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Gene: Dmtf1 MGI:1344415

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cyclin D binding myb like transcription factor 1
Synonyms:
Dmp1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dmtf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dmtf1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Immunodeficiency 24
Decreased circulating IgG level, Lymphoproliferative disorder, Decreased CD4:CD8 ratio, Decreased... OMIM:615897
Urofacial Syndrome 2
Renal insufficiency, Recurrent urinary tract infections, Bladder trabeculation, Spastic/hyperacti... OMIM:615112
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Short stature, Polyuria, Megacystis, Seizure, Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Short stature, Polyuria, Megacystis, Seizure, Polydipsia OMIM:304800
Adrenomyodystrophy
Seizure, Abnormality of the urinary system, Short stature, Megacystis ORPHA:977
Brain-Lung-Thyroid Syndrome
Thyroid dysgenesis, Hypoparathyroidism, Hyperactivity, Short stature, Hypospadias, Abnormal eatin... ORPHA:209905
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased proportion of CD4-positive T cells, Lymphoproliferative disorder, B-cell lymphoma, Auto... OMIM:300853
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano... OMIM:606719
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 4
Recurrent urinary tract infections, Fetal pyelectasis, Megacystis, Nephrolithiasis OMIM:619365
Visceral Myopathy 2
Barrett esophagus, Megacystis, Dysphagia OMIM:619350
Atresia Of Urethra
Renal dysplasia, Renal insufficiency, Hydroureter, Recurrent urinary tract infections, Bladder fi... ORPHA:105
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Hydroureter, Megacystis, Fetal megacystis, Neonatal death, Hydronephrosis OMIM:619362
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Multicystic kidney dysplasia, Hydroureter, Neoplasm of the heart, Cryptorchidism, Megacystis ORPHA:2241
Monocyte Chemotactic Disorder
Cutaneous anergy OMIM:252250
Reticular Dysgenesis
Congenital agranulocytosis, Impaired T cell function, Lack of T cell function, Leukopenia, Hypopl... OMIM:267500
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Immunodeficiency 105
Impaired lymphocyte transformation with phytohemagglutinin, Decreased circulating IgG level, Panc... OMIM:619924
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Familial Visceral Myopathy
Vesicoureteral reflux, Hyperparathyroidism, Hydroureter, Megacystis ORPHA:2604
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Renal dysplasia, Duplicated collecting system, Hydroureter, Absence of Stensen duct, Decreased re... OMIM:604292
Griscelli Syndrome, Type 2
Seizure, Hemophagocytosis, Reduced delayed hypersensitivity, Hepatosplenomegaly OMIM:607624
Visceral Myopathy 1
Megacystis, Urinary retention, Dysphagia, Vesicoureteral reflux, Hydronephrosis OMIM:155310
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Pancytopenia, Decreased helper T cell proportion, Hypersplenism, Splenomegaly, Cutaneous anergy OMIM:183350
Immunodeficiency 64 With Lymphoproliferation
Increased proportion autoreactive unresponsive CD21-/low B cells, Decreased proportion of CD4-pos... OMIM:618534
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Immunodeficiency, Common Variable, 2
Impaired T cell function, Follicular hyperplasia, Splenomegaly, Lymphoma, Lymphadenopathy, Neopla... OMIM:240500
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Hydroureter, Megacystis, Hydronephrosis OMIM:619431
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Decreased proportion of CD8-positive T cells, Increased circulating IgE level, Increased circulat... OMIM:617241
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Chronic noninfectious lymphadenopathy, Eosinophilia, Autoimmune thro... OMIM:601859
Candidiasis, Familial, 1
Cutaneous anergy OMIM:114580
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Anuria, Megacystis, Pyelonephritis, Fetal megacystis, Renal cortical hyperechogenicity OMIM:619351
Schimke Immuno-Osseous Dysplasia
Impaired T cell function, Neutropenia, Nephropathy, Nephrotic range proteinuria, Short stature, M... ORPHA:1830
Autoimmune Lymphoproliferative Syndrome, Type Iia
Iron deficiency anemia, Increased circulating IgG level, Increased B cell count, Decreased lympho... OMIM:603909
Ataxia-Telangiectasia
Non-Hodgkin lymphoma, Tremor, Choreoathetosis, T lymphocytopenia, Hypoplasia of the thymus, Decre... OMIM:208900
Immunodeficiency, Common Variable, 1
Impaired T cell function, Splenomegaly, Neutropenia in presence of anti-neutropil antibodies, Dec... OMIM:607594
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absence of lymph node germinal center, Increased circulating IgE level, Lack of T cell function, ... ORPHA:277
Megabladder, Congenital
Hyperechogenic kidneys, Multiple glomerular cysts, Fetal megacystis, Stage 5 chronic kidney disease OMIM:618719
Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Small scrotum, Proteinuria, Postnatal growth retardation, Cryptorchidism, Multiple bladder divert... ORPHA:2728
Roifman Syndrome
Short stature, Hypogonadotropic hypogonadism, Eosinophilia, Postnatal growth retardation, Hepatos... ORPHA:353298
Purine Nucleoside Phosphorylase Deficiency
Autoimmune hemolytic anemia, Recurrent urinary tract infections, Impaired T cell function, Pure r... OMIM:613179
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Hypoparathyroidism, Renal dysplasia, Renal insufficiency, Abnormality of T cell physiology, Unila... ORPHA:2237
Obesity Due To Congenital Leptin Deficiency
Hypergonadotropic hypogonadism, Pituitary hypothyroidism, Hypoplasia of the ovary, Decreased prop... ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Hypergonadotropic hypogonadism, Pituitary hypothyroidism, Hypoplasia of the ovary, Decreased prop... ORPHA:179494
Congenital Disorder Of Glycosylation, Type Iil
Pancytopenia, Impaired T cell function, Unilateral renal agenesis, Splenomegaly, Decreased specif... OMIM:614576
Immunodeficiency By Defective Expression Of Mhc Class Ii
Pancytopenia, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, Abnormal CD4:CD8 ratio, N... ORPHA:572
Immunodeficiency With Hyper-Igm, Type 1
Hemolytic anemia, Dysgammaglobulinemia, Impaired Ig class switch recombination, Absence of lymph ... OMIM:308230
Visceral Neuropathy-Brain Anomalies-Facial Dysmorphism-Developmental Delay Syndrome
Intrauterine growth retardation, Multicystic kidney dysplasia, Fetal megacystis, Cryptorchidism ORPHA:73246
Immunodeficiency 96
Multicystic kidney dysplasia, Increased proportion of gamma-delta T cells, Growth delay, Decrease... OMIM:619774
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Impaired lymphocyte transformation with phytohemagglutinin, Decreased circulating IgG level, Abse... ORPHA:35078
Posterior Urethral Valve
Renal insufficiency, Recurrent urinary tract infections, Urinary incontinence, Dysuria, Postnatal... ORPHA:93110
Vici Syndrome
Decreased circulating IgG level, Lymphopenia, Postnatal growth retardation, Decreased circulating... OMIM:242840
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Impaired lymphocyte transformation with phytohemagglutinin, Absent natural killer cells, Decrease... OMIM:600802
Pseudoleprechaunism Syndrome, Patterson Type
Intrauterine growth retardation, Bladder diverticulum, Atonic seizure, Bilateral tonic-clonic sei... ORPHA:2976
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Short stature, Impaired T cell function, Tremor, Splenomegaly, Hypogonadism, Decreased testicular... OMIM:201100
T-Cell Immunodeficiency With Thymic Aplasia
Aplasia of the thymus, Hepatosplenomegaly, T lymphocytopenia, Abnormally low T cell receptor exci... OMIM:242700
Wiskott-Aldrich Syndrome
Impaired lymphocyte transformation with phytohemagglutinin, Autoimmune hemolytic anemia, Absent m... OMIM:301000
Immunodeficiency 58
Recurrent cutaneous abscess formation, Short stature, Dysuria, Decreased circulating antibody lev... OMIM:618131
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1
Hydroureter, Fetal megacystis OMIM:249210
Occipital Horn Syndrome
Pelvic bone exostoses, Bladder carcinoma, Growth delay, Seizure, Hydronephrosis, Bladder divertic... OMIM:304150
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Perianal abscess, Leukocytosis, Increased circulating IgE level, Myoclonic seizure, Increased cir... OMIM:618213
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Renal dysplasia, Duplicated collecting system, Hydroureter, Absence of Stensen duct, Decreased re... OMIM:129900
Hereditary Orotic Aciduria
Orotic acid crystalluria, Impaired T cell function, Splenomegaly, Abnormality of the ureter, Amin... ORPHA:30
Acro-Renal-Ocular Syndrome
Renal malrotation, Renal hypoplasia/aplasia, Postnatal growth retardation, Horseshoe kidney, Blad... ORPHA:959
Orotic Aciduria
Orotic acid crystalluria, Impaired T cell function, Anisocytosis, Folate-unresponsive megaloblast... OMIM:258900
Menkes Disease
Intrauterine growth retardation, Bladder diverticulum, Seizure, Exostoses ORPHA:565
T-Cell Immunodeficiency With Thymic Aplasia
Recurrent urinary tract infections, Decreased proportion of naive T cells, Aplasia of the thymus,... ORPHA:83471
Bare Lymphocyte Syndrome, Type Ii
Recurrent urinary tract infections, Agammaglobulinemia, Neutropenia, Cutaneous anergy, Panhypogam... OMIM:209920
Ehlers-Danlos Syndrome, Arthrochalasia Type, 2
Bladder diverticulum OMIM:617821
Williams Syndrome
Hypoplasia of penis, Tremor, Abnormal tubulointerstitial morphology, Nephrocalcinosis, Compulsive... ORPHA:904
Autosomal Recessive Cutis Laxa Type 1
Recurrent urinary tract infections, Severe short stature, Pyelonephritis, Urethral diverticulum, ... ORPHA:90349
Cutis Laxa, Autosomal Recessive, Type Ia
Bladder diverticulum OMIM:219100
Cutis Laxa, Autosomal Recessive, Type Ic
Accessory spleen, Growth delay, Hypoplasia of the thymus, Multiple bladder diverticula, Hydroneph... OMIM:613177
Williams-Beuren Syndrome
Renal insufficiency, Recurrent urinary tract infections, Short stature, Urethral stenosis, Abnorm... OMIM:194050
Velocardiofacial Syndrome
Hypoparathyroidism, Short stature, Impaired T cell function, Aggressive behavior, Cryptorchidism OMIM:192430
Occipital Horn Syndrome
Bladder diverticulum, Recurrent urinary tract infections, Dysphagia, Exostoses ORPHA:198
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Hydroureter, Hypospadias, Asplenia, Dilatation of the renal pelvis, Dilatation of the bladder, Bi... OMIM:265380
Autosomal Dominant Cutis Laxa
Unilateral renal agenesis, Postnatal growth retardation, Pyelonephritis, Bladder diverticulum, In... ORPHA:90348
22Q11.2 Deletion Syndrome
Hypoparathyroidism, Short stature, Hypospadias, Impaired T cell function, Cryptorchidism, Splenom... ORPHA:567
Sarcoidosis, Susceptibility To, 1
Pancytopenia, Generalized lymphadenopathy, Abnormality of T cell physiology, Anorexia, Mediastina... OMIM:181000
Progeroid Short Stature With Pigmented Nevi
Short stature, Impaired T cell function, Hypospadias, Chordee, Delayed puberty OMIM:176690
Kyphoscoliotic Ehlers-Danlos Syndrome
Bladder diverticulum, Short stature ORPHA:536545
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Bladder diverticulum, Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio OMIM:225400
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2
Bladder diverticulum OMIM:614557
Digeorge Syndrome
Renal dysplasia, Renal insufficiency, Short stature, Parathyroid agenesis, Unilateral renal agene... OMIM:188400
Classical Ehlers-Danlos Syndrome
Uterine prolapse, Bladder diverticulum, Cervical insufficiency ORPHA:287
Vascular Ehlers-Danlos Syndrome
Hypospadias, Short stature, Cryptorchidism, Cystocele, Renovascular hypertension, Bladder diverti... ORPHA:286
Cardiac-Urogenital Syndrome
Bifid scrotum, Accessory spleen, Penoscrotal hypospadias, Unilateral cryptorchidism, Cryptorchidi... OMIM:618280

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dmtf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dmtf1.

No publications found that use IMPC mice or data for Dmtf1.

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MGI Allele Allele Type Produced
Dmtf1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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