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Gene: Bphl MGI:1915271

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Gene Summary

Name:
biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
Synonyms:
5730533B08Rik,  2010012D11Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal freezing behavior Bphltm1b(EUCOMM)Hmgu HOM Early adult 7.37×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Bphl mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bphl by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lithium Transport
Bipolar affective disorder OMIM:152420
Major Affective Disorder 2
Bipolar affective disorder OMIM:309200
Major Depressive Disorder
Depression OMIM:608516
Panic Disorder 1
Anxiety OMIM:167870
Major Affective Disorder 1
Depression OMIM:125480
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Severe Primary Trimethylaminuria
Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivity ORPHA:468726
Advanced Sleep Phase Syndrome, Familial, 3
Depression OMIM:616882
Obsessive-Compulsive Disorder
Skin-picking, Depression, Anxiety OMIM:164230
Intellectual Developmental Disorder, Autosomal Recessive 59
Aggressive behavior OMIM:617323
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Depression OMIM:613003
Geniospasm 1
Anxiety OMIM:190100
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Familial Alzheimer-Like Prion Disease
Depression, Emotional lability, Anxiety ORPHA:280397
Dystonia 11, Myoclonic
Agoraphobia, Panic attack, Depression, Anxiety OMIM:159900
Myoclonus-Dystonia Syndrome
Anxiety, Personality disorder, Depression, Panic attack ORPHA:36899
Chorea, Benign Hereditary
Anxiety OMIM:118700
Pandas
Abnormal fear/anxiety-related behavior, Separation insecurity, Emotional lability, Depression, Ag... ORPHA:66624
Huntington Disease-Like 2
Inertia, Apathy, Depression, Anxiety, Irritability OMIM:606438
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Abnormal aggressive, impulsive or vi... ORPHA:3077
Early-Onset Schizophrenia
Diminished motivation, Abnormal emotion/affect behavior, Suicidal ideation, Unhappy demeanor, Emo... ORPHA:96369
Dystonia 26, Myoclonic
Depression, Anxiety OMIM:616398

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bphl

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bphl.

No publications found that use IMPC mice or data for Bphl.

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MGI Allele Allele Type Produced
Bphltm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Bphltm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bphltm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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