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Gene: Lrrc41 MGI:2441984

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Gene Summary

Name:
leucine rich repeat containing 41
Synonyms:
MUF1,  D630045E04Rik,  D730026A16Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased startle reflex Lrrc41em1(IMPC)J HOM Early adult 5.81×10-10
decreased vertical activity Lrrc41em1(IMPC)J HOM   Early adult 5.45×10-05
hyperactivity Lrrc41em1(IMPC)J HOM Early adult 1.67×10-05
increased lean body mass Lrrc41em1(IMPC)J HOM Early adult 5.07×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

2 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

5 Images

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Human diseases caused by Lrrc41 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lrrc41 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Mental Retardation, Autosomal Dominant 45
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617600
Mental Retardation, Autosomal Recessive 2
Attention deficit hyperactivity disorder OMIM:607417
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Mental Retardation, Autosomal Recessive 3
Hyperactivity OMIM:608443
Immunodeficiency 8
Hyperactivity OMIM:615401
Microcephaly 25, Primary, Autosomal Recessive
Attention deficit hyperactivity disorder OMIM:618351
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder OMIM:618830
Mental Retardation, Autosomal Dominant 33
Hyperactivity, Decreased body weight OMIM:616311
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Ataxia OMIM:617113
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Large for gestational age ORPHA:356996
Mental Retardation, Autosomal Dominant 52
Hyperactivity OMIM:617796
Mental Retardation, Autosomal Recessive 37
Hyperactivity OMIM:615493
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Hyperactivity, Inability to walk OMIM:616657
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Gait disturbance, Dysmetria, Tremor, Hyperactivity, Inability to walk OMIM:618090
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Insulin-Like Growth Factor I Deficiency
Hyperactivity, Decreased body weight OMIM:608747
Intellectual Developmental Disorder, Autosomal Recessive 74
Hyperactivity OMIM:617169
Mental Retardation, X-Linked 77
Hyperactivity OMIM:300454
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Microcephaly, Seizures, And Developmental Delay
Hyperactivity, Ataxia OMIM:613402
Encephalopathy, Progressive, With Or Without Lipodystrophy
Hyperactivity, Dystonia, Ataxia, Tremor OMIM:615924
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity, Small for gestational age ORPHA:85288
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder OMIM:301008
Morm Syndrome
Hyperactivity, Truncal obesity ORPHA:75858
Aminoacylase 1 Deficiency
Hyperactivity OMIM:609924
Juvenile Huntington Disease
Dystonia, Weight loss, Bradykinesia, Hyperactivity, Progressive cerebellar ataxia, Ataxia, Broad-... ORPHA:248111
Intellectual Developmental Disorder, X-Linked 104
Tremor, Hyperactivity, Ataxia OMIM:300983
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Tremor, Hyperactivity, Broad-based gait OMIM:619470
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Dystonia, Ataxia, Tremor OMIM:612716
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity OMIM:619031
Dihydropyrimidine Dehydrogenase Deficiency
Failure to thrive, Hyperactivity, Lethargy OMIM:274270
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Hyperprolinemia, Type I
Hyperactivity, Ataxia OMIM:239500
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations
Hyperactivity OMIM:604317
Chromosome 3Q29 Deletion Syndrome
Failure to thrive, Hyperactivity, Gait ataxia, Small for gestational age OMIM:609425
Mannosidosis, Beta A, Lysosomal
Hyperactivity OMIM:248510
Glycine Encephalopathy
Hyperactivity, Lethargy OMIM:605899
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Shuffling gait, Tremor, Hyperactivity, Resting tremor, Broad-based gait, Obesity ORPHA:3077
Coffin-Siris Syndrome 8
Failure to thrive, Hyperactivity OMIM:618362
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity OMIM:309548
Fraxe Intellectual Disability
Hyperactivity ORPHA:100973
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity OMIM:615541
Intellectual Developmental Disorder, X-Linked, Syndromic, Stocco Dos Santos Type
Hyperactivity OMIM:300434
Mental Retardation, Autosomal Dominant 43
Hyperactivity OMIM:616977
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Hyperactivity, Decreased body weight OMIM:618342
Xq25 Microduplication Syndrome
Hyperactivity ORPHA:521258
Chromosome Xq25 Duplication Syndrome
Hyperactivity OMIM:300979
Hyperlysinemia, Type I
Hyperactivity OMIM:238700
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Tremor, Hyperactivity, Inability to walk OMIM:618718
Lennox-Gastaut Syndrome
Hyperactivity, Falls ORPHA:2382
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Hyperactivity, Ataxia, Broad-based gait, Obesity ORPHA:411515
Alazami-Yuan Syndrome
Hyperactivity OMIM:617126
Mental Retardation, Autosomal Recessive 13
Hyperactivity, Truncal obesity OMIM:613192
Clark-Baraitser Syndrome
Hyperactivity, Obesity OMIM:617752
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Unsteady gait, Hyperactivity, Broad-based gait, Failure to thrive OMIM:617865
Cln5 Disease
Dysmetria, Tremor, Hyperactivity, Inability to walk, Dysdiadochokinesis, Ataxia, Truncal ataxia, ... ORPHA:228360
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Attention deficit hyperactivity disorder, Obesity OMIM:301013
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Optic Atrophy 11
Dysmetria, Hyperactivity, Ataxia OMIM:617302
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Stiff Person Spectrum Disorder
Exaggerated startle response, Falls, Difficulty walking ORPHA:3198
Phenylketonuria
Hyperactivity, Attention deficit hyperactivity disorder OMIM:261600
Gand Syndrome
Hyperactivity OMIM:615074
Ck Syndrome
Hyperactivity, Slender build ORPHA:251383
Autosomal Recessive Non-Syndromic Intellectual Disability
Hyperactivity, Dystonia ORPHA:88616
Graves Disease, Susceptibility To, 1
Hyperactivity, Weight loss OMIM:275000
Severe Neurodegenerative Syndrome With Lipodystrophy
Tremor, Hyperactivity, Ataxia, Gait ataxia, Limb dystonia ORPHA:363400
Guanidinoacetate Methyltransferase Deficiency
Hyperactivity, Dystonia, Athetosis, Ataxia ORPHA:382
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome
Hyperactivity, Obesity ORPHA:397973
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
Failure to thrive, Hyperactivity OMIM:615286
Intellectual Developmental Disorder, Autosomal Recessive 71
Hyperactivity, Attention deficit hyperactivity disorder OMIM:618504
Ck Syndrome
Hyperactivity, Slender build OMIM:300831
Spastic Tetraplegia And Axial Hypotonia, Progressive
Ataxia, Exaggerated startle response OMIM:618598
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hyperactivity, Broad-based gait ORPHA:457260
Landau-Kleffner Syndrome
Steppage gait, Hyperactivity, Attention deficit hyperactivity disorder, Gait ataxia ORPHA:98818
Intellectual Developmental Disorder, Autosomal Recessive 38
Unsteady gait, Hyperactivity OMIM:615516
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hyperactivity, Decreased body weight, Broad-based gait OMIM:300958
Rubinstein-Taybi Syndrome 2
Hyperactivity OMIM:613684
Familial Hyperthyroidism Due To Mutations In Tsh Receptor
Hyperactivity, Weight loss, Small for gestational age, Hand tremor ORPHA:424
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Hyperactivity, Dystonia, Inability to walk, Gait ataxia ORPHA:500180
Hyperthyroidism, Nonautoimmune
Hyperactivity, Small for gestational age OMIM:609152
Aromatic L-Amino Acid Decarboxylase Deficiency
Athetosis, Torticollis, Limb tremor, Exaggerated startle response, Limb dystonia, Oculogyric cris... OMIM:608643
Neurodevelopmental Disorder With Or Without Autism Or Seizures
Failure to thrive, Hyperactivity OMIM:619239
Succinic Semialdehyde Dehydrogenase Deficiency
Hyperactivity, Ataxia OMIM:271980
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Failure to thrive, Hyperactivity ORPHA:369939
Myoclonic-Astatic Epilepsy
Tremor, Hyperactivity, Ataxia, Unsteady gait, Attention deficit hyperactivity disorder ORPHA:1942
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Tremor, Hyperactivity, Gait ataxia, Abdominal obesity OMIM:300354
Developmental And Epileptic Encephalopathy 68
Failure to thrive, Exaggerated startle response OMIM:618201
Gm2 Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response ORPHA:309246
Mitochondrial Complex Iii Deficiency, Nuclear Type 7
Hyperactivity OMIM:615824
Familial Gestational Hyperthyroidism
Hyperactivity, Weight loss, Hand tremor ORPHA:99819
Mental Retardation, Autosomal Dominant 7
Gait disturbance, Failure to thrive in infancy, Small for gestational age, Hyperactivity, Ataxia OMIM:614104
X-Linked Creatine Transporter Deficiency
Athetosis, Dystonia, Cachexia, Hyperactivity, Ataxia ORPHA:52503
Histidinemia
Hyperactivity ORPHA:2157
Chromosome 15Q25 Deletion Syndrome
Hyperactivity, Attention deficit hyperactivity disorder OMIM:614294
Rasmussen Subacute Encephalitis
Hyperactivity, Hemidystonia, Attention deficit hyperactivity disorder, Inability to walk ORPHA:1929
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response, Difficulty walking ORPHA:320406
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity OMIM:300143
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity OMIM:619467
Fragile X Syndrome
Hyperactivity OMIM:300624
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Neurodegeneration With Brain Iron Accumulation 2B
Dystonia, Dysmetria, Bradykinesia, Intention tremor, Hyperactivity, Dysdiadochokinesis, Gait ataxia OMIM:610217
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small for gestational age, Failure to thrive, Truncal obesity, Hyperactivity, Attention deficit h... ORPHA:73272
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Intellectual Developmental Disorder, X-Linked 30
Hyperactivity OMIM:300558
Gm2-Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response OMIM:272750
Acrodysostosis 2 With Or Without Hormone Resistance
Hyperactivity, Obesity OMIM:614613
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity ORPHA:101039
Myopathy With Extrapyramidal Signs
Dystonia, Tremor, Hyperactivity, Ataxia, Difficulty walking OMIM:615673
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Gait imbalance, Tremor, Ataxia, Hyperactivity, Broad-based gait, Obesity ORPHA:98794
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity ORPHA:85327
Hypomagnesemia, Seizures, And Mental Retardation 2
Hyperactivity OMIM:618314
Chromosome 2Q37 Deletion Syndrome
Hyperactivity, Obesity OMIM:600430
Angelman Syndrome
Limb tremor, Progressive gait ataxia, Hyperactivity, Broad-based gait, Obesity OMIM:105830
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Dystonia, Ataxia, Exaggerated startle response, Broad-based gait ORPHA:438216
13Q12.3 Microdeletion Syndrome
Failure to thrive, Hyperactivity, Obesity ORPHA:412035
Mend Syndrome
Hyperactivity OMIM:300960
Potocki-Lupski Syndrome
Failure to thrive, Hyperactivity, Small for gestational age OMIM:610883
Infantile Neuroaxonal Dystrophy
Dystonia, Gait disturbance, Hyperactivity, Ataxia, Unsteady gait ORPHA:35069
Lamb-Shaffer Syndrome
Hyperactivity, Ataxia ORPHA:530983
Adenylosuccinase Deficiency
Hyperactivity, Inability to walk, Gait ataxia, Opisthotonus OMIM:103050
2Q23.1 Microdeletion Syndrome
Hyperactivity, Ataxia ORPHA:228402
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Hyperactivity, Ataxia, Obesity OMIM:618430
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Ataxia OMIM:610042
X-Linked Adrenoleukodystrophy
Hyperactivity, Gait disturbance, Attention deficit hyperactivity disorder ORPHA:43
Tay-Sachs Disease
Gait disturbance, Dystonia, Dysmetria, Exaggerated startle response, Laryngeal dystonia, Tremor, ... ORPHA:845
16P12.1P12.3 Triplication Syndrome
Failure to thrive, Hyperactivity, Attention deficit hyperactivity disorder ORPHA:485405
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
X-Linked Intellectual Disability, Cabezas Type
Cachexia, Tremor, Hyperactivity, Broad-based gait, Obesity ORPHA:85293
Mucopolysaccharidosis, Type Iiia
Hyperactivity OMIM:252900
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Hyperactivity, Gait disturbance, Large for gestational age ORPHA:457485
Late Infantile Neuronal Ceroid Lipofuscinosis
Hyperactivity, Gait disturbance, Inability to walk, Ataxia ORPHA:168491
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:391307
Citrullinemia Type Ii
Tremor, Hyperactivity, Decreased body mass index, Lethargy ORPHA:247585
Pediatric-Onset Graves Disease
Failure to thrive, Hyperactivity, Tremor ORPHA:525731
Spastic Paraplegia 29, Autosomal Dominant
Hyperactivity OMIM:609727
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Asparagine Synthetase Deficiency
Failure to thrive, Exaggerated startle response OMIM:615574
X-Linked Cerebral Adrenoleukodystrophy
Gait disturbance, Dysmetria, Hyperactivity, Inability to walk, Ataxia, Difficulty walking ORPHA:139396
Mucopolysaccharidosis, Type Iiib
Hyperactivity OMIM:252920
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Sandhoff Disease
Ataxia, Exaggerated startle response OMIM:268800
Hyperlysinemia
Opisthotonus, Dysmetria, Failure to thrive, Tremor, Hyperactivity, Tip-toe gait ORPHA:2203
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response OMIM:184850
47,Xyy Syndrome
Hyperactivity, Attention deficit hyperactivity disorder ORPHA:8
Neurodegeneration With Brain Iron Accumulation 1
Dystonia, Gait disturbance, Bradykinesia, Tremor, Hyperactivity, Ataxia, Akinesia, Blepharospasm OMIM:234200
Angelman Syndrome
Tremor, Hyperactivity, Inability to walk, Ataxia, Broad-based gait, Obesity ORPHA:72
Brain-Lung-Thyroid Syndrome
Dystonia, Failure to thrive, Falls, Intention tremor, Hyperactivity, Ataxia ORPHA:209905
Cntnap2-Related Developmental And Epileptic Encephalopathy
Hyperactivity, Ataxia, Obesity ORPHA:163681
Plaa-Associated Neurodevelopmental Disorder
Failure to thrive, Dystonia, Exaggerated startle response ORPHA:521426
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Gait ataxia OMIM:300486
Mucopolysaccharidosis, Type Iiic
Hyperactivity OMIM:252930
Purine Nucleoside Phosphorylase Deficiency
Hyperactivity, Ataxia ORPHA:760
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hyperactivity, Attention deficit hyperactivity disorder ORPHA:449291
Dyggve-Melchior-Clausen Disease
Failure to thrive, Hyperactivity, Inability to walk, Difficulty walking ORPHA:239
Insensitivity To Pain, Congenital, With Anhidrosis
Hyperactivity OMIM:256800
Legius Syndrome
Hyperactivity, Dystonia, Attention deficit hyperactivity disorder ORPHA:137605
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Argininemia
Hyperactivity, Spastic gait OMIM:207800
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Failure to thrive, Exaggerated startle response OMIM:617527
Cerebellar Dysfunction With Variable Cognitive And Behavioral Abnormalities
Dysmetria, Hyperactivity, Unsteady gait, Ataxia OMIM:614756
Early Infantile Epileptic Encephalopathy
Dystonia, Failure to thrive, Tremor, Hyperactivity, Episodic ataxia ORPHA:1934
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Gm1 Gangliosidosis Type 1
Exaggerated startle response ORPHA:79255
Brooks-Wisniewski-Brown syndrome
Hyperactivity, Small for gestational age OMIM:300612
Choreoacanthocytosis
Head titubation, Lingual dystonia, Loss of ambulation, Oromandibular dystonia, Weight loss, Falls... ORPHA:2388
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Dystonia, Inability to walk, Exaggerated startle response, Broad-based gait ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Attention deficit hyperactivity disorder, Exaggerated startle response OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrrc41

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrrc41.

No publications found that use IMPC mice or data for Lrrc41.

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MGI Allele Allele Type Produced
Lrrc41tm39148(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Lrrc41em1(IMPC)J Exon Deletion Mice

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