Itih4 | inter alpha-trypsin inhibitor, heavy chain 4

GeneMGI:109536Synonyms: Itih-4

Physiological systems

21 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Mortality/aging

20 No significant impact

3 Not tested

Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance1 supporting datasetItih4tm3b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/1)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/2)0% (0/22)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoten/a0% (0/2)7.75% (22/284)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
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Histopathology

IMPC related publications

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Itih4tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Itih4tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Itih4tm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Itih4tm3a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Itih4tm3b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Itih4tm3e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Itih4tm44787(L1L2_st0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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