Ampd3 | adenosine monophosphate deaminase 3

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

14 No significant impact

4 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

decreased circulating potassium level1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult2.55x10-9 
decreased circulating glucose level1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult1.04x10-6 
abnormal behavior3 supporting datasetsAmpd3tm2a(KOMP)WtsihomozygoteEarly adult3.97x10-9 
increased leukocyte cell number1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult4.63x10-7 
increased lean body mass1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult7.9x10-5 
decreased circulating magnesium level1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult1.08x10-5 
decreased total body fat amount1 supporting datasetAmpd3tm2a(KOMP)WtsihomozygoteEarly adult1.12x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/an/a0.19% (1/533)
blood vesselheterozygoten/a0% (0/2)0% (0/173)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/an/a0.56% (3/532)
cerebral cortexheterozygoten/an/a0.41% (2/491)
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Associated images

Histopathology

IMPC related publications

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Ampd3tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ampd3tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Ampd3tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ampd3tm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Ampd3tm42333(L1L2_Pgk_PM)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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