Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms:
OF45

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mepe mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mepe by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Hypophosphatemic Rickets, Autosomal Recessive, 1
Rickets, Craniosynostosis, Hypophosphatemic rickets, Increased bone mineral density OMIM:241520
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Hypophosphatemic Bone Disease
Rickets, Osteomalacia OMIM:146350
Hypophosphatasia, Adult
Rickets, Pathologic fracture, Osteomalacia, Recurrent fractures, Increased susceptibility to frac... OMIM:146300
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Rickets, Generalized bone demineralization, Rickets of the lower limbs, Delayed epiphyseal ossifi... OMIM:600785
Tyrosinemia Type 1
Splenomegaly, Rickets of the lower limbs ORPHA:882
Hypophosphatemic Rickets, Autosomal Dominant
Rickets, Osteomalacia, Hypophosphatemic rickets OMIM:193100
Axial Osteomalacia
Increased bone mineral density, Osteomalacia OMIM:109130
Renal Tubular Acidosis, Proximal
Rickets, Osteomalacia OMIM:179830
Hypercholanemia, Familial 1
Rickets OMIM:607748
Bile Acid Conjugation Defect 1
Rickets OMIM:619232
Renal Tubular Acidosis Iii
Rickets, Osteomalacia OMIM:267200
Eiken Syndrome
Abnormal bone ossification, Abnormal trabecular bone morphology, Thin bony cortex, Delayed epiphy... ORPHA:79106
Angioosteohypotrophic Syndrome
Abnormal trabecular bone morphology, Thin bony cortex ORPHA:75508
Florid Cemento-Osseous Dysplasia
Multiple bony cystic lesions, Abnormal bone structure, Abnormal trabecular bone morphology ORPHA:83451
Autosomal Dominant Hypophosphatemic Rickets
Rickets, Osteomalacia, Iron deficiency anemia, Tooth abscess ORPHA:89937
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Rickets, Reticulocytosis, Hepatosplenomegaly, Decreased mean corpuscular volume, Hemolytic anemia OMIM:611590
Hypophosphatemic Rickets, X-Linked Recessive
Rickets, Hypophosphatemic rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteo... OMIM:300554
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss
Rickets OMIM:602722
Renal Tubular Acidosis, Distal, 1
Osteomalacia, Pathologic fracture OMIM:179800
Fanconi Renotubular Syndrome 2
Osteopenia, Rickets, Recurrent fractures, Osteomalacia OMIM:613388
Hypocalcemic Vitamin D-Resistant Rickets
Bone cyst, Abnormal bone structure, Coarse metaphyseal trabecularization, Osteomalacia, Recurrent... ORPHA:93160
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:600081
Cystinosis, Late-Onset Juvenile Or Adolescent Nephropathic Type
Rickets OMIM:219900
Cholestasis, Progressive Familial Intrahepatic, 1
Osteopenia, Rickets, Splenomegaly OMIM:211600
Hereditary Hypophosphatemic Rickets With Hypercalciuria
Osteomalacia, Reduced bone mineral density, Pathologic fracture, Hypophosphatemic rickets ORPHA:157215
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Rickets, Hypophosphatemic rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recur... OMIM:241530
Fanconi Renotubular Syndrome 3
Rickets OMIM:615605
Dent Disease 1
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Recurrent fractur... OMIM:300009
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Rickets, Osteoporosis OMIM:560000
Fanconi Renotubular Syndrome 1
Rickets, Osteomalacia OMIM:134600
Dermatosparaxis Ehlers-Danlos Syndrome
Rickets, Osteopenia, Osteoporosis, Joint stiffness, Osteomalacia, Joint hypermobility ORPHA:1901
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:264700
Vitamin D-Dependent Rickets, Type 2A
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:277440
Hypocalcemic Vitamin D-Dependent Rickets
Rickets, Delayed epiphyseal ossification, Leukocytosis, Splenomegaly, Sparse bone trabeculae, Ost... ORPHA:289157
Autosomal Recessive Hypophosphatemic Rickets
Pseudo-fractures, Hypophosphatemic rickets, Rickets of the lower limbs, Increased bone mineral de... ORPHA:289176
Infantile Systemic Hyalinosis
Osteopenia, Osteoporosis, Joint stiffness, Camptodactyly of finger, Osteomalacia, Recurrent fract... ORPHA:2176
Rod-Cone Dystrophy, Sensorineural Deafness, And Fanconi-Type Renal Dysfunction
Rickets, Recurrent fractures OMIM:268315
Hypophosphatemic Rickets And Hyperparathyroidism
Rickets, Hypophosphatemic rickets OMIM:612089
Hypophosphatemic Rickets, X-Linked Dominant
Rickets, Hypophosphatemic rickets, Hepatosplenomegaly, Osteoarthritis, Osteomalacia OMIM:307800
Bile Acid Synthesis Defect, Congenital, 1
Rickets, Splenomegaly OMIM:607765
Fibrous Dysplasia Of Bone
Rickets, Pathologic fracture, Abnormal bone structure, Cortical irregularity, Osteolysis, Osteoma... ORPHA:249
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Rickets OMIM:616026
Dent Disease
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Recurrent fractur... ORPHA:1652
Pancreatic Triacylglycerol Lipase Deficiency
Rickets, Osteomalacia, Iron deficiency anemia, Osteoporosis ORPHA:309031
Cystinosis
Rickets ORPHA:213
Congenital Bile Acid Synthesis Defect Type 2
Rickets, Extramedullary hematopoiesis ORPHA:79303
X-Linked Hypophosphatemia
Rickets, Reduced bone mineral density, Vertebral hyperostosis, Arthritis, Limitation of joint mob... ORPHA:89936
Mccune-Albright Syndrome
Aneurysmal bone cyst, Pancytopenia, Polyostotic fibrous dysplasia, Monostotic fibrous dysplasia, ... ORPHA:562
Celiac Disease, Susceptibility To, 1
Rickets, Iron deficiency anemia, Macrocytic anemia, Osteoporosis, Thrombocytosis OMIM:212750
Fanconi-Bickel Syndrome
Rickets, Osteopenia ORPHA:2088
Neu-Laxova Syndrome
Rickets, Osteopenia, Osteoporosis, Flexion contracture, Osteomalacia, Arthrogryposis multiplex co... ORPHA:2671
Osteopetrosis, Autosomal Recessive 7
Osteopetrosis, Abnormal trabecular bone morphology OMIM:612301
Hypocalciuric Hypercalcemia, Familial, Type Iii
Osteomalacia OMIM:600740
Fanconi-Bickel Syndrome
Rickets, Osteomalacia OMIM:227810
Rothmund-Thomson Syndrome
Osteopenia, Abnormal trabecular bone morphology, Reduced bone mineral density ORPHA:2909
Distal Renal Tubular Acidosis
Rickets, Reduced bone mineral density, Osteomalacia, Hemolytic anemia, Increased susceptibility t... ORPHA:18
Rothmund-Thomson Syndrome Type 1
Osteopenia, Abnormal trabecular bone morphology ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Osteopenia, Abnormal trabecular bone morphology ORPHA:221016
Rajab Interstitial Lung Disease With Brain Calcifications 1
Rickets, Osteopenia, Reduced bone mineral density, Anemia, Pancytopenia, Joint hypermobility, Thi... OMIM:613658
Occipital Horn Syndrome
Rickets, Osteopenia, Synostosis of joints, Osteoporosis, Osteomalacia, Joint hypermobility, Osteo... ORPHA:198
Infantile Nephropathic Cystinosis
Rickets ORPHA:411629
Wilson Disease
Anemia, Osteoporosis, Thrombocytopenia, Splenomegaly, Osteoarthritis, Osteomalacia, Joint hypermo... OMIM:277900
Familial Hypocalciuric Hypercalcemia
Osteomalacia ORPHA:405
Immunodeficiency 82 With Systemic Inflammation
Anemia, Arthritis, B lymphocytopenia, Decreased proportion of naive T cells, T lymphocytopenia, S... OMIM:619381
Primary Fanconi Renotubular Syndrome
Osteomalacia, Hypophosphatemic rickets, Increased susceptibility to fractures ORPHA:3337
Lowe Oculocerebrorenal Syndrome
Rickets, Pathologic fracture, Osteomalacia, Camptodactyly of finger, Joint hypermobility, Joint c... OMIM:309000
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
Rickets, Osteopenia, Abnormally ossified vertebrae, Osteoporosis, Osteomalacia ORPHA:2636
Oculocerebrorenal Syndrome Of Lowe
Anemia, Arthritis, Joint stiffness, Thrombocytopenia, Osteomalacia, Joint hypermobility, Recurren... ORPHA:534
Cystinosis, Nephropathic
Rickets, Hypophosphatemic rickets, Splenomegaly OMIM:219800
Hypomagnesemia 3, Renal
Rickets OMIM:248250
Generalized Arterial Calcification Of Infancy
Osteomalacia, Abnormal calcification of the carpal bones, Fused cervical vertebrae, Hypophosphate... ORPHA:51608

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mepe

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mepe.

No publications found that use IMPC mice or data for Mepe.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mepetm372160(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Mepetm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Mepetm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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