Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
small testis | Slc25a3tm1b(EUCOMM)Wtsi | HET | Early adult | 0.00 | ||
abnormal heart morphology | Slc25a3tm1b(EUCOMM)Wtsi | HET | Early adult | 0.00 | ||
embryonic lethality prior to organogenesis | Slc25a3tm1b(EUCOMM)Wtsi | HOM | E9.5 | 0.00 | ||
enlarged heart | Slc25a3tm1b(EUCOMM)Wtsi | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Slc25a3tm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
abnormal allantois morphology | Slc25a3tm1b(EUCOMM)Wtsi | HET | E9.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 50% (1 of 2) |
Cecum | Section images | heterozygote | 50% (1 of 2) |
Colon | Section images | heterozygote | 50% (1 of 2) |
Duodenum | Section images | heterozygote | 50% (1 of 2) |
Epididymis | Section images | heterozygote | 50% (1 of 2) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Harderian gland | Section images | heterozygote | 50% (1 of 2) |
Ileum | Section images | heterozygote | 50% (1 of 2) |
Kidney | Section images | heterozygote | 50% (1 of 2) |
Mammary gland | Section images | heterozygote | 50% (1 of 2) |
Ovary | Section images | heterozygote | 50% (1 of 2) |
Oviduct | Section images | heterozygote | 50% (1 of 2) |
Pancreas | Section images | heterozygote | 50% (1 of 2) |
Parathyroid gland | Section images | heterozygote | 50% (1 of 2) |
Parotid gland | Section images | heterozygote | 50% (1 of 2) |
Pituitary gland | Section images | heterozygote | 50% (1 of 2) |
Prostate gland | Section images | heterozygote | 50% (1 of 2) |
Skin | Section images | heterozygote | 50% (1 of 2) |
Spleen | Section images | heterozygote | 50% (1 of 2) |
Stomach | Section images | heterozygote | 50% (1 of 2) |
Sublingual gland | Section images | heterozygote | 50% (1 of 2) |
Submandibular gland | Section images | heterozygote | 50% (1 of 2) |
Thymus | Section images | heterozygote | 50% (1 of 2) |
Tongue | Section images | heterozygote | 50% (1 of 2) |
Trachea | Section images | heterozygote | 50% (1 of 2) |
Urinary bladder | Section images | heterozygote | 50% (1 of 2) |
Uterus | Section images | heterozygote | 50% (1 of 2) |
Vagina | Section images | heterozygote | 50% (1 of 2) |
Vas deferens | Section images | heterozygote | 50% (1 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Blood | N/A | heterozygote | 0.0% (0 of 2) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 50% (1 of 2) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Jejunum | N/A | heterozygote | 0.0% (0 of 2) |
Large intestine | N/A | heterozygote | 50% (1 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | Not available |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
Penis | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Quadriceps | N/A | heterozygote | 0.0% (0 of 2) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 2) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 50% (1 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Testis | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | Not available |
Vesicular gland | N/A | heterozygote | 0.0% (0 of 2) |
White adipose tissue | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Heart atrium | N/A | heterozygote | 100% (8 of 8) |
Axial skeleton | N/A | heterozygote | 100% (8 of 8) |
Brain | N/A | heterozygote | 0.0% (0 of 8) |
Central nervous system ganglion | N/A | heterozygote | 25% (2 of 8) |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 8) |
Ear | N/A | heterozygote | 0.0% (0 of 8) |
Embryo | N/A | heterozygote | 100% (8 of 8) |
Outer ear | N/A | heterozygote | 0.0% (0 of 8) |
Eye | N/A | heterozygote | 87.5% (7 of 8) |
Femur pre-cartilage condensation | N/A | heterozygote | 60% (3 of 5) |
Footplate | N/A | heterozygote | 0.0% (0 of 8) |
Forearm | N/A | heterozygote | 87.5% (7 of 8) |
Forebrain | N/A | heterozygote | 0.0% (0 of 8) |
Forelimb | N/A | heterozygote | 87.5% (7 of 8) |
Fronto-nasal process | N/A | heterozygote | 62.5% (5 of 8) |
Gut | N/A | heterozygote | 71.43% (5 of 7) |
Handplate | N/A | heterozygote | 0.0% (0 of 8) |
Head mesenchyme | N/A | heterozygote | 75% (6 of 8) |
Head | N/A | heterozygote | 75% (6 of 8) |
Heart ventricle | N/A | heterozygote | 75% (6 of 8) |
Heart | N/A | heterozygote | 100% (8 of 8) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 8) |
Hindlimb | N/A | heterozygote | 62.5% (5 of 8) |
Humerus pre-cartilage condensation | N/A | heterozygote | 60% (3 of 5) |
Inner ear | N/A | heterozygote | 0.0% (0 of 5) |
Intestine | N/A | heterozygote | 75% (6 of 8) |
Liver | N/A | heterozygote | 0.0% (0 of 8) |
Lower leg | N/A | heterozygote | 25% (2 of 8) |
Lung | N/A | heterozygote | 12.5% (1 of 8) |
Mandibular process | N/A | heterozygote | 62.5% (5 of 8) |
Maxillary process | N/A | heterozygote | 62.5% (5 of 8) |
Meckel's cartilage | N/A | heterozygote | 62.5% (5 of 8) |
Midbrain | N/A | heterozygote | 0.0% (0 of 8) |
Nasal septum | N/A | heterozygote | 0.0% (0 of 8) |
Nose | N/A | heterozygote | 62.5% (5 of 8) |
Notochord | N/A | heterozygote | 37.5% (3 of 8) |
Oral cavity | N/A | heterozygote | 62.5% (5 of 8) |
Outflow tract | N/A | heterozygote | 100% (8 of 8) |
Chorioallantoic placenta | N/A | heterozygote | Not available |
Radius-ulna pre-cartilage condensation | N/A | heterozygote | 87.5% (7 of 8) |
Rib pre-cartilage condensation | N/A | heterozygote | 0.0% (0 of 2) |
Skeleton | N/A | heterozygote | 0.0% (0 of 8) |
Skin | N/A | heterozygote | 0.0% (0 of 8) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 8) |
Tail somite | N/A | heterozygote | 37.5% (3 of 8) |
Tail | N/A | heterozygote | 12.5% (1 of 8) |
Thoracic vertebral cartilage condensation | N/A | heterozygote | 0.0% (0 of 3) |
Tongue | N/A | heterozygote | 0.0% (0 of 5) |
Trunk mesenchyme | N/A | heterozygote | 62.5% (5 of 8) |
Umbilical artery embryonic part | N/A | heterozygote | 87.5% (7 of 8) |
Umbilical vein embryonic part | N/A | heterozygote | 87.5% (7 of 8) |
Upper arm | N/A | heterozygote | 62.5% (5 of 8) |
Upper leg | N/A | heterozygote | 62.5% (5 of 8) |
Vibrissa | N/A | heterozygote | 0.0% (0 of 8) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
atrium | Ambiguous |
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
dorsal root ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
external ear | Ambiguous |
eye | 0.0% |
femur pre-cartilage condensation | Ambiguous |
footplate | 0.0% |
forearm | Ambiguous |
forebrain | 0.0% |
forelimb | 0.0% |
fronto-nasal process | Ambiguous |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
head mesenchyme | Ambiguous |
heart | 0.0% |
heart ventricle | Ambiguous |
hindbrain | 0.0% |
hindlimb | 0.0% |
humerus pre-cartilage condensation | Ambiguous |
inner ear | Ambiguous |
intestine | Ambiguous |
liver | 0.0% |
lower leg | Ambiguous |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
meckel's cartilage | Ambiguous |
midbrain | 0.0% |
nasal septum | Ambiguous |
nose | Ambiguous |
notochord | Ambiguous |
oral cavity | 0.0% |
outflow tract | Ambiguous |
placenta | Ambiguous |
radius-ulna pre cartilage condensation | Ambiguous |
rib pre-cartilage condensation | Ambiguous |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
thoracic vertebral cartilage condensation | Ambiguous |
tongue | Ambiguous |
trunk mesenchyme | Ambiguous |
umbilical artery embryonic part | Ambiguous |
umbilical vein embryonic part | Ambiguous |
upper arm | Ambiguous |
upper leg | Ambiguous |
vibrissa | Ambiguous |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Slc25a3 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mitochondrial Phosphate Carrier Deficiency | Hypertrophic cardiomyopathy, Abnormal mitochondrial shape | OMIM:610773 | |
Cardiomyopathy-Hypotonia-Lactic Acidosis Syndrome | Hypertrophic cardiomyopathy | ORPHA:91130 |
The table below shows human diseases predicted to be associated to Slc25a3 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc25a3.
There are 6 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Slc25a3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
Slc25a3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Slc25a3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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