Gene: Tns3 MGI:2443012

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Gene Summary

Name:
tensin 3
Synonyms:
TEM6,  F830010I22Rik,  Tens1

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral content Tns3em1(IMPC)Bay HET Late adult 5.30×10-05
preweaning lethality, incomplete penetrance Tns3em1(IMPC)Bay HOM   Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

12 Images

X-ray

XRay Images Whole Body Lateral Orientation

13 Images

X-ray

XRay Images Forepaw

12 Images

X-ray

XRay Images Skull Lateral Orientation

12 Images

X-ray

XRay Images Whole Body Dorso Ventral

13 Images

Human diseases caused by Tns3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tns3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Immunodeficiency 31C
Autoimmune hemolytic anemia, Villous atrophy, Growth delay, Lymphopenia, Delayed puberty, Short s... OMIM:614162
Diarrhea 5, With Tufting Enteropathy, Congenital
Villous atrophy, Small for gestational age, Failure to thrive, Arthritis OMIM:613217
Diarrhea 2, With Microvillus Atrophy
Villous atrophy, Growth delay, Abnormal intestine morphology OMIM:251850
Diarrhea 9
Villous atrophy, Failure to thrive OMIM:618168
Autoinflammation With Infantile Enterocolitis
Villous atrophy, Diffuse alveolar hemorrhage, Pancytopenia, Thrombocytopenia, Splenomegaly, Reduc... OMIM:616050
Trichohepatoenteric Syndrome 2
Cirrhosis, Villous atrophy, Colitis, Hepatomegaly, Hepatitis, Small for gestational age, Failure ... OMIM:614602
Diarrhea 7, Protein-Losing Enteropathy Type
Villous atrophy, Failure to thrive, Protein-losing enteropathy OMIM:615863
Congenital Disorder Of Glycosylation, Type Id
Arthrogryposis multiplex congenita, Bulbous nose, Villous atrophy, Flexion contracture, Wide nasa... OMIM:601110
Secondary Short Bowel Syndrome
Small intestinal dysmotility, Villous atrophy, Growth delay, Aganglionic megacolon, Steatorrhea, ... ORPHA:95427
Immunodeficiency, Common Variable, 8, With Autoimmunity
Clubbing of fingers, Bronchiectasis, Generalized lymphadenopathy, Pneumonia, Pancytopenia, Lympha... OMIM:614700
Congenital Disorder Of Glycosylation, Type Ib
Cirrhosis, Villous atrophy, Protein-losing enteropathy, Hepatic fibrosis, Hepatomegaly, Lymphangi... OMIM:602579
Refractory Celiac Disease
Osteoporosis, Iron deficiency anemia, Jejunitis, Microcytic anemia, Villous atrophy, Weight loss,... ORPHA:398063
Diarrhea 11, Malabsorptive, Congenital
Villous atrophy OMIM:618662
Bare Lymphocyte Syndrome, Type Ii
Recurrent upper respiratory tract infections, Viral hepatitis, Villous atrophy, Neutropenia, Bili... OMIM:209920
Distal Osteosclerosis
Hyperostosis, Craniofacial osteosclerosis, Diaphyseal sclerosis OMIM:126250
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
T lymphocytopenia, Hemolytic anemia, Pulmonary interstitial lymphocyte infiltration, Autoimmune h... OMIM:606367
Congenital Tufting Enteropathy
Villous atrophy, Choanal atresia, Abnormal small intestinal mucosa morphology, Steatorrhea, Weigh... ORPHA:92050
Feingold Syndrome 2
3-4 toe syndactyly, Short middle phalanx of the 2nd finger, 2-3 toe syndactyly, Postnatal growth ... OMIM:614326
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Coombs-positive hemolytic anemia, Autoimmune thrombocytopenia, Villous atrophy, Neutropenia, Thro... OMIM:304790
Alpha-Heavy Chain Disease
Growth delay, Hepatomegaly, Anemia, Splenomegaly, Abnormality of the small intestine, Malabsorpti... ORPHA:100025
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis, Failure to thrive OMIM:614328
Spondyloepimetaphyseal Dysplasia, Isidor-Toutain Type
Enlarged metaphyses, Lower-limb metaphyseal irregularity, Severe short stature, Postnatal growth ... OMIM:618728
Netherton Syndrome
Villous atrophy, Hypereosinophilia, Failure to thrive, Abnormal intestine morphology, Intestinal ... OMIM:256500
Proprotein Convertase 1/3 Deficiency
Villous atrophy, Malabsorption, Obesity OMIM:600955
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
Megaloblastic anemia, Growth delay, Absence of intrinsic factor OMIM:243320
Lissencephaly Syndrome, Norman-Roberts Type
Rocker bottom foot, Dysphagia, Hypoplastic spleen, Wide nasal bridge, Abnormality of neuronal mig... ORPHA:89844
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Bronchiectasis, Recurrent upper respiratory tract infections, Esophageal carcinoma, Autoimmune th... ORPHA:391487
Syndromic Diarrhea
Cirrhosis, Thrombocytosis, Villous atrophy, Lymphopenia, Peripheral pulmonary artery stenosis, In... ORPHA:84064
Bronchogenic Cyst
Abnormal sputum, Abnormal stomach morphology, Abnormal pleura morphology, Dysphagia, Abnormality ... ORPHA:2357
Ghosal Hematodiaphyseal Dysplasia
Myelofibrosis, Increased bone mineral density, Thrombocytopenia, Leukopenia, Refractory anemia, D... OMIM:231095
Mucocutaneous Ulceration, Chronic
Ileitis OMIM:618287
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Joint hypermobility, Postnatal growth retardation, Obesity, Cleft palate, Clinodactyly, Small han... ORPHA:96184
Bile Acid Malabsorption, Primary, 1
Growth delay, Failure to thrive, Steatorrhea, Fat malabsorption OMIM:613291
Congenital Short Bowel Syndrome
Decreased intestinal transit time, Abnormal peristalsis, Intestinal malrotation, Steatorrhea, Con... OMIM:615237
Hypophosphatasia
Craniosynostosis, Emphysema, Bowing of the long bones, Recurrent fractures, Failure to thrive in ... ORPHA:436
Parenteral Nutrition-Associated Cholestasis
Cirrhosis, Hepatic steatosis, Villous atrophy, Cholelithiasis, Biliary hyperplasia, Hepatic fibro... ORPHA:567983
Microvillus Inclusion Disease
Villous atrophy, Abnormality of small intestinal villus morphology ORPHA:2290
Gracile Bone Dysplasia
Ankyloglossia, Slender long bone, Asplenia, Flared metaphysis, Short stature, Failure to thrive, ... OMIM:602361
Trichohepatoenteric Syndrome 1
Cirrhosis, Thrombocytosis, Villous atrophy, Increased mean platelet volume, Cholestasis, Hepatic ... OMIM:222470
Sarcoidosis, Susceptibility To, 2
Bronchiectasis, Pulmonary fibrosis, Pleural effusion, Emphysema, Abnormal pulmonary interstitial ... OMIM:612387
Hypercholanemia, Familial 1
Rickets, Fat malabsorption, Failure to thrive, Steatorrhea OMIM:607748
Cholestasis, Progressive Familial Intrahepatic, 1
Cirrhosis, Intrahepatic cholestasis with episodic jaundice, Severe short stature, Hepatomegaly, J... OMIM:211600
Microgastria-Limb Reduction Defect Syndrome
Absent hand, Intestinal malrotation, Abnormality of the metacarpal bones, Rectovaginal fistula, S... ORPHA:2538
Idiopathic Bronchiectasis
Respiratory tract infection, Bronchiectasis, Emphysema, Acute infectious pneumonia, Cachexia, Hem... ORPHA:60033
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Recurrent respiratory infections, Protein-losing enteropathy OMIM:619063
Mirage Syndrome
Overlapping fingers, Radial club hand, Rocker bottom foot, Lymphopenia, Gastroesophageal reflux, ... OMIM:617053
Microgastria-Limb Reduction Defects Association
Hypoplasia of the radius, Gastroesophageal reflux, Intestinal malrotation, Hypoplasia of the ulna... OMIM:156810
Inflammatory Bowel Disease (Crohn Disease) 30
Esophagitis, Duodenitis, Ileitis, Protein-losing enteropathy, Pancolitis, Gastritis, Abnormal int... OMIM:619079
T-Cell Immunodeficiency With Thymic Aplasia
Aplasia of the thymus, Bronchiectasis, Emphysema, Lymphopenia, Recurrent bronchopulmonary infecti... OMIM:242700
Alpha-1-Antitrypsin Deficiency
Cirrhosis, Chronic bronchitis, Hepatocellular carcinoma, Panacinar emphysema OMIM:613490
Disorder Of Bile Acid Synthesis
Rickets, Biliary tract abnormality, Cholestasis, Fat malabsorption, Abnormality of the liver ORPHA:79168
Allergic Bronchopulmonary Aspergillosis
Bronchiectasis, Emphysema, Weight loss, Hemoptysis, Abnormal eosinophil morphology, Abnormal bron... ORPHA:1164
Intrinsic Factor Deficiency
Megaloblastic anemia, Increased mean corpuscular volume, Megaloblastic erythroid hyperplasia, Mal... OMIM:261000
Cholestasis, Progressive Familial Intrahepatic, 2
Cirrhosis, Hepatocellular carcinoma, Intrahepatic cholestasis, Hepatomegaly, Intermittent jaundic... OMIM:601847
Bile Acid Synthesis Defect, Congenital, 1
Cirrhosis, Giant cell hepatitis, Rickets, Intrahepatic cholestasis, Steatorrhea, Hepatomegaly, Ja... OMIM:607765
Syndromic Recessive X-Linked Ichthyosis
Lissencephaly, Abnormal stomach morphology, Acute leukemia, Short stature ORPHA:281090
Immunodeficiency 54
Postnatal growth retardation, Hepatomegaly, Reduced natural killer cell count, Splenomegaly, Shor... OMIM:609981
Visceral Myopathy 2
Megaduodenum, Hiatus hernia, Esophagitis, Dysphagia, Gastroesophageal reflux, Intestinal malrotat... OMIM:619350
Idiopathic Hypereosinophilic Syndrome
Generalized lymphadenopathy, Chronic hepatitis, Anemia, Neutrophilia, Cervical lymphadenopathy, E... ORPHA:3260
Pyloric Atresia
Congenital pyloric atresia OMIM:265950
Common Variable Immunodeficiency
Recurrent bronchitis, Gastrointestinal stroma tumor, Hemolytic anemia, Bronchiectasis, Autoimmune... ORPHA:1572
Polyposis of gastric fundus without polyposis coli
Multiple gastric polyps, Abnormality of the gastric mucosa OMIM:175505
Congenital Disorder Of Glycosylation, Type Ih
Camptodactyly, Protein-losing enteropathy, Thrombocytopenia, Cholestasis, Hepatomegaly, Anemia, F... OMIM:608104
Serrated Polyposis Syndrome
Biliary tract neoplasm, Gastric diverticulum, Colorectal polyposis, Adenomatous colonic polyposis... ORPHA:157798
Cutis Laxa-Marfanoid Syndrome
Emphysema, Flexion contracture, Hip dislocation, Arachnodactyly, Limitation of joint mobility ORPHA:171719
Surfactant Metabolism Dysfunction, Pulmonary, 3
Ground-glass opacification, Absent bronchoalveolar surfactant-protein C, Intraalveolar phospholip... OMIM:610921
Chronic Intestinal Pseudoobstruction
Abnormal intestine morphology, Pyloric stenosis, Intestinal malrotation, Abnormal platelet morpho... ORPHA:2978
Thrombocytopenia, Anemia, And Myelofibrosis
Myelofibrosis, Thrombocytopenia, Anisopoikilocytosis, Anemia, Splenomegaly OMIM:617441
Scedosporiosis
Pleuritis, Arthralgia/arthritis, Pulmonary fibrosis, Pneumonia, Pleural empyema, Septic arthritis... ORPHA:449280
Castleman Disease
Myelofibrosis, Abnormality of the gastrointestinal tract, Generalized lymphadenopathy, Follicular... ORPHA:160
Ossification Anomalies-Psychomotor Developmental Delay Syndrome
Clubbing of fingers, Generalized bone demineralization, Abnormal bone ossification, Anteverted na... ORPHA:73230
Eosinophilic Gastroenteritis
Hematochezia, Leukocytosis, Dysphagia, Abnormality of the gastrointestinal tract, Steatorrhea, Pr... ORPHA:2070
Bronchopulmonary Dysplasia
Pulmonary sequestration, Abnormal lung morphology, Abnormal respiratory system morphology, Emphys... ORPHA:70589
Emphysema, Hereditary Pulmonary
Emphysema, Chronic bronchitis OMIM:130700
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Narrow palate, Camptodactyly, Spina bifida occulta, Depressed nasal bridge, Pachygyria, Rectal pr... OMIM:235510
X-Linked Non-Syndromic Intellectual Disability
Shortening of all distal phalanges of the fingers, Meckel diverticulum, Clinodactyly of the 2nd t... ORPHA:777
Meier-Gorlin Syndrome 6
Hip dysplasia, Short nose, Underdeveloped nasal alae, Short middle phalanx of finger, Emphysema, ... OMIM:616835
Matthew-Wood Syndrome
Abnormal lung morphology, Aplasia/Hypoplasia of the pancreas, Abnormal spleen morphology, Pulmona... ORPHA:2470
Desbuquois Dysplasia 2
Broad thumb, Short phalanx of finger, Cutaneous syndactyly, Joint laxity, Postnatal growth retard... OMIM:615777
Oculoskeletodental Syndrome
Macroglossia, Protein-losing enteropathy, Wide nasal bridge, Hepatomegaly, Small for gestational ... OMIM:618440
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Clubbing of fingers, Hamartomatous polyposis, Glossitis, Hematochezia, Gastrointestinal carcinoma... OMIM:175500
Congenital Bile Acid Synthesis Defect Type 4
Cirrhosis, Biliary tract abnormality, Cholestasis, Hepatomegaly, Fat malabsorption ORPHA:79095
Meier-Gorlin Syndrome 7
Craniosynostosis, Wide anterior fontanel, Joint laxity, Anal stenosis, Growth delay, Preaxial pol... OMIM:617063
Autosomal Dominant Cutis Laxa
Joint hyperflexibility, Emphysema, Bowel diverticulosis ORPHA:90348
Juvenile Polyposis Of Infancy
Clubbing of fingers, Hamartomatous polyposis, Broad thumb, Broad phalanx of the toes, Intestinal ... ORPHA:79076
Polycythemia Vera
Myelofibrosis, Gastrointestinal hemorrhage, Weight loss, Hepatomegaly, Splenomegaly, Portal hyper... ORPHA:729
Rajab Interstitial Lung Disease With Brain Calcifications 1
Joint laxity, Intestinal malrotation, Pancytopenia, Anemia, Thin bony cortex, High palate, Bile d... OMIM:613658
Scleroderma
Abnormal stomach morphology, Osteomyelitis, Intestinal bleeding, Pulmonary fibrosis, Abnormality ... ORPHA:801
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal malrotation, Increased mean platelet volume, Intestinal pseudo-obstruction, Thrombocyt... OMIM:300048
Acute Panmyelosis With Myelofibrosis
Lymphocytosis, Myelofibrosis, Acute myelomonocytic leukemia, Pancytopenia, Acute myeloid leukemia... ORPHA:86843
Martinez-Frias Syndrome
Extrahepatic biliary duct atresia, Intestinal hypoplasia, Jejunal atresia, Intestinal malrotation... OMIM:601346
Cutis Laxa, Autosomal Recessive, Type Ic
Joint laxity, Emphysema, Growth delay, Gastroesophageal reflux, Pyloric stenosis, Tracheomalacia,... OMIM:613177
Trigonocephaly 1
Meckel diverticulum, Craniosynostosis OMIM:190440
Congenital Tracheal Stenosis
Meckel diverticulum, Abnormal lung lobation, Abnormal stomach morphology, Abnormal lung morpholog... ORPHA:141127
Shwachman-Diamond Syndrome
Metaphyseal irregularity, Pneumonia, Neutropenia, Pancytopenia, Pancreatic hypoplasia, Leukopenia... ORPHA:811
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal
Meckel diverticulum, Hypoplasia of the radius, Short nose, Anteverted nares, Hypoplastic pelvis, ... OMIM:602613
Berry Aneurysm, Cirrhosis, Pulmonary Emphysema, And Cerebral Calcification
Cirrhosis, Portal hypertension, Emphysema, Short stature OMIM:210050
Ménétrier Disease
Multiple gastric polyps, Hypochromic microcytic anemia, Gastrointestinal hemorrhage, Helicobacter... ORPHA:2494
Myelofibrosis
Myeloproliferative disorder, Myelofibrosis, Splenomegaly OMIM:254450
Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii
Postnatal growth retardation, Short distal phalanx of finger, Ulnar bowing, Narrow pelvis bone, L... OMIM:210720
Harrod Syndrome
Malrotation of small bowel, Pyloric stenosis, Aganglionic megacolon, Failure to thrive, High pala... OMIM:601095
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Small bowel diverticula, Jejunoileal ulceration OMIM:221400
Cutis Laxa, Neonatal, With Marfanoid Phenotype
Emphysema, Hip dislocation, Arachnodactyly OMIM:614100
Systemic Sclerosis
Abnormal stomach morphology, Osteomyelitis, Intestinal bleeding, Pulmonary fibrosis, Abnormality ... ORPHA:90291
Essential Thrombocythemia
Abnormal platelet morphology, Myelofibrosis, Acute leukemia, Splenomegaly ORPHA:3318
Sarcoidosis, Susceptibility To, 1
Inflammation of the large intestine, Bronchiectasis, Pulmonary fibrosis, Pleural effusion, Emphys... OMIM:181000
Dextrocardia
Meckel diverticulum, Congenital hip dislocation, Abnormal pulmonary situs morphology, Intestinal ... ORPHA:1666
Alpha-1-Antitrypsin Deficiency
Hepatomegaly, Jaundice, Emphysema, Hepatitis ORPHA:60
Oculogastrointestinal Muscular Dystrophy
Spontaneous esophageal perforation, Abnormality of the gastrointestinal tract, Intestinal pseudo-... ORPHA:1876
Ritscher-Schinzel Syndrome 3
Shortening of all distal phalanges of the fingers, Epiphyseal stippling, Wide anterior fontanel, ... OMIM:619135
Meier-Gorlin Syndrome 4
Emphysema, Slender long bone, Birth length less than 3rd percentile, Short stature, Patellar apla... OMIM:613804
Acrocephalopolydactylous Dysplasia
Postaxial hand polydactyly, Craniosynostosis, Short nose, Hypoplastic colon, Polysplenia, Hypopla... OMIM:200995
Microcephalic Primordial Dwarfism, Montreal Type
Congenital pyloric atresia, Reduced bone mineral density, Severe short stature ORPHA:2617
Bile Acid Synthesis Defect, Congenital, 4
Giant cell hepatitis, Intrahepatic cholestasis, Hepatomegaly, Prolonged neonatal jaundice, Failur... OMIM:214950
Whim Syndrome
Respiratory tract infection, Bronchiectasis, Recurrent upper respiratory tract infections, Lympha... ORPHA:51636
Fanconi Renotubular Syndrome 5
Genu valgum, Pulmonary fibrosis, Emphysema, Hypophosphatemic rickets, Lung adenocarcinoma OMIM:618913
Autoinflammatory Syndrome, Familial, Behcet-Like
Hemolytic anemia, Lymphopenia, Ileal ulcer, Colitis, Thrombocytopenia OMIM:616744
Thrombocytopenia 6
Osteoporosis, Thrombocytopenia, Myelofibrosis OMIM:616937
Otopalatodigital Syndrome, Type Ii
Nonossified fifth metatarsal, Broad thumb, Short metatarsal, Congenital hip dislocation, Postnata... OMIM:304120
Diverticulosis, Small-Intestinal
Jejunoileal diverticula, Rheumatoid arthritis, Ulcerative colitis, Duodenal diverticula, Jejunal ... OMIM:223320
Bare Lymphocyte Syndrome, Type I
Recurrent bronchitis, Bronchiectasis, Bronchiolitis, Emphysema, Nasal polyposis, Chronic sinusitis OMIM:604571
Congenital Enterocyte Heparan Sulfate Deficiency
Protein-losing enteropathy, Weight loss, Hematochezia ORPHA:103910
Gray Platelet Syndrome
Thrombocytopenia, Myelofibrosis, Abnormal number of alpha granules, Splenomegaly OMIM:139090
Esophageal Atresia
Morphological abnormality of the gastrointestinal tract, Laryngotracheomalacia, Choanal atresia, ... ORPHA:1199
Chylomicron Retention Disease
Hepatic steatosis, Growth delay, Increased hepatocellular lipid droplets, Steatorrhea, Failure to... ORPHA:71
Dyskeratosis Congenita, Autosomal Recessive 5
Esophageal stenosis, Postnatal growth retardation, Colitis, Leukopenia, Intrauterine growth retar... OMIM:615190
Bleeding Disorder, Platelet-Type, 17
Thrombocytopenia, Absence of alpha granules, Gastrointestinal hemorrhage, Myelofibrosis OMIM:187900
Nk-Cell Enteropathy
Gastric ulcer, Increased T cell count, Hematochezia, Gastroesophageal reflux, Abnormality of the ... ORPHA:263665
Thrombocytopenia-Absent Radius Syndrome
Broad thumb, Short phalanx of finger, Carpal bone hypoplasia, Anemia, Phocomelia, Eosinophilia, T... OMIM:274000
Vascular Hyalinosis
Protein-losing enteropathy, Malabsorption, Hematochezia OMIM:277175
Chronic Granulomatous Disease
Abnormality of neutrophils, Pyloric stenosis, Liver abscess, Hepatomegaly, Splenomegaly, Sinusiti... ORPHA:379
Pancreatic Lipase Deficiency
Fat malabsorption, Steatorrhea OMIM:614338
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Pancreatic lymphangiectasis, Postaxial hand polydactyly, Postnatal growth retardation, Protein-lo... ORPHA:1655
Mitchell-Riley Syndrome
Annular pancreas, Biliary atresia, Intestinal malrotation, Jejunal atresia, Cholestasis, Duodenal... OMIM:615710
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Pancreatic lymphangiectasis, Postaxial hand polydactyly, Wide nasal bridge, Protein-losing entero... OMIM:235255
Juvenile Polyposis Syndrome
Clubbing of fingers, Hamartomatous stomach polyps, Juvenile gastrointestinal polyposis, Anemia, I... ORPHA:2929
Serkal Syndrome
Growth delay, Pulmonary hypoplasia, Malrotation of small bowel ORPHA:139466
Necrotizing Encephalomyelopathy, Subacute, Of Leigh, Adult
Foot acroosteolysis, Gastric ulcer, Gastric hypertrophy, Metacarpal periosteal thickening, Clubbi... OMIM:161700
Chromosome 14Q32 Duplication Syndrome, 700-Kb
Myeloid leukemia, Myelofibrosis OMIM:616604
Postaxial Acrofacial Dysostosis
Hypoplasia of the radius, Congenital hip dislocation, Radioulnar synostosis, Growth delay, Choana... OMIM:263750
Juvenile Polyposis Syndrome
Multiple gastric polyps, Intussusception, Hematochezia, Rectal prolapse, Duodenal adenocarcinoma,... OMIM:174900
Tarp Syndrome
Rocker bottom foot, Abnormal duodenum morphology, Hand polydactyly, Finger syndactyly, Tongue nod... ORPHA:2886
Autosomal Recessive Polycystic Kidney Disease
Jaundice, Hypersplenism, Fat malabsorption, Periportal fibrosis, Thrombocytopenia, Cholangitis, R... ORPHA:731
Birt-Hogg-Dubé Syndrome
Pulmonary sequestration, Emphysema, Pneumothorax ORPHA:122
Congenital Lobar Emphysema
Emphysema ORPHA:1928
Pancreatic Colipase Deficiency
Exocrine pancreatic insufficiency, Megaloblastic anemia, Cholelithiasis, Steatorrhea, Fat malabso... ORPHA:309108
Microphthalmia, Syndromic 9
Wide nasal bridge, Intrauterine growth retardation, Bilateral lung agenesis, Pulmonary hypoplasia... OMIM:601186
Mosaic Trisomy 16
Meckel diverticulum, Abnormal lung morphology, Short forearm, Abnormality of the gastrointestinal... ORPHA:1708
X-Linked Cerebral-Cerebellar-Coloboma Syndrome
Meckel diverticulum, Dysphagia, Short nose ORPHA:163961
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Anteverted nares, Protein-losing enteropathy OMIM:618154
Autosomal Recessive Cutis Laxa Type 1
Joint laxity, Emphysema, Peripheral pulmonary artery stenosis, Small bowel diverticula, Pathologi... ORPHA:90349
Netherton Syndrome
Emphysema, Malabsorption, Recurrent respiratory infections, Short stature ORPHA:634
Dubin-Johnson Syndrome
Biliary tract abnormality, Hepatomegaly, Jaundice, Abnormality of the gastric mucosa, Abnormality... ORPHA:234
Pericardial And Diaphragmatic Defect
Pulmonary sequestration, Meckel diverticulum, Morphological abnormality of the gastrointestinal t... ORPHA:2847
Loeys-Dietz Syndrome 4
Protrusio acetabuli, Joint laxity, Joint hyperflexibility, Emphysema, Broad uvula, Bifid uvula, H... OMIM:614816
Pearson Syndrome
Median cleft lip and palate, Exocrine pancreatic insufficiency, Reticulocytosis, Dysphagia, Growt... ORPHA:699
Isolated Biliary Atresia
Cirrhosis, Atretic gallbladder, Periportal fibrosis, Bile duct proliferation, Cholestasis, Jaundi... ORPHA:30391
Cerebral-Cerebellar-Coloboma Syndrome, X-Linked
Meckel diverticulum OMIM:300864
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1
Joint laxity, Myelofibrosis, Failure to thrive, Short stature, High palate, Large for gestational... OMIM:607721
Fryns Syndrome
Camptodactyly, Intestinal malrotation, Short distal phalanx of finger, Ectopic pancreatic tissue,... OMIM:229850
Hypocomplementemic Urticarial Vasculitis
Pleural effusion, Emphysema, Hepatomegaly, Splenomegaly, Hemoptysis, Lymphadenopathy, Arthritis ORPHA:36412
Combined Immunodeficiency-Enteropathy Spectrum
Gastrointestinal atresia, Peritoneal abscess, Autoimmune hemolytic anemia, Intestinal malrotation... ORPHA:436252
Zygomycosis
Peritonitis, Ileitis, Neutropenia, Melena, Sinusitis, Air crescent sign, Osteolysis, Splenic absc... ORPHA:73263
Fraser Syndrome 1
Laryngeal atresia, Underdeveloped nasal alae, Midline nasal groove, Abnormality of the small inte... OMIM:219000
Mungan Syndrome
Megaduodenum, Hypoperistalsis, Barrett esophagus, Intestinal pseudo-obstruction OMIM:611376
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Hiatus hernia, Abnormal duodenum morphology, Arthrogryposis multiplex congenita, Joint laxity, Ge... OMIM:601776
Congenital Alveolar Capillary Dysplasia
Aganglionic megacolon, Intestinal malrotation, Anal atresia, Asplenia, Volvulus, Absent gallbladd... ORPHA:210122
Cog8-Cdg
Failure to thrive, Protein-losing enteropathy ORPHA:95428
Trisomy 8P
Short fifth metatarsal, Malrotation of small bowel, 3-4 finger cutaneous syndactyly, Peripheral p... ORPHA:264450
Colonic Atresia
Abnormality of mesentery morphology, Colonic atresia, Abdominal situs inversus, Peptic ulcer, Duo... ORPHA:1198
Fanconi Anemia
Choanal atresia, Weight loss, Leukopenia, Anemia, High palate, Abnormality of the ulna, Triphalan... ORPHA:84
Annular Pancreas
Duodenal stenosis, High intestinal obstruction, Annular pancreas ORPHA:675
Pancreas, Annular
Duodenal stenosis, High intestinal obstruction, Annular pancreas OMIM:167750
Cutis Laxa, Autosomal Dominant 1
Emphysema OMIM:123700
Reynolds Syndrome
Cirrhosis, Dysphagia, Gastroesophageal reflux, Hepatomegaly, Xerostomia, Jaundice, Abnormality of... ORPHA:779
Ellis Van Creveld Syndrome
Genu valgum, Hand polydactyly, Synostosis of carpal bones, Emphysema, Short distal phalanx of fin... ORPHA:289
Maternal Uniparental Disomy Of Chromosome 4
Abnormal erythrocyte morphology, Decreased body weight, Postnatal growth retardation, Short statu... ORPHA:96180
Keutel Syndrome
Short hallux, Costal cartilage calcification, Chronic sinusitis, Epiphyseal stippling, Premature ... OMIM:245150
Abetalipoproteinemia
Fat malabsorption, Acanthocytosis OMIM:200100
Epidermodysplasia Verruciformis, Susceptibility To, 4
Emphysema OMIM:618307
Musculocontractural Ehlers-Danlos Syndrome
Abnormality of mesentery morphology, Craniosynostosis, Malrotation of small bowel, Short nose, Ar... ORPHA:2953
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
T lymphocytopenia, Impaired lymphocyte transformation with phytohemagglutinin, Hypoplasia of the ... OMIM:619313
Lymphangioleiomyomatosis
Gastrointestinal hemorrhage, Emphysema, Atelectasis, Lymphadenopathy, Chylothorax, Hemoptysis, Pu... ORPHA:538
Ehlers-Danlos Syndrome, Vascular Type
Foot acroosteolysis, Joint hypermobility, Hypermobility of interphalangeal joints, Repeated pneum... OMIM:130050
Cystic Fibrosis With Helicobacter Pylori Gastritis, Megaloblastic Anemia, And Mental Retardation
Exocrine pancreatic insufficiency, Megaloblastic anemia, Emphysema, Biliary cirrhosis, Wide nasal... OMIM:219721
Metachromatic Leukodystrophy
Abnormal stomach morphology, Abnormal duodenum morphology, Hemobilia, Intussusception, Abnormal g... ORPHA:512
Wolf-Hirschhorn Syndrome
Malrotation of small bowel, Split hand, Biliary tract abnormality, Metatarsus adductus, Small for... OMIM:194190
Marfan Syndrome
Spontaneous pneumothorax, Slender build, Joint hypermobility, Protrusio acetabuli, Arthralgia/art... ORPHA:558
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Meckel diverticulum, Misalignment of the pulmonary veins, Annular pancreas, Pleural effusion, Pul... OMIM:265380
Ulnar-Mammary Syndrome
Hypoplasia of the radius, Postaxial hand polydactyly, Anal stenosis, Hypoplastic scapulae, Pylori... OMIM:181450
Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Congenital pyloric atresia, Arthrogryposis multiplex congenita, Esophageal atresia OMIM:226730
Simpson-Golabi-Behmel Syndrome, Type 1
Broad thumb, Two carpal ossification centers present at birth, Flared iliac wing, Short greater s... OMIM:312870
Diverticulosis Of Bowel, Hernia, And Retinal Detachment
Small bowel diverticula, Colonic diverticula OMIM:223330
Sarcoidosis
Bronchiectasis, Bone cyst, Weight loss, Leukopenia, Anemia, Abnormality of the lymph nodes, Lymph... ORPHA:797
Cutis Laxa, Autosomal Recessive, Type Ia
Emphysema, Arachnodactyly, Joint laxity, Recurrent respiratory infections OMIM:219100
Neonatal Marfan Syndrome
Joint hypermobility, Emphysema, Flexion contracture, Wide nasal bridge, Long toe, Small for gesta... ORPHA:284979
Nocardiosis
Peritonitis, Abnormal sputum, Pleuritis, Lymphadenitis, Pleural effusion, Emphysema, Pneumonia, W... ORPHA:31204
Fabry Disease
Emphysema, Achalasia, Reduced bone mineral density, Delayed puberty, Short stature, Abnormality o... ORPHA:324
Vater/Vacterl Association
Hypoplasia of the radius, Radioulnar synostosis, Abnormal nasopharynx morphology, Preaxial polyda... OMIM:192350
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Joint hypermobility, Proportionate short stature, Failure to thrive in infancy, Absent gallbladde... ORPHA:500150
Abetalipoproteinemia
Cirrhosis, Acanthocytosis, Reticulocytosis, Hepatic steatosis, Steatorrhea, Hepatic fibrosis, Hep... ORPHA:14
Visceral Myopathy 1
Megaduodenum, Dysphagia, Aganglionic megacolon, Intestinal pseudo-obstruction, Microcolon, Pancre... OMIM:155310
Diarrhea 10, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Pleural effusion, Hematochezia OMIM:618183
Cutis Laxa, Autosomal Recessive, Type Ib
Joint hypermobility, Bulbous nose, Emphysema, Pulmonary artery aneurysm, High palate, Arachnodact... OMIM:614437
Marfan Syndrome
Joint hypermobility, Limited elbow extension, Protrusio acetabuli, Narrow palate, Camptodactyly, ... OMIM:154700
Storm Syndrome
Fat malabsorption OMIM:185069
Lmna-Related Cardiocutaneous Progeria Syndrome
Abnormality of the pulmonary artery, Abnormality of the intrahepatic bile duct, Emphysema ORPHA:363618

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tns3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tns3.

No publications found that use IMPC mice or data for Tns3.

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MGI Allele Allele Type Produced
Tns3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tns3em1(IMPC)Bay Exon Deletion Mice

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