Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
trace amine-associated receptor 1
Synonyms:
Tar1,  Trar1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Taar1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taar1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Paragangliomas 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Paragangliomas 1
Chemodectoma, Glomus tympanicum paraganglioma, Glomus jugular tumor, Adrenal pheochromocytoma, Ex... OMIM:168000
Paragangliomas 3
Chemodectoma, Glomus jugular tumor, Adrenal pheochromocytoma, Extraadrenal pheochromocytoma, Elev... OMIM:605373
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Idiopathic Congenital Hypothyroidism
Decreased circulating T4 level, Elevated circulating thyroid-stimulating hormone concentration, H... ORPHA:95717
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Decreased serum insulin-like growth factor 1, Hyperactivity, Elevated circulating growth hormone ... ORPHA:85327
Familial Thyroid Dyshormonogenesis
Positive perchlorate discharge test, Reduced radioactive iodine uptake, Congenital hypothyroidism... ORPHA:95716
Primary Erythromelalgia
Hypothermia ORPHA:90026
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Congenital hypothyroidism, Decreased circulating T4 level, Elevated circulating thyroid-stimulati... ORPHA:226313
Permanent Congenital Hypothyroidism
Goiter, Hypothyroidism, Thyroid dysgenesis, Hypothermia ORPHA:226292
Genetic Transient Congenital Hypothyroidism
Abnormal radioactive iodine uptake test result, Decreased circulating T4 level, Elevated circulat... ORPHA:226316
Hypothyroidism Due To Tsh Receptor Mutations
Reduced radioactive iodine uptake, Impaired sensitivity to thyroid stimulating hormone, Congenita... ORPHA:90673
Isolated Thyroid-Stimulating Hormone Deficiency
Increased pituitary glycoprotein hormone alpha subunit level, Reduced radioactive iodine uptake, ... ORPHA:90674
Von Hippel-Lindau Disease
Paraganglioma, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Elevated circulating catecho... ORPHA:892
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypogonadotropic hypogonadism, Decreased circulating follicle stimulating hormone concentration, ... ORPHA:226307
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothyroidism, Thyroid agenesis, Congenital hypothyroidism, Elevated circulating thyroid-stimula... OMIM:218700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taar1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taar1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2. Molecular pharmacology (August 2019) Taar1tm1(KOMP)Vlcg PMC6744391
The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity. The Journal of pharmacology and experimental therapeutics (July 2019) Taar1tm1(KOMP)Vlcg 31320495
Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. Neurotoxicology (September 2017) Taar1tm1(KOMP)Vlcg 28919515
Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia. European thyroid journal (June 2015) Taar1tm1(KOMP)Vlcg PMC4640295
Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (March 2015) Taar1tm1(KOMP)Vlcg PMC4613607

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MGI Allele Allele Type Produced
Taar1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Taar1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Taar1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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