Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight dysplasia, some molten patches; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; LEFT EYE: Blood vessel early branching and crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Some corneal opacity, some lens opacity, hyaloid and crystallized debris present, slight molten patches

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present, slight rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia ; RIGHT EYE: Slight lens opacity, some rd8, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, blood vessel slightly early branching, some molten patches,
Ophthalmoscope Observation: Both eyes slight corneal opacity (difficult to focus), some lens opacity, hyaloid present (obstructing part of retina and optic disc), some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity, slight dysplasia, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity (difficult to focus), blood vessel early branching, some dysplasia, slight hemorrhage

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; LEFT EYE: Bright crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia ; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Slight dysplasia

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris ; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; LEFT EYE: Multiple crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, somight dysplasia, slight hemorrhage, early blood vessel branching; RIGHT EYE: Small crystallized debris

15 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes blood vessel slightly early branching, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity (difficult to focus), some lens opacity, hyaloid and crystallized debris present

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; LEFT EYE: Slight lens opacity, lesion present, slight hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8, slight dysplasia ; RIGHT EYE: Slight corneal opacity, some lens opacity, small hyaloid present, early blood vessel branching and crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage, abnormal bright retinal patches, slight molten patches; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Small crystallized debris, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Blood vessel crossing

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus); LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; LEFT EYE: Slight lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, very slight hemorrhage; RIGHT EYE: Slight corneal opacity, some lens opacity, bright crystallized debris, hyaloid present (obstructing the optic disc, difficult to focus)

14 weeks old

Rnaseh2aem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, bright crystallized debris (difficult to focus), very slight molten patches

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