Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Yipf5tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
increased prepulse inhibition | Yipf5tm1b(EUCOMM)Hmgu | HET | Early adult | 6.52×10-06 | ||
embryonic lethality prior to tooth bud stage | Yipf5tm1b(EUCOMM)Hmgu | HOM | E12.5 | 0.00 | ||
abnormal retina outer nuclear layer morphology | Yipf5tm1b(EUCOMM)Hmgu | HET | Early adult | 6.73×10-08 | ||
decreased erythrocyte cell number | Yipf5tm1b(EUCOMM)Hmgu | HET | Early adult | 8.56×10-05 | ||
embryonic lethality prior to organogenesis | Yipf5tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
decreased total retina thickness | Yipf5tm1b(EUCOMM)Hmgu | HET | Early adult | 1.83×10-05 | ||
thick ventricular wall | Yipf5tm1b(EUCOMM)Hmgu | HET | Early adult | 3.90×10-05 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 0.0% (0 of 3) |
Ear | N/A | heterozygote | 66.67% (2 of 3) |
Embryo | N/A | heterozygote | 100% (3 of 3) |
Eye | N/A | heterozygote | Not available |
Footplate | N/A | heterozygote | 100% (3 of 3) |
Forebrain | N/A | heterozygote | 0.0% (0 of 3) |
Forelimb | N/A | heterozygote | 100% (3 of 3) |
Handplate | N/A | heterozygote | 100% (3 of 3) |
Head | N/A | heterozygote | 100% (3 of 3) |
Heart | N/A | heterozygote | 100% (3 of 3) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 3) |
Hindlimb | N/A | heterozygote | 100% (3 of 3) |
Liver | N/A | heterozygote | 33.33% (1 of 3) |
Lung | N/A | heterozygote | 100% (3 of 3) |
Mandibular process | N/A | heterozygote | 100% (3 of 3) |
Maxillary process | N/A | heterozygote | 100% (3 of 3) |
Midbrain | N/A | heterozygote | 0.0% (0 of 3) |
Oral cavity | N/A | heterozygote | 100% (3 of 3) |
Chorioallantoic placenta | N/A | heterozygote | 100% (1 of 1) |
Skin | N/A | heterozygote | Ambiguous |
Tail somite | N/A | heterozygote | 100% (3 of 3) |
Tail | N/A | heterozygote | 100% (3 of 3) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
oral cavity | 0.0% |
placenta | Ambiguous |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Yipf5 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Microcephaly, Epilepsy, And Diabetes Syndrome 2 | Elevated hemoglobin A1c | OMIM:619278 |
The table below shows human diseases predicted to be associated to Yipf5 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Yipf5.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress. | The Journal of clinical investigation (December 2020) | Yipf5tm1b(EUCOMM)Hmgu | PMC7685733 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Yipf5tm3e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Yipf5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
Yipf5tm3a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Yipf5tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Yipf5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Yipf5tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Yipf5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Yipf5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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