Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, hyaloid present, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity, crystallized debris, slight dysplasia

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus). Some rd8, some hemorrhage; RIGHT EYE: Crystallized debris, blood vessel crossing, slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity. Blood vessel slightly early branching. Lesions,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Tiny crystallized debris. Moderate rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Crystallized debris (obstructing part of retina). Some rd8, very slight molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Tiny crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, blood vessel early branching, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; LEFT EYE: Blood vessel slightly early branching. Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; LEFT EYE: Slight lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8 ; RIGHT EYE: Some corneal and lens opacity, hyaloid and bright crystallized debris present (obstructing part of optic disc and retina), molten patches

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches ; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity. Multiple tiny hyaloid, crystallized debris. Some dysplasia,
Ophthalmoscope Observation: Both eyes blood vessel early branching and crossing. Some rd8, slight hemorrhage; RIGHT EYE: Some corneal opacity/cataract and lens opacity (difficult to focus and image). Hyaloid (obstructing part of optic disc). Slight molten patches

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE:

13 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris ; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; LEFT EYE: Blood vessel early branching and crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8; RIGHT EYE: Crystallized debris

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Hyaloid present, blood vessel early branching, some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8, moderate dysplasia, slight hemorrhage

15 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; LEFT EYE: Some lens opacity, multiple tiny hyaloid,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris and small hyaloid, blood vessel early branching

14 weeks old

Rnf43em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

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