Gross Pathology and Tissue Collection: Images

59 weeks old

Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum

59 weeks old

Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Both kidneys were surrounded by adipose tissue,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was obese with hair loss on neck and back. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4

59 weeks old

Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules

59 weeks old

Liver: PATO:0000627,
Liver: PATO:0000322,
Liver: MP:0000598,
Liver: PATO:0001323,
Liver: PATO:0000407,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18

59 weeks old

Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3

59 weeks old

Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view

59 weeks old

Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum,
Sternum: MP:0002169

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules

59 weeks old

Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2

59 weeks old

Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3,
Sternum: PATO:0001323,
Sternum: PATO:0000323,
Sternum: PATO:0000386,
Sternum: MP:0000157

58 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4

59 weeks old

Liver: PATO:0000627,
Liver: PATO:0000322,
Liver: MP:0000598,
Liver: PATO:0001323,
Liver: PATO:0000407,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

58 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding

59 weeks old

Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3

59 weeks old

Ovary: MP:0001126,
Ovary: PATO:0000329,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18

59 weeks old

Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view

59 weeks old

Ovary: PATO:0000366,
Ovary: PATO:0000322,
Ovary: PATO:0001323,
Ovary: MP:0001126,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4

59 weeks old

Comments (in English): Animal was obese with hair loss on neck and back. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4,
Sternum: PATO:0000627,
Sternum: MP:0000157,
Sternum: PATO:0001334

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2

59 weeks old

Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding

59 weeks old

Seminal vesicle: PATO:0000366,
Seminal vesicle: PATO:0000322,
Seminal vesicle: PATO:0001323,
Seminal vesicle: MP:0002059,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2

59 weeks old

Skin: PATO:0000627,
Skin: MP:0002060,
Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view

59 weeks old

Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Both kidneys were surrounded by adipose tissue,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view

59 weeks old

Lymph node: MP:0000702,
Lymph node: PATO:0001323,
Lymph node: PATO:0000627,
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2

59 weeks old

Ovary: MP:0001126,
Ovary: PATO:0000952,
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2

59 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Comments (in English): Animal was obese There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3

59 weeks old

Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum

59 weeks old

Comments (in English): Animal was obese There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3

59 weeks old

Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding,
Sternum: MP:0000157

59 weeks old

Comments (in English): Animal was obese with hair loss on neck and back. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4

59 weeks old

Testes: PATO:0000952,
Testes: PATO:0001323,
Testes: PATO:0000366,
Testes: MP:0001147,
Comments (in English): Animal was obese There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; small intestine - abnormal small intestine morphology, area=5x6, nodule on wall of jejunum,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lymph nodes; Internal view of enlarged mesentery lymph node; mesentery; area=10x6,
Comments (in English): jejunum; Internal view of nodule on the wall of jejunum

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): The mouse was obese. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Gray hair interpersed with black hair. There was scabs on lower back skin. Animal was bright, alert and responsive. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, diameter=4,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of scabs on lower back skin; on lower back skin and tail base; area=30x18,
Comments (in English): ankle; Lateral view of ankle that couldn't straighten,
Comments (in English): Internal view

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, left preputial gland was cyst-like tissue,with size of 3x2mm,,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of nodule on inner side of sternum; inner side of sternum; area=3x2

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; small intestine - abnormal small intestine morphology, area=5x6, nodule on wall of jejunum,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lymph nodes; Internal view of enlarged mesentery lymph node; mesentery; area=10x6,
Comments (in English): jejunum; Internal view of nodule on the wall of jejunum

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; small intestine - abnormal small intestine morphology, area=5x6, nodule on wall of jejunum,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lymph nodes; Internal view of enlarged mesentery lymph node; mesentery; area=10x6,
Comments (in English): jejunum; Internal view of nodule on the wall of jejunum

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Gray hair interpersed with black hair. There was scabs on lower back skin. Animal was bright, alert and responsive. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, diameter=4,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of scabs on lower back skin; on lower back skin and tail base; area=30x18,
Comments (in English): ankle; Lateral view of ankle that couldn't straighten,
Comments (in English): Internal view

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Gray hair interpersed with black hair. There was scabs on lower back skin. Animal was bright, alert and responsive. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, diameter=4,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of scabs on lower back skin; on lower back skin and tail base; area=30x18,
Comments (in English): ankle; Lateral view of ankle that couldn't straighten,
Comments (in English): Internal view

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Skin: MP:0002060,
Skin: PATO:0001323,
Skin: PATO:0000627,
Comments (in English): Gray hair interpersed with black hair. There was scabs on lower back skin. Animal was bright, alert and responsive. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, diameter=4,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of scabs on lower back skin; on lower back skin and tail base; area=30x18,
Comments (in English): ankle; Lateral view of ankle that couldn't straighten,
Comments (in English): Internal view

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, left preputial gland was cyst-like tissue,with size of 3x2mm,,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of nodule on inner side of sternum; inner side of sternum; area=3x2

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Lymph node: MP:0000702,
Lymph node: PATO:0000627,
Lymph node: PATO:0002450,
Lymph node: PATO:0000324,
Lymph node: PATO:0001323,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; small intestine - abnormal small intestine morphology, area=5x6, nodule on wall of jejunum,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lymph nodes; Internal view of enlarged mesentery lymph node; mesentery; area=10x6,
Comments (in English): jejunum; Internal view of nodule on the wall of jejunum

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, left preputial gland was cyst-like tissue,with size of 3x2mm,,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of nodule on inner side of sternum; inner side of sternum; area=3x2,
Sternum: PATO:0001323,
Sternum: MP:0000157,
Sternum: PATO:0000627

59 weeks old

Rnf135^em1(IMPC)Tcp homozygote

Comments (in English): The mouse was obese. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; ovary - small ovary, diameter=1; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view