypogonadism-Intellectual Disability-Skeletal Anomalies Syndrome
Obesity, Type II diabetes mellitus, Eunuchoid habitus ORPHA:2234
Short Syndrome
Insulin-resistant diabetes mellitus, Glucose intolerance, Small for gestational age, Hyperglycemia OMIM:269880
Pancreatic And Cerebellar Agenesis
Hyperglycemia, Hypoglycemia, Diabetes mellitus, Failure to thrive OMIM:609069
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Fasting hypoglycemia, Small for gestational age, Insulin resistance, Failure to thrive, Oral aver... ORPHA:96182
Donohue Syndrome
Fasting hypoglycemia, Hyperglycemia, Severe failure to thrive, Postprandial hyperglycemia, Hyperi... OMIM:246200
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:98754
Prader-Willi Syndrome
Failure to thrive in infancy, Type II diabetes mellitus, Polyphagia, Abdominal obesity, Obesity, ... OMIM:176270
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:177901
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Magel2-Related Prader-Willi-Like Syndrome
Type II diabetes mellitus, Polyphagia, Failure to thrive, Abdominal obesity, Increased body weight ORPHA:398069
Pigmented Nodular Adrenocortical Disease, Primary, 4
Diabetes mellitus, Increased body weight OMIM:615830
Dopamine Beta-Hydroxylase Deficiency
Hypoglycemia, Hyperinsulinemia, Insulin resistance ORPHA:230
Cortisone Reductase Deficiency 1
Obesity OMIM:604931
Acquired Generalized Lipodystrophy
Insulin-resistant diabetes mellitus, Hyperinsulinemia, Insulin resistance ORPHA:79086
Werner Syndrome
Slender build, Type II diabetes mellitus, Insulin resistance ORPHA:902
Secondary Short Bowel Syndrome
Failure to thrive, Weight loss, Polyphagia ORPHA:95427
Abcd Syndrome
Large for gestational age OMIM:600501
Prader-Willi-Like Syndrome
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:398073
2Q23.1 Microdeletion Syndrome
Polyphagia ORPHA:228402
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Polyphagia ORPHA:251004
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body mass index, Increased body weight OMIM:614450
Halothane Hepatitis
Obesity OMIM:234350
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Thalidomide Embryopathy
Insulin resistance ORPHA:3312
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Maturity-onset diabetes of the young, Obesity, Small for gestational age, Truncal obesity ORPHA:96184
Pediatric-Onset Graves Disease
Failure to thrive, Polydipsia, Polyphagia ORPHA:525731
Abdominal Obesity-Metabolic Syndrome 4
Obesity, Type II diabetes mellitus OMIM:618620
Craniopharyngioma
Obesity, Type II diabetes mellitus, Polyphagia ORPHA:54595
Acrodysostosis 2 With Or Without Hormone Resistance
Obesity, Diabetes mellitus OMIM:614613
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly
Obesity, Glucose intolerance, Impaired glucose tolerance OMIM:615630
Fanconi-Bickel Syndrome
Fasting hypoglycemia, Failure to thrive, Impaired glucose tolerance, Glycosuria, Diabetes mellitu... ORPHA:2088
Trisomy 18P
Polyphagia ORPHA:1715
Gitelman Syndrome
Maternal diabetes, Type II diabetes mellitus, Polydipsia, Insulin resistance, Failure to thrive, ... ORPHA:358
Subaortic Stenosis-Short Stature Syndrome
Obesity, Type II diabetes mellitus ORPHA:3191
Greig Cephalopolysyndactyly Syndrome
Hyperglycemia OMIM:175700
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Prader-Willi Syndrome
Failure to thrive, Abdominal obesity, Diabetes mellitus, Polyphagia ORPHA:739
Marbach-Rustad Progeroid Syndrome
Insulin resistance OMIM:619322
Chromosome 22Q13 Duplication Syndrome
Polyphagia OMIM:615538
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Necrotizing Enterocolitis
Hyperglycemia, Abnormal glucose homeostasis, Small for gestational age ORPHA:391673
Leprechaunism
Fasting hypoglycemia, Insulin resistance, Failure to thrive, Recurrent infantile hypoglycemia, De... ORPHA:508
Beta-Ketothiolase Deficiency
Hyperglycemia, Weight loss, Hypoglycemia, Oral aversion ORPHA:134
Morgagni-Stewart-Morel Syndrome
Obesity, Diabetes mellitus ORPHA:77296
Mandibuloacral Dysplasia With Type B Lipodystrophy
Insulin-resistant diabetes mellitus, Glucose intolerance, Hyperinsulinemia, Hyperglycemia OMIM:608612
Bloom Syndrome
Abdominal obesity, Diabetes mellitus, Small for gestational age, Insulin resistance ORPHA:125
Bdv Syndrome
Obesity, Type II diabetes mellitus, Hyperinsulinemia OMIM:619326
Autosomal Semi-Dominant Severe Lipodystrophic Laminopathy
Diabetes mellitus, Insulin resistance ORPHA:280365
Angelman Syndrome
Obesity, Dysphagia, Polyphagia ORPHA:72
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia
Obesity, Hypoglycemia OMIM:608624
Lipodystrophy, Congenital Generalized, Type 1
Insulin-resistant diabetes mellitus at puberty, Hyperinsulinemia, Polyphagia, Tall stature OMIM:608594
Hypokalemic Periodic Paralysis
Postprandial hyperglycemia ORPHA:681
Mandibuloacral Dysplasia With Type B Lipodystrophy
Insulin resistance ORPHA:90154
9Q31.1Q31.3 Microdeletion Syndrome
Type II diabetes mellitus, Overweight ORPHA:401923
Intellectual Developmental Disorder, Autosomal Dominant 1
Polyphagia OMIM:156200
Lipodystrophy, Congenital Generalized, Type 2
Insulin-resistant diabetes mellitus at puberty, Hyperinsulinemia, Polyphagia, Tall stature OMIM:269700
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Mandibuloacral Dysplasia With Type A Lipodystrophy
Insulin resistance ORPHA:90153
Symptomatic Form Of Hemochromatosis Type 1
Hyperglycemia, Weight loss, Diabetes mellitus ORPHA:465508
Pituitary Adenoma 4, Acth-Secreting
Obesity, Glucose intolerance, Impaired glucose tolerance, Abdominal obesity OMIM:219090
Low Phospholipid-Associated Cholelithiasis
Obesity, Diabetes mellitus, Overweight ORPHA:69663
Mandibuloacral Dysplasia With Type A Lipodystrophy
Insulin-resistant diabetes mellitus, Impaired glucose tolerance, Hyperinsulinemia, Hyperglycemia OMIM:248370
Isolated Permanent Neonatal Diabetes Mellitus
Hyperglycemia, Failure to thrive, Weight loss, Glycosuria, Neonatal insulin-dependent diabetes me... ORPHA:99885
Primary Pigmented Nodular Adrenocortical Disease
Type II diabetes mellitus, Glucose intolerance, Abdominal obesity, Diabetes mellitus, Increased b... ORPHA:189439
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hyperglycemia, Obesity, Polydipsia, Polyphagia ORPHA:293987
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia ORPHA:251028
Septo-Optic Dysplasia Spectrum
Obesity, Maternal diabetes, Polydipsia ORPHA:3157
7Q11.23 Microduplication Syndrome
Obesity, Polyphagia ORPHA:96121
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Recurrent hypoglycemia, Fasting hypoglycemia, Increased body weight, Ketotic hypoglycemia ORPHA:79240
Adrenocortical Carcinoma
Weight loss, Diabetes mellitus, Increased body weight ORPHA:1501
Gangliocytoma
Polyphagia ORPHA:251937
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Polyphagia OMIM:607485
Pseudohypoparathyroidism Type 1C
Obesity, Polyphagia ORPHA:79444
Adnp Syndrome
Oral-pharyngeal dysphagia, Truncal obesity, Polyphagia ORPHA:404448
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
Glucose intolerance, Abdominal obesity, Increased body weight ORPHA:189427
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Fasting hypoglycemia, Hypoglycemia, Increased body weight ORPHA:264580
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Wilson Disease
Failure to thrive, Weight loss, Increased body weight ORPHA:905
Pseudohypoparathyroidism Type 1A
Obesity, Polyphagia ORPHA:79443
Acquired Aneurysmal Subarachnoid Hemorrhage
Hyperglycemia ORPHA:90065
Steinert Myotonic Dystrophy
Oral-pharyngeal dysphagia, Hyperinsulinemia, Diabetes mellitus, Insulin resistance ORPHA:273
Mitchell-Riley Syndrome
Hyperglycemia OMIM:615710
Lipodystrophy, Familial Partial, Type 2
Insulin-resistant diabetes mellitus, Hyperinsulinemia, Hyperglycemia OMIM:151660
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Dend Syndrome
Hyperglycemia ORPHA:79134
Dysbetalipoproteinemia
Obesity, Diabetes mellitus ORPHA:412
Pyruvate Carboxylase Deficiency
Hyperglycemia, Hypoglycemia, Failure to thrive ORPHA:3008
Hutchinson-Gilford Progeria Syndrome
Weight loss, Severe failure to thrive, Insulin resistance ORPHA:740
1P36 Deletion Syndrome
Failure to thrive, Obesity, Dysphagia, Polyphagia ORPHA:1606
Isolated Sedoheptulokinase Deficiency
Postprandial hyperglycemia ORPHA:440713
Odontochondrodysplasia 2 With Hearing Loss And Diabetes
Obesity, Type I diabetes mellitus OMIM:619269
Thyrotoxic Periodic Paralysis
Obesity, Weight loss, Postprandial hyperglycemia ORPHA:79102
Early-Onset Schizophrenia
Polyphagia ORPHA:96369
Atypical Werner Syndrome
Type II diabetes mellitus, Insulin-resistant diabetes mellitus, Hyperglycemia, Failure to thrive,... ORPHA:79474
Heart Defects, Congenital, And Other Congenital Anomalies
Hyperglycemia, Diabetes mellitus, Glycosuria, Failure to thrive OMIM:600001
Cushing Disease
Impaired glucose tolerance, Truncal obesity, Abdominal obesity, Diabetes mellitus, Increased body... ORPHA:96253
Chromosome 1P36 Deletion Syndrome, Distal
Obesity, Dysphagia, Polyphagia OMIM:607872
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
Hyperglycemia, Obesity ORPHA:444077
Scorpion Envenomation
Hyperglycemia, Glycosuria ORPHA:466677
Alström Syndrome
Type II diabetes mellitus, Polyphagia, Insulin resistance, Truncal obesity, Obesity, Hyperinsulin... ORPHA:64
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Syndrome Due To Ectopic Acth Secretion
Weight loss, Impaired glucose tolerance, Truncal obesity, Abdominal obesity, Diabetes mellitus, I... ORPHA:99889
Pmm2-Cdg
Failure to thrive, Hyperinsulinemia, Insulin resistance ORPHA:79318
Carney Complex
Abdominal obesity, Increased body weight, Tall stature ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Becn2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Becn2.

No publications found that use IMPC mice or data for Becn2.

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