Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

receptor (calcitonin) activity modifying protein 2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ramp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ramp2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Lymphatic Malformation 11
Pedal edema, Lymphedema OMIM:619401
Follicular Lymphoma
Lymphedema, Pleural effusion, Splenomegaly, Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:545
Gjc2-Related Late-Onset Primary Lymphedema
Facial edema, Predominantly lower limb lymphedema, Genital edema, Hypoplasia of lymphatic vessels... ORPHA:568051
Congenital Heart Block
Atrioventricular block, Second degree atrioventricular block, Third degree atrioventricular block... ORPHA:60041
Yellow Nail Syndrome
Predominantly lower limb lymphedema, Hypoplasia of lymphatic vessels, Lymphedema OMIM:153300
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Lymphatic Malformation 9
Tortuous lymphatic vessels, Predominantly lower limb lymphedema OMIM:619319
Hydrops Fetalis
Generalized edema, Lymphedema, Ascites, Abnormal heart morphology, Pleural effusion, Nonimmune hy... ORPHA:1041
Lymphedema And Cerebral Arteriovenous Anomaly
Abnormal cerebral vascular morphology, Lymphedema OMIM:152900
Ascites, Bone-marrow foam cells, Pericardial effusion OMIM:256150
Meige Disease
Facial edema, Predominantly lower limb lymphedema, Absence of lymph node germinal center, Lymphed... ORPHA:90186
Lymphatic Malformation 3
Lymphedema OMIM:613480
Lymphatic Malformation 7
Facial edema, Chylothorax, Lymphedema, Ascites, Increased nuchal translucency, Pleural effusion, ... OMIM:617300
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
Congenital Pulmonary Lymphangiectasia
Congestive heart failure, Ascites, Tricuspid regurgitation, Pleural effusion, Splenomegaly, Pulmo... ORPHA:2414
Lymphatic Malformation 4
Prominent superficial veins, Pedal edema, Lymphedema OMIM:615907
Lymphatic Malformation 14
Lymphedema OMIM:620602
Lymphatic Malformation 2
Lymphedema OMIM:611944
Lymphatic Malformation 8
Generalized edema, Pleural effusion, Nonimmune hydrops fetalis, Stillbirth, Polyhydramnios, Peric... OMIM:618773
Lymphedema, Cardiac Septal Defects, And Characteristic Facies
Lymphedema, Oligohydramnios, Ventricular septal defect, Overriding aorta, Atrial septal defect, H... OMIM:601927
Hennekam Lymphangiectasia-Lymphedema Syndrome 2
Intestinal lymphangiectasia, Lymphedema, Pulmonary lymphangiectasia, Camptodactyly, Pericardial l... OMIM:616006
Lymphatic Malformation 5
Facial edema, Predominantly lower limb lymphedema, Hypoplasia of lymphatic vessels OMIM:153200
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular hypertrophy, Myofiber disarray, Pulmonary edema, Left bundle branch block, Hepatomega... OMIM:115197
Lymphatic Malformation 1
Predominantly lower limb lymphedema, Hyperkeratosis over edematous areas, Hypoplasia of lymphatic... OMIM:153100
Chylous Ascites
Ascites, Lymphedema ORPHA:1160
Dohle Bodies And Leukemia
Secundum atrial septal defect, Lymphedema OMIM:223350
Primary Effusion Lymphoma
Pericardial effusion, Pleural effusion, Abnormal peritoneum morphology ORPHA:48686
Lymphatic Malformation 6
Facial edema, Generalized edema, Chylothorax, Lymphedema, Ascites, Intestinal lymphangiectasia, G... OMIM:616843
Lymphangiectasia, Pulmonary, Congenital
Facial edema, Chylothorax, Edema, Lymphedema, Ascites, Pleural effusion, Nonimmune hydrops fetali... OMIM:265300
Cardiomyopathy, Dilated, 1A
Dilated cardiomyopathy, Atrial flutter, Third degree atrioventricular block, Second degree atriov... OMIM:115200
Cholestasis-Lymphedema Syndrome
Splenomegaly, Lymphedema OMIM:214900
Lymphatic Malformation 12
Fetal ascites, Lymphedema, Neonatal death, Nonimmune hydrops fetalis, Polyhydramnios OMIM:620014
Lissencephaly 7 With Cerebellar Hypoplasia
Neonatal death, Arthrogryposis multiplex congenita, Lymphedema OMIM:616342
Kaposi Sarcoma
Abnormality of the spleen, Generalized lymphadenopathy, Venous insufficiency, Lymphedema ORPHA:33276
Lissencephaly 2
Lymphedema OMIM:257320
German Syndrome
Camptodactyly of finger, Tetralogy of Fallot, Lymphedema, Abnormal cardiac septum morphology, Art... ORPHA:2077
Skeletal muscle atrophy, Peripheral arteriovenous fistula, Lymphedema ORPHA:2485
Preeclampsia/Eclampsia 1
Elevated circulating hepatic transaminase concentration, Hypertension, Edema OMIM:189800
Combined Oxidative Phosphorylation Deficiency 10
Ascites, Hypertrophic cardiomyopathy, Oligohydramnios, Pleural effusion, Cardiomegaly, Bradycardi... OMIM:614702
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Lymphedema, Splenomegaly, Lymphadenopathy, Intracranial hemorrhage ORPHA:3226
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Atrial fibrillation, Dilated cardiomyopathy, Atrial flutter, Sinoatrial block, Congestive heart f... ORPHA:300751
Lymphedema-Hypoparathyroidism Syndrome
Pulmonary lymphangiectasia, Mitral valve prolapse, Lymphedema OMIM:247410
Klippel-Trénaunay Syndrome
Gastrointestinal hemorrhage, Pulmonary embolism, Congestive heart failure, Ascites, Abnormal tric... ORPHA:90308
Alpha-N-Acetylgalactosaminidase Deficiency
Cardiomegaly, Lymphedema ORPHA:3137
Milroy Disease
Predominantly lower limb lymphedema, Abnormal venous morphology, Lymphedema, Varicose veins, Peda... ORPHA:79452
Cinca Syndrome
Eosinophilia, Hepatosplenomegaly, Lymphadenopathy, Lymphedema OMIM:607115
Lymphatic Malformation 10
Lymphedema OMIM:619369
Cantu Syndrome
Congenital hypertrophy of left ventricle, Lymphedema, Cardiomegaly, Bicuspid aortic valve, Perica... OMIM:239850
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
Hypertrophic cardiomyopathy, Generalized amyotrophy, Lymphedema ORPHA:79279
Congenital Enterovirus Infection
Fetal ascites, Hepatic failure, Hypotension, Hepatitis, Abnormal bleeding, Cardiomyopathy, Choles... ORPHA:292
Capillary Malformation-Arteriovenous Malformation
Chylothorax, Arteriovenous malformation, Lymphedema, Abnormal heart morphology, Nonimmune hydrops... ORPHA:137667
Campomelia, Cumming Type
Polysplenia, Lymphedema OMIM:211890
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Predominantly lower limb lymphedema, Ascites, Pleural effusion, Abnormality of the lymphatic syst... ORPHA:69735
Cholestasis-Lymphedema Syndrome
Splenomegaly, Abnormality of the lymphatic system, Lymphedema ORPHA:1414
Craniofaciofrontodigital Syndrome
Aortic valve stenosis, Lower eyelid edema, Gastrointestinal hemorrhage, Congestive heart failure,... ORPHA:363705
Generalized edema, Cholelithiasis, Congestive heart failure, Hepatosplenomegaly, Hypersplenism, P... ORPHA:846
Glycogen Storage Disease Of Heart, Lethal Congenital
Biventricular hypertrophy, Pulmonary edema, Increased myocardial glycogen content, Ventricular fi... OMIM:261740
Lymphedema, Primary, With Myelodysplasia
Lymphedema OMIM:614038
Hypocomplementemic Urticarial Vasculitis
Angioedema, Ascites, Abnormal heart valve morphology, Pleural effusion, Splenomegaly, Skin rash, ... ORPHA:36412
Greenberg Dysplasia
Lymphedema ORPHA:1426
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Lymphedema, Ascites, Pancreatic lymphangiectasis, Splenomegaly, Ventricular septal defect, Thyroi... OMIM:235255
Capillary Malformation Of The Lower Lip, Lymphatic Malformation Of Face And Neck, Asymmetry Of Face And Limbs, And Partial/Generalized Overgrowth
Varicose veins, Venous malformation, Lymphedema OMIM:613089
Klippel-Trenaunay-Weber Syndrome
Lymphangioma, Arteriovenous fistula, Lymphedema OMIM:149000
Congenital Tricuspid Valve Dysplasia
Tricuspid regurgitation, Abnormal tricuspid valve annulus morphology, Patent foramen ovale, Cardi... ORPHA:555874
Transaldolase Deficiency
Biventricular hypertrophy, Hepatosplenomegaly, Telangiectasia, Coarctation of aorta, Cirrhosis, A... ORPHA:101028
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Atrioventricular block, Elevated circulating hepatic transaminase concentration, Dilated cardiomy... ORPHA:26793
Pulmonary Capillary Hemangiomatosis
Diffuse alveolar hemorrhage, Right ventricular failure, Pleural effusion, Hemothorax, Pulmonary e... ORPHA:199241
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Chylothorax, Lymphedema, Tetralogy of Fallot, Nonimmune hydr... OMIM:153400
Arrhythmogenic Cardiomyopathy With Variable Ectodermal Abnormalities
Dilated cardiomyopathy, Ventricular bigeminy, Tricuspid regurgitation, Left ventricular systolic ... OMIM:620519
Aicardi-Goutieres Syndrome 9
Acute pancreatitis, Hepatic fibrosis, Elevated circulating hepatic transaminase concentration, As... OMIM:619487
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Lymphedema OMIM:618154
Drug-Induced Lupus Erythematosus
Malar rash, Petechiae, Pericardial effusion, Prolonged QTc interval, Pericarditis ORPHA:231111
Mucopolysaccharidosis Type 7
Arteriovenous malformation, Lymphedema, Ascites, Splenomegaly, Hydrops fetalis ORPHA:584
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Joint contracture of the hand, Lymphedema, Intestinal lymphangiectasia, Pleural effusion, Nonimmu... OMIM:235510
Lymphangiectasis, Predominantly lower limb lymphedema, Edema, Lymphedema ORPHA:182
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Restrictive cardiomyopathy, Endocardial fibroelastosis, Nonimmune hydrops fetalis, Pericardial ef... OMIM:619313
Hypertelorism And Other Facial Dysmorphism, Brachydactyly, Genital Abnormalities, Impaired Intellectual Development, And Recurrent Inflammatory Episodes
Pericardial effusion, Perianal abscess OMIM:614684
Maternal Uniparental Disomy Of Chromosome X
Predominantly lower limb lymphedema, Flexion contracture, Camptodactyly of finger ORPHA:261519
Cronkhite-Canada Syndrome
Splenomegaly, Lymphedema ORPHA:2930
Q Fever
Vasculitis, Elevated circulating hepatic transaminase concentration, Hepatitis, Abnormal heart va... ORPHA:781
Clapo Syndrome
Varicose veins, Lymphangioma, Venous malformation, Lymphedema ORPHA:168984
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Lymphedema ORPHA:1116
Kaposiform Lymphangiomatosis
Epistaxis, Abnormal bleeding, Bruising susceptibility, Pancreatic cysts, Hepatosplenomegaly, Pleu... ORPHA:464329
Neurodevelopmental Disorder With Short Stature, Prominent Forehead, And Feeding Difficulties
Multiple muscular ventricular septal defects, Aortic aneurysm, Atrial septal defect, Polyhydramni... OMIM:620070
Lymphatic Malformation 13
Lymphedema, Ascites, Patent foramen ovale, Nonimmune hydrops fetalis, Neonatal death, Atrial sept... OMIM:620244
Congenital Disorder Of Glycosylation, Type Il
Ascites, Splenomegaly, Atrial septal defect, Hepatomegaly, Hydrops fetalis, Pericardial effusion OMIM:608776
Yellow Nail Syndrome
Hypoplasia of lymphatic vessels, Lymphedema ORPHA:662
Crimean-Congo Hemorrhagic Fever
Gingival bleeding, Morbilliform rash, Retinal hemorrhage, Erythema nodosum, Hepatomegaly, Jaundic... ORPHA:99827
Al-Gazali-Bakalinova Syndrome
Lymphedema OMIM:607131
Congenital Factor X Deficiency
Gingival bleeding, Epistaxis, Gastrointestinal hemorrhage, Bruising susceptibility, Spontaneous h... ORPHA:328
Lymphangiectasia, Intestinal
Intestinal lymphangiectasia, Stillbirth, Edema, Pedal edema OMIM:152800
Dahlberg-Borer-Newcomer Syndrome
Mitral valve prolapse, Lymphedema ORPHA:1563
Meckel Syndrome, Type 8
Pericardial effusion, Occipital encephalocele, Encephalocele OMIM:613885
Pediatric Systemic Lupus Erythematosus
Discoid lupus rash, Increased circulating lactate dehydrogenase concentration, Ascites, Malar ras... ORPHA:93552
Ring Chromosome 22 Syndrome
Pleural effusion, Edema, Lymphedema ORPHA:1446
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Cholelithiasis, Hypertrophic cardiomyopathy, Ventricular septal defect, Persistent fetal circulat... OMIM:618775
Cardiac-Urogenital Syndrome
Hypoplastic left heart, Coronary sinus enlargement, Interrupted aortic arch, Accessory spleen, Bi... OMIM:618280
Lymphatic Filariasis
Predominantly lower limb lymphedema, Lymphadenitis, Lymphedema, Hypereosinophilia, Abnormality of... ORPHA:2035
Autosomal Erythropoietic Protoporphyria
Cholelithiasis, Eczematoid dermatitis, Decreased liver function, Cirrhosis, Pruritus, Edema ORPHA:79278
Noonan Syndrome 13
Atrial septal defect, Mitral valve prolapse, Lymphedema OMIM:619087
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Pulmonary lymphangiectasia, Palpebral edema, Nonimmune hydrops fetalis, Lymphedema OMIM:137940
Hennekam Syndrome
Chylothorax, Arteriovenous malformation, Lymphedema, Ascites, Camptodactyly of finger, Lymphangio... ORPHA:2136
Fabry Disease
Ventricular septal hypertrophy, Left ventricular hypertrophy, Transient ischemic attack, Lymphedema OMIM:301500
Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Impaired Intellectual Development
Lymphedema OMIM:152950
Amyloidosis, Hereditary Systemic 2
Cholestasis, Splenomegaly, Skin rash, Hepatomegaly, Hypertension, Edema OMIM:105200
Monosomy 18P
Lymphedema ORPHA:1598
Poems Syndrome
Abnormality of skin physiology, Ascites, Pleural effusion, Splenomegaly, Pulmonary arterial hyper... ORPHA:2905
Congenital Disorder Of Glycosylation, Type Ia
Hepatic fibrosis, Elevated circulating hepatic transaminase concentration, Cardiomyopathy, Hepati... OMIM:212065
Chylothorax, Lymphedema, Ascites, Pulmonary lymphangiomyomatosis, Abnormality of the lymphatic sy... ORPHA:538
Distal Xq28 Microduplication Syndrome
Predominantly lower limb lymphedema, Upper eyelid edema, Patent ductus arteriosus, Patent foramen... ORPHA:293939
Acute Interstitial Pneumonia
Pericardial effusion, Peripheral edema, Pleural effusion, Hypertension ORPHA:79126
Takenouchi-Kosaki Syndrome
Lymphedema, Abnormal cardiac septum morphology, Camptodactyly, Patent ductus arteriosus, Pulmonic... OMIM:616737
Primary Intestinal Lymphangiectasia
Generalized edema, Peritoneal effusion, Ascites, Pleural effusion, Pericardial effusion, Edema ORPHA:90362
Protoporphyria, Erythropoietic, 1
Cholelithiasis, Hepatic failure, Eczematoid dermatitis, Pruritus, Edema OMIM:177000
Pulmonary Edema Of Mountaineers, Susceptibility To
Pulmonary edema, Elevated pulmonary artery pressure, Edema OMIM:178400
Aicardi-Goutieres Syndrome 7
Vasculitis, Hematochezia, Atopic dermatitis, Hepatitis, Hypertrophic cardiomyopathy, Oligohydramn... OMIM:615846
Diarrhea 10, Protein-Losing Enteropathy Type
Hematochezia, Anasarca, Ascites, Pleural effusion, Polyhydramnios, Pericardial effusion OMIM:618183
Thymic Carcinoma
Neoplasm of the thymus, Palpebral edema, Abnormal vena cava morphology, Mediastinal lymphadenopat... ORPHA:99868
Pulmonary Non-Tuberculous Mycobacterial Infection
Pericardial effusion, Pleural effusion ORPHA:411703
Lymphoproliferative Syndrome 1
Pericardial effusion, Hepatomegaly, Pleural effusion, Splenomegaly OMIM:613011
Familial Exudative Vitreoretinopathy
Macular edema, Lymphedema ORPHA:891
Cerebrofacioarticular Syndrome
Abnormal heart morphology, Camptodactyly, Pulmonic stenosis, Lymphedema ORPHA:314679
Campomelia, Cumming Type
Oligohydramnios, Hydrops fetalis, Lymphedema ORPHA:1318
Neurodegeneration, Childhood-Onset, With Multisystem Involvement Due To Mitochondrial Dysfunction
Pericardial effusion, Cardiomyopathy OMIM:620089
Hypotrichosis-Lymphedema-Telangiectasia Syndrome
Predominantly lower limb lymphedema, Palpebral edema, Nonimmune hydrops fetalis OMIM:607823
Infantile Systemic Hyalinosis
Aplasia/Hypoplasia of the thymus, Camptodactyly of finger, Lymphedema ORPHA:2176
Tenosynovial Giant Cell Tumor
Joint swelling, Lymphedema ORPHA:66627
Phelan-Mcdermid Syndrome
Palpebral edema, Ventricular septal defect, Patent ductus arteriosus, Lymphedema OMIM:606232
Glycogen Storage Disease Iv
Hepatic failure, Cardiomyopathy, Ascites, Hepatosplenomegaly, Portal hypertension, Cirrhosis, Bra... OMIM:232500
Noonan Syndrome
Lymphedema, Hypertrophic cardiomyopathy, Abnormality of the spleen, Abnormal pulmonary valve morp... ORPHA:648
Chédiak-Higashi Syndrome
Gingival bleeding, Epistaxis, Elevated circulating hepatic transaminase concentration, Increased ... ORPHA:167
Generalized Arterial Calcification Of Infancy
Ventricular hypertrophy, Medial calcification of large arteries, Retinal hemorrhage, Pancreatic c... ORPHA:51608
Congenital Fibrinogen Deficiency
Gingival bleeding, Abnormal bleeding, Bruising susceptibility, Subcutaneous hemorrhage, Abnormal ... ORPHA:335
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Aortic valve stenosis, Chylothorax, Lymphedema, Hepatosplenomegaly, Splenomegaly, Bicuspid aortic... OMIM:613563
Secondary Intestinal Lymphangiectasia
Anasarca, Lymphedema, Pleural effusion, Constrictive pericarditis, Chylous ascites, Intestinal ly... ORPHA:90363
Hepatic fibrosis, Gastrointestinal hemorrhage, Decreased liver function, Abnormal circulating enz... ORPHA:79319
Gaucher Disease Type 3
Aortic valve calcification, Abnormal heart valve morphology, Splenomegaly, Hepatomegaly, Pulmonar... ORPHA:77261
Oculoectodermal Syndrome
Lymphedema, Hypertrophic cardiomyopathy, Transient ischemic attack, Coarctation of aorta, Atrial ... OMIM:600268
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Cardiomegaly, Lymphedema ORPHA:79280
Acquired Purpura Fulminans
Hepatic failure, Macular purpura, Shock, Skin rash, Internal hemorrhage, Prolonged prothrombin ti... ORPHA:49566
Cardiofaciocutaneous Syndrome
Lymphedema, Hypertrophic cardiomyopathy, Abnormal heart valve morphology, Atrial septal defect, P... ORPHA:1340
Bannayan-Riley-Ruvalcaba Syndrome
Skeletal muscle atrophy, Arteriovenous malformation, Lymphedema, Myopathy, Aortic aneurysm, Intra... ORPHA:109
Alkuraya-Kucinskas Syndrome
Pericardial effusion, Pleural effusion, Edema OMIM:617822
Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome
Total anomalous pulmonary venous return, Lymphedema, Abnormal heart morphology, Abnormality of th... ORPHA:487796
Lethal Congenital Contracture Syndrome 2
Dilated cardiomyopathy, Skeletal muscle atrophy, Ventricular septal defect, Polyhydramnios, Arthr... OMIM:607598
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Dilated cardiomyopathy, Congestive heart failure, Pulmonary edema, Hepatic calcification, Pericar... ORPHA:73224
Spondylodysplastic Ehlers-Danlos Syndrome
Aortic valve stenosis, Lymphedema, Abnormal heart valve morphology, Prominent scalp veins, Elbow ... ORPHA:536471
Classical-Like Ehlers-Danlos Syndrome Type 2
Aortic root aneurysm, Bruising susceptibility, Umbilical hernia, Mitral valve prolapse, Carotid a... ORPHA:536532
Cardiac Valvular Dysplasia 1
Left aortic arch with cervical origin of the right subclavian artery, Arteria lusoria, Valvular p... OMIM:212093
Periportal fibrosis, Tricuspid regurgitation, Abnormal heart morphology, Oligohydramnios, Hepatic... ORPHA:79328
Aneurysm Of Sinus Of Valsalva
Aortic regurgitation, Bacterial endocarditis, Congestive heart failure, Heart murmur, Dilatation ... ORPHA:1054
Autosomal Recessive Spastic Paraplegia Type 11
Generalized limb muscle atrophy, Distal amyotrophy, Lower limb muscle weakness, Lymphedema ORPHA:2822
Spondyloocular Syndrome
Dysplastic aortic valve, Atrial septal defect, Mitral valve prolapse, Lymphedema OMIM:605822
Ogden Syndrome
Peripheral pulmonary artery stenosis, Secundum atrial septal defect, Lymphedema, Oligohydramnios,... OMIM:300855
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Patent ductus arteriosus, Varicose veins ORPHA:33001
Phakomatosis Pigmentokeratotica
Rhabdomyosarcoma, Lymphedema ORPHA:2874
Fabry Disease
Lymphedema, Hypertrophic cardiomyopathy, Transient ischemic attack, Abnormal aortic valve morphol... ORPHA:324
Ectodermal Dysplasia And Immunodeficiency 1
Lymphedema OMIM:300291
Rhabdoid Tumor
Neoplasm of the liver, Hypertension, Internal hemorrhage ORPHA:69077
Hellp Syndrome
Generalized edema, Hypotension, Elevated circulating hepatic transaminase concentration, Increase... ORPHA:244242
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Chylothorax, Lymphedema, Pleural effusion, Atrial septal defect, Edema ORPHA:2526
Proteasome-Associated Autoinflammatory Syndrome 4
Skeletal muscle atrophy, Splenomegaly, Myositis, Lymphadenopathy, Flexion contracture, Edema OMIM:619183
Noonan Syndrome 1
Chylothorax, Lymphedema, Hypertrophic cardiomyopathy, Ventricular septal defect, Coarctation of a... OMIM:163950
Myhre Syndrome
Aortic valve stenosis, Ventricular septal defect, Coarctation of aorta, Atrial septal defect, Per... OMIM:139210
Aymé-Gripp Syndrome
Pericardial effusion, Patent ductus arteriosus, Pericarditis ORPHA:1272
Gitelman Syndrome
Prominent U wave, Abnormal T-wave, Palpitations, ST segment depression, Syncope, Prolonged QT int... ORPHA:358
Cardiogenic Shock
Impaired myocardial contractility, Hypotension, Right ventricular failure, Abnormal left ventricu... ORPHA:97292
Turner Syndrome Due To Structural X Chromosome Anomalies
Hypoplastic left heart, Arterial dissection, Aortic dissection, Lymphedema, Aortic arch aneurysm,... ORPHA:99413
Turner Syndrome
Hypoplastic left heart, Arterial dissection, Aortic dissection, Lymphedema, Aortic arch aneurysm,... ORPHA:881
Mosaic Monosomy X
Hypoplastic left heart, Arterial dissection, Aortic dissection, Lymphedema, Aortic arch aneurysm,... ORPHA:99228
Monosomy X
Hypoplastic left heart, Arterial dissection, Aortic dissection, Lymphedema, Aortic arch aneurysm,... ORPHA:99226
Kanzaki Disease
Lacunar stroke, Lymphedema OMIM:609242
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Predominantly lower limb lymphedema OMIM:604121
Sarcoidosis, Susceptibility To, 1
Pleural effusion, Splenomegaly, Hepatomegaly, Pulmonary arterial hypertension, Pericardial effusion OMIM:181000
Tsh-Secreting Pituitary Adenoma
Hypotension, Congestive heart failure, Ventricular arrhythmia, Palpitations, Supraventricular arr... ORPHA:91347
Schneckenbecken Dysplasia
Polyhydramnios, Lymphedema ORPHA:3144
Hemorrhagic Fever-Renal Syndrome
Epistaxis, Hypotension, Elevated circulating hepatic transaminase concentration, Subconjunctival ... ORPHA:340
Proteus Syndrome
Thymus hyperplasia, Arteriovenous malformation, Decreased muscle mass, Lymphedema, Neoplasm of th... ORPHA:744
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Predominantly lower limb lymphedema ORPHA:314404
Monosomy 22Q13.3
Palpebral edema, Lymphedema ORPHA:48652
Marburg Hemorrhagic Fever
Hypotension, Elevated circulating hepatic transaminase concentration, Subconjunctival hemorrhage,... ORPHA:99826
Wiskott-Aldrich Syndrome
Gingival bleeding, Vasculitis, Hematochezia, Epistaxis, Bruising susceptibility, Spontaneous hema... ORPHA:906
Yellow Fever
Abnormal bleeding, Pancreatic hyperplasia, Shock, Elevated circulating aspartate aminotransferase... ORPHA:99829
Hepatic fibrosis, Elevated circulating hepatic transaminase concentration, Anasarca, Lymphedema, ... ORPHA:79318
Tuberous Sclerosis Complex
Cardiac rhabdomyoma, Hepatic cysts, Aortic aneurysm, Internal hemorrhage, Hypertension ORPHA:805
Superficial Siderosis
Subarachnoid hemorrhage, Persistent bleeding after trauma, Abnormal bleeding, Internal hemorrhage ORPHA:247245
Vascular Ehlers-Danlos Syndrome
Pulmonary artery aneurysm, Abnormal bleeding, Bruising susceptibility, Aortic dissection, Umbilic... ORPHA:286


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ramp2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ramp2.

No publications found that use IMPC mice or data for Ramp2.

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MGI Allele Allele Type Produced
Ramp2tm465463(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ramp2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ramp2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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