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Genes Phenotypes Help, News, Blog

Gene: Ifitm3 MGI:1913391

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Gene Summary

Name:
interferon induced transmembrane protein 3
Synonyms:
Fgls,  IP15,  fragilis,  mil-1,  1110004C05Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Ifitm3tm1Masu
body, WT, Male, WTSI
Ifitm3tm1Masu
head, WT, Male, WTSI
Ifitm3tm1Masu
body, WT, Female, WTSI
Ifitm3tm1Masu
head, WT, Female, WTSI
Ifitm3tm1Masu
body, HOM, Male, WTSI

View all 124 images

Ifitm3tm1Masu
back skin, HOM, Female, WTSI
Ifitm3tm1Masu
back skin, HOM, Female, WTSI
Ifitm3tm1Masu
back skin, HOM, Female, WTSI
Ifitm3tm1Masu
tail skin, WT, Female, WTSI
Ifitm3tm1Masu
tail skin, WT, Female, WTSI

Human diseases caused by Ifitm3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ifitm3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Immunodeficiency 31B
Recurrent mycobacterial infections, Herpes simplex encephalitis, Recurrent viral infections OMIM:613796

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ifitm3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ifitm3.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Ifitm3tm1Masu PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ifitm3tm1Masu Ifitm3tm1Masu PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Ifitm3tm1Masu PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Ifitm3tm1Masu PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ifitm3tm1Masu Reporter-tagged deletion allele (with selection cassette) ES Cells
Ifitm3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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