Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased exploration in new environment | Trim66tm1a(EUCOMM)Wtsi | HOM | Early adult | 2.90×10-06 | ||
decreased body weight | Trim66tm1a(EUCOMM)Wtsi | HOM | Early adult | 5.77×10-05 | ||
increased heart weight | Trim66tm1a(EUCOMM)Wtsi | HOM | Early adult | 5.69×10-07 | ||
decreased total body fat amount | Trim66tm1a(EUCOMM)Wtsi | HOM | Early adult | 1.37×10-06 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Trim66 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Ethanolaminosis | Cardiomegaly | OMIM:227150 | |
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome | Obesity, Cardiomegaly | ORPHA:88643 | |
Mitochondrial Complex I Deficiency, Nuclear Type 39 | Small for gestational age, Cardiomegaly, Perimembranous ventricular septal defect, Atrial septal ... | OMIM:620135 | |
Congenitally Uncorrected Transposition Of The Great Arteries | Levotransposition of the great arteries, Hepatomegaly, Small for gestational age, Ventricular sep... | ORPHA:860 | |
Congenital Tricuspid Valve Dysplasia | Hepatomegaly, Small for gestational age, Cardiomegaly, Pericardial effusion, Anomalous pulmonary ... | ORPHA:555874 | |
Double Outlet Left Ventricle | Double outlet left ventricle, Ventricular septal defect, Cardiomegaly, Bicuspid pulmonary valve, ... | ORPHA:3427 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim66.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Trim66tm1a(EUCOMM)Wtsi | PMC6671969 |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. | PLoS biology (April 2019) | Trim66tm1a(EUCOMM)Wtsi | PMC6459510 |
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. | Mammalian genome : official journal of the International Mammalian Genome Society (August 2013) | Trim66tm2a(EUCOMM)Wtsi Trim66tm1a(EUCOMM)Wtsi | PMC3745610 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Trim66tm47408(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Trim66tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Trim66tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Trim66tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Trim66tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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