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Gene: Ramp2 MGI:1859650

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
receptor (calcitonin) activity modifying protein 2
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ramp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ramp2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lymphatic Malformation 11
Pedal edema, Lymphedema OMIM:619401
Follicular Lymphoma
Lymphedema, Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy, Pleural effusion ORPHA:545
Congenital Heart Block
First degree atrioventricular block, Gallop rhythm, Pericardial effusion, Congestive heart failur... ORPHA:60041
Gjc2-Related Late-Onset Primary Lymphedema
Genital edema, Predominantly lower limb lymphedema, Edema of the dorsum of hands, Facial edema, V... ORPHA:568051
Yellow Nail Syndrome
Hypoplasia of lymphatic vessels, Predominantly lower limb lymphedema, Lymphedema OMIM:153300
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Lymphatic Malformation 9
Tortuous lymphatic vessels, Predominantly lower limb lymphedema OMIM:619319
Hydrops Fetalis
Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, Pericardial effusion, Abnormality of the l... ORPHA:1041
Lymphedema And Cerebral Arteriovenous Anomaly
Abnormal cerebral vascular morphology, Lymphedema OMIM:152900
Meige Disease
Predominantly lower limb lymphedema, Edema of the dorsum of hands, Facial edema, Periorbital edem... ORPHA:90186
Nephrosialidosis
Pericardial effusion, Ascites, Bone-marrow foam cells OMIM:256150
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Pericardial effusion, Facial edema, Increased nucha... OMIM:617300
Lymphatic Malformation 3
Lymphedema OMIM:613480
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
Hennekam Lymphangiectasia-Lymphedema Syndrome 2
Pericardial lymphangiectasia, Lymphedema, Pulmonary lymphangiectasia, Camptodactyly, Intestinal l... OMIM:616006
Lymphatic Malformation 2
Lymphedema OMIM:611944
Lymphatic Malformation 4
Prominent superficial veins, Pedal edema, Lymphedema OMIM:615907
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pericardial effusion, Stillbirth, Pleural effusion, Ge... OMIM:618773
Congenital Pulmonary Lymphangiectasia
Hepatomegaly, Tricuspid regurgitation, Congestive heart failure, Splenomegaly, Hydrops fetalis, C... ORPHA:2414
Lymphedema, Cardiac Septal Defects, And Characteristic Facies
Overriding aorta, Ventricular septal defect, Lymphedema, Patent ductus arteriosus, Hydrops fetali... OMIM:601927
Lymphatic Malformation 5
Facial edema, Hypoplasia of lymphatic vessels, Predominantly lower limb lymphedema OMIM:153200
Lymphatic Malformation 1
Prominent superficial veins, Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Hypo... OMIM:153100
Cardiomyopathy, Familial Hypertrophic, 4
First degree atrioventricular block, Cardiomegaly, Right atrial enlargement, Atrioventricular blo... OMIM:115197
Chylous Ascites
Ascites, Lymphedema ORPHA:1160
Primary Effusion Lymphoma
Pericardial effusion, Abnormal peritoneum morphology, Pleural effusion ORPHA:48686
Lymphatic Malformation 6
Genital edema, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Lymphedema, Perior... OMIM:616843
Dohle Bodies And Leukemia
Secundum atrial septal defect, Lymphedema OMIM:223350
Cardiomyopathy, Dilated, 1A
Atrial flutter, Atrial fibrillation, First degree atrioventricular block, Sudden cardiac death, P... OMIM:115200
Cholestasis-Lymphedema Syndrome
Splenomegaly, Lymphedema OMIM:214900
Lymphatic Malformation 12
Nonimmune hydrops fetalis, Fetal ascites, Polyhydramnios, Lymphedema, Neonatal death OMIM:620014
Melorheostosis
Skeletal muscle atrophy, Peripheral arteriovenous fistula, Lymphedema ORPHA:2485
Lissencephaly 7 With Cerebellar Hypoplasia
Neonatal death, Arthrogryposis multiplex congenita, Lymphedema OMIM:616342
Lissencephaly 2
Lymphedema OMIM:257320
Kaposi Sarcoma
Venous insufficiency, Abnormality of the spleen, Generalized lymphadenopathy, Lymphedema ORPHA:33276
Combined Oxidative Phosphorylation Deficiency 10
Cardiomegaly, Pericardial effusion, Pleural effusion, Bradycardia, Hypertrophic cardiomyopathy, A... OMIM:614702
Preeclampsia/Eclampsia 1
Elevated hepatic transaminase, Hypertension, Edema OMIM:189800
German Syndrome
Camptodactyly of finger, Lymphedema, Abnormal cardiac septum morphology, Arthrogryposis multiplex... ORPHA:2077
Deafness-Lymphedema-Leukemia Syndrome
Lymphedema, Splenomegaly, Lymphadenopathy, Intracranial hemorrhage, Bone marrow hypocellularity ORPHA:3226
Klippel-Trénaunay Syndrome
Gastrointestinal hemorrhage, Prolonged bleeding time, Hepatomegaly, Edema, Pulmonary embolism, Co... ORPHA:90308
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Sinoatrial block, Atrial flutter, Atrial fibrillation, Sudden cardiac death, Cardiac conduction a... ORPHA:300751
Lymphedema-Hypoparathyroidism Syndrome
Lymphedema, Pulmonary lymphangiectasia, Mitral valve prolapse OMIM:247410
Alpha-N-Acetylgalactosaminidase Deficiency
Lymphedema, Cardiomegaly ORPHA:3137
Milroy Disease
Predominantly lower limb lymphedema, Lymphedema, Pedal edema, Varicose veins, Abnormal venous mor... ORPHA:79452
Cinca Syndrome
Hepatosplenomegaly, Eosinophilia, Lymphadenopathy, Lymphedema OMIM:607115
Cantu Syndrome
Bicuspid aortic valve, Lymphedema, Pericardial effusion, Cardiomegaly, Patent ductus arteriosus, ... OMIM:239850
Lymphatic Malformation 10
Lymphedema OMIM:619369
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
Hypertrophic cardiomyopathy, Generalized amyotrophy, Lymphedema ORPHA:79279
Congenital Enterovirus Infection
Abnormal bleeding, Skin rash, Polyhydramnios, Fetal ascites, Pericardial effusion, Myocarditis, H... ORPHA:292
Capillary Malformation-Arteriovenous Malformation
Peripheral arteriovenous fistula, Nonimmune hydrops fetalis, Cerebral arteriovenous malformation,... ORPHA:137667
Campomelia, Cumming Type
Polysplenia, Lymphedema OMIM:211890
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Predominantly lower limb lymphedema, Palpebral edema, Abnormality of the lymphatic system, Hydrop... ORPHA:69735
Cholestasis-Lymphedema Syndrome
Splenomegaly, Abnormality of the lymphatic system, Lymphedema ORPHA:1414
Craniofaciofrontodigital Syndrome
Gastrointestinal hemorrhage, Persistent fetal circulation, Bicuspid aortic valve, Ventricular sep... ORPHA:363705
Congenital Disorder Of Glycosylation, Type Il
Hepatomegaly, Edema, Pericardial effusion, Hepatosplenomegaly, Abnormal cardiac septum morphology... OMIM:608776
Glycogen Storage Disease Of Heart, Lethal Congenital
Prolonged QRS complex, Cardiomegaly, Pericardial effusion, Shortened PR interval, Cardiomyopathy,... OMIM:261740
Lymphedema, Primary, With Myelodysplasia
Lymphedema OMIM:614038
Gaucher Disease Type 1
Hepatomegaly, Pericardial effusion, Abnormal myocardium morphology, Hypersplenism, Splenomegaly, ... ORPHA:77259
Klippel-Trenaunay-Weber Syndrome
Lymphangioma, Arteriovenous fistula, Lymphedema OMIM:149000
Capillary Malformation Of The Lower Lip, Lymphatic Malformation Of Face And Neck, Asymmetry Of Face And Limbs, And Partial/Generalized Overgrowth
Varicose veins, Venous malformation, Lymphedema OMIM:613089
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Ventricular septal defect, Polyhydramnios, Lymphedema, Thyroid lymphangiectasia, Splenomegaly, Pa... OMIM:235255
Hypocomplementemic Urticarial Vasculitis
Hepatomegaly, Skin rash, Abnormal heart valve morphology, Pruritus, Pericardial effusion, Angioed... ORPHA:36412
Greenberg Dysplasia
Lymphedema ORPHA:1426
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Ventricular septal defect, Nonimmune hydrops fetalis, Lymphe... OMIM:153400
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Tricuspid regurgitation, Cardiomegaly, Pericardial effusion, Anomalous pulmonary ve... ORPHA:555874
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Prolonged QT interval, Hepatomegaly, Tachycardia, Elevated hepatic transaminase, Inflammatory abn... ORPHA:26793
Aicardi-Goutieres Syndrome 9
Elevated hepatic transaminase, Hepatomegaly, Pericarditis, Acute pancreatitis, Chilblains, Portal... OMIM:619487
Drug-Induced Lupus Erythematosus
Pericarditis, Pericardial effusion, Malar rash, Prolonged QTc interval, Petechiae ORPHA:231111
Transaldolase Deficiency
Edema, Hydrops fetalis, Hepatosplenomegaly, Coarctation of aorta, Telangiectasia, Biventricular h... ORPHA:101028
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Lymphedema OMIM:618154
Pulmonary Capillary Hemangiomatosis
Pulmonary edema, Diffuse alveolar hemorrhage, Right ventricular failure, Pericardial effusion, Pe... ORPHA:199241
Chromomycosis
Lymphangiectasis, Predominantly lower limb lymphedema, Edema, Lymphedema ORPHA:182
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Pericardial lymphangiectasia, Ventricular septal defect, Nonimmune hydrops fetalis, Lymphedema, P... OMIM:235510
Mucopolysaccharidosis Type 7
Lymphedema, Splenomegaly, Hydrops fetalis, Arteriovenous malformation, Ascites ORPHA:584
Hypertelorism And Other Facial Dysmorphism, Brachydactyly, Genital Abnormalities, Mental Retardation, And Recurrent Inflammatory Episodes
Perianal abscess, Pericardial effusion OMIM:614684
Cronkhite-Canada Syndrome
Splenomegaly, Lymphedema ORPHA:2930
Maternal Uniparental Disomy Of Chromosome X
Flexion contracture, Predominantly lower limb lymphedema, Camptodactyly of finger ORPHA:261519
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Nonimmune hydrops fetalis, Pericardial effusion, Endocardial fibroelastosis, Restrictive cardiomy... OMIM:619313
Clapo Syndrome
Lymphangioma, Varicose veins, Venous malformation, Lymphedema ORPHA:168984
Q Fever
Elevated hepatic transaminase, Hepatomegaly, Pericarditis, Maculopapular exanthema, Abnormal hear... ORPHA:781
Neurodevelopmental Disorder With Short Stature, Prominent Forehead, And Feeding Difficulties
Polyhydramnios, Pericardial effusion, Multiple muscular ventricular septal defects, Atrial septal... OMIM:620070
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Lymphedema ORPHA:1116
Kaposiform Lymphangiomatosis
Abnormal bleeding, Epidural hemorrhage, Epistaxis, Pericardial effusion, Pancreatic cysts, Spleno... ORPHA:464329
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Abnormal left ventricular function, Cholecystitis, Morbilliform rash, Ecchym... ORPHA:99827
Yellow Nail Syndrome
Hypoplasia of lymphatic vessels, Lymphedema ORPHA:662
Lymphatic Malformation 13
Nonimmune hydrops fetalis, Lymphedema, Patent ductus arteriosus, Neonatal death, Atrial septal de... OMIM:620244
Dahlberg-Borer-Newcomer Syndrome
Lymphedema, Mitral valve prolapse ORPHA:1563
Al-Gazali-Bakalinova Syndrome
Lymphedema OMIM:607131
Congenital Factor X Deficiency
Gastrointestinal hemorrhage, Epistaxis, Subarachnoid hemorrhage, Prolonged bleeding after surgery... ORPHA:328
Meckel Syndrome, Type 8
Encephalocele, Occipital encephalocele, Pericardial effusion OMIM:613885
Tenosynovial Giant Cell Tumor
Joint swelling, Lymphedema ORPHA:66627
Pediatric Systemic Lupus Erythematosus
Skin rash, Edema, Raynaud phenomenon, Discoid lupus rash, Pericardial effusion, Ascites, Increase... ORPHA:93552
Ring Chromosome 22 Syndrome
Pleural effusion, Edema, Lymphedema ORPHA:1446
Amyloidosis, Familial Visceral
Hepatomegaly, Skin rash, Edema, Splenomegaly, Cholestasis, Hypertension OMIM:105200
Lymphangiectasia, Intestinal
Intestinal lymphangiectasia, Stillbirth, Edema, Pedal edema OMIM:152800
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Persistent fetal circulation, Ventricular septal defect, Pericardial effusion, Bradycardia, Chole... OMIM:618775
Autosomal Erythropoietic Protoporphyria
Eczema, Edema, Pruritus, Decreased liver function, Cirrhosis, Cholelithiasis ORPHA:79278
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Palpebral edema, Nonimmune hydrops fetalis, Pulmonary lymphangiectasia, Lymphedema OMIM:137940
Noonan Syndrome 13
Atrial septal defect, Lymphedema, Mitral valve prolapse OMIM:619087
Hennekam Syndrome
Camptodactyly of finger, Lymphedema, Pericardial effusion, Splenomegaly, Pulmonary lymphangiectas... ORPHA:2136
Cardiac-Urogenital Syndrome
Accessory spleen, Prolonged bleeding time, Tachycardia, Cor triatrium sinister, Ventricular septa... OMIM:618280
Fabry Disease
Left ventricular hypertrophy, Transient ischemic attack, Ventricular septal hypertrophy, Lymphedema OMIM:301500
Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Impaired Intellectual Development
Lymphedema OMIM:152950
Monosomy 18P
Lymphedema ORPHA:1598
Lymphatic Filariasis
Predominantly lower limb lymphedema, Lymphedema, Lymphadenitis, Abnormality of the lymphatic syst... ORPHA:2035
Distal Xq28 Microduplication Syndrome
Predominantly lower limb lymphedema, Patent ductus arteriosus, Patent foramen ovale, Upper eyelid... ORPHA:293939
Congenital Disorder Of Glycosylation, Type Ia
Elevated hepatic transaminase, Hepatomegaly, Pericarditis, Nonimmune hydrops fetalis, Edema, Peri... OMIM:212065
Lymphangioleiomyomatosis
Lymphedema, Abnormality of the lymphatic system, Chylopericardium, Lymphadenopathy, Chylothorax, ... ORPHA:538
Acute Interstitial Pneumonia
Pericardial effusion, Hypertension, Pleural effusion, Peripheral edema ORPHA:79126
Pulmonary Edema Of Mountaineers, Susceptibility To
Elevated pulmonary artery pressure, Edema, Pulmonary edema OMIM:178400
Lymphoproliferative Syndrome 1
Pericardial effusion, Hepatomegaly, Pleural effusion, Splenomegaly OMIM:613011
Takenouchi-Kosaki Syndrome
Lymphedema, Patent ductus arteriosus, Abnormal cardiac septum morphology, Pulmonic stenosis, Camp... OMIM:616737
Glycogen Storage Disease Iv
Portal hypertension, Edema, Polyhydramnios, Hydrops fetalis, Hepatosplenomegaly, Cardiomyopathy, ... OMIM:232500
Primary Intestinal Lymphangiectasia
Peritoneal effusion, Edema, Pericardial effusion, Pleural effusion, Ascites, Generalized edema ORPHA:90362
Protoporphyria, Erythropoietic, 1
Eczema, Edema, Pruritus, Cholelithiasis, Hepatic failure OMIM:177000
Cerebrofacioarticular Syndrome
Lymphedema, Camptodactyly, Pulmonic stenosis, Abnormal heart morphology ORPHA:314679
Aicardi-Goutieres Syndrome 7
Hepatomegaly, Skin rash, Chilblains, Edema, Hematemesis, Pericardial effusion, Splenomegaly, Vasc... OMIM:615846
Diarrhea 10, Protein-Losing Enteropathy Type
Polyhydramnios, Pericardial effusion, Hematochezia, Anasarca, Pleural effusion, Ascites OMIM:618183
Familial Exudative Vitreoretinopathy
Macular edema, Lymphedema ORPHA:891
Poems Syndrome
Edema, Pericardial effusion, Abnormality of skin physiology, Pulmonary arterial hypertension, Ple... ORPHA:2905
Campomelia, Cumming Type
Oligohydramnios, Hydrops fetalis, Lymphedema ORPHA:1318
Pulmonary Non-Tuberculous Mycobacterial Infection
Pericardial effusion, Pleural effusion ORPHA:411703
Phelan-Mcdermid Syndrome
Patent ductus arteriosus, Ventricular septal defect, Palpebral edema, Lymphedema OMIM:606232
Infantile Systemic Hyalinosis
Camptodactyly of finger, Aplasia/Hypoplasia of the thymus, Lymphedema ORPHA:2176
Neurodegeneration, Childhood-Onset, With Multisystem Involvement Due To Mitochondrial Dysfunction
Pericardial effusion, Cardiomyopathy OMIM:620089
Chédiak-Higashi Syndrome
Abnormal bleeding, Elevated hepatic transaminase, Recurrent bacterial skin infections, Skin rash,... ORPHA:167
Thymic Carcinoma
Palpebral edema, Edema, Neoplasm of the thymus, Mediastinal lymphadenopathy, Abnormal vena cava m... ORPHA:99868
Hypotrichosis-Lymphedema-Telangiectasia Syndrome
Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Palpebral edema OMIM:607823
Generalized Arterial Calcification Of Infancy
Medial calcification of large arteries, Edema, Polyhydramnios, Cardiomegaly, Medial calcification... ORPHA:51608
Congenital Fibrinogen Deficiency
Abnormal bleeding, Tachycardia, Internal hemorrhage, Splenic rupture, Prolonged prothrombin time,... ORPHA:335
Noonan Syndrome
Abnormal pulmonary valve morphology, Lymphedema, Abnormality of the spleen, Pulmonary artery sten... ORPHA:648
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Bicuspid aortic valve, Polyhydramnios, Lymphedema, Splenomegaly, Hepatosplenomegaly, Chylothorax,... OMIM:613563
Mpi-Cdg
Gastrointestinal hemorrhage, Hepatomegaly, Abnormal circulating enzyme concentration or activity,... ORPHA:79319
Secondary Intestinal Lymphangiectasia
Intestinal lymphedema, Edema, Lymphedema, Chylous ascites, Anasarca, Constrictive pericarditis, P... ORPHA:90363
Oculoectodermal Syndrome
Transient ischemic attack, Lymphedema, Patent ductus arteriosus, Coarctation of aorta, Atrial sep... OMIM:600268
Gaucher Disease Type 3
Hepatomegaly, Mitral valve calcification, Abnormal heart valve morphology, Pericardial effusion, ... ORPHA:77261
Acquired Purpura Fulminans
Shock, Skin rash, Intracranial hemorrhage, Prolonged prothrombin time, Macular purpura, Hepatic f... ORPHA:49566
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Lymphedema, Cardiomegaly ORPHA:79280
Cardiofaciocutaneous Syndrome
Abnormal heart valve morphology, Lymphedema, Pulmonic stenosis, Atrial septal defect, Hypertrophi... ORPHA:1340
Alkuraya-Kucinskas Syndrome
Pericardial effusion, Pleural effusion, Edema OMIM:617822
Bannayan-Riley-Ruvalcaba Syndrome
Skeletal muscle atrophy, Lymphedema, Intracranial hemorrhage, Myopathy, Arteriovenous malformatio... ORPHA:109
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Sudden cardiac death, Pericardial effusion, Congestive heart failure, Dilated cardiomyopathy, Hep... ORPHA:73224
Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome
Lymphedema, Patent ductus arteriosus, Abnormality of the lymphatic system, Flexion contracture, A... ORPHA:487796
Lethal Congenital Contracture Syndrome 2
Skeletal muscle atrophy, Ventricular septal defect, Polyhydramnios, Edema, Dilated cardiomyopathy... OMIM:607598
Spondylodysplastic Ehlers-Danlos Syndrome
Prominent scalp veins, Abnormal right hemidiaphragm morphology, Multiple joint contractures, Abno... ORPHA:536471
Classical-Like Ehlers-Danlos Syndrome Type 2
Carotid artery stenosis, Pericardial effusion, Mitral valve prolapse, Aortic root aneurysm, Umbil... ORPHA:536532
Autosomal Recessive Spastic Paraplegia Type 11
Distal amyotrophy, Lower limb muscle weakness, Generalized limb muscle atrophy, Lymphedema ORPHA:2822
Alg9-Cdg
Hepatomegaly, Tricuspid regurgitation, Ventricular septal defect, Pericardial effusion, Hydrops f... ORPHA:79328
Lymphangiectasia, Pulmonary, Congenital
Palpebral edema, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Chylous ascites,... OMIM:265300
Lymphedema-Distichiasis Syndrome
Varicose veins, Patent ductus arteriosus, Predominantly lower limb lymphedema ORPHA:33001
Ogden Syndrome
Torticollis, Pulmonary edema, Bicuspid aortic valve, Left atrial enlargement, Ventricular septal ... OMIM:300855
Spondyloocular Syndrome
Atrial septal defect, Lymphedema, Mitral valve prolapse, Dysplastic aortic valve OMIM:605822
Cardiac Valvular Dysplasia 1
Ventricular septal defect, Left atrial enlargement, Tricuspid stenosis, Edema, Valvular pulmonary... OMIM:212093
Fabry Disease
Abnormal endocardium morphology, Transient ischemic attack, Lymphedema, Abnormal aortic valve mor... ORPHA:324
Phakomatosis Pigmentokeratotica
Rhabdomyosarcoma, Lymphedema ORPHA:2874
Aneurysm Of Sinus Of Valsalva
Aortic regurgitation, Edema, Congestive heart failure, Heart murmur, Bacterial endocarditis, Dila... ORPHA:1054
Rhabdoid Tumor
Hypertension, Internal hemorrhage, Neoplasm of the liver ORPHA:69077
Hellp Syndrome
Elevated hepatic transaminase, Pulmonary edema, Cerebral hemorrhage, Prolonged prothrombin time, ... ORPHA:244242
Ectodermal Dysplasia And Immunodeficiency 1
Lymphedema OMIM:300291
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Edema, Lymphedema, Chylothorax, Atrial septal defect, Pleural effusion ORPHA:2526
Noonan Syndrome 1
Ventricular septal defect, Lymphedema, Patent ductus arteriosus, Coarctation of aorta, Chylothora... OMIM:163950
Melkersson-Rosenthal Syndrome
Facial palsy, Edema, Periorbital edema, Lymphadenopathy, Macroglossia ORPHA:2483
Proteasome-Associated Autoinflammatory Syndrome 4
Skeletal muscle atrophy, Myositis, Edema, Splenomegaly, Flexion contracture, Lymphadenopathy OMIM:619183
Aymé-Gripp Syndrome
Patent ductus arteriosus, Pericarditis, Pericardial effusion ORPHA:1272
Myhre Syndrome
Ventricular septal defect, Pericardial effusion, Patent ductus arteriosus, Coarctation of aorta, ... OMIM:139210
Gitelman Syndrome
Prolonged QT interval, Neoplasm of the pancreas, Raynaud phenomenon, Pericardial effusion, Low-to... ORPHA:358
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Predominantly lower limb lymphedema OMIM:604121
Turner Syndrome Due To Structural X Chromosome Anomalies
Aortic arch aneurysm, Arterial dissection, Bicuspid aortic valve, Lymphedema, Gastrointestinal an... ORPHA:99413
Turner Syndrome
Aortic arch aneurysm, Arterial dissection, Bicuspid aortic valve, Lymphedema, Gastrointestinal an... ORPHA:881
Mosaic Monosomy X
Aortic arch aneurysm, Arterial dissection, Bicuspid aortic valve, Lymphedema, Gastrointestinal an... ORPHA:99228
Monosomy X
Aortic arch aneurysm, Arterial dissection, Bicuspid aortic valve, Lymphedema, Gastrointestinal an... ORPHA:99226
Kanzaki Disease
Lacunar stroke, Lymphedema OMIM:609242
Tsh-Secreting Pituitary Adenoma
Supraventricular arrhythmia, Pericardial effusion, Congestive heart failure, Hypertension, Palpit... ORPHA:91347
Sarcoidosis, Susceptibility To, 1
Hepatomegaly, Pericardial effusion, Splenomegaly, Pulmonary arterial hypertension, Pleural effusion OMIM:181000
Schneckenbecken Dysplasia
Polyhydramnios, Lymphedema ORPHA:3144
Proteus Syndrome
Thymus hyperplasia, Decreased muscle mass, Lymphedema, Neoplasm of the thymus, Splenomegaly, Myof... ORPHA:744
Hemorrhagic Fever-Renal Syndrome
Shock, Elevated hepatic transaminase, Tachycardia, Epistaxis, Hematemesis, Capillary leak, Intrac... ORPHA:340
Inhalational Anthrax
Internal hemorrhage, Hypotension ORPHA:247257
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Predominantly lower limb lymphedema ORPHA:314404
Monosomy 22Q13.3
Palpebral edema, Lymphedema ORPHA:48652
Marburg Hemorrhagic Fever
Abnormal bleeding, Shock, Tachycardia, Pericarditis, Elevated hepatic transaminase, Maculopapular... ORPHA:99826
Wiskott-Aldrich Syndrome
Prolonged bleeding time, Recurrent intrapulmonary hemorrhage, Epistaxis, Sudden cardiac death, Ec... ORPHA:906
Yellow Fever
Abnormal bleeding, Shock, Acute pancreatitis, Skin rash, Elevated circulating aspartate aminotran... ORPHA:99829
Pmm2-Cdg
Elevated hepatic transaminase, Pericarditis, Angina pectoris, Lymphedema, Pericardial effusion, A... ORPHA:79318
Tuberous Sclerosis Complex
Cardiac rhabdomyoma, Hypertension, Internal hemorrhage, Hepatic cysts, Aortic aneurysm ORPHA:805
Superficial Siderosis
Abnormal bleeding, Persistent bleeding after trauma, Internal hemorrhage, Subarachnoid hemorrhage ORPHA:247245
Vascular Ehlers-Danlos Syndrome
Abnormal bleeding, Telangiectasia of the skin, Transient ischemic attack, Abnormal heart valve mo... ORPHA:286

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ramp2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ramp2.

No publications found that use IMPC mice or data for Ramp2.

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MGI Allele Allele Type Produced
Ramp2tm465463(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ramp2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ramp2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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