Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform

GeneMGI:107164Synonyms: CnA, Calna, +5 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Growth/size/body region Hematopoietic system Behavior/neurological

13 No significant impact

5 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased body weight2 supporting datasetsPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult2.12x10-6 
increased blood urea nitrogen level1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult1.67x10-6 
abnormal tail movements1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult5.6x10-6 
decreased circulating magnesium level1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult3.4x10-5 
decreased mean corpuscular volume1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult3.84x10-5 
abnormal coat/hair pigmentation1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult2.34x10-6 
decreased circulating amylase level1 supporting datasetPpp3catm2e(EUCOMM)WtsihomozygoteEarly adult6.22x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ppp3catm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ppp3catm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Ppp3catm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ppp3catm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
mouse
Ppp3catm3e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Ppp3catm42411(L1L2_Pgk_PM)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Ppp3catm42411(L1L2_st1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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