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Genes Phenotypes

Gene: Usp22

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Name
ubiquitin specific peptidase 22
MGI ID
MGI:2144157
Synonyms
N/A
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (290) All data table (842)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Usp22tm1a(KOMP)Wtsi HET Early adult 1.91×10-05
decreased circulating insulin level Usp22tm1a(KOMP)Wtsi HET Early adult 7.03×10-06
abnormal gait Usp22tm1b(KOMP)Wtsi HET Early adult 7.76×10-07
thrombocytosis Usp22tm1a(KOMP)Wtsi HET Early adult 8.01×10-05
preweaning lethality, complete penetrance Usp22tm1b(KOMP)Wtsi HOM   Early adult 0.00
prolonged PR interval Usp22tm1b(KOMP)Wtsi HET Early adult 1.19×10-05
prolonged PQ interval Usp22tm1b(KOMP)Wtsi HET Early adult 5.38×10-05
preweaning lethality, complete penetrance Usp22tm1a(KOMP)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/590)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/590)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (2/2)  Wholemount images
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590)  (2/2)  Wholemount images
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590)  (2/2)  Wholemount images
Oral epithelium 2 No  (1/2)  Wholemount images
Ovary 2 No  (1/590)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590)  (2/2)  Wholemount images
Prostate gland 2 No  (12/590)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590)  (2/2)  Wholemount images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590)  (2/2)  Wholemount images
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590)  Wholemount images
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (5)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
nervous system (5)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (22)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (2)
Oral epithelium expression
MA:0000344
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
trunk (13)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (3/3) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (3/3) N/A
Eye 2  (1/506)  (3/3) N/A
Foot 2  (1/506) Image Only N/A
Forebrain 2  (1/506)  (3/3) N/A
Forelimb 2  (1/506)  (3/3) N/A
Hand 2  (1/506) Image Only N/A
Head 2  (5/506)  (3/3) N/A
Heart 2  (1/506) Image Only N/A
Hindbrain 2  (6/506)  (3/3) N/A
Hindlimb 2  (1/506)  (3/3) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506)  (3/3) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Tail 2  (1/506)  (3/3) N/A
Tail somite 2  (1/506)  (3/3) N/A

 Associated Images

thumbnail
X-ray: XRay Images Skull Dorso Ventral Orientation
24 Images
thumbnail
X-ray: XRay Images Whole Body Dorso Ventral
24 Images
X-ray: XRay Images Forepaw
13 Images
thumbnail
X-ray: XRay Images Whole Body Lateral Orientation
24 Images
thumbnail
X-ray: XRay Images Skull Lateral Orientation
14 Images
thumbnail
Echo: M-Mode Images
32 Images
thumbnail
Embryo LacZ: LacZ images wholemount
8 Images
thumbnail
Adult LacZ: LacZ Images Wholemount
22 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Legacy Phenotype Associated Images
Usp22tm1a(KOMP)Wtsi
HET, Female, WTSI
Usp22tm1a(KOMP)Wtsi
HET, Female, WTSI
Usp22tm1a(KOMP)Wtsi
HET, Female, WTSI
Usp22tm1a(KOMP)Wtsi
HET, Female, WTSI
Usp22tm1a(KOMP)Wtsi
HET, Male, WTSI

View all 84 images

Usp22tm1a(KOMP)Wtsi
left eye, WT, Male, WTSI
Usp22tm1a(KOMP)Wtsi
right eye, WT, Male, WTSI
Usp22tm1a(KOMP)Wtsi
back skin, HET, Female, WTSI
Usp22tm1a(KOMP)Wtsi
back skin, HET, Female, WTSI

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Usp22tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Usp22tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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