Med1 | mediator complex subunit 1

GeneMGI:1100846Synonyms: DRIP205, Pparbp, +5 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Reproductive system Integument Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging

12 No significant impact

5 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues

Phenotypes

embryonic lethality prior to tooth bud stage1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
abnormal placenta size1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
abnormal embryo size1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
pallor1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
small superior vagus ganglion1 supporting datasetMed1tm3b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
hydrometra1 supporting datasetMed1tm3b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
pale yolk sac1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetMed1tm3b(EUCOMM)WtsihomozygoteE12.5N/A * 
enlarged uterus1 supporting datasetMed1tm3b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Med1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Med1tm1e(KOMP)WtsiTargeted, non-conditional allelees cell
Med1tm3a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Med1tm3b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Med1tm3e(EUCOMM)WtsiTargeted, non-conditional allelees cell

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