A new consortium paper, ‘International Mouse Phenotyping Consortium Portal: facilitating investigation of gene function and providing insights into human disease’ by Wilson et al. (2025), published in Nucleic Acid Research, reports on the growth of the data resource and the improvements to the web portal. These changes allow for an easier use of the website and data while highlighting the relevance to human diseases.
With the expanding data resource, with over 100 million data points and over 110,000 phenotypes from 9,277 genes, the paper describes the cloud native architecture designed to support the rapidly increasing scale and complexity of this large dataset. The paper describes refinement of the disease-model identification algorithm, PhenoDigm, and a knowledge graph to integrate data across species. The design and infrastucture changes providing a smoother and more interactive user experience through data displays. Additional resources provide help in using the IMPC resources with training materials and code repositories. Finally, the paper looks into ensuring the longevity of the resource with plans for archiving images in the BioImage archive.
With these new improvements, IMPC data is ever more accessible and easier to integrate with other resources or research with the paper highlighting how IMPC data remains a valuable source to the scientific community.
References:
Wilson, R., Bülbül Ataç, T., Cheng, T. K., Frost, A., Güneş, O., Kan, M., Keskivali-Bond, P., López Gómez, F., McLaughlin, J., Mucha, J., Munava, T., Oliveira, C., Pava, D., Peña Estrada, J. F., Selkirk, E., Vardal, B., Wells, S., Cacheiro, P., Smedley, D., & Parkinson, H. (2025). International Mouse Phenotyping Consortium Portal: facilitating investigation of gene function and providing insights into human disease. Nucleic acids research, gkaf1148. Advance online publication. https://doi.org/10.1093/nar/gkaf1148