The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Orc4 by orthology or direct annotation.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Orc4.
There are 1 publication which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication†.||Biology of reproduction (April 2022)||Orc4tm1a(EUCOMM)Wtsi||PMC9040667|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
|MGI Allele||Allele Type||Produced|
|Orc4tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Orc4tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|