Histopathology data for Sirt2

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #3 Stomach [MA:0000353] inflammation [MPATH:212] 1 0 multi-localised chronic-active Gastritis, suppurative
HOM F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Thyroid normal [MPATH:458] 0 0
HOM F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #3 Liver [MA:0000358] lipid deposition [MPATH:42] 2 0 distributed Hepatic lipidosis
HOM F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #3 Eye with optic nerve normal [MPATH:458] 0 0
HOM M #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #3 Lymph node [MA:0000139] hyperplasia [MPATH:134] 1 0 distributed Lymphoid hyperplasia
HOM F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #3 Thyroid normal [MPATH:458] 0 0
HOM M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM F #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #2 Testes normal [MPATH:458] 0 0
HOM M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #2 Prostate normal [MPATH:458] 0 0
HOM F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Thyroid normal [MPATH:458] 0 0
HOM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0

Associated histopathology images

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