Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
ubiquitin specific peptidase 28
Synonyms:
9830148O20Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Usp28 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Usp28 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cephalin Lipidosis
Abnormality of the spleen OMIM:212800
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Fanconi Anemia, Complementation Group J
Chromosomal breakage induced by crosslinking agents, Bone marrow hypocellularity OMIM:609054
Fanconi Anemia, Complementation Group Q
Chromosome breakage, Biliary atresia, Bone marrow hypocellularity OMIM:615272
Immunodeficiency 54
Chromosome breakage, Hepatomegaly, Lymphadenopathy, Splenomegaly, Reduced natural killer cell count OMIM:609981
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Pancytopenia, Abnormality of chromosome stability OMIM:600546
Fanconi Anemia, Complementation Group D1
T-cell acute lymphoblastic leukemias, Chromosomal breakage induced by crosslinking agents, Acute ... OMIM:605724
Nijmegen Breakage Syndrome-Like Disorder
Chromosomal breakage induced by ionizing radiation OMIM:613078
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
Fanconi Anemia, Complementation Group G
Neutropenia, Abnormality of chromosome stability, Leukemia, Anemia, Thrombocytopenia OMIM:614082
Chromosomal Instability With Tissue-Specific Radiosensitivity
Abnormality of chromosome stability OMIM:215510
N Syndrome
Leukemia, Abnormality of chromosome stability OMIM:310465
Radial-Renal Syndrome
Chromosome breakage OMIM:179280
Transcobalamin Deficiency
Neutropenia, Abnormality of chromosome stability, Lymphopenia, Pancytopenia, Thrombocytopenia ORPHA:859
Fanconi Anemia, Complementation Group L
Chromosome breakage, Bone marrow hypocellularity, Abnormality of chromosome stability, Anemia OMIM:614083
Ataxia-Telangiectasia With Generalized Skin Pigmentation And Early Death
Chromosome breakage, Leukemia, Abnormality of the thymus, Abnormality of chromosome stability OMIM:208910
Porokeratosis 1, Multiple Types
Abnormality of chromosome stability OMIM:175800
Fanconi Anemia, Complementation Group S
Chromosome breakage, Anemia OMIM:617883
Fragile X Syndrome
Folate-dependent fragile site at Xq28 OMIM:300624
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Chromosomal breakage induced by crosslinking agents OMIM:619060
Fragile X Syndrome
Folate-dependent fragile site at Xq28 ORPHA:908
Fanconi Anemia, Complementation Group N
Chromosomal breakage induced by crosslinking agents, Aplastic anemia OMIM:610832
Bloom Syndrome
Chromosome breakage, Leukemia, Abnormality of chromosome stability OMIM:210900
Fanconi Anemia, Complementation Group I
Chromosomal breakage induced by crosslinking agents, Neutropenia, Bone marrow hypocellularity OMIM:609053
Ataxia-Telangiectasia
Lymphopenia, Abnormality of chromosome stability, Aplasia/Hypoplasia of the thymus ORPHA:100
Fanconi Anemia, Complementation Group E
Neutropenia, Leukemia, Anemia, Chromosomal breakage induced by crosslinking agents, Reticulocytop... OMIM:600901
Fanconi Anemia, Complementation Group F
Leukopenia, Anemia, Bone marrow hypocellularity, Chromosomal breakage induced by crosslinking age... OMIM:603467
Fanconi Anemia, Complementation Group A
Neutropenia, Leukemia, Anemia, Chromosomal breakage induced by crosslinking agents, Reticulocytop... OMIM:227650
Fanconi Anemia, Complementation Group C
Neutropenia, Leukemia, Bone marrow hypocellularity, Anemia, Chromosomal breakage induced by cross... OMIM:227645
Lig4 Syndrome
Leukocytosis, Hepatomegaly, Abnormality of chromosome stability, Acute leukemia, Lymphadenopathy,... ORPHA:99812
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
B lymphocytopenia, Impaired lymphocyte transformation with phytohemagglutinin, Hypoplasia of the ... OMIM:619313
Fanconi Anemia, Complementation Group D2
Neutropenia, Annular pancreas, Leukemia, Bone marrow hypocellularity, Anemia, Chromosomal breakag... OMIM:227646
Icf Syndrome
Abnormality of neutrophils, Lymphopenia, Anemia, Abnormality of chromosome stability ORPHA:2268
Lissencephaly Syndrome, Norman-Roberts Type
Hypoplastic spleen ORPHA:89844
Riddle Syndrome
Generalized lymphadenopathy, Chromosomal breakage induced by ionizing radiation ORPHA:420741
Gracile Bone Dysplasia
Hypoplastic spleen, Asplenia OMIM:602361
Fanconi Anemia, Complementation Group B
Thrombocytopenia, Aplastic anemia, Abnormality of chromosome stability OMIM:300514
Meningioma
Chromosomal breakage induced by ionizing radiation ORPHA:2495
Mirage Syndrome
Leukopenia, Anemia, Lymphopenia, Thrombocytopenia, Hypoplastic spleen OMIM:617053
Cartilage-Hair Hypoplasia
Hepatomegaly, Neutropenia, Abnormality of chromosome stability, Anemia, Abnormality of the pancreas ORPHA:175
Microphthalmia, Syndromic 9
Hypoplastic spleen, Multilobulated spleen OMIM:601186
Nijmegen Breakage Syndrome
Abnormality of chromosome stability, Acute leukemia, Thrombocytopenia, Hemolytic anemia, Autoimmu... ORPHA:647
Pearson Syndrome
Hepatomegaly, Neutropenia, Thrombocytopenia, Macronodular cirrhosis, Bone marrow hypocellularity,... ORPHA:699
Fanconi Anemia
Abnormality of chromosome stability, Leukopenia, Anemia, Abnormality of the liver, Thrombocytopen... ORPHA:84

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Usp28

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Usp28.

No publications found that use IMPC mice or data for Usp28.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Usp28tm263112(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter