Score Definitions
Severity Score:
- 0 = Normal,
- 1 = Mild (observation barely perceptible and not believed to have clinical significance),
- 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
- 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
- 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)
Significance Score:
- 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
- 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.
| Zyg | Sex | Mouse | Tissue | MPATH Process Term | Severity Score | Significance Score | MPATH Diagnostic | PATO Descriptor | Free Text | Images |
|---|---|---|---|---|---|---|---|---|---|---|
| HET | M | #6 | Testis [MA:0000411] | 1 | 0 | multi-localised | testicular degeneration and atrophy with Leydig cell hyperplasia | |||
| HET | F | #5 | Femur [MA:0001359] | 0 | 0 | |||||
| HET | M | #6 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HET | F | #5 | Prostate gland [MA:0000404] | Not applicable | ||||||
| HET | M | #6 | Ovary [MA:0000384] | Not applicable | ||||||
| HET | M | #6 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HET | F | #2 | Uterus [MA:0000389] | 0 | 0 | |||||
| HOM | M | #3 | Lung [MA:0000415] | 0 | 0 | |||||
| HET | M | #6 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HOM | F | #1 | Trachea [MA:0000441] | 0 | 0 | |||||
| HOM | F | #1 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HET | F | #2 | Tongue [MA:0000347] | 0 | 0 | |||||
| HOM | F | #1 | Epididymis [MA:0000397] | Not applicable | ||||||
| HET | M | #6 | Seminal vesicle [MA:0000410] | 0 | 0 | |||||
| HET | F | #2 | Epididymis [MA:0000397] | Not applicable | ||||||
| HOM | F | #1 | Uterus [MA:0000389] | 0 | 0 | |||||
| HET | F | #5 | Sternum [MA:0001331] | 0 | 0 | |||||
| HET | F | #2 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HET | F | #2 | Trachea [MA:0000441] | 0 | 0 | |||||
| HET | M | #4 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HET | M | #4 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HET | M | #4 | Adrenal gland [MA:0000116] | 0 | 0 | |||||
| HET | F | #5 | Uterus [MA:0000389] | 0 | 0 | |||||
| HET | M | #4 | Testis [MA:0000411] | 1 | 0 | multi-localised | testicular degeneration and atrophy with Leydig cell hyperplasia | |||
| HET | M | #4 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HET | F | #2 | Eye [MA:0000261] | 0 | 0 | |||||
| HET | F | #5 | Epididymis [MA:0000397] | Not applicable | ||||||
| HET | M | #4 | Stomach [MA:0000353] | 0 | 0 | |||||
| HET | M | #4 | Mammary gland [MA:0000145] | Not applicable | ||||||
| HET | M | #4 | Seminal vesicle [MA:0000410] | 0 | 0 | |||||
| HOM | F | #1 | Femur [MA:0001359] | 0 | 0 | |||||
| HET | F | #2 | Sternum [MA:0001331] | Not applicable | 0 | chronic focally extensive | Sternal dislocation and reactive and reparative chondroid hyperplasia ('calus') | |||
| HOM | M | #3 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HOM | M | #3 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HET | F | #5 | Trachea [MA:0000441] | 0 | 0 | |||||
| HOM | M | #3 | Seminal vesicle [MA:0000410] | 0 | 0 | |||||
| HET | M | #4 | Ear [MA:0000236] | 0 | 0 | |||||
| HET | M | #6 | Mammary gland [MA:0000145] | Not applicable | ||||||
| HET | F | #2 | Thyroid | 0 | 0 | |||||
| HET | F | #2 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HET | F | #2 | Mammary gland [MA:0000145] | 0 | 0 | |||||
| HOM | M | #3 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HET | M | #4 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HOM | M | #3 | Testis [MA:0000411] | 0 | 0 | |||||
| HET | F | #2 | Femur [MA:0001359] | 0 | 0 | |||||
| HET | M | #4 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HET | M | #6 | Trachea [MA:0000441] | 0 | 0 | |||||
| HET | F | #5 | Thyroid | 0 | 0 | |||||
| HOM | F | #1 | Testis [MA:0000411] | Not applicable | ||||||
| HET | M | #4 | Epididymis [MA:0000397] | 0 | 0 | |||||
| HET | F | #5 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HOM | F | #1 | Stomach [MA:0000353] | 0 | 0 | |||||
| HOM | M | #3 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HOM | M | #3 | Tooth [MA:0000348] | 0 | 0 | |||||
| HOM | M | #3 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HET | M | #6 | Adrenal gland [MA:0000116] | 0 | 0 | |||||
| HET | F | #5 | Mammary gland [MA:0000145] | 0 | 0 | |||||
| HET | F | #5 | Heart [MA:0000072] | 0 | 0 | |||||
| HOM | M | #3 | Ear [MA:0000236] | 0 | 0 | |||||
| HET | M | #4 | Lung [MA:0000415] | 0 | 0 | |||||
| HET | M | #6 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HOM | F | #1 | Seminal vesicle [MA:0000410] | Not applicable | ||||||
| HOM | F | #1 | Eye [MA:0000261] | 0 | 0 | |||||
| HOM | F | #1 | Tongue [MA:0000347] | 0 | 0 | |||||
| HOM | F | #1 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HET | F | #2 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HET | M | #6 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HET | F | #2 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HET | M | #6 | Uterus [MA:0000389] | Not applicable | ||||||
| HET | M | #6 | Tongue [MA:0000347] | 0 | 0 | |||||
| HET | F | #5 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HOM | M | #3 | Stomach [MA:0000353] | 0 | 0 | |||||
| HET | M | #4 | Femur [MA:0001359] | 0 | 0 | |||||
| HET | F | #5 | Skin [MA:0000151] | 0 | 0 | |||||
| HET | M | #4 | Sternum [MA:0001331] | 0 | 0 | |||||
| HET | M | #4 | Kidney [MA:0000368] | 0 | 0 | |||||
| HET | M | #6 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HOM | F | #1 | Ear [MA:0000236] | 0 | 0 | |||||
| HET | M | #6 | Epididymis [MA:0000397] | 0 | 0 | |||||
| HOM | M | #3 | Eye [MA:0000261] | 0 | 0 | |||||
| HET | F | #5 | Ovary [MA:0000384] | 0 | 0 | |||||
| HET | M | #6 | Femur [MA:0001359] | 0 | 0 | |||||
| HOM | F | #1 | Spleen [MA:0000141] | 0 | 0 | |||||
| HET | F | #5 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HET | F | #5 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HET | M | #4 | Eye [MA:0000261] | 0 | 0 | |||||
| HOM | F | #1 | Lung [MA:0000415] | 0 | 0 | |||||
| HET | M | #4 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HOM | M | #3 | Kidney [MA:0000368] | 0 | 0 | |||||
| HOM | M | #3 | Sternum [MA:0001331] | 0 | 0 | |||||
| HET | F | #5 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HOM | M | #3 | Heart [MA:0000072] | 0 | 0 | |||||
| HOM | M | #3 | Skin [MA:0000151] | 0 | 0 | |||||
| HOM | M | #3 | Ovary [MA:0000384] | Not applicable | ||||||
| HET | F | #5 | Eye [MA:0000261] | 0 | 0 | |||||
| HET | M | #4 | Thymus [MA:0000142] | 0 | 0 | |||||
| HET | F | #5 | Ear [MA:0000236] | 0 | 0 | |||||
| HOM | M | #3 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HET | F | #5 | Liver [MA:0000358] | 1 1 | 0 0 | multi-localised subacute distributed | Mononuclear inflammatory aggregates Hepatocellular vacuolar change (midzonal and pericentral) | |||
| HET | M | #4 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HET | M | #4 | Trachea [MA:0000441] | 0 | 0 | |||||
| HOM | M | #3 | Adrenal gland [MA:0000116] | 0 | 0 | |||||
| HOM | F | #1 | Mammary gland [MA:0000145] | 0 | 0 | |||||
| HET | M | #6 | Tooth [MA:0000348] | 0 | 0 | |||||
| HET | F | #5 | Seminal vesicle [MA:0000410] | Not applicable | ||||||
| HOM | M | #3 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HOM | M | #3 | Thymus [MA:0000142] | 0 | 0 | |||||
| HOM | M | #3 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HOM | M | #3 | Trachea [MA:0000441] | 0 | 0 | |||||
| HET | F | #5 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HET | F | #5 | Testis [MA:0000411] | Not applicable | ||||||
| HET | F | #5 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HOM | M | #3 | Prostate gland [MA:0000404] | 0 | 0 | |||||
| HOM | F | #1 | Thyroid | 0 | 0 | |||||
| HOM | F | #1 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HET | M | #6 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HET | F | #2 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HET | M | #4 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HET | M | #4 | Ovary [MA:0000384] | Not applicable | ||||||
| HET | M | #4 | Prostate gland [MA:0000404] | 0 | 0 | |||||
| HET | F | #2 | Spleen [MA:0000141] | 0 | 0 | |||||
| HOM | F | #1 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HET | F | #5 | Stomach [MA:0000353] | 0 | 0 | |||||
| HET | F | #5 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HOM | F | #1 | Thymus [MA:0000142] | 0 | 0 | |||||
| HET | F | #2 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HET | M | #4 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HOM | M | #3 | Spleen [MA:0000141] | 0 | 0 | |||||
| HET | M | #6 | Heart [MA:0000072] | 0 | 0 | |||||
| HET | M | #6 | Liver [MA:0000358] | 1 1 | 0 0 | multi-localised subacute distributed | Hepatocellular vacuolar change (midzonal and pericentral) Mononuclear inflammatory aggregates | |||
| HET | M | #6 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HOM | M | #3 | Thyroid | 0 | 0 | |||||
| HET | F | #2 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HET | F | #5 | Kidney [MA:0000368] | 0 | 0 | |||||
| HET | M | #4 | Skin [MA:0000151] | 0 | 0 | |||||
| HET | F | #5 | Tooth [MA:0000348] | 0 | 0 | |||||
| HOM | M | #3 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HET | F | #5 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HET | F | #5 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HOM | F | #1 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HOM | F | #1 | Kidney [MA:0000368] | 0 | 0 | |||||
| HET | F | #5 | Lung [MA:0000415] | 0 | 0 | |||||
| HOM | F | #1 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HOM | F | #1 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HET | M | #4 | Liver [MA:0000358] | 1 1 | 0 0 | subacute multi-localised distributed | Mononuclear inflammatory aggregates Hepatocellular vacuolar change (midzonal and pericentral) | |||
| HET | F | #2 | Thymus [MA:0000142] | 0 | 0 | |||||
| HET | F | #2 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HET | M | #6 | Spleen [MA:0000141] | 0 | 0 | |||||
| HET | M | #4 | Heart [MA:0000072] | 0 | 0 | |||||
| HOM | F | #1 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HOM | M | #3 | Liver [MA:0000358] | 1 1 | 0 0 | distributed subacute multi-localised | Hepatocellular vacuolar change (midzonal and pericentral) Mononuclear inflammatory aggregates | |||
| HET | F | #2 | Tooth [MA:0000348] | 0 | 0 | |||||
| HET | F | #2 | Lung [MA:0000415] | 0 | 0 | |||||
| HOM | F | #1 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HET | M | #6 | Thyroid | 0 | 0 | |||||
| HET | F | #5 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HOM | F | #1 | Tooth [MA:0000348] | 0 | 0 | |||||
| HET | M | #4 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HET | F | #2 | Ear [MA:0000236] | 0 | 0 | |||||
| HET | F | #2 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HET | F | #2 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HOM | M | #3 | Femur [MA:0001359] | 0 | 0 | |||||
| HET | F | #5 | Thymus [MA:0000142] | 0 | 0 | |||||
| HOM | F | #1 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HOM | M | #3 | Tongue [MA:0000347] | 0 | 0 | |||||
| HOM | F | #1 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HET | F | #5 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HOM | M | #3 | Epididymis [MA:0000397] | 0 | 0 | |||||
| HET | M | #6 | Thymus [MA:0000142] | 0 | 0 | |||||
| HOM | M | #3 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HET | F | #5 | Adrenal gland [MA:0000116] | 0 | 0 | |||||
| HET | M | #6 | Skin [MA:0000151] | 0 | 0 | |||||
| HET | M | #6 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HET | F | #5 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HOM | M | #3 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HET | M | #4 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HOM | F | #1 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HOM | M | #3 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HET | F | #2 | Ovary [MA:0000384] | 0 | 0 | |||||
| HOM | M | #3 | Mammary gland [MA:0000145] | Not applicable | ||||||
| HET | M | #6 | Sternum [MA:0001331] | 0 | 0 | |||||
| HET | F | #2 | Testis [MA:0000411] | Not applicable | ||||||
| HET | M | #4 | Tongue [MA:0000347] | 0 | 0 | |||||
| HET | F | #2 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HOM | M | #3 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HET | F | #2 | Seminal vesicle [MA:0000410] | Not applicable | ||||||
| HET | F | #2 | Heart [MA:0000072] | 0 | 0 | |||||
| HET | M | #6 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HET | F | #2 | Liver [MA:0000358] | 1 1 | 0 0 | distributed subacute multi-localised | Hepatocellular vacuolar change (midzonal and pericentral) Mononuclear inflammatory aggregates | |||
| HET | M | #4 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HOM | F | #1 | Urinary bladder [MA:0000380] | 0 | 0 | |||||
| HET | M | #4 | Tooth [MA:0000348] | 0 | 0 | |||||
| HET | F | #2 | Brain [MA:0000168] | 1 | 0 | localized | trilateral hydrocephalus | |||
| HET | M | #4 | Pancreas [MA:0000120] | 0 | 0 | |||||
| HOM | F | #1 | Liver [MA:0000358] | 1 1 | 0 0 | distributed multi-localised subacute | Hepatocellular vacuolar change (midzonal and pericentral) Mononuclear inflammatory aggregates | |||
| HOM | F | #1 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HET | M | #6 | Prostate gland [MA:0000404] | 0 | 0 | |||||
| HET | M | #4 | Bone marrow [MA:0000134] | 0 | 0 | |||||
| HET | M | #6 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HET | M | #4 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HET | M | #4 | Thyroid | 0 | 0 | |||||
| HET | F | #5 | Lymph node [MA:0000139] | 1 1 | 0 0 | localized localized | Lymphoid hyperplasia with histiocytosis Lymphoid hyperplasia with histiocytosis | |||
| HET | F | #2 | Adrenal gland [MA:0000116] | 0 | 0 | |||||
| HET | F | #2 | Skin [MA:0000151] | 0 | 0 | |||||
| HOM | F | #1 | Ovary [MA:0000384] | 0 | 0 | |||||
| HET | F | #2 | Salivary gland [MA:0000346] | 0 | 0 | |||||
| HET | M | #6 | Kidney [MA:0000368] | 0 | 0 | |||||
| HOM | M | #3 | Skeletal muscle [MA:0003148] | 0 | 0 | |||||
| HET | M | #6 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HET | M | #6 | Lung [MA:0000415] | 0 | 0 | |||||
| HET | M | #4 | Spleen [MA:0000141] | 0 | 0 | |||||
| HET | M | #6 | Stomach [MA:0000353] | 0 | 0 | |||||
| HOM | F | #1 | Prostate gland [MA:0000404] | Not applicable | ||||||
| HET | F | #2 | Small intestine [MA:0000337] | 0 | 0 | |||||
| HET | M | #6 | Ear [MA:0000236] | 0 | 0 | |||||
| HOM | M | #3 | Gall bladder [MA:0000356] | 0 | 0 | |||||
| HET | M | #6 | Nasal cavity [MA:0000284] | 0 | 0 | |||||
| HET | M | #6 | Sciatic nerve [MA:0001172] | 0 | 0 | |||||
| HET | F | #2 | Stomach [MA:0000353] | 0 | 0 | |||||
| HET | F | #5 | Spleen [MA:0000141] | 0 | 0 | |||||
| HET | F | #2 | Spinal cord [MA:0000216] | 0 | 0 | |||||
| HET | M | #4 | Uterus [MA:0000389] | Not applicable | ||||||
| HET | F | #5 | Optic II nerve [MA:0001097] | 0 | 0 | |||||
| HOM | F | #1 | Sternum [MA:0001331] | 0 | 0 | |||||
| HOM | F | #1 | Heart [MA:0000072] | 0 | 0 | |||||
| HET | F | #2 | Prostate gland [MA:0000404] | Not applicable | ||||||
| HET | M | #6 | Large intestine [MA:0000333] | 0 | 0 | |||||
| HOM | F | #1 | Skin [MA:0000151] | 0 | 0 | |||||
| HET | M | #6 | Eye [MA:0000261] | 0 | 0 | |||||
| HOM | M | #3 | Uterus [MA:0000389] | Not applicable | ||||||
| HET | F | #5 | Tongue [MA:0000347] | 0 | 0 | |||||
| HOM | F | #1 | Esophagus [MA:0000352] | 0 | 0 | |||||
| HET | F | #2 | Kidney [MA:0000368] | 0 | 0 | |||||
| HOM | F | #1 | Adrenal gland [MA:0000116] | 0 | 0 |