Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
forkhead box N4
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Foxn4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxn4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
Persistent Placoid Maculopathy
Hypoplasia of the fovea, Retinal pigment epithelial mottling, Choroidal neovascularization, Abnor... ORPHA:97341
Choroidal Dystrophy, Central Areolar, 1
Pigmentary retinopathy, Chorioretinal atrophy, Choriocapillaris atrophy OMIM:215500
Foveal Hypoplasia 1
Hypoplasia of the fovea OMIM:136520
Stargardt Disease 1
Macular degeneration, Retinitis pigmentosa inversa, Bull's eye maculopathy OMIM:248200
Microphthalmia, Isolated, With Coloboma 6
Hypoplasia of the fovea, Bilateral microphthalmos, Optic disc hypoplasia OMIM:613703
Stargardt Disease
Retinal pigment epithelial atrophy, Retinal thinning, Abnormal foveal morphology, Retinal pigment... ORPHA:827
Night Blindness, Congenital Stationary, Type 1D
Congenital stationary night blindness, Pigmentary retinopathy, Macular atrophy, Attenuation of re... OMIM:613830
Intellectual Developmental Disorder With Ocular Anomalies And Distinctive Facial Features
Hypoplasia of the fovea, Optic atrophy OMIM:620086
Achromatopsia 7
Hypoplasia of the fovea, Absent foveal reflex, Macular atrophy OMIM:616517
Oculocutaneous Albinism Type 6
Aplasia/Hypoplasia of the macula, Abnormal fundus morphology, Abnormal foveal morphology on macul... ORPHA:370097
X-Linked Retinal Dysplasia
Abnormal retinal vascular morphology, Abnormality of retinal pigmentation, Retinal dysplasia ORPHA:1852
Exudative Vitreoretinopathy 7
Retinal detachment, Exudative vitreoretinopathy, Retinal hole, Retinal fold, Retinal degeneration OMIM:617572
Albinism, Oculocutaneous, Type Iv
Macular hypoplasia, Hypopigmentation of the fundus OMIM:606574
Exudative Vitreoretinopathy 3
Retinal detachment, Retinal exudate, Exudative vitreoretinopathy, Retinal hole, Retinal fold OMIM:605750
Albinism, Oculocutaneous, Type V
Hypoplasia of the fovea OMIM:615312
Achromatopsia
Hypoplasia of the fovea, Retinal pigment epithelial atrophy, Retinal pigment epithelial mottling,... ORPHA:49382
Retinopathy, Pericentral Pigmentary, Dominant
Bone spicule pigmentation of the retina, Retinal atrophy, Retinal dystrophy, Pigmentary retinopat... OMIM:180210
Retinoschisis 1, X-Linked, Juvenile
Retinal detachment, Retinal atrophy, Retinal pigment epithelial atrophy, Mizuo phenomenon, Macula... OMIM:312700
Neuroectodermal Melanolysosomal Disease
Macular dystrophy, Optic atrophy, Abnormal optic nerve morphology, Aplasia/Hypoplasia of the macula ORPHA:33445
Familial Drusen
Abnormality of retinal pigmentation, Macular drusen, Peripapillary chorioretinal atrophy, Choroid... ORPHA:75376
Foveal Hypoplasia 2
Hypoplasia of the fovea, Microphthalmia, Foveal hyperpigmentation, Optic nerve misrouting OMIM:609218
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Retinal atrophy, Optic atrophy, Hypoplasia of the retina, Retinal dysplasia, Microphthalmia, Reti... OMIM:253280
Oculocutaneous Albinism, Type Viii
Hypoplasia of the fovea, Chorioretinal hypopigmentation OMIM:619165
Albinism, Oculocutaneous, Type Vi
Hypoplasia of the fovea OMIM:113750
Cataract 21, Multiple Types
Retinal detachment, Macular hypoplasia OMIM:610202
Bardet-Biedl Syndrome 21
Cone/cone-rod dystrophy, Hypoplasia of the fovea, Retinal atrophy, Retinal thinning, Hyperautoflu... OMIM:617406
Ă…land Islands Eye Disease
Hypoplasia of the fovea, Hypopigmentation of the fundus ORPHA:178333
Aland Island Eye Disease
Hypoplasia of the fovea OMIM:300600
Isolated Aniridia
Aniridia, Aplasia/Hypoplasia of the macula ORPHA:250923
Congenital Hydrocephalus
Optic atrophy, Macular hypoplasia ORPHA:2185
Retinitis Pigmentosa 87 With Choroidal Involvement
Pigmentary retinopathy, Bone spicule pigmentation of the retina, Chorioretinal atrophy, Nummular ... OMIM:618697
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Oculocutaneous Albinism Type 5
Hypoplasia of the fovea, Ocular albinism, Abnormal fundus morphology ORPHA:370091
Congenital Primary Aphakia
Microphthalmia, Aplasia/Hypoplasia affecting the anterior segment of the eye, Retinal dysplasia, ... ORPHA:83461
Albinism, Ocular, Type I
Hypoplasia of the fovea, Ocular albinism, Depigmented fundus OMIM:300500
Microphthalmia, Isolated 8
Retinal detachment, Anophthalmia, Optic nerve hypoplasia, Hypoplastic optic chiasm, Retinal colob... OMIM:615113
Coloboma Of Optic Nerve
Retinal detachment, Optic disc coloboma OMIM:120430
Autosomal Dominant Keratitis
Hypoplasia of the fovea, Bilateral microphthalmos, Hypoplastic iris stroma, Macular hypoplasia, A... ORPHA:2334
Oculocutaneous Albinism Type 4
Hypoplasia of the fovea, Abnormality of retinal pigmentation, Ocular albinism, Optic nerve misrou... ORPHA:79435
Microcephaly, Amish Type
Hypoplasia of the fovea, Optic atrophy OMIM:607196
Albinism, Oculocutaneous, Type Ii
Hypoplasia of the fovea, Hypopigmentation of the fundus OMIM:203200
Achromatopsia 2
Hypoplasia of the fovea, Retinal thinning, Absent foveal reflex, Peripapillary atrophy, Dull fove... OMIM:216900
Familial Benign Copper Deficiency
Aplasia/Hypoplasia of the fovea ORPHA:1551
Linear Verrucous Nevus Syndrome
Retinopathy, Aplasia/Hypoplasia of the fovea ORPHA:2611
Oculocutaneous Albinism Type 1
Hypoplasia of the fovea, Abnormal morphology of the choroidal vasculature, Depigmented fundus, Op... ORPHA:352731
X-Linked Recessive Ocular Albinism
Hypoplasia of the fovea, Ocular albinism, Abnormal macular morphology ORPHA:54
Anterior Segment Dysgenesis 5
Hypoplasia of the fovea, Hypoplasia of the iris, Rieger anomaly, Microphthalmia OMIM:604229
Developmental And Epileptic Encephalopathy 83
Hypoplasia of the fovea OMIM:618744
Oculocutaneous Albinism Type 1B
Hypoplasia of the fovea, Abnormality of retinal pigmentation, Abnormal optic nerve morphology ORPHA:79434
Hermansky-Pudlak Syndrome 6
Macular hypoplasia, Ocular albinism, Absent foveal reflex OMIM:614075
Oculoauricular Syndrome
Cone/cone-rod dystrophy, Retinal detachment, Morning glory anomaly, Chorioretinal atrophy, Retina... OMIM:612109
Chromosome 3Pter-P25 Deletion Syndrome
Macular hypoplasia OMIM:613792
Hermansky-Pudlak Syndrome 4
Hypoplasia of the fovea, Ocular albinism OMIM:614073
Persistent Hyperplastic Primary Vitreous
Glial remnants anterior to the optic disc, Hyaloid vascular remnant and retrolental mass, Remnant... ORPHA:91495
Aniridia 1
Hypoplasia of the fovea, Optic nerve hypoplasia, Hypoplasia of the iris, Chorioretinal hypopigmen... OMIM:106210
Pierson Syndrome
Retinal detachment, Rieger anomaly, Hypoplasia of the ciliary body, Remnants of the hyaloid vascu... OMIM:609049
Hydrocephalus, Congenital, 2, With Or Without Brain Or Eye Anomalies
Optic atrophy, Macular hypoplasia, Chorioretinal coloboma OMIM:615219
Oculocutaneous Albinism Type 1A
Hypoplasia of the fovea, Ocular albinism, Abnormal optic nerve morphology ORPHA:79431
Hermansky-Pudlak Syndrome 11
Hypoplasia of the fovea, Ocular albinism OMIM:619172
Congenital Sialidosis Type 2
Hypoplasia of the fovea, Cherry red spot of the macula, Optic atrophy, Yellow/white lesions of th... ORPHA:93400
Hermansky-Pudlak Syndrome 5
Hypoplasia of the fovea, Ocular albinism OMIM:614074
Oculocutaneous Albinism Type 2
Hypoplasia of the fovea, Abnormality of retinal pigmentation, Macular hypopigmentation, Optic ner... ORPHA:79432
Knobloch Syndrome 1
Retinal detachment, Optic disc pallor, Patent ductus arteriosus, Chorioretinal atrophy, Vitreoret... OMIM:267750
Hermansky-Pudlak Syndrome 8
Hypoplasia of the fovea, Optic disc pallor, Ocular albinism OMIM:614077
Albinism, Oculocutaneous, Type Ia
Hypoplasia of the fovea, Ocular albinism OMIM:203100
Chediak-Higashi Syndrome
Decreased nerve conduction velocity, Macular hypoplasia, Ocular albinism OMIM:214500
Incontinentia Pigmenti
Hypoplasia of the fovea, Retinal detachment, Retinal vascular proliferation, Optic atrophy, Retin... OMIM:308300
Jacobsen Syndrome
Microphthalmia, Optic atrophy, Macular hypoplasia, Chorioretinal coloboma OMIM:147791
Vici Syndrome
Macular hypoplasia, Macular atrophy, Hypopigmentation of the fundus, Ocular albinism OMIM:242840
Dihydropyrimidine Dehydrogenase Deficiency
Macular hypoplasia ORPHA:1675
Mend Syndrome
Macular hypoplasia OMIM:300960
Neuroocular Syndrome
Hypoplasia of the fovea, Microphthalmia, Lens coloboma, Remnants of the hyaloid vascular system OMIM:619539

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxn4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxn4.

No publications found that use IMPC mice or data for Foxn4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Foxn4tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Foxn4tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Foxn4em1(IMPC)Ccpcz Inter-exon deletion Mice
Foxn4tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Foxn4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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