Gene: Sdha

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Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
MGI ID
MGI:1914195
Synonyms
SDHF FP SDH2 2310034D06Rik
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Sdhatm2b(KOMP)Wtsi HOM n/a 0.00
abnormal tooth morphology Sdhatm2b(KOMP)Wtsi HET postnatal 7.84×10-05
increased circulating sodium level Sdhatm2b(KOMP)Wtsi HET postnatal 1.70×10-05
decreased circulating glucose level Sdhatm2b(KOMP)Wtsi HET postnatal 7.59×10-05
embryonic lethality prior to organogenesis Sdhatm2b(KOMP)Wtsi HOM embryonic day 9.5 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Bone marrow 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2) N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No  (2/2) N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/485)  (1/1) N/A
Ear 1  (1/485) N/A
Embryo 1  (1/485)  (1/1)  Wholemount images
Eye 1  (1/485)  (1/1) N/A
Foot 1  (1/485)  (1/1) N/A
Forebrain 1  (1/485)  (1/1) N/A
Forelimb 1  (1/485)  (1/1) N/A
Hand 1  (1/485)  (1/1) N/A
Head 1  (5/485)  (1/1) N/A
Heart 1  (1/485)  (1/1) N/A
Hindbrain 1  (6/485)  (1/1) N/A
Hindlimb 1  (1/485)  (1/1) N/A
Liver 1  (1/485) N/A
Lung 1  (1/485) N/A
Mandibular process 1  (1/485)  (1/1) N/A
Maxillary process 1  (1/485)  (1/1) N/A
Midbrain 1  (1/485)  (1/1) N/A
Oral cavity 1  (1/485)  (1/1) N/A
Skin 1  (1/485)  (1/1) N/A
Tail 1  (1/485)  (1/1) N/A
Tail somite 1  (1/485)  (1/1) N/A

 Associated Images

X-ray: XRay Images Skull Lateral Orientation
10 Images
Combined SHIRPA and Dysmorphology
6 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
Sleep Wake: Wake state (bmp file)
1 Images
Embryo LacZ: LacZ images wholemount
4 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sdhatm50282(L1L2_Bact_P) Targeting vectors
Sdhatm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sdhatm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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