The IMPC has collected over 850,000 images (DR23, April 2025) derived from systematic phenotyping of wild-type and mutant mouse lines. The collection spans multiple imaging modalities, including X-Ray, slit lamp eye imaging, Optical Coherence Tomography, light microscopy, microCT reconstructions of embryos, and histological sections, and has contributed to identification of candidate mouse models for more than 1,400 human diseases.
Sustainable Storage
To ensure long-term image preservation, we’ve deposited over 640,000 X-ray and eye morphology images in The BioImage Archive (BIA) [1] , a permanent repository for image data:
- X-Ray Collection: S-BIAD2244
- Eye Morphology Collection: S-BIAD2786
The remaining IMPC image collections will follow.
Each submission includes experimental protocols, instrument details, and gene information linked to mutant lines, meeting the REMBI metadata standard (see [2]) to ensure data is Findable, Accessible, Interoperable, and Reusable (FAIR).
Inclusion of these data in BIA means these images are available to the wider image analysis community as reference datasets for AI method development. As new tools emerge, IMPC benefits from improved analytical capabilities while the data reaches new research communities.
References
Hartley M. et. al., J Mol Biol. 2022 434:167505. doi: 10.1016/j.jmb.2022.167505.
Sarkans U et. al., Nat Methods. 2021 18:1418-1422. doi: 10.1038/s41592-021-01166-8.