Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

5-hydroxytryptamine (serotonin) receptor 2A
Htr2,  Htr-2,  5-HT2A receptor

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Htr2a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Htr2a by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Alcohol Dependence

The table below shows human diseases predicted to be associated to Htr2a by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Lithium Transport
Bipolar affective disorder OMIM:152420
Major Affective Disorder 2
Bipolar affective disorder OMIM:309200
Panic Disorder 1
Anxiety OMIM:167870
Mental Retardation, Autosomal Recessive 25
Anxiety OMIM:614346
Major Affective Disorder 1
Depression OMIM:125480
Severe Primary Trimethylaminuria
Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity, Anxiety, Depression ORPHA:468726
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Mental Retardation, Autosomal Recessive 59
Aggressive behavior OMIM:617323
Epilepsy With Bilateral Occipital Calcifications
Celiac disease OMIM:226810
Familial Alzheimer-Like Prion Disease
Anxiety, Attention deficit hyperactivity disorder, Emotional lability, Depression ORPHA:280397
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Chorea, Benign Hereditary
Gait disturbance, Anxiety OMIM:118700
Developmental And Epileptic Encephalopathy 56
Ataxia, Attention deficit hyperactivity disorder, Broad-based gait, Anxiety OMIM:617665
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Mental Retardation, Autosomal Dominant 52
Hyperactivity, Anxiety OMIM:617796
Geniospasm 1
Anxiety OMIM:190100
Persistent Idiopathic Facial Pain
Anxiety, Depression ORPHA:398147
Colonic Varices Without Portal Hypertension
Intestinal bleeding, Colonic varices OMIM:120440
Myoclonus-Dystonia Syndrome
Dystonia, Writer's cramp, Torticollis, Personality disorder, Panic attack, Anxiety, Depression ORPHA:36899
Dystonia 11, Myoclonic
Writer's cramp, Torticollis, Agoraphobia, Anxiety, Depression OMIM:159900
Sagliker Syndrome
Anxiety, Waddling gait, Depression ORPHA:300493
Epilepsy, Progressive Myoclonic, 12
Dysmetria, Ataxia, Anxiety, Attention deficit hyperactivity disorder, Depression, Difficulty walking OMIM:619191
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Hyperactivity, Aggressive behavior, Anxiety OMIM:619031
Dystonia 12
Dystonia, Torticollis, Bradykinesia, Emotional lability, Unsteady gait, Anxiety, Depression OMIM:128235
Abnormal fear/anxiety-related behavior, Agoraphobia, Claustrophobia, Irritability, Emotional labi... ORPHA:66624
Wolfram-Like Syndrome, Autosomal Dominant
Anxiety, Depression OMIM:614296
Huntington Disease-Like 2
Dystonia, Apathy, Bradykinesia, Irritability, Anxiety, Depression OMIM:606438
Dystonia 26, Myoclonic
Torticollis, Laryngeal dystonia, Depression, Anxiety, Blepharospasm OMIM:616398
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Inappropriate behavior, Falls, Apathy, Shuffling gait, Bradykinesia, Short stepped shuffling gait... ORPHA:412066
Parkinson Disease 6, Autosomal Recessive Early-Onset
Dystonia, Anxiety, Depression, Bradykinesia OMIM:605909
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis
Paroxysmal dystonia, Anxiety OMIM:602066
Rapid-Onset Dystonia-Parkinsonism
Torticollis, Bradykinesia, Craniofacial dystonia, Emotional lability, Anxiety, Gait ataxia, Depre... ORPHA:71517
Huntington Disease-Like 1
Dysmetria, Aggressive behavior, Unsteady gait, Anxiety, Depression OMIM:603218
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Dystonia, Inappropriate behavior, Ataxia, Anxiety, Depression ORPHA:401901
Creutzfeldt-Jakob Disease
Apathy, Irritability, Anxiety, Gait ataxia, Depression OMIM:123400
Gastric Volvulus, Intrathoracic
Volvulus, Hiatus hernia OMIM:137210
Childhood-Onset Benign Chorea With Striatal Involvement
Anxiety ORPHA:494541
Spinocerebellar Ataxia 12
Axial dystonia, Dysmetria, Progressive cerebellar ataxia, Dysdiadochokinesis, Anxiety, Depression OMIM:604326
Chronic Intestinal Pseudoobstruction
Pyloric stenosis, Abnormal intestine morphology, Intestinal malrotation ORPHA:2978
Parkinsonism With Polyneuropathy
Anxiety, Depression, Bradykinesia OMIM:619279
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Ataxia, Anxiety, Depression, Difficulty walking OMIM:619425
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Shuffling gait, Hyperactivity, Irrit... ORPHA:3077
Parkinson Disease 7, Autosomal Recessive Early-Onset
Anxiety, Leg dystonia, Blepharospasm, Bradykinesia OMIM:606324
Basal Ganglia Calcification, Idiopathic, 5
Athetosis, Anxiety, Apathy, Depression OMIM:615483
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Ataxia, Anxiety OMIM:618970
Spinocerebellar Ataxia 48
Dystonia, Dysmetria, Ataxia, Irritability, Anxiety, Gait ataxia, Depression OMIM:618093
Pancreatic Lipase Deficiency
Steatorrhea, Fat malabsorption OMIM:614338
Aggressive behavior, Self-mutilation, Hyperactivity, Irritability, Anxiety, Attention deficit hyp... OMIM:261600
Early-Onset Schizophrenia
Unhappy demeanor, Low self esteem, Suicidal ideation, Irritability, Anhedonia, Emotional lability... ORPHA:96369
Perry Syndrome
Dystonia, Inappropriate behavior, Suicidal ideation, Apathy, Bradykinesia, Short stepped shufflin... OMIM:168605
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear/anxiety-related behavior, Aggressive behavior, Suicidal ideation ORPHA:208441
Inflammatory Bowel Disease (Crohn Disease) 30
Abnormal intestine morphology, Esophagitis, Duodenitis, Gastritis, Pancolitis, Protein-losing ent... OMIM:619079
Intellectual Developmental Disorder With Behavioral Abnormalities And Craniofacial Dysmorphism With Or Without Seizures
Anxiety, Attention deficit hyperactivity disorder OMIM:618725
Rolandic Epilepsy
Anxiety, Attention deficit hyperactivity disorder, Emotional lability, Depression ORPHA:1945
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Dystonia, Dysmetria, Aggressive behavior, Bradykinesia, Ataxia, Dysdiadochokinesis, Anxiety, Depr... OMIM:615157
Dyskinesia With Orofacial Involvement, Autosomal Dominant
Dystonia, Anxiety OMIM:606703
Annular Pancreas
High intestinal obstruction, Duodenal stenosis, Annular pancreas ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis, Annular pancreas OMIM:167750
Intussusception OMIM:147710
Distal 7Q11.23 Microduplication Syndrome
Anxiety, Attention deficit hyperactivity disorder ORPHA:261102
Visceral Myopathy 2
Dysphagia, Rectal prolapse, Megaduodenum, Intestinal pseudo-obstruction, Volvulus, Esophagitis, I... OMIM:619350
Stiff Person Spectrum Disorder
Agoraphobia, Falls, Emotional lability, Anxiety, Difficulty walking ORPHA:3198
Mal De Débarquement
Unsteady gait, Anxiety, Gait imbalance ORPHA:210272
Intellectual Developmental Disorder With Autistic Features And Language Delay, With Or Without Seizures
Anxiety, Attention deficit hyperactivity disorder, Spastic ataxia OMIM:618906
Intellectual Developmental Disorder, X-Linked 107
Aggressive behavior, Hyperactivity, Attention deficit hyperactivity disorder, Anxiety OMIM:301013
Duodenal Atresia
Duodenal atresia OMIM:223400
Dystonia, Aggressive behavior, Self-mutilation of tongue and lips due to involuntary movements, E... OMIM:200150
Gist-Plus Syndrome
Intussusception, Gastrointestinal stroma tumor, Intestinal polyposis OMIM:175510
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 5
Anxiety, Gait ataxia, Depression OMIM:613077
Gm2 Gangliosidosis, Ab Variant
Dystonia, Anxiety, Abnormal fear/anxiety-related behavior, Inappropriate behavior ORPHA:309246
Porphyria Due To Ala Dehydratase Deficiency
Abnormal fear/anxiety-related behavior, Apathy, Anxiety, Depression, Difficulty walking ORPHA:100924
Microcolon OMIM:251400
Congenital Heart Defects, Multiple Types, 7
Anxiety, Depression OMIM:618780
Alcohol Dependence


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Htr2a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Htr2a.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nature communications (November 2018) Htr2atm1c(EUCOMM)Hmgu Htr2atm1a(EUCOMM)Hmgu PMC6240035

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Htr2atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Htr2atm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Htr2atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter