Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms:
6330570N16Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Camkk2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Camkk2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Childhood-onset truncal obesity, Hyperinsulinemia, Increased adipose tissue, Polyphagia, Obesity,... ORPHA:71529
Body Mass Index Quantitative Trait Locus 19
Hyperinsulinemia, Polyphagia, Obesity, Increased serum leptin, Insulin resistance OMIM:617885
Akt2-Related Familial Partial Lipodystrophy
Decreased serum leptin, Increased intraabdominal fat, Lipodystrophy, Decreased adiponectin level,... ORPHA:79085
Lipe-Related Familial Partial Lipodystrophy
Loss of gluteal subcutaneous adipose tissue, Increased adipose tissue around the neck, Loss of su... ORPHA:435660
Leptin Deficiency Or Dysfunction
Decreased serum leptin, Obesity, Polyphagia, Hypogonadism OMIM:614962
Obesity Due To Congenital Leptin Deficiency
Absence of secondary sex characteristics, Hyperinsulinemia, Hypoplasia of the ovary, Decreased se... ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Absence of secondary sex characteristics, Hyperinsulinemia, Hypoplasia of the ovary, Decreased se... ORPHA:179494
Cidec-Related Familial Partial Lipodystrophy
Loss of gluteal subcutaneous adipose tissue, Loss of subcutaneous adipose tissue in limbs, Decrea... ORPHA:435651
Lipodystrophy, Familial Partial, Type 5
Diabetic ketoacidosis, Decreased serum leptin, Lipodystrophy, Decreased adiponectin level OMIM:615238
Obesity Due To Sim1 Deficiency
Hyperinsulinemia, Polyphagia, Obesity, Attention deficit hyperactivity disorder, Glucose intolerance ORPHA:369873
Insulin-Resistance Syndrome Type B
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Increased serum testosterone level, Fasting hypo... ORPHA:2298
Idiopathic Congenital Hypothyroidism
Elevated circulating thyroid-stimulating hormone concentration, Decreased circulating T4 concentr... ORPHA:95717
Autosomal Semi-Dominant Severe Lipodystrophic Laminopathy
Lipoatrophy, Loss of subcutaneous adipose tissue in limbs, Increased adipose tissue around the ne... ORPHA:280365
Lipodystrophy, Congenital Generalized, Type 1
Hyperinsulinemia, Decreased serum leptin, Polyphagia, Reduced subcutaneous adipose tissue, Lipody... OMIM:608594
Riboflavin Deficiency
Hypoglycemia, Hypothermia OMIM:615026
Familial Thyroid Dyshormonogenesis
Elevated circulating thyroid-stimulating hormone concentration, Hypothermia, Congenital hypothyro... ORPHA:95716
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypoglycemia, Hypothermia OMIM:610006
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Elevated circulating thyroid-stimulating hormone concentration, Large for gestational age, Hypoth... ORPHA:226313
Lipodystrophy, Congenital Generalized, Type 2
Hyperinsulinemia, Decreased serum leptin, Polyphagia, Reduced subcutaneous adipose tissue, Lipody... OMIM:269700
Mody
Large for gestational age, Neonatal hypoglycemia, Hypoinsulinemia, Abnormal circulating insulin c... ORPHA:552
Genetic Transient Congenital Hypothyroidism
Elevated circulating thyroid-stimulating hormone concentration, Hypothermia, Thyroid hypoplasia, ... ORPHA:226316
Isolated Thyroid-Stimulating Hormone Deficiency
Decreased thyroid-stimulating hormone level, Hypothermia, Pituitary hypothyroidism, Increased pit... ORPHA:90674
Hypothyroidism Due To Tsh Receptor Mutations
Elevated circulating thyroid-stimulating hormone concentration, Hypothermia, Impaired sensitivity... ORPHA:90673
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Failure to thrive, Hypoglycemia, Hypothermia OMIM:245400
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Decreased response to growth hormone stimulation test, Decreased thyroid-stimulating hormone leve... ORPHA:226307
Rett Syndrome
Agitation, Stereotypical hand wringing, Failure to thrive, Motor stereotypy, Increased serum lept... ORPHA:778
N-Acetylglutamate Synthase Deficiency
Anorexia, Failure to thrive, Hypothermia, Aggressive behavior OMIM:237310
Primary Erythromelalgia
Hypothermia ORPHA:90026
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Joint contracture, Hypothermia, Inguinal hernia OMIM:614498
Meningococcal Meningitis
Anorexia, Increased circulating procalcitonin concentration, Hypothermia ORPHA:33475
Atypical Werner Syndrome
Lipoatrophy, Delayed puberty, Neoplasm of the thyroid gland, Hyperinsulinemia, Generalized lipody... ORPHA:79474
Timothy Syndrome
Hypothyroidism, Hypoglycemia, Hypothermia OMIM:601005
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Keppen-Lubinsky Syndrome
Generalized lipodystrophy, Decreased serum leptin, Lack of facial subcutaneous fat, Absence of su... OMIM:614098
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Coenzyme Q10 Deficiency, Primary, 5
Hypothermia OMIM:614654
Nestor-Guillermo Progeria Syndrome
Lipoatrophy, Failure to thrive, Decreased serum leptin, Flexion contracture OMIM:614008
Alexander Disease
Hypothermia, Hypothyroidism, Precocious puberty, Failure to thrive, Dysphagia, Self-injurious beh... ORPHA:58
Dopamine Beta-Hydroxylase Deficiency
Insulin resistance, Hypoglycemia, Hyperinsulinemia, Hypothermia ORPHA:230
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Delayed puberty, Decreased response to growth hormone stimulation test, Central diabe... ORPHA:293987
Hypothyroidism, Congenital, Nongoitrous, 2
Elevated circulating thyroid-stimulating hormone concentration, Thyroid agenesis, Hypothermia, Th... OMIM:218700
3-Hydroxy-3-Methylglutaric Aciduria
Anorexia, Hypothermia, Nonketotic hypoglycemia, Weight loss, Recurrent hypoglycemia ORPHA:20
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia, Hypoketotic hypoglycemia, Obesity, Overweight, Small for gestational age ORPHA:26793
Carnitine-Acylcarnitine Translocase Deficiency
Fasting hypoglycemia, Hypothermia, Hypoketotic hypoglycemia ORPHA:159
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Hip contracture, Elbow flexion contracture, Hypothermia, Obesity OMIM:618493
Combined Oxidative Phosphorylation Deficiency 37
Failure to thrive, Hypoglycemia, Hypothermia OMIM:618329
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia, Failure to thrive, Flexion contracture, Hypoglycemia, Aggressive behavior ORPHA:17
Orthostatic Hypotension 1
Neonatal hypoglycemia, Intermittent hypothermia, Reduced circulating prolactin concentration OMIM:223360
Menkes Disease
Hypothermia OMIM:309400
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Failure to thrive, Hypoglycemia, Hypothermia OMIM:251880
Menkes Disease
Hypothermia, Inguinal hernia, Umbilical hernia, Atypical scarring of skin, Hypoglycemia, Hernia, ... ORPHA:565
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Hutchinson-Gilford Progeria Syndrome
Severe failure to thrive, Pubertal developmental failure in females, Decreased serum leptin, Dela... ORPHA:740
Adult-Onset Autosomal Dominant Leukodystrophy
Hypothermia, Flexion contracture, Dysphagia ORPHA:99027
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia, Small for gestational age OMIM:618775
Occipital Horn Syndrome
Scarring, Hypothermia, Inguinal hernia, Femoral hernia, Dysphagia, Atypical scarring of skin, Kel... ORPHA:198
Congenital Enterovirus Infection
Hypothermia ORPHA:292
Sepsis In Premature Infants
Hypothermia, Decreased body weight, Small for gestational age ORPHA:90051
Mitochondrial Dna-Associated Leigh Syndrome
Failure to thrive, Hypothermia, Dysphagia ORPHA:255210
Tbck-Related Intellectual Disability Syndrome
Decreased response to growth hormone stimulation test, Hypothermia, Hypothyroidism, Hyperthyroidi... ORPHA:488632
Hereditary Sensory And Autonomic Neuropathy Type 4
Hypothermia, Nail-biting, Hyperactivity, Corneal scarring, Impulsivity, Dysphagia, Atypical scarr... ORPHA:642
Neuroleptic Malignant Syndrome
Agitation, Hypothermia, Dysphagia ORPHA:94093
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Failure to thrive, Hypoglycemia, Hypothermia ORPHA:79282
Ethylene Glycol Poisoning
Addictive alcohol use, Hypothermia ORPHA:31826
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Hypothermia, Abnormality of the endocrine system, Stereotypical hand wringing, Hypothyroidism, Ut... ORPHA:438213
Marburg Hemorrhagic Fever
Anorexia, Hypoglycemia, Hypothermia, Aggressive behavior ORPHA:99826
Sarcoidosis
Scarring, Abnormality of the adrenal glands, Hypothermia, Diabetes insipidus, Hypothyroidism, Hyp... ORPHA:797

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Camkk2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Camkk2.

No publications found that use IMPC mice or data for Camkk2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Camkk2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Camkk2tm372599(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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