Gene: Penk

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Penktm1(KOMP)Mbp HOM Early adult 1.93×10-06
abnormal adipose tissue amount Penktm1(KOMP)Mbp HOM Early adult 7.18×10-05
abnormal retina morphology Penktm1(KOMP)Mbp HOM Early adult 4.77×10-05
abnormal bone mineralization Penktm1(KOMP)Mbp HOM Early adult 2.37×10-06
absent testes Penktm1(KOMP)Mbp HOM Early adult 0.00
abnormal locomotor activation Penktm1(KOMP)Mbp HOM Early adult 8.07×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 Yes  (3/589)  Wholemount images
Aorta 4 No  (1/589) N/A
Bone 4 Yes  Wholemount images
Brain 4 Yes  (3/589)  (6/6)  Wholemount images
Brainstem 4 No  (2/589)  (6/6) N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No N/A
Cecum 4 Yes  (12/379)  (4/6)  Wholemount images
Cerebellum 4 No  (3/589)  (6/6) N/A
Cerebral cortex 4 No  (2/589) N/A
Chest bone 4 Yes  Wholemount images
Colon 4 No  (12/127)  (6/6) N/A
Cranium 4 No N/A
Diaphragm 4 No N/A
Duodenum 4 Yes  (2/127)  Wholemount images
Epididymis 4 Yes  (18/134)  Wholemount images
Esophagus 4 Yes  (7/415)  (6/6)  Wholemount images
Eye 4 No N/A
Gall bladder 4 Yes  Wholemount images
Gonadal fat pad 4 No N/A
Harderian gland 4 Yes  Wholemount images
Heart 4 No  (1/589) N/A
Hindlimb 4 No N/A
Hippocampus 4 No  (3/589) N/A
Hypothalamus 4 No  (2/589)  (6/6) N/A
Ileum 4 Yes  (14/127)  (6/6)  Wholemount images
Jejunum 4 Yes  (6/127)  Wholemount images
Kidney 4 Yes  (20/589)  (6/6)  Wholemount images
Large intestine 4 Yes  (10/589)  (6/6)  Wholemount images
Liver 4 Yes  Wholemount images
Lower urinary tract 4 No  (1/589) N/A
Lung 4 No  (1/589) N/A
Lymph node 4 Yes  Wholemount images
Main olfactory bulb 4 No N/A
Mammary gland 4 No N/A
Mesenteric adipose tissue 4 No N/A
Mesenteric lymph node 4 Yes  Wholemount images
Midbrain 4 No  (6/6) N/A
Olfactory lobe 4 No  (2/589) N/A
Oral epithelium 4 No N/A
Ovary 4 Yes  (1/589)  Wholemount images
Oviduct 4 No  Wholemount images
Pancreas 4 No  (5/589) N/A
Parathyroid gland 4 No N/A
Parotid gland 4 No N/A
Penis 4 Yes  Wholemount images
Peripheral nervous system 4 No  (1/589) N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/589) N/A
Prostate gland 4 Yes  (12/589)  Wholemount images
Quadriceps 4 No N/A
Sciatic nerve 4 No N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/589)  (4/6) N/A
Spinal cord 4 Yes  (2/589)  (6/6)  Wholemount images
Spleen 4 No  (2/589)  Wholemount images
Stomach 4 Yes  (13/589)  Wholemount images
Stomach pyloric region 4 No N/A
Striatum 4 No  (3/589)  (6/6) N/A
Sublingual gland 4 Yes  Wholemount images
Submandibular gland 4 Yes  (2/132)  Wholemount images
Testis 4 Yes  (5/589)  (3/6)  Wholemount images
Thalamus 4 No  (6/6) N/A
Thymus 4 No N/A
Thyroid gland 4 Yes  (16/589)  Wholemount images
Tongue 4 Yes  (5/127)  (6/6)  Wholemount images
Trachea 4 Yes  (2/589)  (6/6)  Wholemount images
Trigeminal V nerve 4 No N/A
Urinary bladder 4 Yes  Wholemount images
Uterus 4 Yes  Wholemount images
Vagina 4 Yes  Wholemount images
Vas deferens 4 No  (15/388) N/A
Vascular system 4 No N/A
Vesicular gland 4 Yes  Wholemount images
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 7  (6/506)  (7/7) N/A
Ear 7  (1/506) N/A
Embryo 7  (1/507)  (7/7)  Wholemount images
Eye 7  (1/506) N/A
Foot 7  (1/506) N/A
Forearm 7  (1/301) N/A
Forebrain 7  (1/506) N/A
Forelimb 7  (1/506) N/A
Hand 7  (1/505) N/A
Head 7  (5/506)  (7/7)  Wholemount images
Heart 7  (1/506)  (3/7)  Wholemount images
Hindbrain 7  (6/506) N/A
Hindlimb 7  (1/505) N/A
Liver 7  (1/506) N/A
Lower leg 7  (1/301) N/A
Lung 7  (1/502) N/A
Mandibular process 7  (1/506)  (5/7) N/A
Maxillary process 7  (1/506)  (7/7)  Wholemount images
Midbrain 7  (1/506)  (7/7) N/A
Oral cavity 7  (1/506) N/A
Skin 7  (1/506) N/A
Tail 7  (1/506) N/A
Tail somite 7  (1/506) N/A
Upper arm 7  (1/301) N/A
Upper leg 7  (1/301) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
52 Images
Adult LacZ: LacZ Images Wholemount
291 Images
Eye Morphology: Images Slit Lamp
1 Images
X-ray: XRay Images Whole Body Lateral Orientation
32 Images
X-ray: XRay Images Whole Body Dorso Ventral
41 Images
Gross Pathology and Tissue Collection
3 Images
Eye Morphology: Images Ophthalmoscopy
9 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Penktm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Penktm429447(L1L2_GT0_LF2A_LacZ_BetactP_neo) Targeting vectors
Penktm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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