Gene Summary

Name:
biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
Synonyms:
5730533B08Rik,  2010012D11Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal freezing behavior Bphltm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Bphl mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bphl by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lithium Transport
Bipolar affective disorder OMIM:152420
Major Affective Disorder 2
Bipolar affective disorder OMIM:309200
Major Depressive Disorder
Depression OMIM:608516
Panic Disorder 1
Anxiety OMIM:167870
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Major Affective Disorder 1
Depression OMIM:125480
Obsessive-Compulsive Disorder
Depression, Anxiety, Skin-picking OMIM:164230
Severe Primary Trimethylaminuria
Depression, Anxiety, Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity ORPHA:468726
Intellectual Developmental Disorder, Autosomal Recessive 59
Aggressive behavior OMIM:617323
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Geniospasm 1
Anxiety OMIM:190100
Persistent Idiopathic Facial Pain
Depression, Anxiety ORPHA:398147
Familial Alzheimer-Like Prion Disease
Depression, Anxiety, Emotional lability ORPHA:280397
Chorea, Benign Hereditary
Anxiety OMIM:118700
Myoclonus-Dystonia Syndrome
Depression, Personality disorder, Anxiety, Panic attack ORPHA:36899
Dystonia 11, Myoclonic
Depression, Agoraphobia, Anxiety OMIM:159900
Pandas
Agoraphobia, Abnormal fear/anxiety-related behavior, Impulsivity, Depression, Separation insecuri... ORPHA:66624
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Anxiety, Self-injurious behavior, Aggressive behavior OMIM:619031
Childhood-Onset Benign Chorea With Striatal Involvement
Anxiety ORPHA:494541
Huntington Disease-Like 2
Depression, Apathy, Anxiety, Irritability OMIM:606438
Early-Onset Schizophrenia
Impairment in personality functioning, Abnormal emotion/affect behavior, Depression, Anxiety, Low... ORPHA:96369
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Abnormal aggressive, impulsive or vi... ORPHA:3077
Dystonia 26, Myoclonic
Depression, Anxiety OMIM:616398
Gm2 Gangliosidosis, Ab Variant
Abnormal fear/anxiety-related behavior, Anxiety, Inappropriate behavior ORPHA:309246

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bphl

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bphl.

No publications found that use IMPC mice or data for Bphl.

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MGI Allele Allele Type Produced
Bphltm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Bphltm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bphltm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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