Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Left eye images accidentally not saved,
Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Left eye images accidentally not saved,
Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; LEFT EYE: Slight lens opacity, some hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, early blood vessel branching; RIGHT EYE: Some lens opacity, slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage; LEFT EYE: Left eye images accidentally not saved,
Ophthalmoscope Observation: RIGHT EYE: Some lens opacity, small crystallized debris, some rd8, slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; LEFT EYE: Slight lens opacity and slightly early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, and slight hemorrhaging.; RIGHT EYE: Some lens opacity, and slight dysplasia.

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and hemorrhaging, slight dysplasia, early blood vessel branching; RIGHT EYE: Blood vessel crossing . White large spots/lesions. Slight lens opacity.

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8, hemorrhaging and slight dysplasia.; RIGHT EYE: Slightly early vessel branching. Some lens opacity (difficult to focus).

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, slight dysplasia, some rd8, early blood vessel branching ; RIGHT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Bright crystallized debris, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Some debris (difficult to focus),,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; LEFT EYE: Some hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes some lens opacity, early blood vessel branching, some rd8 ; RIGHT EYE: Slight hemorrhage

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, some molten patches.; RIGHT EYE: Early blood vessel branching, slight lens opacity

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Crystallized debris, slight lens opacity, early blood vessel branching

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8 ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; LEFT EYE: Some rd8, crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, hyaloid present ; RIGHT EYE: Slight hemorrhage, small crystallized debris, early blood vessel branching, slight rd8

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; LEFT EYE: Hyaloid present, crystallized debris, some lens opacity (difficult to focus), slight dysplasia and hemorrhage, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, blood vessel crossing; RIGHT EYE: Slight lens opacity, some dysplasia, small crystallized debris, early blood vessel branching and structure,

15 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate hemorrhaging/abnormal bright red patches, some rd8 and slight dysplasia, some lens opacity (difficult to image and focus).; RIGHT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; RIGHT EYE: Vessel crossing and early branching, bright crystallized debris (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8, slight dysplasia, hemorrhaging and lens opacity.; LEFT EYE:

14 weeks old

Fam135aem1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, bright crystallized debris, blood vessel crossing and early branching,
Ophthalmoscope Observation: Both eyes hyaloid present, some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity (difficult to focus), multiple early blood vessel branching , small crystallized debris, slight dysplasia

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