Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
angiomotin
Synonyms:
Sii6,  D0Kist1,  E230009N18Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Amot mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Amot by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Placental Insufficiency
Small placenta, Intrauterine growth retardation, Abnormal placenta morphology, Abnormal umbilical... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small placenta, Intrauterine growth retardation, Severe intrauterine growth retardation ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Small placenta, Intrauterine growth retardation, Oligohydramnios ORPHA:397590
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Large placenta, Umbilical hernia ORPHA:254534
Restrictive Dermopathy
Premature birth, Small placenta, Intrauterine growth retardation, Large placenta, Short umbilical... ORPHA:1662
Fetal Akinesia Deformation Sequence 1
Small placenta, Intrauterine growth retardation, Increased nuchal translucency, Short umbilical c... OMIM:208150
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Intrauterine growth retardation, Short umbilical cord, Decreased... OMIM:256520
Arteriovenous Malformations Of The Brain
Cerebral arteriovenous malformation OMIM:108010
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Polyhydramnios, Intrauterine growth retardation, Large placenta, Umbilical hernia ORPHA:254528
Mosaic Trisomy 16
Intrauterine growth retardation, Large placenta, Single umbilical artery, Patent ductus arteriosu... ORPHA:1708
Congenital Syphilis
Intrauterine growth retardation, Large placenta, Hydrops fetalis, Premature birth ORPHA:499009
Greenberg Dysplasia
Large placenta, Increased nuchal translucency, Nonimmune hydrops fetalis, Neonatal death, Stillbi... OMIM:215140
Trichohepatoenteric Syndrome 1
Polyhydramnios, Intrauterine growth retardation, Large placenta, Abnormalities of placenta or umb... OMIM:222470
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Premature birth ORPHA:254519
Restrictive Dermopathy 1
Premature rupture of membranes, Spontaneous chorioamniotic separation, Intrauterine growth retard... OMIM:275210
Meckel Syndrome, Type 1
Occipital encephalocele, Intrauterine growth retardation, Large placenta, Oligohydramnios, Breech... OMIM:249000
Capillary Malformation-Arteriovenous Malformation
Cerebral arteriovenous malformation, Nonimmune hydrops fetalis ORPHA:137667
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome
Aortic aneurysm, Cerebral arteriovenous malformation OMIM:175050
Parkes Weber Syndrome
Cerebral arteriovenous malformation, Myelopathy ORPHA:90307
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Intrauterine growth retardation, Large placenta, Polyhydramnios, Premature birth ORPHA:96334
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Umbilical hernia, Large placenta, Polyhydramnios, Premature birth ORPHA:116
Phace Syndrome
Cerebral arteriovenous malformation, Aortic root aneurysm ORPHA:42775
Trichorhinophalangeal Syndrome, Type Ii
Cerebral arteriovenous malformation OMIM:150230
Telangiectasia, Hereditary Hemorrhagic, Type 4
Cerebral arteriovenous malformation OMIM:610655
Juvenile Polyposis Syndrome
Cerebral arteriovenous malformation ORPHA:2929
Hereditary Hemorrhagic Telangiectasia
Cerebral arteriovenous malformation ORPHA:774
Telangiectasia, Hereditary Hemorrhagic, Type 2
Cerebral arteriovenous malformation OMIM:600376
Telangiectasia, Hereditary Hemorrhagic, Type 1
Cerebral arteriovenous malformation OMIM:187300

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Amot

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Amot.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Amotl1tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Amotl1tm1a(EUCOMM)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Amottm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Amottm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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