Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data; LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data; LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris,
Ophthalmoscope Observation: Restless mouse. Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data; LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris (difficult to focus), blood vessel slightly early branching, slight rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage; LEFT EYE: Some corneal and lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; RIGHT EYE: Slight lens opacity, blood vessel crossing, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, hyaloid present, some rd8; LEFT EYE: Some corneal and lens opacity, blood vessel early branching

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, small hyaloid present

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity, slight rd8; RIGHT EYE: Difficult to focus, crystallized debris

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus ), crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; LEFT EYE: Slight hemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity difficult to image and focus), very slight rd8; RIGHT EYE: Blood vessel early branching and crossing.

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8 ; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes crystallized debris; RIGHT EYE: Slight corneal opacity, some lens opacity, hyaloid present, slight rd8

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

15 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes crystallized debris, slight rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data; LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, blood vessel slightly early branching, slight rd8, slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Right eye closed, retina no data

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; LEFT EYE: Slight dysplasia and very slight hemorrhaging,
Ophthalmoscope Observation: Both eyes slight rd8, slight lens opacity.; RIGHT EYE:

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8; RIGHT EYE: Some hemorrhage

14 weeks old

Osbpl8em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), crystallized debris, slight rd8, slight hemorrhage ; LEFT EYE:

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