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Gene: Amot MGI:108440

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
angiomotin
Synonyms:
Sii6,  D0Kist1,  E230009N18Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Amot mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Amot by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Placental Insufficiency
Abnormal placenta morphology, Abnormal umbilical cord blood vessel morphology, Small placenta, In... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Intrauterine growth retardation, Severe intrauterine growth retardation, Small placenta ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Intrauterine growth retardation, Small placenta, Oligohydramnios ORPHA:397590
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Large placenta, Polyhydramnios, Umbilical hernia ORPHA:254534
Restrictive Dermopathy
Short umbilical cord, Large placenta, Polyhydramnios, Small placenta, Patent ductus arteriosus, A... ORPHA:1662
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Stillbirth, Polyhydramnios, Small placenta, Increased nuchal translucency, ... OMIM:208150
Neu-Laxova Syndrome 1
Short umbilical cord, Stillbirth, Polyhydramnios, Small placenta, Patent ductus arteriosus, Hydra... OMIM:256520
Arteriovenous Malformations Of The Brain
Cerebral arteriovenous malformation OMIM:108010
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Intrauterine growth retardation, Large placenta, Polyhydramnios, Umbilical hernia ORPHA:254528
Mosaic Trisomy 16
Single umbilical artery, Large placenta, Premature birth, Patent ductus arteriosus, Intrauterine ... ORPHA:1708
Congenital Syphilis
Intrauterine growth retardation, Hydrops fetalis, Large placenta, Premature birth ORPHA:499009
Greenberg Dysplasia
Stillbirth, Large placenta, Hydrops fetalis, Polyhydramnios, Increased nuchal translucency, Neona... OMIM:215140
Trichohepatoenteric Syndrome 1
Intrauterine growth retardation, Large placenta, Polyhydramnios, Abnormalities of placenta or umb... OMIM:222470
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Premature birth ORPHA:254519
Restrictive Dermopathy 1
Short umbilical cord, Stillbirth, Polyhydramnios, Patent ductus arteriosus, Premature birth, Neon... OMIM:275210
Meckel Syndrome, Type 1
Single umbilical artery, Occipital encephalocele, Large placenta, Breech presentation, Anencephal... OMIM:249000
Capillary Malformation-Arteriovenous Malformation
Nonimmune hydrops fetalis, Cerebral arteriovenous malformation ORPHA:137667
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome
Cerebral arteriovenous malformation, Aortic aneurysm OMIM:175050
Parkes Weber Syndrome
Myelopathy, Cerebral arteriovenous malformation ORPHA:90307
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Large placenta, Polyhydramnios, Premature birth, Intrauterine growth retardation, Spinal dysraphism ORPHA:96334
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Large placenta, Polyhydramnios, Premature birth, Umbilical hernia ORPHA:116
Phace Syndrome
Aortic root aneurysm, Cerebral arteriovenous malformation ORPHA:42775
Trichorhinophalangeal Syndrome, Type Ii
Cerebral arteriovenous malformation OMIM:150230
Telangiectasia, Hereditary Hemorrhagic, Type 4
Cerebral arteriovenous malformation OMIM:610655
Juvenile Polyposis Syndrome
Cerebral arteriovenous malformation ORPHA:2929
Hereditary Hemorrhagic Telangiectasia
Cerebral arteriovenous malformation ORPHA:774
Telangiectasia, Hereditary Hemorrhagic, Type 2
Cerebral arteriovenous malformation OMIM:600376
Telangiectasia, Hereditary Hemorrhagic, Type 1
Cerebral arteriovenous malformation OMIM:187300

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Amot

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Amot.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Amotl1tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Amotl1tm1a(EUCOMM)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Amottm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Amottm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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