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Gene: Nlgn1 MGI:2179435

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
neuroligin 1
Synonyms:
Nlg1,  NL1,  6330415N05Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nlgn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Nlgn1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Reduced social reciprocity OMIM:618830

The table below shows human diseases predicted to be associated to Nlgn1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Reduced social reciprocity OMIM:618830
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Childhood Disintegrative Disorder
Mental deterioration, Abnormal emotion, Reduced social reciprocity, Social and occupational deter... ORPHA:168782
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships OMIM:608631
Intellectual Developmental Disorder, Autosomal Recessive 64
Reduced social reciprocity OMIM:618103
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Intellectual Developmental Disorder With Autism And Speech Delay
Reduced social reciprocity OMIM:606053
Intellectual Developmental Disorder, Autosomal Recessive 6
Reduced social reciprocity OMIM:611092
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Reduced social reciprocity ORPHA:329249
11Q22.2Q22.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Short attention span, Abnormal social behavior ORPHA:444002
Early-Onset Autosomal Dominant Alzheimer Disease
Memory impairment, Confusion, Dementia, Semantic dementia, Abnormal social behavior ORPHA:1020
Hsd10 Disease
Short attention span, Abnormal social behavior ORPHA:391417
Childhood Absence Epilepsy
Attention deficit hyperactivity disorder, Depression, Abnormal social behavior ORPHA:64280
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior ORPHA:101039
Metachromatic Leukodystrophy, Adult Form
Memory impairment, Depression, Progressive psychomotor deterioration, Short attention span, Emoti... ORPHA:309271
Metachromatic Leukodystrophy, Juvenile Form
Short attention span, Emotional lability, Abnormal social behavior, Progressive psychomotor deter... ORPHA:309263
Lamb-Shaffer Syndrome
Abnormal social behavior ORPHA:530983
48,Xxxy Syndrome
Attention deficit hyperactivity disorder, Abnormal aggressive, impulsive or violent behavior, Abn... ORPHA:96263
Metachromatic Leukodystrophy, Late Infantile Form
Emotional lability, Abnormal social behavior ORPHA:309256
Fg Syndrome Type 1
Attention deficit hyperactivity disorder, Abnormal social behavior ORPHA:93932
Prader-Willi Syndrome Due To Translocation
Attention deficit hyperactivity disorder, Abnormal social behavior, Reduced social reciprocity ORPHA:177907
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal aggressive, impulsive or violent behavior, Abnormal social behavior, Irritability ORPHA:1675
Niemann-Pick Disease Type C
Progressive neurologic deterioration, Mental deterioration, Depression, Low frustration tolerance... ORPHA:646
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Memory impairment, Abnormal social behavior ORPHA:314647
Koolen-De Vries Syndrome Due To A Point Mutation
Abnormal social behavior, Attention deficit hyperactivity disorder, Inappropriate laughter, Overf... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Abnormal social behavior, Attention deficit hyperactivity disorder, Inappropriate laughter, Overf... ORPHA:363958
Tuberous Sclerosis Complex
Attention deficit hyperactivity disorder, Depression, Abnormal social behavior ORPHA:805
Mend Syndrome
Abnormal social behavior ORPHA:401973
Williams Syndrome
Attention deficit hyperactivity disorder, Depression, Abnormal social behavior, Overfriendliness ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nlgn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nlgn1.

No publications found that use IMPC mice or data for Nlgn1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nlgn1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Nlgn1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nlgn1tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Nlgn1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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