Histopathology data for Rnf135

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #4 White adipose tissue [MA:0000058] 0 0
HOM F #1 Mammary gland [MA:0000145] 0 0
HOM F #8 Large intestine [MA:0000333] 0 0
HOM F #1 Stomach [MA:0000353] 0 0
HOM M #3 Ear [MA:0000236] 0 0
HOM F #7 Tibia [MA:0001361] 0 0
HOM M #5 Trachea [MA:0000441] 0 0
HOM F #1 Large intestine [MA:0000333] 0 0
HOM F #2 Sternum [MA:0001331] 0 0
HOM F #8 Seminal vesicle [MA:0000410] Not applicable
HOM M #3 Salivary gland [MA:0000346] 2 0 multi-localised chronic Lymphoid aggregates, salivary gland
HOM M #3 Small intestine [MA:0000337] 0 0
HOM M #4 Tongue [MA:0000347] 0 0
HOM M #5 Lymph node [MA:0000139] 0 0
HOM M #5 Salivary gland [MA:0000346] 0 0
HOM M #4 Sternum [MA:0001331] 2 0 localized chronic Segmental sternum dislocation
HOM M #4 Femur [MA:0001359] 0 0
HOM F #2 Spleen [MA:0000141] 0 0
HOM F #1 Eye [MA:0000261] 0 0
HOM F #7 Sciatic nerve [MA:0001172] 0 0
HOM F #7 Brain [MA:0000168] 0 0 Hydrocephalus, lateral ventricle
HOM M #5 Gall bladder [MA:0000356] 0 0
HOM F #7 Heart [MA:0000072] 0 0
HOM F #7 Skin [MA:0000151] 0 0
HOM M #4 Uterus [MA:0000389] Not applicable
HOM M #3 Lymph node [MA:0000139] 0 0
HOM M #6 Liver [MA:0000358] 0 0
HOM F #1 Epididymis [MA:0000397] Not applicable
HOM M #6 Tibia [MA:0001361] 0 0
HOM F #8 Uterus [MA:0000389] 0 0
HOM M #5 Nasal cavity [MA:0000284] 0 0
HOM F #8 Prostate gland [MA:0000404] Not applicable
HOM M #6 Small intestine [MA:0000337] 0 0
HOM F #1 Trachea [MA:0000441] 0 0
HOM M #6 Salivary gland [MA:0000346] 0 0
HOM F #2 Ovary [MA:0000384] 0 0
HOM F #2 Epididymis [MA:0000397] Not applicable
HOM F #8 Urinary bladder [MA:0000380] 0 0
HOM F #8 Adrenal gland [MA:0000116] 0 0
HOM M #4 Prostate gland [MA:0000404] 0 0
HOM M #3 Spinal cord [MA:0000216] 0 0
HOM M #3 Lung [MA:0000415] 3 0 localized chronic Carcinoid tumor
HOM F #1 Uterus [MA:0000389] 0 0
HOM M #6 Trachea [MA:0000441] 0 0
HOM M #3 Ovary [MA:0000384] Not applicable
HOM M #4 Epididymis [MA:0000397] 0 0
HOM F #2 Lymph node [MA:0000139] Not applicable 0 distributed chronic Lymphoma
HOM M #5 Tongue [MA:0000347] 0 0
HOM F #1 Tongue [MA:0000347] 0 0
HOM M #6 Spinal cord [MA:0000216] 0 0
HOM F #7 Liver [MA:0000358] 0 0
HOM M #6 Lymph node [MA:0000139] 0 0
HOM M #5 Brain [MA:0000168] 0 0
HOM M #4 Large intestine [MA:0000333] 0 0
HOM F #7 Thymus [MA:0000142] 0 0
HOM F #8 Eye [MA:0000261] 0 0
HOM F #2 Sciatic nerve [MA:0001172] 0 0
HOM M #6 Femur [MA:0001359] 0 0
HOM F #1 Optic II nerve [MA:0001097] 0 0
HOM M #4 Eye [MA:0000261] 0 0
HOM F #1 Ovary [MA:0000384] 0 0
HOM F #8 Spinal cord [MA:0000216] 0 0
HOM F #2 Esophagus [MA:0000352] 0 0
HOM F #1 Seminal vesicle [MA:0000410] Not applicable
HOM M #5 Small intestine [MA:0000337] 0 0
HOM F #8 Femur [MA:0001359] 0 0
HOM F #1 Testis [MA:0000411] Not applicable
HOM F #8 Thymus [MA:0000142] 0 0
HOM M #4 Spleen [MA:0000141] 0 0
HOM M #4 Pituitary gland [MA:0000176] 0 0
HOM F #8 Tibia [MA:0001361] 0 0
HOM M #6 Thymus [MA:0000142] 0 0
HOM M #3 Esophagus [MA:0000352] 0 0
HOM M #3 Gall bladder [MA:0000356] 0 0
HOM F #7 Kidney [MA:0000368] 0 0
HOM F #2 Brain [MA:0000168] 0 0
HOM M #5 Sciatic nerve [MA:0001172] 0 0
HOM M #3 Adrenal gland [MA:0000116] 0 0
HOM F #2 Kidney [MA:0000368] 0 0
HOM M #4 Brown adipose tissue [MA:0000057] 0 0
HOM M #4 Liver [MA:0000358] 0 0
HOM F #8 Skin [MA:0000151] 0 0
HOM F #7 Spleen [MA:0000141] 0 0
HOM F #7 Skeletal muscle [MA:0003148] 0 0
HOM M #5 Brown adipose tissue [MA:0000057] 0 0
HOM F #2 Salivary gland [MA:0000346] 0 0
HOM F #8 Skeletal muscle [MA:0003148] 0 0
HOM F #7 Spinal cord [MA:0000216] 0 0
HOM F #2 Tongue [MA:0000347] 0 0
HOM M #4 Stomach [MA:0000353] 0 0
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM M #6 Gall bladder [MA:0000356] 0 0
HOM M #5 Esophagus [MA:0000352] 0 0
HOM F #1 Urinary bladder [MA:0000380] 0 0
HOM F #8 Thyroid 0 0
HOM F #7 Pancreas [MA:0000120] 0 0
HOM F #1 Ear [MA:0000236] 0 0
HOM F #2 Pancreas [MA:0000120] 0 0
HOM F #7 Tooth [MA:0000348] 0 0
HOM M #5 Ovary [MA:0000384] Not applicable
HOM F #1 Spleen [MA:0000141] 0 0
HOM F #8 Testis [MA:0000411] Not applicable
HOM M #6 Sternum [MA:0001331] 2 0 localized chronic Segmental sternum dislocation
HOM F #7 Prostate gland [MA:0000404] Not applicable
HOM M #4 Heart [MA:0000072] 0 0
HOM F #8 Tooth [MA:0000348] 0 0
HOM F #1 Lung [MA:0000415] 0 0
HOM F #1 Thyroid 0 0
HOM M #6 Prostate gland [MA:0000404] 0 0
HOM F #1 Bone marrow [MA:0000134] 0 0
HOM M #6 Seminal vesicle [MA:0000410] 0 0
HOM M #6 Spleen [MA:0000141] 0 0
HOM M #4 Skin [MA:0000151] 0 0
HOM M #6 Uterus [MA:0000389] Not applicable
HOM M #3 Uterus [MA:0000389] Not applicable
HOM M #5 Spleen [MA:0000141] 1 0 chronic distributed Tri-lineage hyperplasia
HOM F #7 Tongue [MA:0000347] 0 0
HOM M #4 Lymph node [MA:0000139] Not applicable 0 distributed chronic Lymphoma, cervical lymph node.
HOM F #2 Mammary gland [MA:0000145] 0 0
HOM M #6 Urinary bladder [MA:0000380] 0 0
HOM M #5 Large intestine [MA:0000333] 0 0
HOM M #6 Heart [MA:0000072] 0 0
HOM M #4 Ovary [MA:0000384] Not applicable
HOM F #7 Sternum [MA:0001331] 0 0
HOM F #8 White adipose tissue [MA:0000058] 0 0
HOM F #7 Pituitary gland [MA:0000176] 0 0
HOM F #2 Thyroid 0 0
HOM F #8 Small intestine [MA:0000337] 0 0
HOM F #8 Trachea [MA:0000441] 0 0
HOM F #2 Gall bladder [MA:0000356] 0 0
HOM F #8 Salivary gland [MA:0000346] 0 0
HOM F #8 Knee joint [MA:0000471] 0 0
HOM M #3 Epididymis [MA:0000397] 0 0
HOM F #7 Brown adipose tissue [MA:0000057] 0 0
HOM F #7 Epididymis [MA:0000397] Not applicable
HOM F #2 Spinal cord [MA:0000216] 0 0
HOM M #6 Sciatic nerve [MA:0001172] 0 0
HOM M #4 Trachea [MA:0000441] 0 0
HOM M #5 Lung [MA:0000415] 0 0
HOM F #8 Nasal cavity [MA:0000284] 0 0
HOM M #3 Tongue [MA:0000347] 0 0
HOM F #7 Esophagus [MA:0000352] 0 0
HOM M #5 Skin [MA:0000151] 0 0
HOM F #8 Brown adipose tissue [MA:0000057] 0 0
HOM F #2 Femur [MA:0001359] 0 0
HOM M #4 Thymus [MA:0000142] 0 0
HOM M #5 Skeletal muscle [MA:0003148] 0 0
HOM M #3 Tooth [MA:0000348] 0 0
HOM M #4 Salivary gland [MA:0000346] 2 0 chronic multi-localised Lymphoid aggregates, salivary gland
HOM M #6 Esophagus [MA:0000352] 0 0
HOM M #5 Stomach [MA:0000353] 1 0 localized acute Suppurative gastritis.
HOM F #1 Gall bladder [MA:0000356] 0 0
HOM F #1 White adipose tissue [MA:0000058] 0 0
HOM F #7 Lymph node [MA:0000139] Not applicable 0 distributed chronic Lymphoma
HOM M #3 Pancreas [MA:0000120] 0 0
HOM M #3 Skeletal muscle [MA:0003148] 0 0
HOM F #8 Ear [MA:0000236] 0 0
HOM M #3 Brown adipose tissue [MA:0000057] 0 0
HOM M #4 Esophagus [MA:0000352] 0 0
HOM F #2 Liver [MA:0000358] 0 0
HOM M #3 Optic II nerve [MA:0001097] 0 0
HOM F #2 Heart [MA:0000072] 0 0
HOM M #5 Eye [MA:0000261] 0 0
HOM M #4 Adrenal gland [MA:0000116] 0 0
HOM M #5 Tooth [MA:0000348] 0 0
HOM M #6 Bone marrow [MA:0000134] 0 0
HOM F #7 Femur [MA:0001359] 0 0
HOM F #1 Tibia [MA:0001361] 0 0
HOM M #5 Thymus [MA:0000142] 0 0
HOM F #8 Pituitary gland [MA:0000176] 0 0
HOM F #8 Sternum [MA:0001331] 0 0
HOM F #8 Spleen [MA:0000141] 0 0
HOM M #5 Optic II nerve [MA:0001097] 0 0
HOM M #6 Pancreas [MA:0000120] 0 0
HOM F #2 Large intestine [MA:0000333] 0 0
HOM M #4 Spinal cord [MA:0000216] 0 0
HOM F #1 Nasal cavity [MA:0000284] 0 0
HOM M #5 White adipose tissue [MA:0000058] 1 0 acute localized Acute inflammation, white adipose tissue,
HOM F #2 Prostate gland [MA:0000404] Not applicable
HOM M #4 Tooth [MA:0000348] 0 0
HOM M #5 Knee joint [MA:0000471] 0 0
HOM M #4 Skeletal muscle [MA:0003148] 0 0
HOM F #8 Ovary [MA:0000384] 0 0
HOM M #4 Pancreas [MA:0000120] 0 0
HOM F #8 Epididymis [MA:0000397] Not applicable
HOM M #6 Tooth [MA:0000348] 0 0
HOM F #8 Kidney [MA:0000368] 0 0
HOM F #2 Seminal vesicle [MA:0000410] Not applicable
HOM M #3 Spleen [MA:0000141] 0 0
HOM M #3 Pituitary gland [MA:0000176] 0 0
HOM M #6 Testis [MA:0000411] 0 0
HOM F #2 Uterus [MA:0000389] 0 0
HOM M #4 Kidney [MA:0000368] 0 0
HOM M #5 Thyroid 0 0
HOM M #5 Pituitary gland [MA:0000176] 0 0
HOM F #2 Skin [MA:0000151] 0 0
HOM F #8 Tongue [MA:0000347] 0 0
HOM F #8 Heart [MA:0000072] 0 0
HOM F #1 Thymus [MA:0000142] 0 0
HOM F #2 Skeletal muscle [MA:0003148] 0 0
HOM F #7 Mammary gland [MA:0000145] 0 0
HOM F #8 Lung [MA:0000415] 0 0
HOM F #2 Ear [MA:0000236] 0 0
HOM M #4 Lung [MA:0000415] 0 0
HOM M #6 Knee joint [MA:0000471] 0 0
HOM M #4 Knee joint [MA:0000471] 0 0
HOM F #2 Bone marrow [MA:0000134] 0 0
HOM F #7 Stomach [MA:0000353] 0 0
HOM F #7 Optic II nerve [MA:0001097] 0 0
HOM F #7 Large intestine [MA:0000333] 0 0
HOM F #1 Knee joint [MA:0000471] 0 0
HOM F #8 Stomach [MA:0000353] 0 0
HOM M #6 White adipose tissue [MA:0000058] 0 0
HOM F #7 Seminal vesicle [MA:0000410] Not applicable
HOM F #7 Eye [MA:0000261] 0 0
HOM M #6 Optic II nerve [MA:0001097] 0 0
HOM M #3 Prostate gland [MA:0000404] 2 0 chronic localized Lymphoid aggregates, prostate
HOM F #7 Testis [MA:0000411] Not applicable
HOM F #8 Brain [MA:0000168] 0 0
HOM F #1 Sciatic nerve [MA:0001172] 0 0
HOM F #7 Adrenal gland [MA:0000116] 0 0
HOM F #1 Brain [MA:0000168] 0 0
HOM M #3 White adipose tissue [MA:0000058] 0 0
HOM F #7 Salivary gland [MA:0000346] 2 0 localized chronic Lymphoid aggregates
HOM M #5 Ear [MA:0000236] 0 0
HOM F #1 Kidney [MA:0000368] 0 0
HOM M #5 Prostate gland [MA:0000404] 0 0
HOM M #3 Femur [MA:0001359] 0 0
HOM M #4 Ear [MA:0000236] 0 0
HOM F #8 Lymph node [MA:0000139] 0 0
HOM M #6 Eye [MA:0000261] 0 0
HOM F #1 Skeletal muscle [MA:0003148] 0 0
HOM F #7 Trachea [MA:0000441] 0 0
HOM F #1 Spinal cord [MA:0000216] 0 0
HOM M #3 Skin [MA:0000151] 0 0
HOM F #8 Mammary gland [MA:0000145] 0 0
HOM F #7 Uterus [MA:0000389] 0 0
HOM F #7 Urinary bladder [MA:0000380] 0 0
HOM M #3 Sternum [MA:0001331] 2 0 localized chronic Segmental sternum dislocation
HOM M #4 Urinary bladder [MA:0000380] 0 0
HOM M #6 Skin [MA:0000151] 0 0
HOM M #6 Mammary gland [MA:0000145] Not applicable
HOM M #3 Bone marrow [MA:0000134] 0 0
HOM F #2 Small intestine [MA:0000337] 0 0
HOM F #1 Liver [MA:0000358] 0 0
HOM F #2 Urinary bladder [MA:0000380] 0 0
HOM M #5 Testis [MA:0000411] 0 0
HOM M #3 Thyroid 0 0
HOM F #2 Tibia [MA:0001361] 0 0
HOM M #4 Optic II nerve [MA:0001097] 0 0
HOM M #5 Bone marrow [MA:0000134] 0 0
HOM M #4 Small intestine [MA:0000337] 0 0
HOM M #6 Epididymis [MA:0000397] 0 0
HOM M #4 Seminal vesicle [MA:0000410] 0 0
HOM M #5 Urinary bladder [MA:0000380] 0 0
HOM M #6 Thyroid 0 0
HOM F #7 Ovary [MA:0000384] 0 0
HOM F #2 White adipose tissue [MA:0000058] 0 0
HOM M #3 Heart [MA:0000072] 0 0
HOM F #8 Gall bladder [MA:0000356] 0 0
HOM M #5 Uterus [MA:0000389] Not applicable
HOM M #3 Tibia [MA:0001361] 0 0
HOM M #6 Skeletal muscle [MA:0003148] 0 0
HOM F #2 Optic II nerve [MA:0001097] 0 0
HOM F #1 Small intestine [MA:0000337] 0 0
HOM M #5 Seminal vesicle [MA:0000410] 0 0
HOM F #2 Adrenal gland [MA:0000116] 0 0
HOM M #4 Brain [MA:0000168] 0 0
HOM M #3 Sciatic nerve [MA:0001172] 0 0
HOM M #6 Large intestine [MA:0000333] 0 0
HOM M #5 Adrenal gland [MA:0000116] 0 0
HOM M #3 Thymus [MA:0000142] 0 0
HOM F #1 Pituitary gland [MA:0000176] 0 0
HOM F #8 Pancreas [MA:0000120] 0 0
HOM M #3 Trachea [MA:0000441] 0 0
HOM F #7 Small intestine [MA:0000337] 0 0
HOM F #2 Testis [MA:0000411] Not applicable
HOM F #1 Brown adipose tissue [MA:0000057] 0 0
HOM M #3 Large intestine [MA:0000333] 0 0
HOM M #4 Testis [MA:0000411] 0 0
HOM F #2 Pituitary gland [MA:0000176] 0 0
HOM F #7 Ear [MA:0000236] 0 0
HOM F #2 Thymus [MA:0000142] 0 0
HOM F #1 Salivary gland [MA:0000346] 2 0 chronic multi-localised Lymphoid aggregates, salivary gland
HOM M #3 Knee joint [MA:0000471] 0 0
HOM F #1 Tooth [MA:0000348] 0 0
HOM F #2 Brown adipose tissue [MA:0000057] 0 0
HOM M #6 Brain [MA:0000168] 0 0
HOM F #8 Optic II nerve [MA:0001097] 0 0
HOM F #1 Prostate gland [MA:0000404] Not applicable
HOM M #6 Kidney [MA:0000368] 0 0
HOM F #1 Pancreas [MA:0000120] 0 0
HOM M #4 Sciatic nerve [MA:0001172] 0 0
HOM F #7 Thyroid 0 0
HOM M #6 Tongue [MA:0000347] 0 0
HOM M #5 Kidney [MA:0000368] 0 0
HOM F #7 Gall bladder [MA:0000356] 0 0
HOM M #3 Nasal cavity [MA:0000284] 0 0
HOM M #5 Tibia [MA:0001361] 0 0
HOM F #7 Bone marrow [MA:0000134] 0 0
HOM M #5 Liver [MA:0000358] 0 0
HOM F #7 White adipose tissue [MA:0000058] 0 0
HOM F #1 Lymph node [MA:0000139] 0 0
HOM M #6 Nasal cavity [MA:0000284] 0 0
HOM M #6 Adrenal gland [MA:0000116] 0 0
HOM M #6 Stomach [MA:0000353] 0 0
HOM M #6 Lung [MA:0000415] 0 0
HOM F #1 Heart [MA:0000072] 0 0
HOM F #1 Skin [MA:0000151] 0 0
HOM M #5 Heart [MA:0000072] 0 0
HOM M #4 Nasal cavity [MA:0000284] 0 0
HOM F #8 Bone marrow [MA:0000134] 0 0
HOM F #8 Sciatic nerve [MA:0001172] 0 0
HOM M #3 Brain [MA:0000168] 0 0
HOM F #2 Eye [MA:0000261] 0 0
HOM F #1 Sternum [MA:0001331] 0 0
HOM F #7 Knee joint [MA:0000471] 0 0
HOM M #3 Kidney [MA:0000368] 0 0
HOM F #8 Esophagus [MA:0000352] 0 0
HOM F #1 Femur [MA:0001359] 0 0
HOM F #1 Adrenal gland [MA:0000116] 0 0
HOM F #8 Liver [MA:0000358] 1 0 chronic localized Focal inflammation, liver
HOM M #6 Pituitary gland [MA:0000176] 0 0
HOM F #7 Nasal cavity [MA:0000284] 0 0
HOM M #4 Bone marrow [MA:0000134] 0 0
HOM M #5 Sternum [MA:0001331] 0 0
HOM F #2 Tooth [MA:0000348] 0 0
HOM F #1 Esophagus [MA:0000352] 0 0
HOM M #6 Ear [MA:0000236] 0 0
HOM M #3 Liver [MA:0000358] 0 0
HOM M #3 Testis [MA:0000411] 0 0
HOM M #3 Urinary bladder [MA:0000380] 0 0
HOM M #4 Gall bladder [MA:0000356] 0 0
HOM M #6 Ovary [MA:0000384] Not applicable
HOM M #4 Thyroid 0 0
HOM F #2 Knee joint [MA:0000471] 0 0
HOM M #4 Mammary gland [MA:0000145] Not applicable
HOM M #5 Spinal cord [MA:0000216] 0 0
HOM M #3 Eye [MA:0000261] 0 0
HOM M #3 Seminal vesicle [MA:0000410] 0 0
HOM M #5 Pancreas [MA:0000120] 0 0
HOM M #5 Epididymis [MA:0000397] 0 0
HOM F #7 Lung [MA:0000415] 0 0
HOM M #5 Femur [MA:0001359] 0 0
HOM M #6 Brown adipose tissue [MA:0000057] 0 0
HOM M #4 Tibia [MA:0001361] 0 0
HOM F #2 Trachea [MA:0000441] 0 0
HOM F #2 Nasal cavity [MA:0000284] 0 0
HOM F #2 Lung [MA:0000415] 0 0
HOM M #3 Stomach [MA:0000353] 0 0
HOM M #5 Mammary gland [MA:0000145] Not applicable
HOM F #2 Stomach [MA:0000353] 0 0

Associated histopathology images

Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental
Rnf135
homozygote
Rnf135em1(IMPC)Tcp
experimental

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