Gene: Sik1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Sik1tm1.1(KOMP)Vlcg HOM Early adult 9.98×10-09
increased lean body mass Sik1tm1.1(KOMP)Vlcg HOM Early adult 2.02×10-07
increased heart weight Sik1tm1.1(KOMP)Vlcg HOM Early adult 3.64×10-11
decreased lean body mass Sik1tm1.1(KOMP)Vlcg HOM Early adult 6.36×10-06
improved glucose tolerance Sik1tm1.1(KOMP)Vlcg HOM Early adult 2.31×10-05
increased bone mineral content Sik1tm1.1(KOMP)Vlcg HOM Early adult 6.92×10-07
decreased body length Sik1tm1.1(KOMP)Vlcg HOM Early adult 9.37×10-09

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (4/4)  Wholemount images  Section images
Aorta 4 No  (3/4)  Wholemount images  Section images
Blood 4 No N/A
Bone marrow 4 No N/A
Brain 4 No  (2/4)  Wholemount images
Brainstem 4 No N/A
Brown adipose tissue 4 No  (4/4)  Wholemount images  Section images
Cartilage tissue 4 No N/A
Cecum 4 No  (12/379)  (4/4)  Wholemount images  Section images
Cerebellum 4 No  (4/4)  Wholemount images  Section images
Cerebral cortex 4 No N/A
Chest bone 4 No  (2/4)  Wholemount images
Colon 4 No  (12/127)  (4/4)  Wholemount images  Section images
Diaphragm 4 No  (4/4)  Wholemount images  Section images
Duodenum 4 No  (2/127)  (3/4)  Wholemount images  Section images
Epididymis 4 No  (18/134)  (2/4)  Wholemount images  Section images
Esophagus 4 No  (7/415)  (4/4)  Wholemount images  Section images
Eye 4 No  (4/4)  Wholemount images  Section images
Gall bladder 4 No  (2/4)  Wholemount images
Gonadal fat pad 4 No  (2/4)  Wholemount images
Harderian gland 4 No  (4/4)  Wholemount images  Section images
Heart 4 No N/A
Hindlimb 4 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Ileum 4 No  (14/127)  (3/4)  Wholemount images  Section images
Jejunum 4 No  (6/127)  (3/4)  Wholemount images  Section images
Kidney 4 No  (18/584)  (4/4)  Wholemount images  Section images
Large intestine 4 No  (10/584) N/A
Liver 4 No  (3/4)  Wholemount images  Section images
Lower urinary tract 4 No N/A
Lung 4 No  (4/4)  Wholemount images  Section images
Lymph node 4 No N/A
Mammary gland 4 No N/A
Mesenteric adipose tissue 4 No  (3/4)  Wholemount images  Section images
Mesenteric lymph node 4 No  (3/4)  Wholemount images  Section images
Midbrain 4 No  (4/4)  Wholemount images  Section images
Olfactory lobe 4 No  (4/4)  Wholemount images  Section images
Ovary 4 No  (1/584)  (2/4)  Wholemount images  Section images
Oviduct 4 No  (2/4)  Wholemount images  Section images
Pancreas 4 No  (5/584)  (3/4)  Wholemount images  Section images
Parathyroid gland 4 No  (2/4)  Section images
Parotid gland 4 No  (1/4)  Section images
Penis 4 No  (1/4)  Section images
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (4/4)  Wholemount images  Section images
Prostate gland 4 No  (12/584)  (2/4)  Wholemount images  Section images
Quadriceps 4 No  (4/4)  Wholemount images  Section images
Sciatic nerve 4 No N/A
Skeletal muscle 4 No N/A
Skin 4 No  (4/4)  Wholemount images  Section images
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No  (3/4)  Wholemount images  Section images
Spleen 4 No  (2/584)  (4/4)  Wholemount images  Section images
Stomach 4 No  (12/584)  (4/4)  Wholemount images  Section images
Stomach pyloric region 4 No N/A
Striatum 4 No N/A
Sublingual gland 4 No  (2/4)  Section images
Submandibular gland 4 No  (2/132)  (2/4)  Section images
Testis 4 No  (2/584)  (2/4)  Wholemount images  Section images
Thymus 4 No  (4/4)  Wholemount images  Section images
Thyroid gland 4 No  (15/584)  (3/4)  Wholemount images  Section images
Tongue 4 No  (5/127)  (4/4)  Wholemount images  Section images
Trachea 4 No  (4/4)  Wholemount images  Section images
Trigeminal V nerve 4 No  (1/4)  Section images
Urinary bladder 4 No  (4/4)  Wholemount images  Section images
Uterus 4 No  (2/4)  Wholemount images  Section images
Vagina 4 No  (1/4)  Section images
Vas deferens 4 No  (15/388)  (2/4)  Wholemount images  Section images
Vascular system 4 No N/A
Vesicular gland 4 No  (2/4)  Wholemount images  Section images
White adipose tissue 4 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Wholemount
58 Images
Adult LacZ: LacZ Images Section
216 Images
X-ray: XRay Images Whole Body Dorso Ventral
42 Images
X-ray: XRay Images Whole Body Lateral Orientation
20 Images

 Disease Models

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MGI Allele Allele Type Produced
Sik1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Sik1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Sik1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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