Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
trace amine-associated receptor 1
Synonyms:
Tar1,  Trar1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Taar1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taar1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Paragangliomas 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Mental Retardation, Autosomal Dominant 45
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617600
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301008
Mental Retardation, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Thyroid Hormone Resistance, Generalized, Autosomal Dominant
Impaired sensitivity to thyroid hormone, Goiter, Attention deficit hyperactivity disorder, Increa... OMIM:188570
Paragangliomas 1
Extraadrenal pheochromocytoma, Vagal paraganglioma, Adrenal pheochromocytoma, Elevated circulatin... OMIM:168000
Paragangliomas 3
Extraadrenal pheochromocytoma, Adrenal pheochromocytoma, Elevated circulating catecholamine level... OMIM:605373
Idiopathic Congenital Hypothyroidism
Decreased circulating T4 level, Lethargy, Hypothermia, Elevated circulating thyroid-stimulating h... ORPHA:95717
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Familial Thyroid Dyshormonogenesis
Lethargy, Goiter, Increased radioactive iodine uptake, Decreased circulating T4 level, Elevated c... ORPHA:95716
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Lethargy, Hypothermia OMIM:610006
Spontaneous Periodic Hypothermia
Gait disturbance, Hypothermia, Ataxia ORPHA:29822
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Decreased serum insulin-like growth factor 1, Elevated circulating growth hormone concentration, ... ORPHA:85327
Genetic Transient Congenital Hypothyroidism
Lethargy, Goiter, Decreased circulating T4 level, Abnormal radioactive iodine uptake test result,... ORPHA:226316
Hypothyroidism Due To Tsh Receptor Mutations
Compensated hypothyroidism, Lethargy, Increased radioactive iodine uptake, Decreased circulating ... ORPHA:90673
Developmental And Epileptic Encephalopathy 78
Inability to walk, Hypothermia OMIM:618557
Primary Erythromelalgia
Hypothermia ORPHA:90026
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Goiter, Decreased circulating T4 level, Elevated circulating thyroid-stimulating hormone concentr... ORPHA:226313
Permanent Congenital Hypothyroidism
Hypothyroidism, Hypothermia, Goiter, Thyroid dysgenesis ORPHA:226292
Isolated Thyroid-Stimulating Hormone Deficiency
Lethargy, Goiter, Increased pituitary glycoprotein hormone alpha subunit level, Decreased circula... ORPHA:90674
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Panhypopituitarism, Lethargy, Decreased circulating ACTH level, Decreased circulating follicle st... ORPHA:226307
Hypothyroidism, Congenital, Nongoitrous, 2
Thyroid agenesis, Lethargy, Goiter, Hypothyroidism, Elevated circulating thyroid-stimulating horm... OMIM:218700
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paraganglioma, Elevated circulating catecho... ORPHA:892

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taar1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taar1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2. Molecular pharmacology (August 2019) Taar1tm1(KOMP)Vlcg PMC6744391
The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity. The Journal of pharmacology and experimental therapeutics (July 2019) Taar1tm1(KOMP)Vlcg 31320495
Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. Neurotoxicology (September 2017) Taar1tm1(KOMP)Vlcg 28919515
Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia. European thyroid journal (June 2015) Taar1tm1(KOMP)Vlcg PMC4640295
Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (March 2015) Taar1tm1(KOMP)Vlcg PMC4613607

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MGI Allele Allele Type Produced
Taar1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Taar1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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