Gene: Tfeb

Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Tfebtm1a(EUCOMM)Wtsi HET postnatal 9.20×10-08
embryonic lethality prior to tooth bud stage Tfebtm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00
decreased lean body mass Tfebtm1b(EUCOMM)Wtsi HET postnatal 7.39×10-05
preweaning lethality, complete penetrance Tfebtm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased bone mineral content Tfebtm1b(EUCOMM)Wtsi HET postnatal 6.49×10-06
trunk curl Tfebtm1b(EUCOMM)Wtsi HET postnatal 5.39×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (2/584)  (3/3)  Wholemount images
Aorta 3 No  (3/3)  Wholemount images
Bone 3 No  (3/3)  Wholemount images
Brain 3 No  (3/3)  Wholemount images
Brainstem 3 No  (3/3)  Wholemount images
Brown adipose tissue 3 No N/A
Cartilage tissue 3 No  (3/3)  Wholemount images
Cecum 3 No  (12/383) N/A
Cerebellum 3 No  (3/3)  Wholemount images
Cerebral cortex 3 No  (3/3)  Wholemount images
Esophagus 3 No  (7/415)  (3/3) N/A
Eye 3 No N/A
Gall bladder 3 No  (3/3)  Wholemount images
Heart 3 No  (3/3)  Wholemount images
Hippocampus 3 No  (3/3)  Wholemount images
Hypothalamus 3 No  (3/3)  Wholemount images
Kidney 3 No  (18/584)  (3/3)  Wholemount images
Large intestine 3 No  (10/584) N/A
Liver 3 No N/A
Lower urinary tract 3 No  Wholemount images
Lung 3 No  (3/3) N/A
Lymph node 3 No N/A
Mammary gland 3 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 3 No  (3/3)  Wholemount images
Oral epithelium 3 No N/A
Ovary 3 No  (1/584) N/A
Oviduct 3 No  (1/3)  Wholemount images
Pancreas 3 No  (5/584)  (3/3)  Wholemount images
Parathyroid gland 3 No  (3/3)  Wholemount images
Peripheral nervous system 3 No  (3/3) N/A
Peyer's patch 3 No  (3/3)  Wholemount images
Pituitary gland 3 No  (3/3)  Wholemount images
Prostate gland 3 No  (12/584) N/A
Skeletal muscle 3 No N/A
Skin 3 No N/A
Small intestine 3 No  (9/584) N/A
Spinal cord 3 No  (3/3)  Wholemount images
Spleen 3 No  (2/584) N/A
Stomach 3 No  (12/584) N/A
Striatum 3 No  (3/3)  Wholemount images
Testis 3 No  (2/584)  (2/3)  Wholemount images
Thymus 3 No N/A
Thyroid gland 3 No  (15/584)  (3/3)  Wholemount images
Trachea 3 No  (3/3)  Wholemount images
Trigeminal V nerve 3 No  (3/3) N/A
Urinary bladder 2 No N/A
Uterus 3 No N/A
Vas deferens 3 No  (15/388)  (2/3)  Wholemount images
Vascular system 3 No  (1/3)  Wholemount images
White adipose tissue 3 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3  (1/47) N/A
Axial skeleton 3  (1/51) N/A
Brain 3  (6/485) N/A
Central nervous system ganglion 3  (1/51)  (3/3) N/A
Cranium 3  (1/46) N/A
Dorsal root ganglion 3  (1/47) N/A
Ear 3  (1/485) N/A
Embryo 3  (1/485)  (3/3) N/A
Outer ear 3  (1/47) N/A
Eye 3  (1/485) N/A
Femur pre-cartilage condensation 3  (1/46) N/A
Foot 3  (1/485) N/A
Forearm 3  (1/282) N/A
Forebrain 3  (1/485) N/A
Forelimb 3  (1/485) N/A
Fronto-nasal process 3  (1/48) N/A
Gut 3  (1/50) N/A
Hand 3  (1/485) N/A
Head 3  (5/485) N/A
Head mesenchyme 3  (1/47) N/A
Heart 3  (1/485)  (3/3) N/A
Heart ventricle 3  (1/47)  (3/3) N/A
Hindbrain 3  (6/485) N/A
Hindlimb 3  (1/485) N/A
Humerus pre-cartilage condensation 3  (1/46) N/A
Inner ear 3  (1/46) N/A
Intestine 3  (1/47) N/A
Liver 3  (1/485) N/A
Lower leg 3  (1/282) N/A
Lung 3  (1/485) N/A
Mandibular process 3  (1/485) N/A
Maxillary process 3  (1/485) N/A
Mesonephros of female 3  (1/46) N/A
Mesonephros of male 3  (1/46) N/A
Metanephros 3  (1/46) N/A
Midbrain 3  (1/485) N/A
Nasal septum 3  (1/47) N/A
Nose 3  (1/51) N/A
Notochord 3  (1/47) N/A
Oral cavity 3  (1/485) N/A
Outflow tract 3  (1/47) N/A
Pancreas 3  (1/46) N/A
Pericardium 3  (1/46) N/A
Pharynx 3  (1/46) N/A
Radius-ulna pre-cartilage condensation 3  (1/46) N/A
Rib pre-cartilage condensation 3  (1/46) N/A
Skeleton 3  (1/51) N/A
Skin 3  (1/485) N/A
Spinal cord 3  (1/50) N/A
Stomach 3  (1/46) N/A
Tail 3  (1/485) N/A
Tail somite 3  (1/485) N/A
Thoracic vertebral cartilage condensation 3  (1/46) N/A
Tongue 3  (1/46) N/A
Trachea 3  (1/50) N/A
Trunk mesenchyme 3  (1/47) N/A
Umbilical artery embryonic part 3  (1/47) N/A
Umbilical vein embryonic part 3  (1/47) N/A
Upper arm 3  (1/282) N/A
Upper leg 3  (1/282) N/A
Urinary system 3  (1/50) N/A
Vibrissa 3  (1/47) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
18 Images
X-ray: XRay Images Dorso Ventral
17 Images
X-ray: XRay Images Skull Lateral Orientation
17 Images
X-ray: XRay Images Lateral Orientation
17 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
17 Images
X-ray: XRay Images Forepaw
17 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Tfebtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Tfebtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells, Tissue
Tfebtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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