Cxcr4 | C-X-C motif chemokine receptor 4

GeneMGI:109563Synonyms: PB-CKR, Cmkar4, +4 more

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Cxcr4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	heterozygote	Early adult	1.69x10^-9
edema	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta size	1 supporting dataset	Cxcr4^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cxcr4.

Associated images

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Histopathology

There is no histopathology data found for Cxcr4.

IMPC related publications

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External links

No external links available for Cxcr4.

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*Cxcr4^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Cxcr4^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Cxcr4^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cxcr4^{tm374833(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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