Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

RAB25, member RAS oncogene family

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rab25 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rab25 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Tracheoesophageal Fistula With Or Without Esophageal Atresia
Esophageal atresia, Tracheoesophageal fistula OMIM:189960
Esophageal Cancer
Esophageal carcinoma OMIM:133239
Jejunal Atresia
Jejunal atresia OMIM:243600
Intestinal atresia ORPHA:2368
Leiomyoma Of Vulva And Esophagus
Clitoral hypertrophy, Esophageal obstruction OMIM:150700
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Autoinflammatory Disease, Familial, Behcet-Like 3
Vaginal mucosal ulceration, Ileitis OMIM:618287
Proton-Pump Inhibitor-Responsive Esophageal Eosinophilia
Abnormal peristalsis, Esophageal food impaction, Lactose intolerance, Esophageal stenosis, Eosino... ORPHA:411696
Non-Syndromic Posterior Hypospadias
Bifid scrotum, Esophageal atresia, Cryptorchidism, Ventral shortening of foreskin, Cleft palate, ... ORPHA:95706
Methimazole Embryofetopathy
Esophageal atresia, Hypospadias, Tracheoesophageal fistula ORPHA:1923
Uterine Anomalies
Bicornuate uterus, Abnormality of the uterus OMIM:192000
Barrett Esophagus
Esophageal ulceration, Esophageal carcinoma, Barrett esophagus, Gastroesophageal reflux OMIM:614266
Gastroesophageal Reflux
Esophageal neoplasm, Barrett esophagus, Gastroesophageal reflux, Esophagitis OMIM:109350
Aganglionic megacolon, Esophageal atresia, Tracheoesophageal fistula, Abnormality of the uterus, ... ORPHA:59315
Fanconi Anemia, Complementation Group Q
Anteriorly placed anus, Esophageal atresia OMIM:615272
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Hypoplasia of penis, Hypospadias, Esophageal atresia, Cryptorchidism, Tracheoesophageal fistula ORPHA:77298
Coffin-Siris Syndrome 11
Esophageal atresia, High palate, Bifid uvula, Cleft soft palate OMIM:618779
Cocaine Embryofetopathy
Intestinal atresia ORPHA:1911
Phosphoribosylaminoimidazole Carboxylase Deficiency
Bilateral cryptorchidism, Esophageal atresia, Coronal hypospadias, Tracheoesophageal fistula OMIM:619859
Fanconi Anemia, Complementation Group B
Hypergonadotropic hypogonadism, Esophageal atresia, Tracheoesophageal fistula, Hypogonadism, Micr... OMIM:300514
Chromosome 17Q12 Duplication Syndrome
Esophageal atresia, Cleft soft palate OMIM:614526
Septo-Optic Dysplasia Spectrum
Hypoplasia of penis, Esophageal atresia, Cryptorchidism, Tracheoesophageal fistula, Cleft palate ORPHA:3157
Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia
Esophageal atresia, Congenital pyloric atresia OMIM:226730
Feingold Syndrome 2
Intestinal atresia OMIM:614326
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Esophageal atresia, Submucous cleft hard palate, Tracheoesophageal fistula, Duodenal atresia OMIM:619227
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Esophageal atresia, Tracheoesophageal fistula, Anal atresia OMIM:314390
Visceral Myopathy 2
Intestinal obstruction, Necrotizing enterocolitis, Intestinal pseudo-obstruction, Intestinal malr... OMIM:619350
Feingold Syndrome
Esophageal atresia, Duodenal atresia ORPHA:1305
Duodenal Atresia
Duodenal atresia OMIM:223400
Microgastria-Limb Reduction Defect Syndrome
Intestinal malrotation, Hiatus hernia, Esophageal atresia, Rectal atresia, Tracheoesophageal fist... ORPHA:2538
Hereditary Leiomyomatosis And Renal Cell Cancer
Barrett esophagus, Vaginal neoplasm, Esophageal neoplasm, Uterine leiomyoma, Uterine leiomyosarcoma ORPHA:523
Vacterl With Hydrocephalus
Cryptorchidism, Esophageal atresia, Tracheoesophageal fistula, Abnormal fallopian tube morphology... ORPHA:3412
Hypomelia With Mullerian Duct Anomalies
Uterus didelphys, Longitudinal vaginal septum OMIM:146160
Portal Hypertension, Noncirrhotic, 1
Esophageal varix OMIM:617068
Congenital Short Bowel Syndrome
Abnormal peristalsis, Intestinal malrotation, Decreased intestinal transit time, Steatorrhea, Con... OMIM:615237
Vaginal Atresia
Cervicitis, Vaginal hematocele, Transverse vaginal septum, Uterus didelphys, Bicornuate uterus, A... ORPHA:65681
Apert Syndrome
Esophageal atresia, Cleft palate, Narrow palate, Ovarian neoplasm, Ectopic anus, Bifid uvula ORPHA:87
Fanconi Anemia, Complementation Group L
Esophageal atresia, Tracheoesophageal fistula, Cleft palate, Aplasia of the uterus, Micropenis, A... OMIM:614083
Mandibulofacial Dysostosis, Guion-Almeida Type
Esophageal atresia, Cleft palate OMIM:610536
Cartilage-Hair Hypoplasia
Esophageal atresia, Anal stenosis, Aganglionic megacolon, Malabsorption OMIM:250250
Anorectal Anomalies
Rectovaginal fistula, Anal atresia OMIM:107100
Feingold Syndrome Type 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Anal atresia, Duodenal atresia ORPHA:391641
Apert Syndrome
Pyloric stenosis, Esophageal atresia, Cryptorchidism, Narrow palate, Cleft palate, Ectopic anus, ... OMIM:101200
Double Uterus-Hemivagina-Renal Agenesis Syndrome
Hydrocolpos, Uterus didelphys, Partial vaginal septum, Abnormal uterine cervix morphology ORPHA:3411
Small Bowel Atresia
Intestinal hypoplasia, Jejunal atresia, Intestinal malrotation ORPHA:1201
Fryns Syndrome
Bifid scrotum, Aganglionic megacolon, Intestinal malrotation, Hypospadias, Esophageal atresia, Cr... OMIM:229850
Trisomy 18
Esophageal atresia, Cryptorchidism, Narrow palate, Cleft palate, Abnormal morphology of female in... ORPHA:3380
Feingold Syndrome Type 2
Jejunal atresia ORPHA:391646
Martinez-Frias Syndrome
Intestinal hypoplasia, Jejunal atresia, Intestinal malrotation, Hypospadias, Tracheoesophageal fi... OMIM:601346
Mayer-Rokitansky-Kuster-Hauser Syndrome
Hypoplasia of the uterus, Aplasia of the vagina OMIM:277000
Testicular Regression Syndrome
Decreased testicular size, Abnormal male internal genitalia morphology, Hypoplasia of penis, Male... ORPHA:983
Feingold Syndrome 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Tracheoesophageal fistula, High pa... OMIM:164280
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Duodenal atresia, Intestinal atresia ORPHA:3405
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Esophageal stenosis, Congenital pyloric atresia OMIM:619817
Mckusick-Kaufman Syndrome
Aganglionic megacolon, Cryptorchidism, Transverse vaginal septum, Hydrometrocolpos, Rectovaginal ... OMIM:236700
Fanconi Anemia, Complementation Group D2
Hypergonadotropic hypogonadism, Esophageal atresia, Cryptorchidism, Tracheoesophageal fistula, Mi... OMIM:227646
Microphthalmia, Syndromic 3
Hypogonadotropic hypogonadism, Hypospadias, Esophageal atresia, Cryptorchidism, Micropenis OMIM:206900
Van Esch-O'Driscoll Syndrome
Esophageal atresia, Tracheoesophageal fistula, Bifid uvula, Hypogonadotropic hypogonadism OMIM:301030
Oculogastrointestinal Muscular Dystrophy
Abnormality of the gastrointestinal tract, Spontaneous esophageal perforation, Intestinal pseudo-... ORPHA:1876
Prune Belly Syndrome
Intestinal malrotation, Cryptorchidism, Urogenital sinus anomaly, Abnormality of the uterus, Volv... ORPHA:2970
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Hypospadias, Intestinal malrotation, Esophageal atresia, Tracheoesophageal fistula, Cleft palate,... OMIM:265380
Distal Deletion 12Q
Unilateral cryptorchidism, High, narrow palate, Esophageal atresia, Pyloric stenosis, Micropenis,... ORPHA:96149
46,Xx Ovotesticular Difference Of Sex Development
Bifid scrotum, Abnormal male internal genitalia morphology, Hypoplasia of penis, Small scrotum, H... ORPHA:2138
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Intestinal obstruction, Jejunal atresia, Intestinal malrotation, Ileal atresia, Rectal atresia, E... OMIM:243150
Maternal Phenylketonuria
Esophageal atresia, High palate ORPHA:2209
Renal, Genital, And Middle Ear Anomalies
Vaginal atresia OMIM:267400
Laryngotracheoesophageal Cleft Type 4
Tracheoesophageal fistula, Intestinal atresia ORPHA:93941
Secondary Short Bowel Syndrome
Abnormal small intestine morphology, Villous atrophy, Aganglionic megacolon, Small intestinal dys... ORPHA:95427
Duplication Of Urethra
Bifid scrotum, Clitoral hypertrophy, Hypospadias, Septate vagina, Rectourethral fistula, Epispadi... ORPHA:237
Colonic Atresia
Peptic ulcer, Colonic atresia, Duodenal stenosis ORPHA:1198
46,Xx Sex Reversal 2
Bifid scrotum, Hypoplasia of the vagina, Small scrotum, True hermaphroditism, Ovotestis, Perineal... OMIM:278850
Congenital Tracheomalacia
Esophageal atresia, Gastroesophageal reflux, Tracheoesophageal fistula ORPHA:95430
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Hypoplasia of penis, Urethrovaginal fistula, Esophageal atresia, Cryptorchidism, Uterus didelphys... ORPHA:93271
Mullerian Aplasia And Hyperandrogenism
Aplasia of the fallopian tube, Aplasia of the vagina, Abnormal external genitalia, Aplasia of the... OMIM:158330
Retinitis Pigmentosa 89
Esophageal varix OMIM:618955
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal stenosis, Vaginal neoplasm, Hypoperistalsis, Esophageal neoplasm, Abnormal esophagus m... ORPHA:1018
Cholesteryl Ester Storage Disease
Esophageal varix ORPHA:75234
Absent Radius-Anogenital Anomalies Syndrome
Rectal atresia, Rectovaginal fistula, Anal atresia, Perineal fistula ORPHA:3016
Currarino Syndrome
Anal stenosis, Septate vagina, Perianal abscess, Gastrointestinal obstruction, Bicornuate uterus,... OMIM:176450
Gabriele-De Vries Syndrome
Cryptorchidism, Esophageal atresia, High palate, Oral-pharyngeal dysphagia ORPHA:506358
Charge Syndrome
Anal stenosis, Hypogonadotropic hypogonadism, External genital hypoplasia, Esophageal atresia, Cr... OMIM:214800
Bardet-Biedl Syndrome 6
Vaginal atresia, Hypospadias, External genital hypoplasia OMIM:605231
Dyskeratosis Congenita, Autosomal Recessive 5
Esophageal stenosis, Colitis OMIM:615190
Mckusick-Kaufman Syndrome
Aganglionic megacolon, Cryptorchidism, Hydrometrocolpos, Glandular hypospadias, Cleft palate, Uro... ORPHA:2473
Vater/Vacterl Association
Esophageal atresia, Hypospadias, Tracheoesophageal fistula, Anal atresia OMIM:192350
Septate vagina OMIM:114150
Denys-Drash Syndrome
True hermaphroditism, Septate vagina, Gonadal tissue inappropriate for external genitalia or chro... OMIM:194080
Visceral Myopathy, Familial, With External Ophthalmoplegia
Spontaneous esophageal perforation OMIM:277320
Septate vagina ORPHA:1319
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Spontaneous esophageal perforation, Esophageal stricture, Abnormal esophagus morphology, Dysphagia OMIM:226600
15Q24 Microdeletion Syndrome
Hypospadias, Cryptorchidism, Microphallus, Anal atresia, Intestinal atresia ORPHA:94065
46,Xy Partial Gonadal Dysgenesis
Hypoplasia of the vagina, Hypoplasia of penis, Vanishing testis, Micropenis, Ovarian gonadoblasto... ORPHA:251510
Dyskeratosis Congenita, Autosomal Dominant 6
Esophageal stenosis, Oral leukoplakia OMIM:616553
Cerebroretinal Microangiopathy With Calcifications And Cysts 2
Gastrointestinal hemorrhage, Esophageal varix OMIM:617341
Mitchell-Riley Syndrome
Jejunal atresia, Intestinal malrotation, Malabsorption, Anteriorly placed anus, Acholic stools, M... OMIM:615710
Bardet-Biedl Syndrome 12
Hypogonadism, Hydrometrocolpos, Vaginal atresia OMIM:615989
Portal Hypertension, Noncirrhotic, 2
Esophageal varix, Hepatocellular carcinoma OMIM:619463
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Intestinal obstruction, Malabsorption, Esophageal varix, Gastrointes... ORPHA:131
Wolman Disease
Esophageal varix, Steatorrhea ORPHA:75233
Plummer-Vinson Syndrome
Glossitis, Tongue atrophy, Esophageal web, Dysphagia ORPHA:54028
Manitoba Oculotrichoanal Syndrome
Anteriorly placed anus, Anal stenosis, Vaginal atresia OMIM:248450
Bronchogenic Cyst
Abnormal esophagus morphology, Dysphagia, Abnormal stomach morphology ORPHA:2357
Testicular Agenesis
Abnormal vas deferens morphology, Urethrovaginal fistula, Absent external genitalia, Hypoplasia o... ORPHA:325124
Netherton Syndrome
Villous atrophy, Recurrent infection of the gastrointestinal tract, Intestinal atresia OMIM:256500
Meacham Syndrome
Hypoplasia of penis, Cryptorchidism, Hydrometrocolpos, Abnormal fallopian tube morphology, Ambigu... ORPHA:3097
Adams-Oliver Syndrome 6
Esophageal varix OMIM:616589
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Esophageal ulceration, Gastric ulcer, Duodenal ulcer OMIM:618372
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Aplasia of the uterus, Aplasia of the vagina, Uterus didelphys, Septate vagina OMIM:146255
Ectodermal Dysplasia/Short Stature Syndrome
Esophageal stricture, Dysphagia OMIM:616029
Duodenal Atresia
Duodenal atresia ORPHA:1203
Recessive Dystrophic Epidermolysis Bullosa Inversa
Vaginal stricture, Esophageal stricture, Gastrointestinal inflammation ORPHA:79409
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations
Septate vagina, Bicornuate uterus, Rectovaginal fistula, Labial hypoplasia, Anal atresia, Clitora... OMIM:300707
Meckel Syndrome 12
Hypoplasia of the uterus, Vaginal atresia, Bifid uvula OMIM:616258
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Septate vagina, Uterus didelphys, Cleft palate, Aplasia of the uterus, Vaginal atresia ORPHA:2237
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Esophageal diverticulum, Hamartoma of tongue, Septate vagina, Uterus didelphys, Cleft palate, Mic... OMIM:617925
Noonan Syndrome 7
Impaired oropharyngeal swallow response, Abnormal esophagus morphology, Dysphagia OMIM:613706
Renal Hypodysplasia/Aplasia 1
Bicornuate uterus, Vaginal atresia OMIM:191830
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Cryptorchidism, High palate, Abnormality of the uterus, Protein-losing enteropathy, Abnormal fall... ORPHA:1655
Glycogen Storage Disease Iv
Esophageal varix OMIM:232500
Gastrointestinal Defects And Immunodeficiency Syndrome 2
Inflammation of the large intestine, Rectovaginal fistula, Dysphagia, Absent uvula, Intestinal at... OMIM:619708
Popliteal Pterygium Syndrome
Bifid scrotum, Hypoplasia of the vagina, Small scrotum, Cryptorchidism, Cleft palate, Hypoplasia ... OMIM:119500
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Esophageal stenosis, Anal fissure, Esophageal stricture, Gastroesophageal reflux, Dysphagia, Anky... ORPHA:89842
Dyskeratosis Congenita, Autosomal Recessive 8
Oral leukoplakia, Pancolitis, Inflammation of the large intestine, Esophageal stricture OMIM:620133
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the uterus, Aplasia of the vagina, Anal atresia, Absent external genitalia OMIM:271520
Hand-Foot-Genital Syndrome
Bifid scrotum, Hypospadias, Uterus didelphys, Chordee, Longitudinal vaginal septum, Micropenis OMIM:140000
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Esophageal varix, Gastric varix, Hepatocellular carcinoma ORPHA:64743
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility
Intestinal malrotation, Duodenal atresia OMIM:619608
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 14
Ileal atresia OMIM:615351
Mirror Polydactyly-Vertebral Segmentation-Limbs Defects Syndrome
Duodenal atresia ORPHA:3004
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Abnormal small intestine morphology, Barrett esophagus... ORPHA:90291
Tetraamelia-Multiple Malformations Syndrome
Cryptorchidism, Vaginal atresia, Anal atresia ORPHA:3301
Abnormal esophagus morphology ORPHA:1163
Linear Skin Defects With Multiple Congenital Anomalies 1
Clitoral hypertrophy, Hypospadias, Ovotestis, Cleft palate, Anteriorly placed anus, Hypoplasia of... OMIM:309801
Localized Dystrophic Epidermolysis Bullosa, Acral Form
Esophageal stricture ORPHA:158673
Microcephaly 20, Primary, Autosomal Recessive
Hypoplasia of the uterus, Vaginal atresia OMIM:617914
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Hypoplasia of the vagina, Clitoral hypertrophy, Ambiguous genitalia, female, Long penis, Hypoplas... OMIM:202010
Combined Immunodeficiency-Enteropathy Spectrum
Intestinal malrotation, Jejunoileal ulceration, Gastrointestinal atresia, Rectal abscess, Intesti... ORPHA:436252
Mirage Syndrome
Hypospadias, Hypergonadotropic hypogonadism, Cryptorchidism, Esophageal stricture, Gastroesophage... OMIM:617053
Congenital Disorder Of Glycosylation, Type Iil
Inflammation of the large intestine, Esophageal varix OMIM:614576
Smith-Lemli-Opitz Syndrome
Bifid scrotum, Small scrotum, Aganglionic megacolon, Intestinal malrotation, Septate vagina, Hypo... OMIM:270400
Cirrhosis, Familial
Esophageal varix OMIM:215600
46,Xy Difference Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Hypoplasia of the vagina, Hypospadias, Hypergonadotropic hypogonadism, Enlarged polycystic ovarie... ORPHA:90796
Bardet-Biedl Syndrome 1
Decreased testicular size, Aganglionic megacolon, High, narrow palate, High palate, Hypogonadism,... OMIM:209900
Kindler Syndrome
Anal stenosis, Esophageal stenosis, Phimosis, Dysphagia, Oral leukoplakia OMIM:173650
Meacham Syndrome
Male pseudohermaphroditism, Blind vagina, Bicornuate uterus, Septate vagina OMIM:608978
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Esophageal varix ORPHA:367
Cholestasis, Progressive Familial Intrahepatic, 8
Esophageal varix OMIM:619662
Antley-Bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis
Hypoplastic labia majora, Vaginal atresia, Fused labia minora OMIM:207410
Mayer-Rokitansky-Küster-Hauser Syndrome
Hypoplasia of the vagina, Aplasia of the uterus ORPHA:3109
Junctional Epidermolysis Bullosa With Pyloric Atresia
Congenital pyloric atresia, Intestinal atresia ORPHA:79403
Adams-Oliver Syndrome 5
Esophageal varix OMIM:616028
Benign Schwannoma
Intestinal polyposis, Abnormal parotid gland morphology, Abnormal esophagus morphology ORPHA:252164
Dyskeratosis Congenita
Esophageal stenosis, Abnormal testis morphology, Malabsorption, Anorectal anomaly, Tracheoesophag... ORPHA:1775
Coach Syndrome 1
Esophageal varix OMIM:216360
Tetraamelia Syndrome 1
Hypoplasia of the fallopian tube, Absent external genitalia, Cleft palate, Vaginal atresia, Anal ... OMIM:273395
Cholesteryl Ester Storage Disease
Esophageal varix, Steatorrhea OMIM:278000
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Esophageal varix, Hepatocellular adenoma, Polycystic ovaries ORPHA:264580
Genitourinary And/Or Brain Malformation Syndrome
Streak ovary, Jejunal atresia, Hypospadias, Ileal atresia, Cryptorchidism, Uterus didelphys, Gona... OMIM:618820
Fraser Syndrome
Anal stenosis, Hypoplasia of penis, Small scrotum, Hypospadias, Cryptorchidism, Abnormal vagina m... ORPHA:2052
Immunodeficiency 12
Esophageal stricture OMIM:615468
Mednik Syndrome
Volvulus, Jejunal atresia, Microcolon OMIM:609313
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Esophageal varix ORPHA:974
Chromosome 17Q12 Deletion Syndrome
Cryptorchidism, Ovarian cyst, Aplasia of the vagina, High palate, Aplasia of the uterus, Unicornu... OMIM:614527
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome
Achalasia, Esophageal stenosis, Dysphagia OMIM:615510
Chronic Graft Versus Host Disease
Phimosis, Esophageal stricture, Xerostomia, Abnormal esophagus morphology, Gastroesophageal reflu... ORPHA:99921
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Anal stenosis, Absence of Stensen duct, Hypogonadotropic hypogonadism, Cryptorchidism, Xerostomia... OMIM:604292
Hypoplasia of penis, Cryptorchidism, Intestinal atresia, Gastroesophageal reflux, Median cleft li... ORPHA:2162
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Absence of Stensen duct, Hypogonadotropic hypogonadism, Cryptorchidism, Xerostomia, Transverse va... OMIM:129900
Pallister-Hall Syndrome
Decreased testicular size, Small scrotum, Hypospadias, Precocious puberty, Cryptorchidism, Hydrom... ORPHA:672
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Hydrometrocolpos, Vaginal atresia, Aplasia of the epiglottis OMIM:617088
Degcags Syndrome
Jejunal atresia, Hypospadias, Oral-pharyngeal dysphagia, Protruding tongue, Pyloric stenosis, Hia... OMIM:619488
Ulnar-Mammary Syndrome
Anal stenosis, Small scrotum, Pyloric stenosis, Bicornuate uterus, Shawl scrotum, Micropenis, Imp... OMIM:181450
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Hematemesis, Esophageal varix OMIM:263200
Dyskeratosis Congenita, Autosomal Recessive 1
Esophageal stricture, Oral leukoplakia OMIM:224230
Chand Syndrome
Bifid tongue, Imperforate hymen, Cleft palate ORPHA:1401
Stromme Syndrome
Jejunal atresia, Intestinal malrotation, Cleft palate, Duodenal atresia OMIM:243605
Fraser Syndrome 1
Abnormal small intestine morphology, Hypospadias, Cryptorchidism, Cleft palate, Bicornuate uterus... OMIM:219000
Hypoglossia-Hypodactyly Syndrome
Jejunal atresia, Aplasia/Hypoplasia of the tongue, Cleft palate, High palate, Anal atresia ORPHA:989
Johanson-Blizzard Syndrome
Colonic diverticula, Clitoral hypertrophy, Hypospadias, Septate vagina, Malabsorption, Urethrovag... OMIM:243800
Dyskeratosis Congenita, Autosomal Dominant 2
Esophageal stricture, Oral leukoplakia OMIM:613989
Hereditary Hemorrhagic Telangiectasia
Intestinal polyposis, Esophageal varix, Gastrointestinal hemorrhage ORPHA:774
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Aplasia of the vagina, Aplasia of the uterus ORPHA:457284
Kindler Epidermolysis Bullosa
Phimosis, Esophageal stricture, Inflammation of the large intestine, Colitis, Esophagitis, Dyspha... ORPHA:2908
Immunodeficiency 23
Esophageal stricture, High palate OMIM:615816
Classic Homocystinuria
Gastrointestinal hemorrhage, Esophageal varix, High palate ORPHA:394
Caroli Disease
Cholangiocarcinoma, Esophageal varix ORPHA:53035
Waardenburg Syndrome, Type 1
Aplasia of the vagina OMIM:193500
Microphthalmia, Syndromic 2
Hypospadias, Septate vagina, Cryptorchidism, Submucous cleft hard palate, Bifid uvula OMIM:300166
Zttk Syndrome
Submucous cleft hard palate, High palate, Bifid uvula, Intestinal atresia OMIM:617140
Caroli Syndrome
Melena, Cholangiocarcinoma, Esophageal varix, Hematemesis ORPHA:480520
Trichorhinophalangeal Syndrome, Type Ii
Bilateral cryptorchidism, Chronic gastritis, Gastroesophageal reflux, Hydrometrocolpos OMIM:150230
Rajab Interstitial Lung Disease With Brain Calcifications 1
Small scrotum, Intestinal malrotation, Esophageal varix, Gastroesophageal reflux, High palate OMIM:613658
Progeroid Short Stature With Pigmented Nevi
Esophageal ulceration, Chordee, Hypospadias OMIM:176690
Wilson Disease
Esophageal varix, Dysphagia, Hepatocellular carcinoma OMIM:277900
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Esophageal varix ORPHA:309854
Hardikar Syndrome
Cleft soft palate, Intestinal malrotation, Celiac disease, Hematemesis, Esophageal varix, Bilater... OMIM:301068
Mowat-Wilson Syndrome
Bifid scrotum, Aganglionic megacolon, Hypospadias, Septate vagina, Cleft hard palate, Pyloric ste... ORPHA:2152
Senior-Boichis Syndrome
Esophageal varix ORPHA:84081
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Bifid scrotum, Aganglionic megacolon, Hypospadias, Septate vagina, Cleft hard palate, Pyloric ste... ORPHA:261537
Stevens-Johnson Syndrome
Gastrointestinal hemorrhage, Esophageal stricture, Dysphagia ORPHA:36426
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Cholangiocarcinoma, Esophageal varix, Protein-losing enteropathy, He... ORPHA:731
Lysosomal Acid Lipase Deficiency
Esophageal varix, Steatorrhea ORPHA:275761
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Bifid scrotum, Aganglionic megacolon, Hypospadias, Septate vagina, Cleft hard palate, Pyloric ste... ORPHA:261552
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Hypospadias, Cryptorchidism, Hydrocele testis, Chordee, High palate, Dysphagia, Hematocolpos, Imp... OMIM:619522
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Microcolon, Ileal atresia OMIM:619351
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Esophageal varix OMIM:615688
Arima Syndrome
Esophageal varix OMIM:243910
Dyskeratosis Congenita, X-Linked
Decreased testicular size, Hypospadias, Phimosis, Cryptorchidism, Esophageal stricture, Oral leuk... OMIM:305000
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Azoospermia, Gastric ulcer, Esophageal varix ORPHA:2072
Adams-Oliver Syndrome 1
Imperforate hymen, Cleft palate OMIM:100300
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Cleft soft palate, Cryptorchidism, Esophageal varix, High palate, Dysphagia, Unicornuate uterus, ... OMIM:619503
Peters-Plus Syndrome
Hypoplasia of the vagina, Hypospadias, Cryptorchidism, Cleft palate, Anteriorly placed anus, Hypo... OMIM:261540
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Anal fissure, Gastrointestinal inflammation, Gastroesophageal reflux, Dysphagia, Esophageal ulcer... ORPHA:79408
Severe Generalized Junctional Epidermolysis Bullosa
Esophageal stricture, Gastrointestinal inflammation ORPHA:79404
Pallister-Killian Syndrome
Anal stenosis, Small scrotum, Hypospadias, Intestinal malrotation, Cryptorchidism, Cleft palate, ... OMIM:601803
Biliary, Renal, Neurologic, And Skeletal Syndrome
Gastroesophageal reflux, Esophageal varix OMIM:619534
Alström Syndrome
Precocious puberty in females, Hypergonadotropic hypogonadism, Testicular fibrosis, Esophageal va... ORPHA:64


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rab25

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rab25.

No publications found that use IMPC mice or data for Rab25.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Rab25tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rab25tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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